Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania major

UniProt:

Q4Q2Y0_LEIMA

TriTrypDb:

LmjF.34.2200 , LMJSD75_340027600

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Y0

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	11
GO:0003824	catalytic activity	1	11
GO:0015035	protein-disulfide reductase activity	3	2
GO:0015036	disulfide oxidoreductase activity	4	2
GO:0016491	oxidoreductase activity	2	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	2
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.600
CLV_NRD_NRD_1	316	318	PF00675	0.548
CLV_PCSK_SKI1_1	146	150	PF00082	0.475
CLV_PCSK_SKI1_1	253	257	PF00082	0.444
CLV_PCSK_SKI1_1	286	290	PF00082	0.817
CLV_PCSK_SKI1_1	398	402	PF00082	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DOC_MAPK_gen_1	165	172	PF00069	0.455
DOC_MAPK_gen_1	190	198	PF00069	0.569
DOC_MAPK_gen_1	317	327	PF00069	0.529
DOC_MAPK_MEF2A_6	165	172	PF00069	0.576
DOC_MAPK_MEF2A_6	190	198	PF00069	0.588
DOC_MAPK_MEF2A_6	290	298	PF00069	0.723
DOC_MAPK_MEF2A_6	344	351	PF00069	0.551
DOC_PP4_FxxP_1	311	314	PF00568	0.463
DOC_PP4_FxxP_1	58	61	PF00568	0.368
DOC_PP4_MxPP_1	372	375	PF00568	0.478
DOC_USP7_MATH_1	133	137	PF00917	0.441
DOC_USP7_MATH_1	378	382	PF00917	0.639
DOC_USP7_UBL2_3	113	117	PF12436	0.356
DOC_WW_Pin1_4	185	190	PF00397	0.481
DOC_WW_Pin1_4	200	205	PF00397	0.494
DOC_WW_Pin1_4	223	228	PF00397	0.611
DOC_WW_Pin1_4	301	306	PF00397	0.552
DOC_WW_Pin1_4	320	325	PF00397	0.329
DOC_WW_Pin1_4	37	42	PF00397	0.343
LIG_14-3-3_CanoR_1	290	295	PF00244	0.762
LIG_14-3-3_CanoR_1	3	12	PF00244	0.652
LIG_14-3-3_CanoR_1	32	39	PF00244	0.519
LIG_Actin_WH2_2	210	226	PF00022	0.600
LIG_Clathr_ClatBox_1	348	352	PF01394	0.462
LIG_FHA_1	114	120	PF00498	0.466
LIG_FHA_1	302	308	PF00498	0.539
LIG_FHA_1	81	87	PF00498	0.388
LIG_FHA_2	149	155	PF00498	0.621
LIG_FHA_2	224	230	PF00498	0.513
LIG_HP1_1	53	57	PF01393	0.480
LIG_LIR_Apic_2	309	314	PF02991	0.489
LIG_LIR_Gen_1	233	242	PF02991	0.567
LIG_LIR_Gen_1	72	80	PF02991	0.368
LIG_LIR_Nem_3	233	239	PF02991	0.591
LIG_LIR_Nem_3	245	251	PF02991	0.488
LIG_LIR_Nem_3	72	76	PF02991	0.366
LIG_NRBOX	11	17	PF00104	0.585
LIG_PCNA_yPIPBox_3	210	223	PF02747	0.574
LIG_Pex14_2	364	368	PF04695	0.385
LIG_Pex14_2	58	62	PF04695	0.368
LIG_SH2_NCK_1	225	229	PF00017	0.600
LIG_SH2_NCK_1	248	252	PF00017	0.421
LIG_SH2_SRC	248	251	PF00017	0.413
LIG_SH2_STAP1	73	77	PF00017	0.509
LIG_SH2_STAT3	125	128	PF00017	0.480
LIG_SH2_STAT5	225	228	PF00017	0.552
LIG_SH2_STAT5	303	306	PF00017	0.553
LIG_SH2_STAT5	342	345	PF00017	0.618
LIG_SH3_3	291	297	PF00018	0.577
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.535
LIG_TYR_ITIM	246	251	PF00017	0.432
LIG_TYR_ITIM	397	402	PF00017	0.471
LIG_UBA3_1	167	175	PF00899	0.576
LIG_UBA3_1	181	190	PF00899	0.553
MOD_CDK_SPK_2	185	190	PF00069	0.493
MOD_CDK_SPK_2	301	306	PF00069	0.574
MOD_CDK_SPxxK_3	185	192	PF00069	0.494
MOD_CK1_1	118	124	PF00069	0.480
MOD_CK1_1	264	270	PF00069	0.695
MOD_CK1_1	34	40	PF00069	0.489
MOD_CK1_1	392	398	PF00069	0.592
MOD_CK2_1	148	154	PF00069	0.587
MOD_CK2_1	272	278	PF00069	0.808
MOD_CK2_1	326	332	PF00069	0.555
MOD_GlcNHglycan	113	116	PF01048	0.512
MOD_GlcNHglycan	172	175	PF01048	0.481
MOD_GlcNHglycan	262	266	PF01048	0.670
MOD_GlcNHglycan	33	36	PF01048	0.472
MOD_GlcNHglycan	6	9	PF01048	0.680
MOD_GSK3_1	111	118	PF00069	0.512
MOD_GSK3_1	142	149	PF00069	0.512
MOD_GSK3_1	266	273	PF00069	0.614
MOD_GSK3_1	278	285	PF00069	0.767
MOD_GSK3_1	286	293	PF00069	0.724
MOD_GSK3_1	30	37	PF00069	0.593
MOD_GSK3_1	378	385	PF00069	0.611
MOD_GSK3_1	76	83	PF00069	0.406
MOD_NEK2_1	148	153	PF00069	0.567
MOD_NEK2_1	198	203	PF00069	0.507
MOD_NEK2_1	21	26	PF00069	0.595
MOD_NEK2_1	212	217	PF00069	0.424
MOD_NEK2_1	351	356	PF00069	0.497
MOD_NEK2_1	382	387	PF00069	0.572
MOD_NEK2_1	389	394	PF00069	0.520
MOD_NEK2_1	47	52	PF00069	0.367
MOD_NEK2_1	76	81	PF00069	0.382
MOD_PIKK_1	119	125	PF00454	0.509
MOD_PIKK_1	212	218	PF00454	0.622
MOD_PIKK_1	278	284	PF00454	0.831
MOD_PIKK_1	306	312	PF00454	0.501
MOD_PIKK_1	351	357	PF00454	0.587
MOD_PK_1	290	296	PF00069	0.660
MOD_PKA_2	2	8	PF00069	0.607
MOD_PKA_2	289	295	PF00069	0.762
MOD_PKA_2	31	37	PF00069	0.567
MOD_PKA_2	389	395	PF00069	0.503
MOD_Plk_1	267	273	PF00069	0.686
MOD_Plk_4	133	139	PF00069	0.436
MOD_Plk_4	382	388	PF00069	0.611
MOD_ProDKin_1	185	191	PF00069	0.475
MOD_ProDKin_1	200	206	PF00069	0.501
MOD_ProDKin_1	223	229	PF00069	0.617
MOD_ProDKin_1	301	307	PF00069	0.545
MOD_ProDKin_1	320	326	PF00069	0.322
MOD_ProDKin_1	37	43	PF00069	0.343
TRG_DiLeu_BaEn_3	233	239	PF01217	0.545
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.523
TRG_ENDOCYTIC_2	248	251	PF00928	0.424
TRG_ENDOCYTIC_2	399	402	PF00928	0.487
TRG_ENDOCYTIC_2	73	76	PF00928	0.499
TRG_ER_diArg_1	396	399	PF00400	0.350
TRG_NES_CRM1_1	358	371	PF08389	0.527
TRG_NLS_MonoExtN_4	314	321	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y0	Leptomonas seymouri	58%	95%
A0A0S4J6N7	Bodo saltans	35%	99%
A0A1X0PAY2	Trypanosomatidae	40%	100%
A0A3Q8IL31	Leishmania donovani	91%	100%
A4HAT2	Leishmania braziliensis	74%	100%
A4I9Z2	Leishmania infantum	91%	100%
C9ZMN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B506	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BFX1	Trypanosoma cruzi	39%	98%