Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 2-alpha kinase 2

Species:

Leishmania major

UniProt:

Q4Q2Y5_LEIMA

TriTrypDb:

LmjF.34.2150 , LMJLV39_340026300 , LMJSD75_340027100

Length:

1474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	4
GO:0031090	organelle membrane	3	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	4
GO:1990578	perinuclear endoplasmic reticulum membrane	4	2

Expansion

Sequence features

Q4Q2Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	2
GO:0006417	regulation of translation	6	2
GO:0006446	regulation of translational initiation	7	2
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	7
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	6	2
GO:0010999	regulation of eIF2 alpha phosphorylation by heme	5	2
GO:0016310	phosphorylation	5	7
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031399	regulation of protein modification process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0036211	protein modification process	4	7
GO:0042325	regulation of phosphorylation	7	2
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043555	regulation of translation in response to stress	7	2
GO:0043558	regulation of translational initiation in response to stress	8	2
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0048583	regulation of response to stimulus	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	7
GO:0080090	regulation of primary metabolic process	4	2
GO:0080134	regulation of response to stress	4	2
GO:0080135	regulation of cellular response to stress	4	2
GO:1901564	organonitrogen compound metabolic process	3	7
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004683	calmodulin-dependent protein kinase activity	5	2
GO:0004686	elongation factor-2 kinase activity	6	2
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	2	2
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0020037	heme binding	4	2
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0045182	translation regulator activity	1	5
GO:0046906	tetrapyrrole binding	3	2
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003676	nucleic acid binding	3	3
GO:0003743	translation initiation factor activity	4	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1323	1327	PF00656	0.699
CLV_C14_Caspase3-7	171	175	PF00656	0.444
CLV_NRD_NRD_1	1110	1112	PF00675	0.338
CLV_NRD_NRD_1	1147	1149	PF00675	0.252
CLV_NRD_NRD_1	1219	1221	PF00675	0.311
CLV_NRD_NRD_1	1381	1383	PF00675	0.637
CLV_NRD_NRD_1	1405	1407	PF00675	0.707
CLV_NRD_NRD_1	199	201	PF00675	0.565
CLV_NRD_NRD_1	25	27	PF00675	0.597
CLV_NRD_NRD_1	357	359	PF00675	0.690
CLV_PCSK_KEX2_1	1109	1111	PF00082	0.341
CLV_PCSK_KEX2_1	1147	1149	PF00082	0.252
CLV_PCSK_KEX2_1	1381	1383	PF00082	0.666
CLV_PCSK_KEX2_1	1396	1398	PF00082	0.711
CLV_PCSK_KEX2_1	1404	1406	PF00082	0.714
CLV_PCSK_KEX2_1	1462	1464	PF00082	0.654
CLV_PCSK_KEX2_1	199	201	PF00082	0.565
CLV_PCSK_KEX2_1	24	26	PF00082	0.588
CLV_PCSK_KEX2_1	30	32	PF00082	0.545
CLV_PCSK_KEX2_1	357	359	PF00082	0.704
CLV_PCSK_KEX2_1	40	42	PF00082	0.259
CLV_PCSK_PC1ET2_1	1109	1111	PF00082	0.346
CLV_PCSK_PC1ET2_1	1396	1398	PF00082	0.770
CLV_PCSK_PC1ET2_1	1462	1464	PF00082	0.626
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.546
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.287
CLV_PCSK_PC7_1	20	26	PF00082	0.567
CLV_PCSK_SKI1_1	1065	1069	PF00082	0.419
CLV_PCSK_SKI1_1	1180	1184	PF00082	0.330
CLV_PCSK_SKI1_1	1206	1210	PF00082	0.346
CLV_PCSK_SKI1_1	1220	1224	PF00082	0.346
CLV_PCSK_SKI1_1	1338	1342	PF00082	0.397
CLV_PCSK_SKI1_1	1377	1381	PF00082	0.667
CLV_PCSK_SKI1_1	341	345	PF00082	0.603
CLV_PCSK_SKI1_1	40	44	PF00082	0.411
CLV_PCSK_SKI1_1	771	775	PF00082	0.494
CLV_Separin_Metazoa	1062	1066	PF03568	0.619
CLV_Separin_Metazoa	743	747	PF03568	0.767
DEG_APCC_DBOX_1	1219	1227	PF00400	0.558
DEG_APCC_DBOX_1	1337	1345	PF00400	0.536
DEG_APCC_DBOX_1	516	524	PF00400	0.439
DEG_MDM2_SWIB_1	970	978	PF02201	0.546
DEG_SCF_FBW7_1	1288	1295	PF00400	0.602
DEG_SCF_FBW7_1	166	172	PF00400	0.367
DEG_SIAH_1	298	306	PF03145	0.425
DEG_SPOP_SBC_1	1292	1296	PF00917	0.724
DEG_SPOP_SBC_1	1299	1303	PF00917	0.652
DEG_SPOP_SBC_1	1362	1366	PF00917	0.525
DEG_SPOP_SBC_1	317	321	PF00917	0.520
DEG_SPOP_SBC_1	370	374	PF00917	0.517
DEG_SPOP_SBC_1	417	421	PF00917	0.471
DEG_SPOP_SBC_1	826	830	PF00917	0.691
DOC_CDC14_PxL_1	460	468	PF14671	0.494
DOC_CKS1_1	1445	1450	PF01111	0.449
DOC_CKS1_1	166	171	PF01111	0.365
DOC_CKS1_1	568	573	PF01111	0.398
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.409
DOC_MAPK_gen_1	1220	1231	PF00069	0.691
DOC_MAPK_gen_1	1336	1344	PF00069	0.591
DOC_MAPK_gen_1	199	205	PF00069	0.370
DOC_MAPK_gen_1	40	48	PF00069	0.472
DOC_MAPK_MEF2A_6	1224	1233	PF00069	0.696
DOC_MAPK_MEF2A_6	144	151	PF00069	0.404
DOC_MAPK_MEF2A_6	273	280	PF00069	0.357
DOC_MAPK_MEF2A_6	40	48	PF00069	0.544
DOC_MAPK_NFAT4_5	273	281	PF00069	0.357
DOC_MAPK_NFAT4_5	41	49	PF00069	0.619
DOC_PP1_RVXF_1	914	920	PF00149	0.546
DOC_PP2B_LxvP_1	1188	1191	PF13499	0.619
DOC_PP2B_LxvP_1	147	150	PF13499	0.400
DOC_PP4_FxxP_1	1328	1331	PF00568	0.775
DOC_PP4_FxxP_1	461	464	PF00568	0.413
DOC_USP7_MATH_1	1114	1118	PF00917	0.591
DOC_USP7_MATH_1	1235	1239	PF00917	0.801
DOC_USP7_MATH_1	1298	1302	PF00917	0.771
DOC_USP7_MATH_1	1363	1367	PF00917	0.502
DOC_USP7_MATH_1	1427	1431	PF00917	0.421
DOC_USP7_MATH_1	169	173	PF00917	0.459
DOC_USP7_MATH_1	317	321	PF00917	0.520
DOC_USP7_MATH_1	370	374	PF00917	0.517
DOC_USP7_MATH_1	417	421	PF00917	0.554
DOC_USP7_MATH_1	426	430	PF00917	0.488
DOC_USP7_MATH_1	438	442	PF00917	0.507
DOC_USP7_MATH_1	469	473	PF00917	0.429
DOC_USP7_MATH_1	52	56	PF00917	0.408
DOC_USP7_MATH_1	593	597	PF00917	0.506
DOC_USP7_MATH_1	723	727	PF00917	0.714
DOC_USP7_MATH_1	730	734	PF00917	0.645
DOC_USP7_MATH_1	797	801	PF00917	0.764
DOC_USP7_MATH_1	815	819	PF00917	0.706
DOC_USP7_MATH_1	825	829	PF00917	0.699
DOC_USP7_MATH_1	832	836	PF00917	0.645
DOC_USP7_MATH_1	841	845	PF00917	0.646
DOC_USP7_MATH_1	94	98	PF00917	0.442
DOC_USP7_UBL2_3	1068	1072	PF12436	0.452
DOC_USP7_UBL2_3	912	916	PF12436	0.546
DOC_WW_Pin1_4	1135	1140	PF00397	0.546
DOC_WW_Pin1_4	1246	1251	PF00397	0.763
DOC_WW_Pin1_4	1288	1293	PF00397	0.736
DOC_WW_Pin1_4	1327	1332	PF00397	0.718
DOC_WW_Pin1_4	1356	1361	PF00397	0.457
DOC_WW_Pin1_4	1407	1412	PF00397	0.520
DOC_WW_Pin1_4	1444	1449	PF00397	0.447
DOC_WW_Pin1_4	165	170	PF00397	0.399
DOC_WW_Pin1_4	231	236	PF00397	0.563
DOC_WW_Pin1_4	244	249	PF00397	0.502
DOC_WW_Pin1_4	295	300	PF00397	0.423
DOC_WW_Pin1_4	329	334	PF00397	0.521
DOC_WW_Pin1_4	364	369	PF00397	0.530
DOC_WW_Pin1_4	567	572	PF00397	0.392
DOC_WW_Pin1_4	693	698	PF00397	0.726
DOC_WW_Pin1_4	700	705	PF00397	0.624
DOC_WW_Pin1_4	753	758	PF00397	0.720
DOC_WW_Pin1_4	817	822	PF00397	0.762
DOC_WW_Pin1_4	828	833	PF00397	0.675
DOC_WW_Pin1_4	867	872	PF00397	0.608
LIG_14-3-3_CanoR_1	1180	1189	PF00244	0.530
LIG_14-3-3_CanoR_1	1397	1402	PF00244	0.520
LIG_14-3-3_CanoR_1	1468	1473	PF00244	0.583
LIG_14-3-3_CanoR_1	154	159	PF00244	0.363
LIG_14-3-3_CanoR_1	199	204	PF00244	0.371
LIG_14-3-3_CanoR_1	250	260	PF00244	0.486
LIG_14-3-3_CanoR_1	291	299	PF00244	0.386
LIG_14-3-3_CanoR_1	334	343	PF00244	0.432
LIG_14-3-3_CanoR_1	371	378	PF00244	0.543
LIG_14-3-3_CanoR_1	383	392	PF00244	0.388
LIG_14-3-3_CanoR_1	394	399	PF00244	0.422
LIG_14-3-3_CanoR_1	481	485	PF00244	0.558
LIG_14-3-3_CanoR_1	498	504	PF00244	0.351
LIG_14-3-3_CanoR_1	675	685	PF00244	0.712
LIG_14-3-3_CanoR_1	771	776	PF00244	0.661
LIG_14-3-3_CanoR_1	872	878	PF00244	0.658
LIG_14-3-3_CanoR_1	887	892	PF00244	0.525
LIG_14-3-3_CanoR_1	90	94	PF00244	0.373
LIG_14-3-3_CanoR_1	931	939	PF00244	0.546
LIG_Actin_WH2_2	1073	1090	PF00022	0.452
LIG_BIR_III_4	123	127	PF00653	0.465
LIG_BIR_III_4	487	491	PF00653	0.506
LIG_BRCT_BRCA1_1	1155	1159	PF00533	0.546
LIG_BRCT_BRCA1_1	235	239	PF00533	0.618
LIG_BRCT_BRCA1_1	573	577	PF00533	0.341
LIG_BRCT_BRCA1_1	62	66	PF00533	0.442
LIG_BRCT_BRCA1_1	647	651	PF00533	0.411
LIG_Clathr_ClatBox_1	616	620	PF01394	0.321
LIG_deltaCOP1_diTrp_1	1050	1058	PF00928	0.507
LIG_deltaCOP1_diTrp_1	861	869	PF00928	0.713
LIG_DLG_GKlike_1	1382	1389	PF00625	0.422
LIG_DLG_GKlike_1	887	895	PF00625	0.714
LIG_eIF4E_1	1003	1009	PF01652	0.563
LIG_FHA_1	1266	1272	PF00498	0.722
LIG_FHA_1	128	134	PF00498	0.489
LIG_FHA_1	1283	1289	PF00498	0.618
LIG_FHA_1	1362	1368	PF00498	0.437
LIG_FHA_1	1444	1450	PF00498	0.397
LIG_FHA_1	174	180	PF00498	0.455
LIG_FHA_1	200	206	PF00498	0.420
LIG_FHA_1	211	217	PF00498	0.381
LIG_FHA_1	372	378	PF00498	0.488
LIG_FHA_1	417	423	PF00498	0.488
LIG_FHA_1	442	448	PF00498	0.507
LIG_FHA_1	543	549	PF00498	0.511
LIG_FHA_1	568	574	PF00498	0.402
LIG_FHA_1	604	610	PF00498	0.459
LIG_FHA_1	685	691	PF00498	0.727
LIG_FHA_1	714	720	PF00498	0.679
LIG_FHA_1	722	728	PF00498	0.620
LIG_FHA_1	729	735	PF00498	0.661
LIG_FHA_1	852	858	PF00498	0.676
LIG_FHA_1	996	1002	PF00498	0.470
LIG_FHA_2	1019	1025	PF00498	0.544
LIG_FHA_2	1045	1051	PF00498	0.546
LIG_FHA_2	1172	1178	PF00498	0.546
LIG_FHA_2	166	172	PF00498	0.450
LIG_FHA_2	323	329	PF00498	0.512
LIG_FHA_2	564	570	PF00498	0.435
LIG_FHA_2	772	778	PF00498	0.719
LIG_FHA_2	814	820	PF00498	0.634
LIG_FHA_2	881	887	PF00498	0.711
LIG_FHA_2	896	902	PF00498	0.598
LIG_GSK3_LRP6_1	1246	1251	PF00069	0.779
LIG_Integrin_RGD_1	1382	1384	PF01839	0.621
LIG_Integrin_RGD_1	489	491	PF01839	0.620
LIG_LIR_Apic_2	1138	1144	PF02991	0.546
LIG_LIR_Apic_2	1326	1331	PF02991	0.749
LIG_LIR_Apic_2	1440	1445	PF02991	0.462
LIG_LIR_Apic_2	458	464	PF02991	0.401
LIG_LIR_Apic_2	566	571	PF02991	0.387
LIG_LIR_Apic_2	760	765	PF02991	0.768
LIG_LIR_Gen_1	1031	1040	PF02991	0.540
LIG_LIR_Gen_1	1050	1059	PF02991	0.409
LIG_LIR_Gen_1	1171	1179	PF02991	0.546
LIG_LIR_Gen_1	1319	1328	PF02991	0.660
LIG_LIR_Gen_1	157	167	PF02991	0.376
LIG_LIR_Gen_1	188	198	PF02991	0.302
LIG_LIR_Gen_1	590	597	PF02991	0.501
LIG_LIR_Gen_1	634	645	PF02991	0.359
LIG_LIR_Gen_1	703	712	PF02991	0.640
LIG_LIR_Nem_3	1031	1036	PF02991	0.540
LIG_LIR_Nem_3	1050	1054	PF02991	0.409
LIG_LIR_Nem_3	1056	1061	PF02991	0.540
LIG_LIR_Nem_3	11	15	PF02991	0.616
LIG_LIR_Nem_3	1171	1175	PF02991	0.585
LIG_LIR_Nem_3	1319	1324	PF02991	0.653
LIG_LIR_Nem_3	157	162	PF02991	0.364
LIG_LIR_Nem_3	188	194	PF02991	0.308
LIG_LIR_Nem_3	574	578	PF02991	0.441
LIG_LIR_Nem_3	590	594	PF02991	0.359
LIG_LIR_Nem_3	634	640	PF02991	0.359
LIG_LIR_Nem_3	703	708	PF02991	0.616
LIG_Pex14_2	307	311	PF04695	0.470
LIG_Pex14_2	335	339	PF04695	0.515
LIG_Pex14_2	43	47	PF04695	0.397
LIG_Pex14_2	907	911	PF04695	0.607
LIG_Pex14_2	970	974	PF04695	0.546
LIG_PTB_Apo_2	1436	1443	PF02174	0.539
LIG_PTB_Apo_2	350	357	PF02174	0.461
LIG_PTB_Phospho_1	1436	1442	PF10480	0.540
LIG_PTB_Phospho_1	350	356	PF10480	0.457
LIG_Rb_pABgroove_1	338	346	PF01858	0.411
LIG_REV1ctd_RIR_1	1056	1064	PF16727	0.619
LIG_SH2_CRK	1033	1037	PF00017	0.546
LIG_SH2_CRK	1442	1446	PF00017	0.457
LIG_SH2_CRK	91	95	PF00017	0.442
LIG_SH2_NCK_1	1141	1145	PF00017	0.619
LIG_SH2_PTP2	451	454	PF00017	0.393
LIG_SH2_SRC	775	778	PF00017	0.693
LIG_SH2_STAP1	1451	1455	PF00017	0.482
LIG_SH2_STAP1	286	290	PF00017	0.409
LIG_SH2_STAP1	937	941	PF00017	0.546
LIG_SH2_STAT3	1066	1069	PF00017	0.619
LIG_SH2_STAT3	561	564	PF00017	0.496
LIG_SH2_STAT5	1042	1045	PF00017	0.546
LIG_SH2_STAT5	1076	1079	PF00017	0.514
LIG_SH2_STAT5	1451	1454	PF00017	0.538
LIG_SH2_STAT5	189	192	PF00017	0.375
LIG_SH2_STAT5	211	214	PF00017	0.470
LIG_SH2_STAT5	391	394	PF00017	0.448
LIG_SH2_STAT5	451	454	PF00017	0.393
LIG_SH2_STAT5	91	94	PF00017	0.413
LIG_SH2_STAT5	971	974	PF00017	0.546
LIG_SH3_1	1244	1250	PF00018	0.779
LIG_SH3_1	1442	1448	PF00018	0.460
LIG_SH3_2	245	250	PF14604	0.457
LIG_SH3_3	1149	1155	PF00018	0.546
LIG_SH3_3	1242	1248	PF00018	0.764
LIG_SH3_3	1442	1448	PF00018	0.478
LIG_SH3_3	1467	1473	PF00018	0.579
LIG_SH3_3	242	248	PF00018	0.456
LIG_SH3_3	277	283	PF00018	0.362
LIG_SH3_3	299	305	PF00018	0.481
LIG_SH3_3	570	576	PF00018	0.442
LIG_SH3_3	729	735	PF00018	0.750
LIG_SH3_3	755	761	PF00018	0.799
LIG_SUMO_SIM_anti_2	1337	1343	PF11976	0.536
LIG_SUMO_SIM_anti_2	96	105	PF11976	0.394
LIG_SUMO_SIM_par_1	1162	1167	PF11976	0.546
LIG_SUMO_SIM_par_1	1229	1234	PF11976	0.716
LIG_SUMO_SIM_par_1	127	132	PF11976	0.407
LIG_SUMO_SIM_par_1	848	858	PF11976	0.748
LIG_TRAF2_1	1238	1241	PF00917	0.778
LIG_TRAF2_1	740	743	PF00917	0.778
LIG_UBA3_1	906	912	PF00899	0.607
LIG_WRC_WIRS_1	1169	1174	PF05994	0.598
LIG_WRC_WIRS_1	637	642	PF05994	0.411
LIG_WRC_WIRS_1	709	714	PF05994	0.634
LIG_WW_3	247	251	PF00397	0.572
LIG_WW_3	656	660	PF00397	0.599
LIG_WW_3	756	760	PF00397	0.716
MOD_CDC14_SPxK_1	247	250	PF00782	0.570
MOD_CDC14_SPxK_1	756	759	PF00782	0.715
MOD_CDK_SPK_2	295	300	PF00069	0.407
MOD_CDK_SPK_2	329	334	PF00069	0.521
MOD_CDK_SPK_2	693	698	PF00069	0.597
MOD_CDK_SPK_2	867	872	PF00069	0.580
MOD_CDK_SPxK_1	244	250	PF00069	0.568
MOD_CDK_SPxK_1	753	759	PF00069	0.713
MOD_CDK_SPxK_1	817	823	PF00069	0.733
MOD_CDK_SPxxK_3	1140	1147	PF00069	0.452
MOD_CDK_SPxxK_3	364	371	PF00069	0.552
MOD_CDK_SPxxK_3	817	824	PF00069	0.785
MOD_CK1_1	1004	1010	PF00069	0.538
MOD_CK1_1	1013	1019	PF00069	0.383
MOD_CK1_1	1044	1050	PF00069	0.462
MOD_CK1_1	1327	1333	PF00069	0.715
MOD_CK1_1	1385	1391	PF00069	0.484
MOD_CK1_1	157	163	PF00069	0.352
MOD_CK1_1	185	191	PF00069	0.333
MOD_CK1_1	312	318	PF00069	0.515
MOD_CK1_1	329	335	PF00069	0.508
MOD_CK1_1	404	410	PF00069	0.471
MOD_CK1_1	436	442	PF00069	0.528
MOD_CK1_1	526	532	PF00069	0.506
MOD_CK1_1	596	602	PF00069	0.465
MOD_CK1_1	677	683	PF00069	0.737
MOD_CK1_1	713	719	PF00069	0.636
MOD_CK1_1	728	734	PF00069	0.548
MOD_CK1_1	737	743	PF00069	0.690
MOD_CK1_1	828	834	PF00069	0.701
MOD_CK1_1	83	89	PF00069	0.457
MOD_CK1_1	846	852	PF00069	0.727
MOD_CK1_1	889	895	PF00069	0.778
MOD_CK2_1	1139	1145	PF00069	0.619
MOD_CK2_1	1171	1177	PF00069	0.546
MOD_CK2_1	1235	1241	PF00069	0.732
MOD_CK2_1	165	171	PF00069	0.446
MOD_CK2_1	250	256	PF00069	0.586
MOD_CK2_1	469	475	PF00069	0.502
MOD_CK2_1	563	569	PF00069	0.397
MOD_CK2_1	737	743	PF00069	0.771
MOD_CK2_1	771	777	PF00069	0.697
MOD_CK2_1	813	819	PF00069	0.717
MOD_CK2_1	895	901	PF00069	0.676
MOD_Cter_Amidation	28	31	PF01082	0.565
MOD_GlcNHglycan	1012	1015	PF01048	0.386
MOD_GlcNHglycan	104	107	PF01048	0.601
MOD_GlcNHglycan	1116	1119	PF01048	0.336
MOD_GlcNHglycan	1273	1277	PF01048	0.478
MOD_GlcNHglycan	1313	1316	PF01048	0.516
MOD_GlcNHglycan	1373	1376	PF01048	0.689
MOD_GlcNHglycan	1407	1410	PF01048	0.726
MOD_GlcNHglycan	1429	1432	PF01048	0.668
MOD_GlcNHglycan	1470	1473	PF01048	0.792
MOD_GlcNHglycan	239	242	PF01048	0.647
MOD_GlcNHglycan	26	29	PF01048	0.611
MOD_GlcNHglycan	31	34	PF01048	0.522
MOD_GlcNHglycan	311	314	PF01048	0.723
MOD_GlcNHglycan	320	323	PF01048	0.646
MOD_GlcNHglycan	428	432	PF01048	0.723
MOD_GlcNHglycan	454	457	PF01048	0.605
MOD_GlcNHglycan	467	470	PF01048	0.640
MOD_GlcNHglycan	500	503	PF01048	0.666
MOD_GlcNHglycan	525	528	PF01048	0.651
MOD_GlcNHglycan	585	588	PF01048	0.625
MOD_GlcNHglycan	595	598	PF01048	0.563
MOD_GlcNHglycan	606	609	PF01048	0.573
MOD_GlcNHglycan	62	65	PF01048	0.664
MOD_GlcNHglycan	620	624	PF01048	0.568
MOD_GlcNHglycan	753	756	PF01048	0.447
MOD_GlcNHglycan	787	790	PF01048	0.443
MOD_GlcNHglycan	834	837	PF01048	0.573
MOD_GlcNHglycan	843	846	PF01048	0.489
MOD_GlcNHglycan	875	878	PF01048	0.462
MOD_GSK3_1	1009	1016	PF00069	0.519
MOD_GSK3_1	1018	1025	PF00069	0.478
MOD_GSK3_1	1135	1142	PF00069	0.547
MOD_GSK3_1	1153	1160	PF00069	0.470
MOD_GSK3_1	1274	1281	PF00069	0.687
MOD_GSK3_1	1288	1295	PF00069	0.678
MOD_GSK3_1	1344	1351	PF00069	0.423
MOD_GSK3_1	1363	1370	PF00069	0.454
MOD_GSK3_1	1385	1392	PF00069	0.550
MOD_GSK3_1	1425	1432	PF00069	0.464
MOD_GSK3_1	165	172	PF00069	0.409
MOD_GSK3_1	233	240	PF00069	0.520
MOD_GSK3_1	250	257	PF00069	0.526
MOD_GSK3_1	286	293	PF00069	0.412
MOD_GSK3_1	312	319	PF00069	0.535
MOD_GSK3_1	322	329	PF00069	0.517
MOD_GSK3_1	390	397	PF00069	0.416
MOD_GSK3_1	412	419	PF00069	0.464
MOD_GSK3_1	427	434	PF00069	0.535
MOD_GSK3_1	437	444	PF00069	0.459
MOD_GSK3_1	465	472	PF00069	0.460
MOD_GSK3_1	519	526	PF00069	0.471
MOD_GSK3_1	52	59	PF00069	0.417
MOD_GSK3_1	563	570	PF00069	0.412
MOD_GSK3_1	583	590	PF00069	0.250
MOD_GSK3_1	593	600	PF00069	0.364
MOD_GSK3_1	604	611	PF00069	0.357
MOD_GSK3_1	674	681	PF00069	0.749
MOD_GSK3_1	721	728	PF00069	0.707
MOD_GSK3_1	730	737	PF00069	0.628
MOD_GSK3_1	753	760	PF00069	0.755
MOD_GSK3_1	76	83	PF00069	0.453
MOD_GSK3_1	771	778	PF00069	0.577
MOD_GSK3_1	785	792	PF00069	0.652
MOD_GSK3_1	793	800	PF00069	0.694
MOD_GSK3_1	813	820	PF00069	0.779
MOD_GSK3_1	828	835	PF00069	0.681
MOD_GSK3_1	841	848	PF00069	0.640
MOD_GSK3_1	882	889	PF00069	0.688
MOD_GSK3_1	89	96	PF00069	0.330
MOD_GSK3_1	891	898	PF00069	0.666
MOD_GSK3_1	997	1004	PF00069	0.545
MOD_LATS_1	1403	1409	PF00433	0.615
MOD_N-GLC_1	1114	1119	PF02516	0.323
MOD_N-GLC_1	192	197	PF02516	0.564
MOD_N-GLC_1	401	406	PF02516	0.641
MOD_N-GLC_1	431	436	PF02516	0.662
MOD_N-GLC_1	441	446	PF02516	0.653
MOD_N-GLC_1	846	851	PF02516	0.572
MOD_NEK2_1	1008	1013	PF00069	0.563
MOD_NEK2_1	1168	1173	PF00069	0.507
MOD_NEK2_1	1204	1209	PF00069	0.533
MOD_NEK2_1	1293	1298	PF00069	0.730
MOD_NEK2_1	1361	1366	PF00069	0.490
MOD_NEK2_1	1389	1394	PF00069	0.445
MOD_NEK2_1	1425	1430	PF00069	0.425
MOD_NEK2_1	192	197	PF00069	0.364
MOD_NEK2_1	221	226	PF00069	0.519
MOD_NEK2_1	239	244	PF00069	0.554
MOD_NEK2_1	309	314	PF00069	0.361
MOD_NEK2_1	339	344	PF00069	0.340
MOD_NEK2_1	381	386	PF00069	0.488
MOD_NEK2_1	401	406	PF00069	0.323
MOD_NEK2_1	46	51	PF00069	0.442
MOD_NEK2_1	619	624	PF00069	0.479
MOD_NEK2_1	645	650	PF00069	0.411
MOD_NEK2_1	782	787	PF00069	0.756
MOD_NEK2_1	804	809	PF00069	0.707
MOD_NEK2_1	880	885	PF00069	0.665
MOD_NEK2_1	89	94	PF00069	0.376
MOD_NEK2_1	996	1001	PF00069	0.563
MOD_NEK2_2	1363	1368	PF00069	0.414
MOD_NEK2_2	286	291	PF00069	0.318
MOD_NEK2_2	636	641	PF00069	0.411
MOD_NEK2_2	921	926	PF00069	0.619
MOD_PIKK_1	233	239	PF00454	0.613
MOD_PIKK_1	290	296	PF00454	0.424
MOD_PIKK_1	334	340	PF00454	0.515
MOD_PIKK_1	383	389	PF00454	0.438
MOD_PIKK_1	56	62	PF00454	0.564
MOD_PIKK_1	684	690	PF00454	0.711
MOD_PIKK_1	891	897	PF00454	0.781
MOD_PK_1	394	400	PF00069	0.443
MOD_PKA_1	1405	1411	PF00069	0.554
MOD_PKA_1	199	205	PF00069	0.373
MOD_PKA_1	24	30	PF00069	0.759
MOD_PKA_2	1044	1050	PF00069	0.546
MOD_PKA_2	1405	1411	PF00069	0.550
MOD_PKA_2	199	205	PF00069	0.373
MOD_PKA_2	24	30	PF00069	0.762
MOD_PKA_2	290	296	PF00069	0.386
MOD_PKA_2	370	376	PF00069	0.547
MOD_PKA_2	426	432	PF00069	0.433
MOD_PKA_2	480	486	PF00069	0.503
MOD_PKA_2	497	503	PF00069	0.352
MOD_PKA_2	674	680	PF00069	0.733
MOD_PKA_2	782	788	PF00069	0.599
MOD_PKA_2	793	799	PF00069	0.572
MOD_PKA_2	886	892	PF00069	0.766
MOD_PKA_2	89	95	PF00069	0.375
MOD_PKA_2	930	936	PF00069	0.546
MOD_PKB_1	1178	1186	PF00069	0.530
MOD_Plk_1	1004	1010	PF00069	0.525
MOD_Plk_1	1455	1461	PF00069	0.465
MOD_Plk_1	1466	1472	PF00069	0.498
MOD_Plk_1	15	21	PF00069	0.685
MOD_Plk_1	192	198	PF00069	0.363
MOD_Plk_1	284	290	PF00069	0.401
MOD_Plk_1	401	407	PF00069	0.444
MOD_Plk_1	612	618	PF00069	0.329
MOD_Plk_1	737	743	PF00069	0.764
MOD_Plk_1	74	80	PF00069	0.442
MOD_Plk_1	851	857	PF00069	0.743
MOD_Plk_1	880	886	PF00069	0.646
MOD_Plk_1	996	1002	PF00069	0.568
MOD_Plk_2-3	542	548	PF00069	0.509
MOD_Plk_2-3	710	716	PF00069	0.673
MOD_Plk_2-3	851	857	PF00069	0.670
MOD_Plk_4	1004	1010	PF00069	0.563
MOD_Plk_4	1130	1136	PF00069	0.452
MOD_Plk_4	1204	1210	PF00069	0.619
MOD_Plk_4	1390	1396	PF00069	0.499
MOD_Plk_4	1456	1462	PF00069	0.498
MOD_Plk_4	154	160	PF00069	0.363
MOD_Plk_4	193	199	PF00069	0.361
MOD_Plk_4	443	449	PF00069	0.439
MOD_Plk_4	469	475	PF00069	0.486
MOD_Plk_4	519	525	PF00069	0.388
MOD_Plk_4	563	569	PF00069	0.469
MOD_Plk_4	612	618	PF00069	0.332
MOD_Plk_4	921	927	PF00069	0.598
MOD_ProDKin_1	1135	1141	PF00069	0.546
MOD_ProDKin_1	1246	1252	PF00069	0.763
MOD_ProDKin_1	1288	1294	PF00069	0.738
MOD_ProDKin_1	1327	1333	PF00069	0.715
MOD_ProDKin_1	1356	1362	PF00069	0.457
MOD_ProDKin_1	1407	1413	PF00069	0.516
MOD_ProDKin_1	1444	1450	PF00069	0.447
MOD_ProDKin_1	165	171	PF00069	0.400
MOD_ProDKin_1	231	237	PF00069	0.566
MOD_ProDKin_1	244	250	PF00069	0.503
MOD_ProDKin_1	295	301	PF00069	0.424
MOD_ProDKin_1	329	335	PF00069	0.517
MOD_ProDKin_1	364	370	PF00069	0.529
MOD_ProDKin_1	567	573	PF00069	0.394
MOD_ProDKin_1	693	699	PF00069	0.720
MOD_ProDKin_1	700	706	PF00069	0.622
MOD_ProDKin_1	753	759	PF00069	0.721
MOD_ProDKin_1	817	823	PF00069	0.762
MOD_ProDKin_1	828	834	PF00069	0.673
MOD_ProDKin_1	867	873	PF00069	0.609
MOD_SUMO_rev_2	1081	1090	PF00179	0.546
MOD_SUMO_rev_2	1329	1337	PF00179	0.695
MOD_SUMO_rev_2	901	907	PF00179	0.647
TRG_DiLeu_BaEn_4	475	481	PF01217	0.480
TRG_DiLeu_LyEn_5	264	269	PF01217	0.479
TRG_ENDOCYTIC_2	1033	1036	PF00928	0.546
TRG_ENDOCYTIC_2	189	192	PF00928	0.375
TRG_ENDOCYTIC_2	451	454	PF00928	0.393
TRG_ER_diArg_1	1052	1055	PF00400	0.546
TRG_ER_diArg_1	1178	1181	PF00400	0.530
TRG_ER_diArg_1	1304	1307	PF00400	0.608
TRG_ER_diArg_1	1404	1406	PF00400	0.508
TRG_ER_diArg_1	198	200	PF00400	0.360
TRG_ER_diArg_1	24	26	PF00400	0.782
TRG_ER_diArg_1	356	358	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	1180	1184	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	1463	1467	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U7	Leptomonas seymouri	48%	100%
A0A3S5H7W8	Leishmania donovani	91%	100%
A4HAS7	Leishmania braziliensis	71%	100%
A4I9Y7	Leishmania infantum	91%	100%
E9B501	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%