Ubiquitin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-like protein

Species:

Leishmania major

UniProt:

Q4Q2Y8_LEIMA

TriTrypDb:

LmjF.34.2125 , LMJLV39_340026000 , LMJSD75_340026700

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q2Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Y8

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030162	regulation of proteolysis	6	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031386	protein tag	1	2
GO:0031625	ubiquitin protein ligase binding	5	2
GO:0044389	ubiquitin-like protein ligase binding	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	50	52	PF00675	0.361
DEG_SPOP_SBC_1	7	11	PF00917	0.444
LIG_14-3-3_CanoR_1	14	20	PF00244	0.561
LIG_Actin_WH2_2	61	79	PF00022	0.561
LIG_FHA_1	34	40	PF00498	0.549
LIG_FHA_2	23	29	PF00498	0.490
LIG_FHA_2	56	62	PF00498	0.561
LIG_LIR_Nem_3	2	8	PF02991	0.490
LIG_NRP_CendR_1	77	80	PF00754	0.616
LIG_SH3_3	16	22	PF00018	0.561

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAA2	Leptomonas seymouri	96%	100%
A0A0S4JFN2	Bodo saltans	41%	100%
A0A3Q8IFJ6	Leishmania donovani	99%	100%
A0A3S5IS95	Trypanosoma rangeli	48%	72%
A0A422N1A4	Trypanosoma rangeli	38%	72%
A4HAS4	Leishmania braziliensis	98%	100%
A4IAM5	Leishmania infantum	99%	100%
C9ZMP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ATD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B4Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%

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