Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2Y4_LEIMA

TriTrypDb:

LmjF.34.2160 , LMJLV39_340026400 , LMJSD75_340027200

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q2Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.693
CLV_NRD_NRD_1	63	65	PF00675	0.477
CLV_NRD_NRD_1	80	82	PF00675	0.385
CLV_NRD_NRD_1	86	88	PF00675	0.554
CLV_PCSK_FUR_1	61	65	PF00082	0.576
CLV_PCSK_KEX2_1	425	427	PF00082	0.651
CLV_PCSK_KEX2_1	63	65	PF00082	0.477
CLV_PCSK_KEX2_1	79	81	PF00082	0.410
CLV_PCSK_KEX2_1	86	88	PF00082	0.482
CLV_PCSK_KEX2_1	99	101	PF00082	0.682
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.613
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.706
CLV_PCSK_SKI1_1	404	408	PF00082	0.599
CLV_PCSK_SKI1_1	426	430	PF00082	0.619
CLV_PCSK_SKI1_1	432	436	PF00082	0.556
DEG_APCC_DBOX_1	186	194	PF00400	0.573
DEG_APCC_DBOX_1	340	348	PF00400	0.615
DEG_SCF_FBW7_1	470	475	PF00400	0.627
DEG_SPOP_SBC_1	39	43	PF00917	0.466
DEG_SPOP_SBC_1	472	476	PF00917	0.745
DOC_CYCLIN_RxL_1	183	195	PF00134	0.629
DOC_MAPK_FxFP_2	216	219	PF00069	0.599
DOC_MAPK_gen_1	173	181	PF00069	0.538
DOC_MAPK_gen_1	79	85	PF00069	0.633
DOC_MAPK_MEF2A_6	14	22	PF00069	0.635
DOC_PP4_FxxP_1	216	219	PF00568	0.580
DOC_USP7_MATH_1	297	301	PF00917	0.603
DOC_USP7_MATH_2	122	128	PF00917	0.761
DOC_USP7_UBL2_3	197	201	PF12436	0.546
DOC_WW_Pin1_4	103	108	PF00397	0.663
DOC_WW_Pin1_4	115	120	PF00397	0.628
DOC_WW_Pin1_4	2	7	PF00397	0.546
DOC_WW_Pin1_4	228	233	PF00397	0.675
DOC_WW_Pin1_4	237	242	PF00397	0.746
DOC_WW_Pin1_4	405	410	PF00397	0.618
DOC_WW_Pin1_4	468	473	PF00397	0.673
LIG_14-3-3_CanoR_1	100	107	PF00244	0.719
LIG_14-3-3_CanoR_1	110	115	PF00244	0.783
LIG_14-3-3_CanoR_1	147	155	PF00244	0.644
LIG_14-3-3_CanoR_1	183	187	PF00244	0.595
LIG_14-3-3_CanoR_1	251	260	PF00244	0.597
LIG_14-3-3_CanoR_1	353	357	PF00244	0.604
LIG_14-3-3_CanoR_1	410	414	PF00244	0.575
LIG_14-3-3_CanoR_1	86	90	PF00244	0.672
LIG_AP2alpha_2	214	216	PF02296	0.567
LIG_APCC_ABBA_1	128	133	PF00400	0.546
LIG_APCC_ABBA_1	20	25	PF00400	0.624
LIG_BRCT_BRCA1_1	407	411	PF00533	0.652
LIG_Clathr_ClatBox_1	190	194	PF01394	0.615
LIG_DLG_GKlike_1	110	118	PF00625	0.706
LIG_FHA_1	144	150	PF00498	0.671
LIG_FHA_1	480	486	PF00498	0.687
LIG_FHA_2	272	278	PF00498	0.640
LIG_FHA_2	41	47	PF00498	0.578
LIG_FHA_2	410	416	PF00498	0.481
LIG_IRF3_LxIS_1	12	19	PF10401	0.553
LIG_LIR_Apic_2	152	158	PF02991	0.518
LIG_LIR_Apic_2	214	219	PF02991	0.531
LIG_LIR_Gen_1	377	386	PF02991	0.606
LIG_LIR_Gen_1	412	419	PF02991	0.649
LIG_LIR_Nem_3	377	381	PF02991	0.565
LIG_LIR_Nem_3	412	416	PF02991	0.653
LIG_LIR_Nem_3	88	92	PF02991	0.705
LIG_MAD2	211	219	PF02301	0.639
LIG_NRBOX	54	60	PF00104	0.471
LIG_PCNA_yPIPBox_3	425	437	PF02747	0.638
LIG_Rb_pABgroove_1	342	350	PF01858	0.645
LIG_SH2_STAP1	318	322	PF00017	0.520
LIG_SH2_STAP1	348	352	PF00017	0.648
LIG_SH3_1	116	122	PF00018	0.652
LIG_SH3_3	116	122	PF00018	0.723
LIG_SH3_3	129	135	PF00018	0.575
LIG_SH3_3	209	215	PF00018	0.563
LIG_SH3_3	238	244	PF00018	0.642
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.645
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.642
LIG_SUMO_SIM_par_1	482	490	PF11976	0.634
LIG_SUMO_SIM_par_1	70	75	PF11976	0.586
LIG_TRAF2_1	135	138	PF00917	0.690
LIG_TRAF2_1	428	431	PF00917	0.590
LIG_UBA3_1	190	197	PF00899	0.613
MOD_CDK_SPK_2	115	120	PF00069	0.747
MOD_CDK_SPK_2	405	410	PF00069	0.606
MOD_CDK_SPxxK_3	103	110	PF00069	0.686
MOD_CK1_1	108	114	PF00069	0.665
MOD_CK1_1	142	148	PF00069	0.649
MOD_CK1_1	150	156	PF00069	0.736
MOD_CK1_1	221	227	PF00069	0.614
MOD_CK1_1	228	234	PF00069	0.658
MOD_CK1_1	237	243	PF00069	0.629
MOD_CK1_1	304	310	PF00069	0.612
MOD_CK1_1	324	330	PF00069	0.639
MOD_CK1_1	5	11	PF00069	0.684
MOD_CK1_1	88	94	PF00069	0.694
MOD_CK2_1	352	358	PF00069	0.646
MOD_CK2_1	40	46	PF00069	0.587
MOD_CK2_1	72	78	PF00069	0.533
MOD_GlcNHglycan	110	113	PF01048	0.708
MOD_GlcNHglycan	141	144	PF01048	0.780
MOD_GlcNHglycan	227	230	PF01048	0.682
MOD_GlcNHglycan	287	290	PF01048	0.553
MOD_GlcNHglycan	305	309	PF01048	0.607
MOD_GlcNHglycan	323	327	PF01048	0.566
MOD_GlcNHglycan	475	478	PF01048	0.640
MOD_GlcNHglycan	7	10	PF01048	0.639
MOD_GSK3_1	101	108	PF00069	0.631
MOD_GSK3_1	139	146	PF00069	0.706
MOD_GSK3_1	147	154	PF00069	0.656
MOD_GSK3_1	159	166	PF00069	0.677
MOD_GSK3_1	221	228	PF00069	0.597
MOD_GSK3_1	252	259	PF00069	0.731
MOD_GSK3_1	297	304	PF00069	0.580
MOD_GSK3_1	321	328	PF00069	0.621
MOD_GSK3_1	385	392	PF00069	0.658
MOD_GSK3_1	405	412	PF00069	0.549
MOD_GSK3_1	468	475	PF00069	0.630
MOD_N-GLC_1	271	276	PF02516	0.608
MOD_N-GLC_1	301	306	PF02516	0.586
MOD_NEK2_1	149	154	PF00069	0.763
MOD_NEK2_1	16	21	PF00069	0.588
MOD_NEK2_1	225	230	PF00069	0.653
MOD_NEK2_1	298	303	PF00069	0.561
MOD_NEK2_1	322	327	PF00069	0.559
MOD_NEK2_1	65	70	PF00069	0.568
MOD_NEK2_1	85	90	PF00069	0.630
MOD_PIKK_1	192	198	PF00454	0.524
MOD_PIKK_1	234	240	PF00454	0.689
MOD_PIKK_1	252	258	PF00454	0.536
MOD_PIKK_1	385	391	PF00454	0.658
MOD_PIKK_1	451	457	PF00454	0.659
MOD_PIKK_1	72	78	PF00454	0.592
MOD_PIKK_1	90	96	PF00454	0.727
MOD_PKA_2	182	188	PF00069	0.551
MOD_PKA_2	285	291	PF00069	0.522
MOD_PKA_2	340	346	PF00069	0.614
MOD_PKA_2	352	358	PF00069	0.526
MOD_PKA_2	368	374	PF00069	0.585
MOD_PKA_2	409	415	PF00069	0.568
MOD_PKA_2	85	91	PF00069	0.673
MOD_Plk_1	256	262	PF00069	0.716
MOD_Plk_2-3	124	130	PF00069	0.714
MOD_Plk_2-3	163	169	PF00069	0.570
MOD_Plk_4	110	116	PF00069	0.589
MOD_Plk_4	221	227	PF00069	0.575
MOD_Plk_4	368	374	PF00069	0.549
MOD_Plk_4	479	485	PF00069	0.681
MOD_ProDKin_1	103	109	PF00069	0.662
MOD_ProDKin_1	115	121	PF00069	0.628
MOD_ProDKin_1	2	8	PF00069	0.533
MOD_ProDKin_1	228	234	PF00069	0.678
MOD_ProDKin_1	237	243	PF00069	0.746
MOD_ProDKin_1	405	411	PF00069	0.619
MOD_ProDKin_1	468	474	PF00069	0.673
MOD_SUMO_rev_2	355	361	PF00179	0.686
MOD_SUMO_rev_2	415	422	PF00179	0.607
TRG_DiLeu_BaEn_1	54	59	PF01217	0.563
TRG_ER_diArg_1	61	64	PF00400	0.504
TRG_ER_diArg_1	79	81	PF00400	0.419
TRG_ER_diArg_1	85	87	PF00400	0.560
TRG_NES_CRM1_1	11	25	PF08389	0.639
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED0	Leptomonas seymouri	57%	100%
A0A0S4J9S2	Bodo saltans	26%	98%
A0A1X0P9K0	Trypanosomatidae	28%	100%
A0A3Q8INC5	Leishmania donovani	92%	100%
A0A422NY19	Trypanosoma rangeli	28%	100%
A4HAS8	Leishmania braziliensis	75%	100%
A4I9Y8	Leishmania infantum	92%	100%
E9B502	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BPZ9	Trypanosoma cruzi	29%	97%