Putative cardiolipin synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cardiolipin synthetase, putative

Species:

Leishmania major

UniProt:

Q4Q2Z0_LEIMA

TriTrypDb:

LmjF.34.2110 , LMJLV39_340025800 , LMJSD75_340026500

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Z0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.770
CLV_C14_Caspase3-7	742	746	PF00656	0.618
CLV_NRD_NRD_1	180	182	PF00675	0.546
CLV_NRD_NRD_1	22	24	PF00675	0.701
CLV_NRD_NRD_1	248	250	PF00675	0.450
CLV_NRD_NRD_1	314	316	PF00675	0.628
CLV_NRD_NRD_1	326	328	PF00675	0.567
CLV_NRD_NRD_1	498	500	PF00675	0.566
CLV_NRD_NRD_1	505	507	PF00675	0.529
CLV_NRD_NRD_1	526	528	PF00675	0.516
CLV_NRD_NRD_1	572	574	PF00675	0.427
CLV_NRD_NRD_1	577	579	PF00675	0.363
CLV_NRD_NRD_1	589	591	PF00675	0.323
CLV_NRD_NRD_1	601	603	PF00675	0.376
CLV_PCSK_KEX2_1	107	109	PF00082	0.630
CLV_PCSK_KEX2_1	180	182	PF00082	0.546
CLV_PCSK_KEX2_1	22	24	PF00082	0.701
CLV_PCSK_KEX2_1	240	242	PF00082	0.539
CLV_PCSK_KEX2_1	314	316	PF00082	0.628
CLV_PCSK_KEX2_1	326	328	PF00082	0.567
CLV_PCSK_KEX2_1	498	500	PF00082	0.566
CLV_PCSK_KEX2_1	505	507	PF00082	0.529
CLV_PCSK_KEX2_1	518	520	PF00082	0.437
CLV_PCSK_KEX2_1	526	528	PF00082	0.520
CLV_PCSK_KEX2_1	577	579	PF00082	0.376
CLV_PCSK_KEX2_1	601	603	PF00082	0.430
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.630
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.533
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.601
CLV_PCSK_PC7_1	18	24	PF00082	0.689
CLV_PCSK_PC7_1	573	579	PF00082	0.430
CLV_PCSK_SKI1_1	104	108	PF00082	0.574
CLV_PCSK_SKI1_1	156	160	PF00082	0.594
CLV_PCSK_SKI1_1	249	253	PF00082	0.409
CLV_PCSK_SKI1_1	326	330	PF00082	0.709
CLV_PCSK_SKI1_1	37	41	PF00082	0.700
CLV_PCSK_SKI1_1	396	400	PF00082	0.577
CLV_PCSK_SKI1_1	413	417	PF00082	0.604
CLV_PCSK_SKI1_1	499	503	PF00082	0.593
CLV_PCSK_SKI1_1	506	510	PF00082	0.511
CLV_PCSK_SKI1_1	590	594	PF00082	0.376
DEG_COP1_1	532	539	PF00400	0.599
DEG_MDM2_SWIB_1	115	123	PF02201	0.450
DEG_MDM2_SWIB_1	148	155	PF02201	0.430
DOC_CDC14_PxL_1	525	533	PF14671	0.635
DOC_CKS1_1	476	481	PF01111	0.590
DOC_CKS1_1	581	586	PF01111	0.376
DOC_CYCLIN_RxL_1	246	257	PF00134	0.481
DOC_CYCLIN_RxL_1	587	594	PF00134	0.430
DOC_CYCLIN_RxL_1	709	720	PF00134	0.490
DOC_CYCLIN_RxL_1	8	17	PF00134	0.670
DOC_CYCLIN_yClb5_NLxxxL_5	670	679	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.744
DOC_MAPK_gen_1	246	254	PF00069	0.416
DOC_MAPK_gen_1	573	581	PF00069	0.420
DOC_MAPK_gen_1	601	608	PF00069	0.473
DOC_MAPK_gen_1	631	639	PF00069	0.501
DOC_MAPK_gen_1	710	718	PF00069	0.504
DOC_MAPK_MEF2A_6	601	608	PF00069	0.430
DOC_MAPK_MEF2A_6	710	718	PF00069	0.485
DOC_PP1_RVXF_1	159	165	PF00149	0.482
DOC_PP1_RVXF_1	233	240	PF00149	0.529
DOC_PP1_RVXF_1	730	736	PF00149	0.449
DOC_PP4_FxxP_1	457	460	PF00568	0.578
DOC_USP7_MATH_1	147	151	PF00917	0.551
DOC_USP7_MATH_1	359	363	PF00917	0.660
DOC_USP7_MATH_1	421	425	PF00917	0.681
DOC_USP7_MATH_1	448	452	PF00917	0.732
DOC_USP7_MATH_1	481	485	PF00917	0.727
DOC_USP7_MATH_1	492	496	PF00917	0.551
DOC_USP7_MATH_1	80	84	PF00917	0.719
DOC_WW_Pin1_4	110	115	PF00397	0.612
DOC_WW_Pin1_4	239	244	PF00397	0.476
DOC_WW_Pin1_4	475	480	PF00397	0.785
DOC_WW_Pin1_4	580	585	PF00397	0.376
DOC_WW_Pin1_4	70	75	PF00397	0.714
DOC_WW_Pin1_4	746	751	PF00397	0.647
DOC_WW_Pin1_4	76	81	PF00397	0.745
LIG_14-3-3_CanoR_1	108	114	PF00244	0.612
LIG_14-3-3_CanoR_1	11	16	PF00244	0.587
LIG_14-3-3_CanoR_1	131	139	PF00244	0.543
LIG_14-3-3_CanoR_1	227	233	PF00244	0.486
LIG_14-3-3_CanoR_1	385	394	PF00244	0.728
LIG_14-3-3_CanoR_1	400	408	PF00244	0.727
LIG_14-3-3_CanoR_1	493	501	PF00244	0.620
LIG_14-3-3_CanoR_1	519	528	PF00244	0.511
LIG_14-3-3_CanoR_1	578	584	PF00244	0.376
LIG_14-3-3_CanoR_1	717	722	PF00244	0.455
LIG_14-3-3_CanoR_1	732	736	PF00244	0.535
LIG_AP2alpha_2	617	619	PF02296	0.376
LIG_APCC_ABBA_1	138	143	PF00400	0.566
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BIR_III_4	745	749	PF00653	0.663
LIG_BIR_III_4	87	91	PF00653	0.629
LIG_BRCT_BRCA1_1	111	115	PF00533	0.606
LIG_BRCT_BRCA1_1	256	260	PF00533	0.326
LIG_BRCT_BRCA1_1	60	64	PF00533	0.672
LIG_BRCT_BRCA1_1	719	723	PF00533	0.469
LIG_deltaCOP1_diTrp_1	617	622	PF00928	0.376
LIG_eIF4E_1	627	633	PF01652	0.430
LIG_eIF4E_1	724	730	PF01652	0.482
LIG_EVH1_2	459	463	PF00568	0.579
LIG_FHA_1	190	196	PF00498	0.413
LIG_FHA_1	207	213	PF00498	0.471
LIG_FHA_1	229	235	PF00498	0.546
LIG_FHA_1	323	329	PF00498	0.737
LIG_FHA_1	372	378	PF00498	0.490
LIG_FHA_1	434	440	PF00498	0.718
LIG_FHA_1	520	526	PF00498	0.524
LIG_FHA_1	53	59	PF00498	0.588
LIG_FHA_1	531	537	PF00498	0.441
LIG_FHA_1	548	554	PF00498	0.335
LIG_FHA_1	587	593	PF00498	0.420
LIG_FHA_1	627	633	PF00498	0.430
LIG_FHA_1	650	656	PF00498	0.430
LIG_FHA_1	690	696	PF00498	0.430
LIG_FHA_1	717	723	PF00498	0.395
LIG_FHA_2	100	106	PF00498	0.616
LIG_FHA_2	111	117	PF00498	0.534
LIG_FHA_2	144	150	PF00498	0.370
LIG_FHA_2	390	396	PF00498	0.649
LIG_FHA_2	414	420	PF00498	0.684
LIG_LIR_Apic_2	454	460	PF02991	0.582
LIG_LIR_Apic_2	582	588	PF02991	0.376
LIG_LIR_Gen_1	116	127	PF02991	0.508
LIG_LIR_Gen_1	14	24	PF02991	0.668
LIG_LIR_Gen_1	146	155	PF02991	0.487
LIG_LIR_Gen_1	656	665	PF02991	0.376
LIG_LIR_Gen_1	713	723	PF02991	0.437
LIG_LIR_Nem_3	116	122	PF02991	0.455
LIG_LIR_Nem_3	14	19	PF02991	0.661
LIG_LIR_Nem_3	149	155	PF02991	0.436
LIG_LIR_Nem_3	339	344	PF02991	0.658
LIG_LIR_Nem_3	61	67	PF02991	0.638
LIG_LIR_Nem_3	656	662	PF02991	0.376
LIG_LIR_Nem_3	713	718	PF02991	0.453
LIG_LIR_Nem_3	719	724	PF02991	0.404
LIG_LIR_Nem_3	734	738	PF02991	0.365
LIG_PCNA_yPIPBox_3	170	183	PF02747	0.490
LIG_Pex14_2	115	119	PF04695	0.448
LIG_Pex14_2	148	152	PF04695	0.431
LIG_PTB_Apo_2	553	560	PF02174	0.513
LIG_PTB_Apo_2	722	729	PF02174	0.489
LIG_PTB_Phospho_1	553	559	PF10480	0.505
LIG_REV1ctd_RIR_1	223	231	PF16727	0.544
LIG_RPA_C_Fungi	500	512	PF08784	0.585
LIG_RPA_C_Fungi	596	608	PF08784	0.430
LIG_SH2_CRK	724	728	PF00017	0.485
LIG_SH2_GRB2like	109	112	PF00017	0.580
LIG_SH2_STAP1	47	51	PF00017	0.623
LIG_SH2_STAP1	521	525	PF00017	0.544
LIG_SH2_STAP1	562	566	PF00017	0.477
LIG_SH2_STAT3	562	565	PF00017	0.472
LIG_SH2_STAT3	640	643	PF00017	0.424
LIG_SH2_STAT5	167	170	PF00017	0.443
LIG_SH2_STAT5	222	225	PF00017	0.434
LIG_SH2_STAT5	232	235	PF00017	0.472
LIG_SH2_STAT5	270	273	PF00017	0.408
LIG_SH2_STAT5	521	524	PF00017	0.550
LIG_SH2_STAT5	542	545	PF00017	0.569
LIG_SH2_STAT5	586	589	PF00017	0.430
LIG_SH2_STAT5	627	630	PF00017	0.430
LIG_SH2_STAT5	95	98	PF00017	0.641
LIG_SH3_1	218	224	PF00018	0.503
LIG_SH3_3	134	140	PF00018	0.489
LIG_SH3_3	218	224	PF00018	0.503
LIG_SH3_3	285	291	PF00018	0.439
LIG_SH3_3	72	78	PF00018	0.827
LIG_SH3_3	741	747	PF00018	0.628
LIG_Sin3_3	593	600	PF02671	0.430
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.518
LIG_SUMO_SIM_par_1	250	255	PF11976	0.409
LIG_SUMO_SIM_par_1	651	657	PF11976	0.429
LIG_TRAF2_1	343	346	PF00917	0.692
LIG_TYR_ITIM	45	50	PF00017	0.460
LIG_TYR_ITIM	722	727	PF00017	0.481
LIG_WRC_WIRS_1	735	740	PF05994	0.562
MOD_CDK_SPxxK_3	239	246	PF00069	0.465
MOD_CK1_1	228	234	PF00069	0.537
MOD_CK1_1	386	392	PF00069	0.673
MOD_CK1_1	451	457	PF00069	0.720
MOD_CK1_1	461	467	PF00069	0.716
MOD_CK1_1	510	516	PF00069	0.597
MOD_CK1_1	612	618	PF00069	0.376
MOD_CK1_1	661	667	PF00069	0.382
MOD_CK1_1	68	74	PF00069	0.692
MOD_CK1_1	689	695	PF00069	0.501
MOD_CK1_1	7	13	PF00069	0.598
MOD_CK1_1	76	82	PF00069	0.678
MOD_CK2_1	11	17	PF00069	0.671
MOD_CK2_1	143	149	PF00069	0.555
MOD_CK2_1	413	419	PF00069	0.774
MOD_CK2_1	99	105	PF00069	0.692
MOD_CMANNOS	313	316	PF00535	0.658
MOD_CMANNOS	619	622	PF00535	0.376
MOD_GlcNHglycan	143	146	PF01048	0.489
MOD_GlcNHglycan	202	205	PF01048	0.548
MOD_GlcNHglycan	28	31	PF01048	0.723
MOD_GlcNHglycan	350	353	PF01048	0.684
MOD_GlcNHglycan	359	362	PF01048	0.679
MOD_GlcNHglycan	385	388	PF01048	0.669
MOD_GlcNHglycan	41	44	PF01048	0.599
MOD_GlcNHglycan	430	433	PF01048	0.769
MOD_GlcNHglycan	454	457	PF01048	0.804
MOD_GlcNHglycan	462	466	PF01048	0.727
MOD_GlcNHglycan	484	487	PF01048	0.727
MOD_GlcNHglycan	490	493	PF01048	0.630
MOD_GlcNHglycan	494	497	PF01048	0.537
MOD_GlcNHglycan	593	596	PF01048	0.501
MOD_GlcNHglycan	67	70	PF01048	0.800
MOD_GlcNHglycan	81	85	PF01048	0.761
MOD_GSK3_1	143	150	PF00069	0.474
MOD_GSK3_1	318	325	PF00069	0.707
MOD_GSK3_1	383	390	PF00069	0.650
MOD_GSK3_1	448	455	PF00069	0.733
MOD_GSK3_1	463	470	PF00069	0.639
MOD_GSK3_1	488	495	PF00069	0.722
MOD_GSK3_1	547	554	PF00069	0.453
MOD_GSK3_1	609	616	PF00069	0.376
MOD_GSK3_1	622	629	PF00069	0.376
MOD_GSK3_1	654	661	PF00069	0.382
MOD_GSK3_1	7	14	PF00069	0.586
MOD_GSK3_1	76	83	PF00069	0.751
MOD_LATS_1	517	523	PF00433	0.578
MOD_N-GLC_1	110	115	PF02516	0.534
MOD_N-GLC_1	200	205	PF02516	0.519
MOD_N-GLC_1	448	453	PF02516	0.577
MOD_N-GLC_1	612	617	PF02516	0.430
MOD_NEK2_1	141	146	PF00069	0.487
MOD_NEK2_1	225	230	PF00069	0.486
MOD_NEK2_1	26	31	PF00069	0.678
MOD_NEK2_1	281	286	PF00069	0.428
MOD_NEK2_1	381	386	PF00069	0.734
MOD_NEK2_1	428	433	PF00069	0.548
MOD_NEK2_1	463	468	PF00069	0.815
MOD_NEK2_1	609	614	PF00069	0.376
MOD_NEK2_1	67	72	PF00069	0.776
MOD_NEK2_1	716	721	PF00069	0.467
MOD_NEK2_1	99	104	PF00069	0.536
MOD_NEK2_2	175	180	PF00069	0.428
MOD_NEK2_2	359	364	PF00069	0.663
MOD_NEK2_2	404	409	PF00069	0.713
MOD_PIKK_1	254	260	PF00454	0.441
MOD_PIKK_1	318	324	PF00454	0.578
MOD_PIKK_1	399	405	PF00454	0.810
MOD_PIKK_1	547	553	PF00454	0.455
MOD_PIKK_1	59	65	PF00454	0.691
MOD_PIKK_1	689	695	PF00454	0.430
MOD_PIKK_1	73	79	PF00454	0.695
MOD_PK_1	560	566	PF00069	0.492
MOD_PKA_2	130	136	PF00069	0.561
MOD_PKA_2	206	212	PF00069	0.534
MOD_PKA_2	281	287	PF00069	0.427
MOD_PKA_2	300	306	PF00069	0.489
MOD_PKA_2	381	387	PF00069	0.594
MOD_PKA_2	399	405	PF00069	0.763
MOD_PKA_2	492	498	PF00069	0.618
MOD_PKA_2	510	516	PF00069	0.567
MOD_PKA_2	7	13	PF00069	0.540
MOD_PKA_2	716	722	PF00069	0.472
MOD_PKA_2	731	737	PF00069	0.550
MOD_PKB_1	558	566	PF00069	0.502
MOD_Plk_1	413	419	PF00069	0.570
MOD_Plk_1	560	566	PF00069	0.438
MOD_Plk_4	11	17	PF00069	0.653
MOD_Plk_4	147	153	PF00069	0.519
MOD_Plk_4	163	169	PF00069	0.271
MOD_Plk_4	228	234	PF00069	0.537
MOD_Plk_4	284	290	PF00069	0.437
MOD_Plk_4	376	382	PF00069	0.649
MOD_Plk_4	389	395	PF00069	0.696
MOD_Plk_4	439	445	PF00069	0.709
MOD_Plk_4	649	655	PF00069	0.387
MOD_Plk_4	717	723	PF00069	0.478
MOD_ProDKin_1	110	116	PF00069	0.612
MOD_ProDKin_1	239	245	PF00069	0.469
MOD_ProDKin_1	475	481	PF00069	0.786
MOD_ProDKin_1	580	586	PF00069	0.376
MOD_ProDKin_1	70	76	PF00069	0.716
MOD_ProDKin_1	746	752	PF00069	0.652
MOD_SUMO_rev_2	298	306	PF00179	0.547
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.430
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.410
TRG_ENDOCYTIC_2	222	225	PF00928	0.462
TRG_ENDOCYTIC_2	341	344	PF00928	0.673
TRG_ENDOCYTIC_2	47	50	PF00928	0.703
TRG_ENDOCYTIC_2	521	524	PF00928	0.550
TRG_ENDOCYTIC_2	724	727	PF00928	0.429
TRG_ER_diArg_1	179	181	PF00400	0.570
TRG_ER_diArg_1	205	208	PF00400	0.471
TRG_ER_diArg_1	22	24	PF00400	0.701
TRG_ER_diArg_1	313	315	PF00400	0.637
TRG_ER_diArg_1	326	328	PF00400	0.556
TRG_ER_diArg_1	332	335	PF00400	0.481
TRG_ER_diArg_1	366	369	PF00400	0.706
TRG_ER_diArg_1	497	499	PF00400	0.572
TRG_ER_diArg_1	525	527	PF00400	0.524
TRG_ER_diArg_1	543	546	PF00400	0.557
TRG_ER_diArg_1	577	579	PF00400	0.376
TRG_NES_CRM1_1	693	708	PF08389	0.453
TRG_NLS_Bipartite_1	22	37	PF00514	0.509
TRG_NLS_MonoExtC_3	32	37	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC19	Leptomonas seymouri	67%	89%
A0A0S4J7Q2	Bodo saltans	42%	100%
A0A3Q8III3	Leishmania donovani	93%	100%
A4IAM8	Leishmania infantum	93%	100%
E9AI68	Leishmania braziliensis	82%	100%
E9B4Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%