Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2Z7_LEIMA

TriTrypDb:

LmjF.34.2040 , LMJLV39_340024900 , LMJSD75_340025400

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Z7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.681
CLV_NRD_NRD_1	13	15	PF00675	0.532
CLV_NRD_NRD_1	355	357	PF00675	0.559
CLV_NRD_NRD_1	371	373	PF00675	0.397
CLV_NRD_NRD_1	41	43	PF00675	0.529
CLV_NRD_NRD_1	81	83	PF00675	0.556
CLV_PCSK_FUR_1	369	373	PF00082	0.424
CLV_PCSK_FUR_1	79	83	PF00082	0.575
CLV_PCSK_KEX2_1	13	15	PF00082	0.529
CLV_PCSK_KEX2_1	355	357	PF00082	0.554
CLV_PCSK_KEX2_1	371	373	PF00082	0.396
CLV_PCSK_KEX2_1	396	398	PF00082	0.675
CLV_PCSK_KEX2_1	81	83	PF00082	0.556
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.642
CLV_PCSK_SKI1_1	118	122	PF00082	0.603
CLV_PCSK_SKI1_1	310	314	PF00082	0.507
CLV_PCSK_SKI1_1	355	359	PF00082	0.406
CLV_PCSK_SKI1_1	393	397	PF00082	0.581
CLV_PCSK_SKI1_1	408	412	PF00082	0.680
DEG_APCC_DBOX_1	388	396	PF00400	0.530
DEG_Nend_UBRbox_3	1	3	PF02207	0.614
DEG_SPOP_SBC_1	398	402	PF00917	0.414
DOC_ANK_TNKS_1	50	57	PF00023	0.778
DOC_CKS1_1	183	188	PF01111	0.758
DOC_CKS1_1	8	13	PF01111	0.726
DOC_CYCLIN_RxL_1	405	416	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.411
DOC_MAPK_gen_1	369	379	PF00069	0.686
DOC_PP2B_LxvP_1	388	391	PF13499	0.411
DOC_PP2B_PxIxI_1	152	158	PF00149	0.669
DOC_PP4_FxxP_1	116	119	PF00568	0.812
DOC_PP4_FxxP_1	8	11	PF00568	0.726
DOC_USP7_MATH_1	109	113	PF00917	0.722
DOC_USP7_MATH_1	141	145	PF00917	0.761
DOC_USP7_MATH_1	176	180	PF00917	0.762
DOC_USP7_MATH_1	196	200	PF00917	0.772
DOC_USP7_MATH_1	215	219	PF00917	0.695
DOC_USP7_MATH_1	317	321	PF00917	0.598
DOC_WW_Pin1_4	149	154	PF00397	0.714
DOC_WW_Pin1_4	155	160	PF00397	0.722
DOC_WW_Pin1_4	182	187	PF00397	0.726
DOC_WW_Pin1_4	198	203	PF00397	0.743
DOC_WW_Pin1_4	272	277	PF00397	0.759
DOC_WW_Pin1_4	49	54	PF00397	0.757
DOC_WW_Pin1_4	7	12	PF00397	0.751
DOC_WW_Pin1_4	74	79	PF00397	0.790
DOC_WW_Pin1_4	94	99	PF00397	0.577
LIG_14-3-3_CanoR_1	108	116	PF00244	0.760
LIG_14-3-3_CanoR_1	14	20	PF00244	0.719
LIG_14-3-3_CanoR_1	143	151	PF00244	0.786
LIG_14-3-3_CanoR_1	197	202	PF00244	0.775
LIG_14-3-3_CanoR_1	236	241	PF00244	0.790
LIG_14-3-3_CanoR_1	279	284	PF00244	0.726
LIG_14-3-3_CanoR_1	288	295	PF00244	0.794
LIG_14-3-3_CanoR_1	356	362	PF00244	0.766
LIG_14-3-3_CanoR_1	397	407	PF00244	0.451
LIG_14-3-3_CanoR_1	82	88	PF00244	0.768
LIG_Actin_WH2_2	118	136	PF00022	0.762
LIG_Actin_WH2_2	383	398	PF00022	0.432
LIG_BIR_III_2	195	199	PF00653	0.754
LIG_BRCT_BRCA1_1	200	204	PF00533	0.726
LIG_BRCT_BRCA1_1	4	8	PF00533	0.682
LIG_FHA_1	27	33	PF00498	0.721
LIG_FHA_1	372	378	PF00498	0.452
LIG_FHA_1	39	45	PF00498	0.795
LIG_FHA_2	156	162	PF00498	0.761
LIG_FHA_2	167	173	PF00498	0.724
LIG_FHA_2	190	196	PF00498	0.795
LIG_FHA_2	50	56	PF00498	0.834
LIG_LIR_Apic_2	115	119	PF02991	0.754
LIG_LIR_Apic_2	5	11	PF02991	0.698
LIG_LIR_Gen_1	201	208	PF02991	0.749
LIG_LIR_Gen_1	385	395	PF02991	0.422
LIG_LIR_Nem_3	201	207	PF02991	0.712
LIG_LIR_Nem_3	385	390	PF02991	0.422
LIG_MYND_1	293	297	PF01753	0.627
LIG_MYND_3	292	296	PF01753	0.627
LIG_NRBOX	405	411	PF00104	0.439
LIG_SH2_STAT5	206	209	PF00017	0.826
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.723
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.739
LIG_SUMO_SIM_par_1	408	413	PF11976	0.470
LIG_SUMO_SIM_par_1	70	75	PF11976	0.732
LIG_TRAF2_1	35	38	PF00917	0.709
LIG_WW_3	10	14	PF00397	0.769
MOD_CDK_SPK_2	74	79	PF00069	0.828
MOD_CDK_SPK_2	98	103	PF00069	0.743
MOD_CDK_SPxK_1	7	13	PF00069	0.735
MOD_CDK_SPxxK_3	272	279	PF00069	0.789
MOD_CDK_SPxxK_3	7	14	PF00069	0.745
MOD_CDK_SPxxK_3	74	81	PF00069	0.753
MOD_CK1_1	112	118	PF00069	0.767
MOD_CK1_1	124	130	PF00069	0.668
MOD_CK1_1	170	176	PF00069	0.758
MOD_CK1_1	200	206	PF00069	0.715
MOD_CK1_1	218	224	PF00069	0.697
MOD_CK1_1	282	288	PF00069	0.744
MOD_CK1_1	62	68	PF00069	0.817
MOD_CK1_1	86	92	PF00069	0.830
MOD_CK2_1	155	161	PF00069	0.839
MOD_CK2_1	166	172	PF00069	0.708
MOD_CK2_1	252	258	PF00069	0.740
MOD_CK2_1	356	362	PF00069	0.626
MOD_GlcNHglycan	145	148	PF01048	0.555
MOD_GlcNHglycan	169	172	PF01048	0.605
MOD_GlcNHglycan	19	22	PF01048	0.545
MOD_GlcNHglycan	208	211	PF01048	0.628
MOD_GlcNHglycan	217	221	PF01048	0.576
MOD_GlcNHglycan	230	233	PF01048	0.427
MOD_GlcNHglycan	401	404	PF01048	0.619
MOD_GlcNHglycan	88	91	PF01048	0.536
MOD_GSK3_1	104	111	PF00069	0.714
MOD_GSK3_1	121	128	PF00069	0.734
MOD_GSK3_1	149	156	PF00069	0.737
MOD_GSK3_1	166	173	PF00069	0.752
MOD_GSK3_1	185	192	PF00069	0.747
MOD_GSK3_1	196	203	PF00069	0.740
MOD_GSK3_1	215	222	PF00069	0.749
MOD_GSK3_1	26	33	PF00069	0.731
MOD_GSK3_1	278	285	PF00069	0.710
MOD_GSK3_1	287	294	PF00069	0.764
MOD_GSK3_1	3	10	PF00069	0.644
MOD_GSK3_1	371	378	PF00069	0.580
MOD_GSK3_1	70	77	PF00069	0.757
MOD_GSK3_1	82	89	PF00069	0.824
MOD_GSK3_1	94	101	PF00069	0.701
MOD_N-GLC_1	141	146	PF02516	0.625
MOD_N-GLC_1	15	20	PF02516	0.501
MOD_N-GLC_1	252	257	PF02516	0.543
MOD_N-GLC_1	49	54	PF02516	0.555
MOD_N-GLC_1	62	67	PF02516	0.549
MOD_NEK2_1	1	6	PF00069	0.681
MOD_NEK2_1	121	126	PF00069	0.756
MOD_NEK2_1	235	240	PF00069	0.756
MOD_NEK2_1	267	272	PF00069	0.692
MOD_NEK2_1	382	387	PF00069	0.422
MOD_NEK2_1	399	404	PF00069	0.347
MOD_NEK2_2	3	8	PF00069	0.724
MOD_PIKK_1	283	289	PF00454	0.764
MOD_PIKK_1	410	416	PF00454	0.485
MOD_PK_1	236	242	PF00069	0.763
MOD_PK_1	279	285	PF00069	0.656
MOD_PK_1	375	381	PF00069	0.319
MOD_PKA_1	371	377	PF00069	0.633
MOD_PKA_2	112	118	PF00069	0.727
MOD_PKA_2	142	148	PF00069	0.826
MOD_PKA_2	196	202	PF00069	0.800
MOD_PKA_2	235	241	PF00069	0.753
MOD_PKA_2	278	284	PF00069	0.793
MOD_PKA_2	287	293	PF00069	0.731
MOD_PKA_2	371	377	PF00069	0.633
MOD_PKB_1	369	377	PF00069	0.622
MOD_Plk_1	15	21	PF00069	0.693
MOD_Plk_1	23	29	PF00069	0.654
MOD_Plk_1	252	258	PF00069	0.631
MOD_Plk_1	310	316	PF00069	0.706
MOD_Plk_1	62	68	PF00069	0.774
MOD_Plk_4	170	176	PF00069	0.736
MOD_Plk_4	185	191	PF00069	0.761
MOD_Plk_4	23	29	PF00069	0.732
MOD_Plk_4	375	381	PF00069	0.436
MOD_Plk_4	44	50	PF00069	0.771
MOD_ProDKin_1	149	155	PF00069	0.715
MOD_ProDKin_1	182	188	PF00069	0.728
MOD_ProDKin_1	198	204	PF00069	0.745
MOD_ProDKin_1	272	278	PF00069	0.758
MOD_ProDKin_1	49	55	PF00069	0.758
MOD_ProDKin_1	7	13	PF00069	0.751
MOD_ProDKin_1	74	80	PF00069	0.789
MOD_ProDKin_1	94	100	PF00069	0.578
MOD_SUMO_rev_2	255	262	PF00179	0.788
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.574
TRG_ER_diArg_1	12	14	PF00400	0.730
TRG_ER_diArg_1	369	372	PF00400	0.670
TRG_ER_diArg_1	78	81	PF00400	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U0	Leptomonas seymouri	28%	95%
A0A3Q8IHI2	Leishmania donovani	85%	100%
A4HBI6	Leishmania braziliensis	55%	100%
A4I9Y1	Leishmania infantum	85%	100%
E9B4Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%