DNA-(apurinic or apyrimidinic site) lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

8-oxoguanine DNA glycosylase, putative

Species:

Leishmania major

UniProt:

Q4Q2Y3_LEIMA

TriTrypDb:

LmjF.34.2170 , LMJLV39_340026500 , LMJSD75_340027300

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Y3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006285	base-excision repair, AP site formation	5	2
GO:0006289	nucleotide-excision repair	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006284	base-excision repair	6	9

Molecular functions
Term	Name	Level	Count
GO:0000702	oxidized base lesion DNA N-glycosylase activity	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003684	damaged DNA binding	5	11
GO:0003824	catalytic activity	1	11
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0005488	binding	1	11
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	11
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	11
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0019104	DNA N-glycosylase activity	4	11
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	7	2
GO:0097159	organic cyclic compound binding	2	11
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.451
CLV_NRD_NRD_1	114	116	PF00675	0.333
CLV_NRD_NRD_1	180	182	PF00675	0.359
CLV_NRD_NRD_1	193	195	PF00675	0.222
CLV_NRD_NRD_1	274	276	PF00675	0.241
CLV_NRD_NRD_1	298	300	PF00675	0.260
CLV_NRD_NRD_1	421	423	PF00675	0.271
CLV_NRD_NRD_1	463	465	PF00675	0.558
CLV_NRD_NRD_1	488	490	PF00675	0.451
CLV_NRD_NRD_1	523	525	PF00675	0.702
CLV_NRD_NRD_1	543	545	PF00675	0.233
CLV_NRD_NRD_1	563	565	PF00675	0.440
CLV_NRD_NRD_1	86	88	PF00675	0.332
CLV_PCSK_FUR_1	82	86	PF00082	0.235
CLV_PCSK_KEX2_1	114	116	PF00082	0.282
CLV_PCSK_KEX2_1	193	195	PF00082	0.195
CLV_PCSK_KEX2_1	298	300	PF00082	0.332
CLV_PCSK_KEX2_1	465	467	PF00082	0.564
CLV_PCSK_KEX2_1	84	86	PF00082	0.293
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.564
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.259
CLV_PCSK_PC7_1	82	88	PF00082	0.259
CLV_PCSK_SKI1_1	13	17	PF00082	0.422
CLV_PCSK_SKI1_1	196	200	PF00082	0.354
CLV_PCSK_SKI1_1	371	375	PF00082	0.317
CLV_PCSK_SKI1_1	411	415	PF00082	0.289
CLV_PCSK_SKI1_1	544	548	PF00082	0.311
DEG_APCC_DBOX_1	410	418	PF00400	0.436
DEG_SCF_FBW7_1	6	11	PF00400	0.389
DEG_SPOP_SBC_1	14	18	PF00917	0.410
DEG_SPOP_SBC_1	92	96	PF00917	0.539
DOC_CKS1_1	38	43	PF01111	0.525
DOC_CYCLIN_RxL_1	156	166	PF00134	0.517
DOC_CYCLIN_RxL_1	193	201	PF00134	0.515
DOC_CYCLIN_RxL_1	337	348	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.451
DOC_MAPK_gen_1	20	29	PF00069	0.567
DOC_MAPK_gen_1	371	379	PF00069	0.389
DOC_MAPK_gen_1	39	48	PF00069	0.422
DOC_MAPK_gen_1	422	430	PF00069	0.463
DOC_MAPK_gen_1	479	486	PF00069	0.365
DOC_MAPK_gen_1	489	497	PF00069	0.387
DOC_MAPK_MEF2A_6	159	167	PF00069	0.452
DOC_MAPK_MEF2A_6	20	27	PF00069	0.482
DOC_PP1_RVXF_1	338	345	PF00149	0.436
DOC_PP2B_LxvP_1	217	220	PF13499	0.451
DOC_PP2B_LxvP_1	362	365	PF13499	0.404
DOC_PP2B_LxvP_1	415	418	PF13499	0.449
DOC_PP2B_LxvP_1	453	456	PF13499	0.424
DOC_USP7_MATH_1	133	137	PF00917	0.553
DOC_USP7_MATH_1	142	146	PF00917	0.500
DOC_USP7_MATH_1	21	25	PF00917	0.480
DOC_USP7_MATH_1	274	278	PF00917	0.542
DOC_USP7_MATH_1	303	307	PF00917	0.531
DOC_USP7_MATH_1	454	458	PF00917	0.579
DOC_USP7_MATH_1	8	12	PF00917	0.553
DOC_USP7_MATH_1	93	97	PF00917	0.496
DOC_WW_Pin1_4	129	134	PF00397	0.544
DOC_WW_Pin1_4	174	179	PF00397	0.482
DOC_WW_Pin1_4	301	306	PF00397	0.466
DOC_WW_Pin1_4	37	42	PF00397	0.449
DOC_WW_Pin1_4	4	9	PF00397	0.479
DOC_WW_Pin1_4	499	504	PF00397	0.515
DOC_WW_Pin1_4	523	528	PF00397	0.648
DOC_WW_Pin1_4	88	93	PF00397	0.486
LIG_14-3-3_CanoR_1	13	23	PF00244	0.535
LIG_14-3-3_CanoR_1	159	164	PF00244	0.526
LIG_14-3-3_CanoR_1	86	92	PF00244	0.504
LIG_Actin_WH2_1	42	59	PF00022	0.482
LIG_Actin_WH2_2	41	59	PF00022	0.420
LIG_BRCT_BRCA1_1	229	233	PF00533	0.531
LIG_BRCT_BRCA1_1	340	344	PF00533	0.420
LIG_BRCT_BRCA1_1	555	559	PF00533	0.308
LIG_deltaCOP1_diTrp_1	168	174	PF00928	0.531
LIG_deltaCOP1_diTrp_1	318	325	PF00928	0.523
LIG_FHA_1	129	135	PF00498	0.537
LIG_FHA_1	14	20	PF00498	0.501
LIG_FHA_1	245	251	PF00498	0.470
LIG_FHA_1	266	272	PF00498	0.436
LIG_FHA_1	434	440	PF00498	0.539
LIG_FHA_2	146	152	PF00498	0.447
LIG_FHA_2	295	301	PF00498	0.556
LIG_FHA_2	331	337	PF00498	0.389
LIG_LIR_Apic_2	321	326	PF02991	0.531
LIG_LIR_Gen_1	158	167	PF02991	0.531
LIG_LIR_Gen_1	318	326	PF02991	0.451
LIG_LIR_Nem_3	107	113	PF02991	0.479
LIG_LIR_Nem_3	11	15	PF02991	0.467
LIG_LIR_Nem_3	158	163	PF02991	0.531
LIG_LIR_Nem_3	230	236	PF02991	0.509
LIG_LIR_Nem_3	318	322	PF02991	0.440
LIG_LIR_Nem_3	324	328	PF02991	0.459
LIG_LIR_Nem_3	44	48	PF02991	0.415
LIG_LIR_Nem_3	541	546	PF02991	0.560
LIG_MYND_1	305	309	PF01753	0.435
LIG_MYND_2	380	384	PF01753	0.451
LIG_Pex14_1	319	323	PF04695	0.531
LIG_Pex14_2	543	547	PF04695	0.340
LIG_PTB_Apo_2	390	397	PF02174	0.482
LIG_PTB_Phospho_1	390	396	PF10480	0.482
LIG_SH2_CRK	323	327	PF00017	0.482
LIG_SH2_CRK	38	42	PF00017	0.435
LIG_SH2_CRK	396	400	PF00017	0.482
LIG_SH2_PTP2	218	221	PF00017	0.531
LIG_SH2_SRC	218	221	PF00017	0.517
LIG_SH2_STAP1	396	400	PF00017	0.439
LIG_SH2_STAT3	405	408	PF00017	0.435
LIG_SH2_STAT5	104	107	PF00017	0.388
LIG_SH2_STAT5	160	163	PF00017	0.436
LIG_SH2_STAT5	188	191	PF00017	0.467
LIG_SH2_STAT5	218	221	PF00017	0.531
LIG_SH2_STAT5	350	353	PF00017	0.429
LIG_SH2_STAT5	452	455	PF00017	0.369
LIG_SH3_1	466	472	PF00018	0.497
LIG_SH3_1	524	530	PF00018	0.600
LIG_SH3_3	268	274	PF00018	0.531
LIG_SH3_3	466	472	PF00018	0.512
LIG_SH3_3	524	530	PF00018	0.543
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.482
LIG_TRAF2_1	152	155	PF00917	0.529
LIG_TRAF2_1	474	477	PF00917	0.667
LIG_TRAF2_1	508	511	PF00917	0.528
LIG_TYR_ITIM	111	116	PF00017	0.531
LIG_WRC_WIRS_1	232	237	PF05994	0.438
LIG_WW_1	529	532	PF00397	0.527
MOD_CDK_SPK_2	37	42	PF00069	0.449
MOD_CDK_SPxxK_3	174	181	PF00069	0.482
MOD_CDK_SPxxK_3	301	308	PF00069	0.466
MOD_CK1_1	145	151	PF00069	0.501
MOD_CK1_1	177	183	PF00069	0.482
MOD_CK1_1	321	327	PF00069	0.502
MOD_CK1_1	4	10	PF00069	0.638
MOD_CK1_1	457	463	PF00069	0.476
MOD_CK1_1	502	508	PF00069	0.648
MOD_CK1_1	523	529	PF00069	0.545
MOD_CK1_1	91	97	PF00069	0.434
MOD_CK2_1	145	151	PF00069	0.498
MOD_CK2_1	330	336	PF00069	0.424
MOD_CK2_1	91	97	PF00069	0.577
MOD_CMANNOS	171	174	PF00535	0.236
MOD_Cter_Amidation	420	423	PF01082	0.236
MOD_Cter_Amidation	462	465	PF01082	0.622
MOD_GlcNHglycan	144	147	PF01048	0.238
MOD_GlcNHglycan	200	203	PF01048	0.349
MOD_GlcNHglycan	276	279	PF01048	0.345
MOD_GlcNHglycan	310	313	PF01048	0.201
MOD_GlcNHglycan	396	399	PF01048	0.307
MOD_GlcNHglycan	456	459	PF01048	0.622
MOD_GlcNHglycan	514	517	PF01048	0.727
MOD_GSK3_1	129	136	PF00069	0.544
MOD_GSK3_1	138	145	PF00069	0.507
MOD_GSK3_1	155	162	PF00069	0.464
MOD_GSK3_1	21	28	PF00069	0.513
MOD_GSK3_1	227	234	PF00069	0.529
MOD_GSK3_1	274	281	PF00069	0.521
MOD_GSK3_1	285	292	PF00069	0.501
MOD_GSK3_1	294	301	PF00069	0.480
MOD_GSK3_1	353	360	PF00069	0.466
MOD_GSK3_1	37	44	PF00069	0.444
MOD_GSK3_1	4	11	PF00069	0.420
MOD_GSK3_1	87	94	PF00069	0.473
MOD_N-GLC_1	241	246	PF02516	0.334
MOD_N-GLC_1	433	438	PF02516	0.282
MOD_N-GLC_2	103	105	PF02516	0.181
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	138	143	PF00069	0.503
MOD_NEK2_1	15	20	PF00069	0.501
MOD_NEK2_1	189	194	PF00069	0.428
MOD_NEK2_1	198	203	PF00069	0.418
MOD_NEK2_1	235	240	PF00069	0.435
MOD_NEK2_1	25	30	PF00069	0.492
MOD_NEK2_1	357	362	PF00069	0.482
MOD_NEK2_1	433	438	PF00069	0.542
MOD_NEK2_1	520	525	PF00069	0.561
MOD_NEK2_1	70	75	PF00069	0.551
MOD_PIKK_1	235	241	PF00454	0.436
MOD_PIKK_1	357	363	PF00454	0.482
MOD_PIKK_1	72	78	PF00454	0.435
MOD_PKA_1	298	304	PF00069	0.552
MOD_PKA_1	464	470	PF00069	0.585
MOD_PKA_2	138	144	PF00069	0.527
MOD_PKA_2	244	250	PF00069	0.449
MOD_PKA_2	274	280	PF00069	0.495
MOD_PKA_2	298	304	PF00069	0.425
MOD_PKA_2	41	47	PF00069	0.484
MOD_PKA_2	520	526	PF00069	0.659
MOD_PKB_1	85	93	PF00069	0.389
MOD_Plk_1	241	247	PF00069	0.534
MOD_Plk_1	335	341	PF00069	0.550
MOD_Plk_1	433	439	PF00069	0.482
MOD_Plk_4	318	324	PF00069	0.531
MOD_Plk_4	353	359	PF00069	0.476
MOD_Plk_4	41	47	PF00069	0.470
MOD_Plk_4	553	559	PF00069	0.351
MOD_ProDKin_1	129	135	PF00069	0.544
MOD_ProDKin_1	174	180	PF00069	0.482
MOD_ProDKin_1	301	307	PF00069	0.466
MOD_ProDKin_1	37	43	PF00069	0.449
MOD_ProDKin_1	4	10	PF00069	0.464
MOD_ProDKin_1	499	505	PF00069	0.515
MOD_ProDKin_1	523	529	PF00069	0.630
MOD_ProDKin_1	88	94	PF00069	0.486
MOD_SUMO_rev_2	366	373	PF00179	0.490
TRG_DiLeu_BaEn_2	352	358	PF01217	0.451
TRG_ENDOCYTIC_2	113	116	PF00928	0.544
TRG_ENDOCYTIC_2	160	163	PF00928	0.468
TRG_ENDOCYTIC_2	218	221	PF00928	0.531
TRG_ENDOCYTIC_2	396	399	PF00928	0.446
TRG_ENDOCYTIC_2	560	563	PF00928	0.430
TRG_ER_diArg_1	113	115	PF00400	0.482
TRG_ER_diArg_1	123	126	PF00400	0.431
TRG_ER_diArg_1	193	196	PF00400	0.389
TRG_ER_diArg_1	466	469	PF00400	0.611
TRG_ER_diArg_1	561	564	PF00400	0.446
TRG_ER_diArg_1	85	87	PF00400	0.430
TRG_NES_CRM1_1	155	168	PF08389	0.482
TRG_NLS_MonoCore_2	83	88	PF00514	0.389
TRG_NLS_MonoExtC_3	463	468	PF00514	0.602
TRG_NLS_MonoExtN_4	464	469	PF00514	0.595
TRG_NLS_MonoExtN_4	82	88	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I223	Leptomonas seymouri	45%	96%
A0A1X0P9L2	Trypanosomatidae	32%	100%
A0A3R7MS38	Trypanosoma rangeli	36%	100%
A0A3S7X7Y5	Leishmania donovani	87%	100%
A4HAS9	Leishmania braziliensis	70%	99%
A4I9Y9	Leishmania infantum	87%	100%
C9ZMN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B503	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BKI1	Trypanosoma cruzi	33%	100%