DoxX family membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2Y7_LEIMA

TriTrypDb:

LmjF.34.2130 , LMJLV39_340026100 , LMJSD75_340026800

Length:

159

Annotations

LeishMANIAdb annotations

A protein family with Prokaryotic affinities. Might be a subunit for some uncharacterized complex

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q2Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.465
CLV_PCSK_FUR_1	139	143	PF00082	0.492
CLV_PCSK_KEX2_1	141	143	PF00082	0.499
CLV_PCSK_SKI1_1	84	88	PF00082	0.237
DOC_MAPK_MEF2A_6	10	19	PF00069	0.463
DOC_MAPK_MEF2A_6	46	55	PF00069	0.393
DOC_MAPK_MEF2A_6	65	74	PF00069	0.401
DOC_PP2B_LxvP_1	29	32	PF13499	0.375
DOC_USP7_MATH_1	150	154	PF00917	0.679
DOC_USP7_MATH_1	30	34	PF00917	0.340
DOC_USP7_UBL2_3	50	54	PF12436	0.322
DOC_WW_Pin1_4	53	58	PF00397	0.415
LIG_14-3-3_CanoR_1	141	150	PF00244	0.640
LIG_14-3-3_CanoR_1	84	90	PF00244	0.504
LIG_BRCT_BRCA1_1	70	74	PF00533	0.205
LIG_eIF4E_1	11	17	PF01652	0.368
LIG_FHA_1	21	27	PF00498	0.330
LIG_FHA_1	64	70	PF00498	0.293
LIG_FHA_1	71	77	PF00498	0.299
LIG_FHA_2	110	116	PF00498	0.406
LIG_LIR_Gen_1	58	67	PF02991	0.247
LIG_LIR_Gen_1	71	82	PF02991	0.255
LIG_LIR_Gen_1	85	95	PF02991	0.248
LIG_LIR_Nem_3	58	63	PF02991	0.294
LIG_LIR_Nem_3	71	77	PF02991	0.255
LIG_LIR_Nem_3	85	90	PF02991	0.248
LIG_NRBOX	75	81	PF00104	0.289
LIG_SH2_PTP2	103	106	PF00017	0.314
LIG_SH2_PTP2	11	14	PF00017	0.400
LIG_SH2_PTP2	60	63	PF00017	0.304
LIG_SH2_SRC	60	63	PF00017	0.257
LIG_SH2_STAT5	103	106	PF00017	0.348
LIG_SH2_STAT5	11	14	PF00017	0.289
LIG_SH2_STAT5	60	63	PF00017	0.248
LIG_TRAF2_1	112	115	PF00917	0.338
LIG_TYR_ITIM	9	14	PF00017	0.448
LIG_WRC_WIRS_1	86	91	PF05994	0.409
MOD_CK1_1	85	91	PF00069	0.351
MOD_CK2_1	109	115	PF00069	0.427
MOD_CK2_1	53	59	PF00069	0.373
MOD_GlcNHglycan	135	138	PF01048	0.412
MOD_GSK3_1	133	140	PF00069	0.412
MOD_GSK3_1	68	75	PF00069	0.413
MOD_N-GLC_1	122	127	PF02516	0.323
MOD_NEK2_1	131	136	PF00069	0.356
MOD_NEK2_1	20	25	PF00069	0.300
MOD_NEK2_1	39	44	PF00069	0.203
MOD_NEK2_1	70	75	PF00069	0.321
MOD_NEK2_1	95	100	PF00069	0.377
MOD_PIKK_1	141	147	PF00454	0.707
MOD_PKA_1	141	147	PF00069	0.584
MOD_PKA_2	141	147	PF00069	0.633
MOD_PKB_1	139	147	PF00069	0.579
MOD_Plk_1	122	128	PF00069	0.334
MOD_Plk_4	122	128	PF00069	0.400
MOD_ProDKin_1	53	59	PF00069	0.414
TRG_ENDOCYTIC_2	103	106	PF00928	0.314
TRG_ENDOCYTIC_2	11	14	PF00928	0.289
TRG_ENDOCYTIC_2	60	63	PF00928	0.237
TRG_ER_diArg_1	139	142	PF00400	0.690
TRG_ER_diLys_1	156	159	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P4	Leptomonas seymouri	63%	100%
A0A0S4JBG1	Bodo saltans	42%	95%
A0A1X0P9I8	Trypanosomatidae	47%	100%
A0A3S7X803	Leishmania donovani	89%	100%
A0A422NY54	Trypanosoma rangeli	45%	100%
A4HAS5	Leishmania braziliensis	71%	100%
A4IAM6	Leishmania infantum	89%	100%
C9ZMP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B4Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BQ15	Trypanosoma cruzi	51%	100%