Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2Z1_LEIMA

TriTrypDb:

LmjF.34.2100 , LMJLV39_340025700 , LMJSD75_340026400

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.477
CLV_C14_Caspase3-7	349	353	PF00656	0.738
CLV_C14_Caspase3-7	406	410	PF00656	0.808
CLV_NRD_NRD_1	190	192	PF00675	0.592
CLV_NRD_NRD_1	2	4	PF00675	0.655
CLV_NRD_NRD_1	36	38	PF00675	0.512
CLV_NRD_NRD_1	496	498	PF00675	0.447
CLV_NRD_NRD_1	544	546	PF00675	0.649
CLV_NRD_NRD_1	547	549	PF00675	0.651
CLV_NRD_NRD_1	655	657	PF00675	0.594
CLV_NRD_NRD_1	671	673	PF00675	0.415
CLV_NRD_NRD_1	742	744	PF00675	0.542
CLV_NRD_NRD_1	8	10	PF00675	0.613
CLV_NRD_NRD_1	825	827	PF00675	0.581
CLV_PCSK_FUR_1	545	549	PF00082	0.488
CLV_PCSK_KEX2_1	496	498	PF00082	0.447
CLV_PCSK_KEX2_1	544	546	PF00082	0.647
CLV_PCSK_KEX2_1	547	549	PF00082	0.674
CLV_PCSK_KEX2_1	655	657	PF00082	0.621
CLV_PCSK_KEX2_1	671	673	PF00082	0.502
CLV_PCSK_KEX2_1	729	731	PF00082	0.628
CLV_PCSK_KEX2_1	827	829	PF00082	0.503
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.678
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.429
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.503
CLV_PCSK_PC7_1	545	551	PF00082	0.629
CLV_PCSK_SKI1_1	381	385	PF00082	0.651
CLV_PCSK_SKI1_1	632	636	PF00082	0.534
CLV_PCSK_SKI1_1	672	676	PF00082	0.563
CLV_PCSK_SKI1_1	716	720	PF00082	0.445
DEG_APCC_DBOX_1	670	678	PF00400	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DEG_SCF_FBW7_1	209	215	PF00400	0.573
DEG_SCF_FBW7_1	361	367	PF00400	0.492
DEG_SPOP_SBC_1	185	189	PF00917	0.772
DEG_SPOP_SBC_1	88	92	PF00917	0.495
DOC_ANK_TNKS_1	659	666	PF00023	0.631
DOC_CDC14_PxL_1	99	107	PF14671	0.422
DOC_CKS1_1	209	214	PF01111	0.684
DOC_CKS1_1	361	366	PF01111	0.568
DOC_CKS1_1	48	53	PF01111	0.471
DOC_CYCLIN_RxL_1	669	680	PF00134	0.643
DOC_MAPK_gen_1	112	120	PF00069	0.438
DOC_MAPK_gen_1	235	243	PF00069	0.574
DOC_MAPK_gen_1	260	269	PF00069	0.608
DOC_MAPK_gen_1	283	291	PF00069	0.530
DOC_MAPK_gen_1	304	312	PF00069	0.480
DOC_MAPK_gen_1	582	591	PF00069	0.527
DOC_MAPK_gen_1	625	635	PF00069	0.595
DOC_MAPK_gen_1	655	661	PF00069	0.665
DOC_MAPK_gen_1	671	677	PF00069	0.429
DOC_MAPK_gen_1	729	735	PF00069	0.417
DOC_MAPK_gen_1	826	834	PF00069	0.547
DOC_MAPK_HePTP_8	780	792	PF00069	0.452
DOC_MAPK_MEF2A_6	783	792	PF00069	0.463
DOC_MAPK_MEF2A_6	826	834	PF00069	0.464
DOC_PP2B_LxvP_1	771	774	PF13499	0.540
DOC_PP2B_LxvP_1	790	793	PF13499	0.512
DOC_PP4_FxxP_1	151	154	PF00568	0.542
DOC_PP4_FxxP_1	486	489	PF00568	0.517
DOC_USP7_MATH_1	13	17	PF00917	0.514
DOC_USP7_MATH_1	212	216	PF00917	0.590
DOC_USP7_MATH_1	643	647	PF00917	0.643
DOC_USP7_MATH_1	66	70	PF00917	0.445
DOC_USP7_MATH_1	666	670	PF00917	0.545
DOC_USP7_MATH_1	754	758	PF00917	0.609
DOC_USP7_MATH_1	759	763	PF00917	0.476
DOC_USP7_MATH_2	463	469	PF00917	0.638
DOC_USP7_UBL2_3	82	86	PF12436	0.405
DOC_WW_Pin1_4	106	111	PF00397	0.532
DOC_WW_Pin1_4	208	213	PF00397	0.670
DOC_WW_Pin1_4	223	228	PF00397	0.642
DOC_WW_Pin1_4	360	365	PF00397	0.554
DOC_WW_Pin1_4	456	461	PF00397	0.672
DOC_WW_Pin1_4	47	52	PF00397	0.413
DOC_WW_Pin1_4	512	517	PF00397	0.522
DOC_WW_Pin1_4	527	532	PF00397	0.490
DOC_WW_Pin1_4	533	538	PF00397	0.584
LIG_14-3-3_CanoR_1	184	194	PF00244	0.680
LIG_14-3-3_CanoR_1	476	481	PF00244	0.527
LIG_14-3-3_CanoR_1	645	650	PF00244	0.710
LIG_14-3-3_CanoR_1	70	80	PF00244	0.472
LIG_14-3-3_CanoR_1	737	742	PF00244	0.539
LIG_14-3-3_CanoR_1	743	750	PF00244	0.654
LIG_14-3-3_CanoR_1	758	764	PF00244	0.408
LIG_Actin_WH2_2	267	285	PF00022	0.483
LIG_Actin_WH2_2	69	84	PF00022	0.418
LIG_APCC_ABBA_1	731	736	PF00400	0.448
LIG_APCC_ABBAyCdc20_2	730	736	PF00400	0.410
LIG_BRCT_BRCA1_1	798	802	PF00533	0.409
LIG_Clathr_ClatBox_1	148	152	PF01394	0.552
LIG_Clathr_ClatBox_1	391	395	PF01394	0.531
LIG_Clathr_ClatBox_1	674	678	PF01394	0.518
LIG_CSK_EPIYA_1	164	168	PF00017	0.592
LIG_CtBP_PxDLS_1	240	244	PF00389	0.532
LIG_CtBP_PxDLS_1	33	38	PF00389	0.536
LIG_deltaCOP1_diTrp_1	558	563	PF00928	0.532
LIG_eIF4E_1	238	244	PF01652	0.489
LIG_FHA_1	24	30	PF00498	0.516
LIG_FHA_1	269	275	PF00498	0.505
LIG_FHA_1	386	392	PF00498	0.708
LIG_FHA_1	62	68	PF00498	0.375
LIG_FHA_1	89	95	PF00498	0.474
LIG_FHA_2	404	410	PF00498	0.671
LIG_FHA_2	48	54	PF00498	0.479
LIG_FHA_2	512	518	PF00498	0.570
LIG_FHA_2	759	765	PF00498	0.468
LIG_FHA_2	795	801	PF00498	0.434
LIG_FXI_DFP_1	148	152	PF00024	0.552
LIG_KLC1_Yacidic_2	732	736	PF13176	0.456
LIG_LIR_Apic_2	150	154	PF02991	0.548
LIG_LIR_Apic_2	30	34	PF02991	0.587
LIG_LIR_Apic_2	484	489	PF02991	0.532
LIG_LIR_Gen_1	271	280	PF02991	0.435
LIG_LIR_Gen_1	687	698	PF02991	0.472
LIG_LIR_Nem_3	100	105	PF02991	0.411
LIG_LIR_Nem_3	122	127	PF02991	0.411
LIG_LIR_Nem_3	236	241	PF02991	0.544
LIG_LIR_Nem_3	271	276	PF02991	0.443
LIG_LIR_Nem_3	558	564	PF02991	0.527
LIG_LIR_Nem_3	56	61	PF02991	0.486
LIG_LIR_Nem_3	567	573	PF02991	0.476
LIG_LIR_Nem_3	583	588	PF02991	0.563
LIG_LIR_Nem_3	687	693	PF02991	0.480
LIG_LIR_Nem_3	799	805	PF02991	0.437
LIG_LYPXL_yS_3	102	105	PF13949	0.340
LIG_MAD2	660	668	PF02301	0.539
LIG_Pex14_1	246	250	PF04695	0.392
LIG_PTB_Apo_2	368	375	PF02174	0.495
LIG_REV1ctd_RIR_1	540	549	PF16727	0.604
LIG_SH2_CRK	20	24	PF00017	0.384
LIG_SH2_CRK	238	242	PF00017	0.553
LIG_SH2_CRK	585	589	PF00017	0.547
LIG_SH2_GRB2like	629	632	PF00017	0.514
LIG_SH2_NCK_1	690	694	PF00017	0.459
LIG_SH2_PTP2	273	276	PF00017	0.524
LIG_SH2_SRC	273	276	PF00017	0.578
LIG_SH2_SRC	607	610	PF00017	0.625
LIG_SH2_SRC	690	693	PF00017	0.467
LIG_SH2_STAP1	629	633	PF00017	0.580
LIG_SH2_STAP1	690	694	PF00017	0.459
LIG_SH2_STAT5	108	111	PF00017	0.564
LIG_SH2_STAT5	273	276	PF00017	0.498
LIG_SH2_STAT5	31	34	PF00017	0.477
LIG_SH2_STAT5	48	51	PF00017	0.366
LIG_SH2_STAT5	494	497	PF00017	0.488
LIG_SH2_STAT5	607	610	PF00017	0.570
LIG_SH2_STAT5	704	707	PF00017	0.424
LIG_SH2_STAT5	734	737	PF00017	0.479
LIG_SH2_STAT5	815	818	PF00017	0.386
LIG_SH3_1	204	210	PF00018	0.555
LIG_SH3_3	204	210	PF00018	0.531
LIG_SH3_3	307	313	PF00018	0.610
LIG_SH3_3	358	364	PF00018	0.670
LIG_SH3_3	454	460	PF00018	0.663
LIG_SH3_3	54	60	PF00018	0.473
LIG_SH3_3	616	622	PF00018	0.538
LIG_SH3_3	630	636	PF00018	0.531
LIG_SH3_3	676	682	PF00018	0.536
LIG_SH3_3	695	701	PF00018	0.411
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.475
LIG_SUMO_SIM_par_1	673	678	PF11976	0.518
LIG_TRAF2_1	335	338	PF00917	0.742
LIG_TRAF2_1	489	492	PF00917	0.539
LIG_TRAF2_1	762	765	PF00917	0.484
LIG_TRFH_1	20	24	PF08558	0.342
LIG_TYR_ITIM	688	693	PF00017	0.470
LIG_TYR_ITSM	269	276	PF00017	0.446
LIG_UBA3_1	279	284	PF00899	0.550
LIG_UBA3_1	770	777	PF00899	0.374
LIG_UBA3_1	80	86	PF00899	0.463
LIG_ULM_U2AF65_1	547	552	PF00076	0.503
LIG_WRC_WIRS_1	667	672	PF05994	0.648
LIG_WW_3	473	477	PF00397	0.539
MOD_CDK_SPK_2	360	365	PF00069	0.492
MOD_CDK_SPxK_1	106	112	PF00069	0.453
MOD_CDK_SPxxK_3	459	466	PF00069	0.543
MOD_CK1_1	315	321	PF00069	0.641
MOD_CK1_1	459	465	PF00069	0.541
MOD_CK1_1	530	536	PF00069	0.650
MOD_CK1_1	90	96	PF00069	0.465
MOD_CK2_1	158	164	PF00069	0.640
MOD_CK2_1	459	465	PF00069	0.685
MOD_CK2_1	47	53	PF00069	0.439
MOD_CK2_1	758	764	PF00069	0.524
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.593
MOD_GlcNHglycan	160	163	PF01048	0.597
MOD_GlcNHglycan	297	300	PF01048	0.582
MOD_GlcNHglycan	314	317	PF01048	0.656
MOD_GlcNHglycan	356	359	PF01048	0.728
MOD_GlcNHglycan	600	604	PF01048	0.586
MOD_GlcNHglycan	644	648	PF01048	0.634
MOD_GSK3_1	138	145	PF00069	0.668
MOD_GSK3_1	208	215	PF00069	0.722
MOD_GSK3_1	23	30	PF00069	0.498
MOD_GSK3_1	323	330	PF00069	0.615
MOD_GSK3_1	360	367	PF00069	0.685
MOD_GSK3_1	403	410	PF00069	0.701
MOD_GSK3_1	519	526	PF00069	0.642
MOD_GSK3_1	754	761	PF00069	0.674
MOD_N-GLC_1	185	190	PF02516	0.708
MOD_NEK2_1	510	515	PF00069	0.665
MOD_NEK2_1	523	528	PF00069	0.623
MOD_NEK2_1	725	730	PF00069	0.433
MOD_NEK2_1	788	793	PF00069	0.530
MOD_PIKK_1	13	19	PF00454	0.518
MOD_PIKK_1	138	144	PF00454	0.501
MOD_PIKK_1	186	192	PF00454	0.561
MOD_PIKK_1	213	219	PF00454	0.657
MOD_PIKK_1	268	274	PF00454	0.566
MOD_PIKK_1	467	473	PF00454	0.545
MOD_PK_1	192	198	PF00069	0.513
MOD_PK_1	262	268	PF00069	0.423
MOD_PKA_1	743	749	PF00069	0.520
MOD_PKB_1	182	190	PF00069	0.550
MOD_Plk_1	327	333	PF00069	0.579
MOD_Plk_1	338	344	PF00069	0.500
MOD_Plk_1	820	826	PF00069	0.486
MOD_Plk_2-3	407	413	PF00069	0.724
MOD_Plk_4	262	268	PF00069	0.443
MOD_Plk_4	27	33	PF00069	0.484
MOD_Plk_4	523	529	PF00069	0.570
MOD_Plk_4	645	651	PF00069	0.615
MOD_ProDKin_1	106	112	PF00069	0.548
MOD_ProDKin_1	208	214	PF00069	0.675
MOD_ProDKin_1	223	229	PF00069	0.638
MOD_ProDKin_1	360	366	PF00069	0.555
MOD_ProDKin_1	456	462	PF00069	0.672
MOD_ProDKin_1	47	53	PF00069	0.410
MOD_ProDKin_1	512	518	PF00069	0.522
MOD_ProDKin_1	527	533	PF00069	0.491
MOD_SUMO_rev_2	226	233	PF00179	0.600
MOD_SUMO_rev_2	318	326	PF00179	0.497
TRG_DiLeu_BaEn_1	292	297	PF01217	0.631
TRG_DiLeu_BaEn_1	692	697	PF01217	0.531
TRG_DiLeu_BaEn_2	653	659	PF01217	0.559
TRG_DiLeu_BaEn_4	389	395	PF01217	0.591
TRG_ENDOCYTIC_2	102	105	PF00928	0.349
TRG_ENDOCYTIC_2	20	23	PF00928	0.595
TRG_ENDOCYTIC_2	238	241	PF00928	0.564
TRG_ENDOCYTIC_2	273	276	PF00928	0.445
TRG_ENDOCYTIC_2	570	573	PF00928	0.472
TRG_ENDOCYTIC_2	585	588	PF00928	0.447
TRG_ENDOCYTIC_2	690	693	PF00928	0.467
TRG_ENDOCYTIC_2	704	707	PF00928	0.337
TRG_ENDOCYTIC_2	815	818	PF00928	0.428
TRG_ER_diArg_1	181	184	PF00400	0.742
TRG_ER_diArg_1	495	497	PF00400	0.418
TRG_ER_diArg_1	543	545	PF00400	0.642
TRG_ER_diArg_1	547	550	PF00400	0.641
TRG_ER_diArg_1	670	672	PF00400	0.510
TRG_ER_diArg_1	826	829	PF00400	0.601
TRG_ER_diArg_1	832	835	PF00400	0.539
TRG_NES_CRM1_1	765	778	PF08389	0.529
TRG_NLS_Bipartite_1	729	747	PF00514	0.445
TRG_NLS_MonoExtC_3	547	552	PF00514	0.503
TRG_NLS_MonoExtN_4	545	552	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	810	814	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P998	Leptomonas seymouri	44%	80%
A0A0S4JAQ4	Bodo saltans	28%	79%
A0A1X0PAE2	Trypanosomatidae	32%	76%
A0A3Q8IED0	Leishmania donovani	92%	100%
A0A3R7KV38	Trypanosoma rangeli	32%	82%
A4HAS2	Leishmania braziliensis	74%	83%
A4I9Y6	Leishmania infantum	92%	83%
C9ZMQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	82%
E9B4Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%