Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2Z5_LEIMA

TriTrypDb:

LmjF.34.2060 , LMJLV39_340025100 , LMJSD75_340025600

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q2Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.654
CLV_C14_Caspase3-7	141	145	PF00656	0.573
CLV_C14_Caspase3-7	84	88	PF00656	0.504
CLV_NRD_NRD_1	174	176	PF00675	0.536
CLV_NRD_NRD_1	197	199	PF00675	0.723
CLV_NRD_NRD_1	21	23	PF00675	0.627
CLV_NRD_NRD_1	210	212	PF00675	0.546
CLV_PCSK_KEX2_1	197	199	PF00082	0.664
CLV_PCSK_KEX2_1	21	23	PF00082	0.621
CLV_PCSK_KEX2_1	210	212	PF00082	0.634
CLV_PCSK_PC7_1	17	23	PF00082	0.550
CLV_PCSK_SKI1_1	297	301	PF00082	0.682
DEG_COP1_1	101	109	PF00400	0.593
DEG_COP1_1	239	250	PF00400	0.493
DEG_SPOP_SBC_1	92	96	PF00917	0.597
DOC_CKS1_1	133	138	PF01111	0.551
DOC_CKS1_1	52	57	PF01111	0.585
DOC_MAPK_gen_1	19	28	PF00069	0.556
DOC_PP1_RVXF_1	231	237	PF00149	0.476
DOC_PP2B_LxvP_1	104	107	PF13499	0.683
DOC_PP2B_LxvP_1	300	303	PF13499	0.590
DOC_PP4_FxxP_1	289	292	PF00568	0.488
DOC_PP4_FxxP_1	52	55	PF00568	0.571
DOC_USP7_MATH_1	13	17	PF00917	0.761
DOC_USP7_MATH_1	55	59	PF00917	0.612
DOC_USP7_UBL2_3	19	23	PF12436	0.485
DOC_WW_Pin1_4	132	137	PF00397	0.585
DOC_WW_Pin1_4	217	222	PF00397	0.496
DOC_WW_Pin1_4	51	56	PF00397	0.581
LIG_14-3-3_CanoR_1	238	243	PF00244	0.524
LIG_14-3-3_CanoR_1	69	75	PF00244	0.513
LIG_ActinCP_TwfCPI_2	289	297	PF01115	0.482
LIG_APCC_ABBAyCdc20_2	226	232	PF00400	0.458
LIG_BIR_II_1	1	5	PF00653	0.712
LIG_BIR_III_4	163	167	PF00653	0.521
LIG_BRCT_BRCA1_1	29	33	PF00533	0.599
LIG_BRCT_BRCA1_1	85	89	PF00533	0.511
LIG_BRCT_BRCA1_2	85	91	PF00533	0.496
LIG_FHA_1	165	171	PF00498	0.479
LIG_FHA_1	229	235	PF00498	0.554
LIG_FHA_1	241	247	PF00498	0.749
LIG_FHA_1	29	35	PF00498	0.588
LIG_FHA_1	40	46	PF00498	0.524
LIG_FHA_1	65	71	PF00498	0.583
LIG_FHA_1	99	105	PF00498	0.799
LIG_FHA_2	106	112	PF00498	0.648
LIG_FHA_2	30	36	PF00498	0.539
LIG_FHA_2	42	48	PF00498	0.394
LIG_FHA_2	52	58	PF00498	0.645
LIG_FHA_2	79	85	PF00498	0.557
LIG_LIR_Apic_2	199	203	PF02991	0.586
LIG_LIR_Apic_2	50	55	PF02991	0.578
LIG_LIR_Gen_1	124	134	PF02991	0.606
LIG_LIR_Gen_1	30	40	PF02991	0.507
LIG_LIR_Nem_3	124	130	PF02991	0.633
LIG_LIR_Nem_3	217	222	PF02991	0.531
LIG_LIR_Nem_3	273	279	PF02991	0.540
LIG_LIR_Nem_3	30	36	PF02991	0.499
LIG_MYND_3	79	83	PF01753	0.554
LIG_PDZ_Class_2	310	315	PF00595	0.547
LIG_Pex14_2	52	56	PF04695	0.582
LIG_PTAP_UEV_1	135	140	PF05743	0.523
LIG_SH2_CRK	127	131	PF00017	0.610
LIG_SH2_GRB2like	110	113	PF00017	0.683
LIG_SH2_NCK_1	110	114	PF00017	0.613
LIG_SH2_NCK_1	127	131	PF00017	0.588
LIG_SH2_NCK_1	200	204	PF00017	0.627
LIG_SH2_SRC	110	113	PF00017	0.673
LIG_SH2_STAP1	127	131	PF00017	0.532
LIG_SH2_STAP1	272	276	PF00017	0.543
LIG_SH2_STAT5	27	30	PF00017	0.525
LIG_SH2_STAT5	272	275	PF00017	0.512
LIG_SH3_1	200	206	PF00018	0.574
LIG_SH3_3	133	139	PF00018	0.562
LIG_SH3_3	200	206	PF00018	0.586
LIG_SH3_3	244	250	PF00018	0.498
LIG_SH3_3	72	78	PF00018	0.637
LIG_SH3_5	262	266	PF00018	0.454
LIG_SUMO_SIM_par_1	189	194	PF11976	0.619
LIG_SUMO_SIM_par_1	41	47	PF11976	0.538
LIG_TRAF2_1	305	308	PF00917	0.408
LIG_TRAF2_1	44	47	PF00917	0.492
LIG_TYR_ITIM	129	134	PF00017	0.553
LIG_TYR_ITSM	123	130	PF00017	0.584
MOD_CDC14_SPxK_1	220	223	PF00782	0.491
MOD_CDK_SPxK_1	217	223	PF00069	0.492
MOD_CK1_1	217	223	PF00069	0.499
MOD_CK1_1	240	246	PF00069	0.621
MOD_CK1_1	41	47	PF00069	0.588
MOD_CK2_1	29	35	PF00069	0.544
MOD_CK2_1	302	308	PF00069	0.457
MOD_CK2_1	41	47	PF00069	0.674
MOD_CK2_1	51	57	PF00069	0.558
MOD_GlcNHglycan	247	250	PF01048	0.711
MOD_GlcNHglycan	292	295	PF01048	0.683
MOD_GlcNHglycan	57	60	PF01048	0.575
MOD_GSK3_1	13	20	PF00069	0.581
MOD_GSK3_1	228	235	PF00069	0.611
MOD_GSK3_1	236	243	PF00069	0.630
MOD_GSK3_1	271	278	PF00069	0.571
MOD_GSK3_1	51	58	PF00069	0.494
MOD_GSK3_1	91	98	PF00069	0.767
MOD_NEK2_1	191	196	PF00069	0.615
MOD_NEK2_1	236	241	PF00069	0.611
MOD_NEK2_1	271	276	PF00069	0.573
MOD_NEK2_1	28	33	PF00069	0.546
MOD_NEK2_1	8	13	PF00069	0.730
MOD_PIKK_1	191	197	PF00454	0.637
MOD_PIKK_1	214	220	PF00454	0.572
MOD_PIKK_1	8	14	PF00454	0.586
MOD_PKA_2	237	243	PF00069	0.550
MOD_PKA_2	290	296	PF00069	0.456
MOD_PKA_2	64	70	PF00069	0.487
MOD_Plk_1	102	108	PF00069	0.776
MOD_Plk_4	122	128	PF00069	0.566
MOD_Plk_4	232	238	PF00069	0.558
MOD_Plk_4	271	277	PF00069	0.624
MOD_Plk_4	29	35	PF00069	0.587
MOD_ProDKin_1	132	138	PF00069	0.596
MOD_ProDKin_1	217	223	PF00069	0.492
MOD_ProDKin_1	51	57	PF00069	0.585
MOD_SUMO_for_1	90	93	PF00179	0.685
TRG_DiLeu_BaEn_1	204	209	PF01217	0.543
TRG_ENDOCYTIC_2	127	130	PF00928	0.611
TRG_ENDOCYTIC_2	131	134	PF00928	0.553
TRG_ER_diArg_1	209	211	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I215	Leptomonas seymouri	51%	100%
A0A1X0P9H8	Trypanosomatidae	33%	100%
A0A3S5IS94	Trypanosoma rangeli	32%	100%
A0A3S7X7Y3	Leishmania donovani	88%	100%
A4HAR8	Leishmania braziliensis	73%	100%
A4I9Y3	Leishmania infantum	88%	100%
E9B4Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BT40	Trypanosoma cruzi	33%	98%