Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2X9_LEIMA

TriTrypDb:

LmjF.34.2210 , LMJLV39_340026800 , LMJSD75_340027700

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.577
CLV_NRD_NRD_1	459	461	PF00675	0.654
CLV_NRD_NRD_1	496	498	PF00675	0.765
CLV_PCSK_KEX2_1	459	461	PF00082	0.654
CLV_PCSK_KEX2_1	495	497	PF00082	0.760
CLV_PCSK_PC7_1	492	498	PF00082	0.780
CLV_PCSK_SKI1_1	328	332	PF00082	0.553
CLV_PCSK_SKI1_1	344	348	PF00082	0.625
CLV_PCSK_SKI1_1	558	562	PF00082	0.579
CLV_PCSK_SKI1_1	69	73	PF00082	0.572
DEG_APCC_DBOX_1	648	656	PF00400	0.521
DEG_SCF_FBW7_1	162	169	PF00400	0.646
DEG_SCF_FBW7_1	267	273	PF00400	0.665
DEG_SCF_FBW7_1	281	286	PF00400	0.570
DEG_SCF_FBW7_1	418	424	PF00400	0.636
DEG_SPOP_SBC_1	523	527	PF00917	0.592
DOC_ANK_TNKS_1	3	10	PF00023	0.577
DOC_CDC14_PxL_1	143	151	PF14671	0.609
DOC_CKS1_1	129	134	PF01111	0.643
DOC_CKS1_1	267	272	PF01111	0.666
DOC_CKS1_1	38	43	PF01111	0.613
DOC_CKS1_1	406	411	PF01111	0.645
DOC_CKS1_1	418	423	PF01111	0.541
DOC_CKS1_1	54	59	PF01111	0.620
DOC_CKS1_1	99	104	PF01111	0.669
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.549
DOC_MAPK_MEF2A_6	534	543	PF00069	0.671
DOC_MAPK_MEF2A_6	63	70	PF00069	0.794
DOC_MAPK_NFAT4_5	63	71	PF00069	0.635
DOC_PP2B_LxvP_1	382	385	PF13499	0.560
DOC_PP2B_LxvP_1	395	398	PF13499	0.512
DOC_PP2B_LxvP_1	440	443	PF13499	0.551
DOC_PP2B_LxvP_1	452	455	PF13499	0.549
DOC_PP2B_LxvP_1	629	632	PF13499	0.729
DOC_PP4_FxxP_1	129	132	PF00568	0.644
DOC_PP4_FxxP_1	54	57	PF00568	0.679
DOC_PP4_FxxP_1	556	559	PF00568	0.616
DOC_USP7_MATH_1	166	170	PF00917	0.681
DOC_USP7_MATH_1	174	178	PF00917	0.541
DOC_USP7_MATH_1	209	213	PF00917	0.611
DOC_USP7_MATH_1	270	274	PF00917	0.667
DOC_USP7_MATH_1	346	350	PF00917	0.605
DOC_USP7_MATH_1	399	403	PF00917	0.608
DOC_USP7_MATH_1	421	425	PF00917	0.642
DOC_USP7_MATH_1	524	528	PF00917	0.606
DOC_USP7_MATH_1	539	543	PF00917	0.597
DOC_USP7_MATH_1	611	615	PF00917	0.596
DOC_USP7_MATH_1	86	90	PF00917	0.639
DOC_WW_Pin1_4	114	119	PF00397	0.571
DOC_WW_Pin1_4	128	133	PF00397	0.575
DOC_WW_Pin1_4	162	167	PF00397	0.646
DOC_WW_Pin1_4	168	173	PF00397	0.595
DOC_WW_Pin1_4	192	197	PF00397	0.628
DOC_WW_Pin1_4	22	27	PF00397	0.703
DOC_WW_Pin1_4	252	257	PF00397	0.637
DOC_WW_Pin1_4	266	271	PF00397	0.557
DOC_WW_Pin1_4	279	284	PF00397	0.582
DOC_WW_Pin1_4	318	323	PF00397	0.631
DOC_WW_Pin1_4	338	343	PF00397	0.635
DOC_WW_Pin1_4	34	39	PF00397	0.709
DOC_WW_Pin1_4	405	410	PF00397	0.642
DOC_WW_Pin1_4	417	422	PF00397	0.538
DOC_WW_Pin1_4	425	430	PF00397	0.481
DOC_WW_Pin1_4	503	508	PF00397	0.680
DOC_WW_Pin1_4	515	520	PF00397	0.540
DOC_WW_Pin1_4	53	58	PF00397	0.710
DOC_WW_Pin1_4	535	540	PF00397	0.514
DOC_WW_Pin1_4	543	548	PF00397	0.576
DOC_WW_Pin1_4	617	622	PF00397	0.656
DOC_WW_Pin1_4	78	83	PF00397	0.647
DOC_WW_Pin1_4	89	94	PF00397	0.573
DOC_WW_Pin1_4	98	103	PF00397	0.515
LIG_14-3-3_CanoR_1	260	270	PF00244	0.628
LIG_14-3-3_CanoR_1	599	605	PF00244	0.672
LIG_14-3-3_CanoR_1	610	617	PF00244	0.607
LIG_14-3-3_CanoR_1	63	69	PF00244	0.662
LIG_14-3-3_CanoR_1	85	94	PF00244	0.684
LIG_APCC_ABBAyCdc20_2	344	350	PF00400	0.653
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BIR_III_2	544	548	PF00653	0.541
LIG_BRCT_BRCA1_1	291	295	PF00533	0.788
LIG_BRCT_BRCA1_1	363	367	PF00533	0.567
LIG_Clathr_ClatBox_1	540	544	PF01394	0.642
LIG_CSL_BTD_1	267	270	PF09270	0.664
LIG_FHA_1	12	18	PF00498	0.654
LIG_FHA_1	262	268	PF00498	0.631
LIG_FHA_1	387	393	PF00498	0.649
LIG_FHA_1	413	419	PF00498	0.627
LIG_FHA_1	573	579	PF00498	0.616
LIG_FHA_1	658	664	PF00498	0.713
LIG_FHA_1	79	85	PF00498	0.568
LIG_FXI_DFP_1	296	300	PF00024	0.635
LIG_HP1_1	539	543	PF01393	0.665
LIG_LIR_Apic_2	127	132	PF02991	0.642
LIG_LIR_Apic_2	52	57	PF02991	0.679
LIG_LIR_Gen_1	117	126	PF02991	0.654
LIG_LIR_Nem_3	117	123	PF02991	0.707
LIG_LIR_Nem_3	140	146	PF02991	0.720
LIG_LIR_Nem_3	171	176	PF02991	0.553
LIG_LIR_Nem_3	642	648	PF02991	0.699
LIG_LYPXL_yS_3	146	149	PF13949	0.606
LIG_PDZ_Class_1	662	667	PF00595	0.595
LIG_PDZ_Wminus1_1	665	667	PF00595	0.590
LIG_Pex14_1	570	574	PF04695	0.620
LIG_Pex14_2	295	299	PF04695	0.643
LIG_Pex14_2	662	666	PF04695	0.592
LIG_SH2_SRC	448	451	PF00017	0.545
LIG_SH2_STAT5	238	241	PF00017	0.647
LIG_SH2_STAT5	39	42	PF00017	0.599
LIG_SH2_STAT5	411	414	PF00017	0.570
LIG_SH2_STAT5	448	451	PF00017	0.636
LIG_SH2_STAT5	645	648	PF00017	0.800
LIG_SH3_1	496	502	PF00018	0.672
LIG_SH3_3	264	270	PF00018	0.661
LIG_SH3_3	278	284	PF00018	0.575
LIG_SH3_3	302	308	PF00018	0.645
LIG_SH3_3	35	41	PF00018	0.687
LIG_SH3_3	438	444	PF00018	0.525
LIG_SH3_3	496	502	PF00018	0.674
LIG_SH3_3	527	533	PF00018	0.642
LIG_SH3_3	88	94	PF00018	0.725
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.626
LIG_SUMO_SIM_par_1	414	420	PF11976	0.538
LIG_SUMO_SIM_par_1	538	544	PF11976	0.639
LIG_SxIP_EBH_1	131	141	PF03271	0.636
LIG_TRAF2_1	352	355	PF00917	0.641
LIG_WW_3	531	535	PF00397	0.628
LIG_WW_3	60	64	PF00397	0.543
MOD_CDC14_SPxK_1	255	258	PF00782	0.643
MOD_CDC14_SPxK_1	341	344	PF00782	0.650
MOD_CDC14_SPxK_1	60	63	PF00782	0.631
MOD_CDK_SPK_2	405	410	PF00069	0.642
MOD_CDK_SPxK_1	128	134	PF00069	0.640
MOD_CDK_SPxK_1	252	258	PF00069	0.639
MOD_CDK_SPxK_1	338	344	PF00069	0.640
MOD_CDK_SPxK_1	57	63	PF00069	0.644
MOD_CDK_SPxxK_3	100	107	PF00069	0.670
MOD_CDK_SPxxK_3	78	85	PF00069	0.642
MOD_CK1_1	114	120	PF00069	0.580
MOD_CK1_1	241	247	PF00069	0.610
MOD_CK1_1	250	256	PF00069	0.560
MOD_CK1_1	273	279	PF00069	0.673
MOD_CK1_1	337	343	PF00069	0.567
MOD_CK1_1	417	423	PF00069	0.547
MOD_CK1_1	436	442	PF00069	0.573
MOD_CK1_1	573	579	PF00069	0.629
MOD_CK1_1	593	599	PF00069	0.600
MOD_CK1_1	603	609	PF00069	0.622
MOD_CK1_1	89	95	PF00069	0.630
MOD_CK2_1	119	125	PF00069	0.656
MOD_CK2_1	283	289	PF00069	0.678
MOD_CK2_1	507	513	PF00069	0.654
MOD_DYRK1A_RPxSP_1	266	270	PF00069	0.665
MOD_GlcNHglycan	113	116	PF01048	0.596
MOD_GlcNHglycan	143	146	PF01048	0.617
MOD_GlcNHglycan	168	171	PF01048	0.623
MOD_GlcNHglycan	176	179	PF01048	0.558
MOD_GlcNHglycan	240	243	PF01048	0.647
MOD_GlcNHglycan	301	304	PF01048	0.680
MOD_GlcNHglycan	336	339	PF01048	0.624
MOD_GlcNHglycan	400	404	PF01048	0.628
MOD_GlcNHglycan	51	54	PF01048	0.661
MOD_GlcNHglycan	526	529	PF01048	0.563
MOD_GlcNHglycan	586	589	PF01048	0.663
MOD_GlcNHglycan	591	595	PF01048	0.674
MOD_GlcNHglycan	88	91	PF01048	0.668
MOD_GSK3_1	124	131	PF00069	0.645
MOD_GSK3_1	133	140	PF00069	0.599
MOD_GSK3_1	158	165	PF00069	0.720
MOD_GSK3_1	237	244	PF00069	0.627
MOD_GSK3_1	262	269	PF00069	0.657
MOD_GSK3_1	279	286	PF00069	0.550
MOD_GSK3_1	290	297	PF00069	0.563
MOD_GSK3_1	334	341	PF00069	0.623
MOD_GSK3_1	342	349	PF00069	0.606
MOD_GSK3_1	354	361	PF00069	0.502
MOD_GSK3_1	417	424	PF00069	0.635
MOD_GSK3_1	49	56	PF00069	0.693
MOD_GSK3_1	503	510	PF00069	0.675
MOD_GSK3_1	515	522	PF00069	0.545
MOD_GSK3_1	535	542	PF00069	0.514
MOD_GSK3_1	569	576	PF00069	0.616
MOD_GSK3_1	589	596	PF00069	0.692
MOD_GSK3_1	599	606	PF00069	0.684
MOD_GSK3_1	630	637	PF00069	0.763
MOD_GSK3_1	653	660	PF00069	0.583
MOD_GSK3_1	70	77	PF00069	0.761
MOD_GSK3_1	85	92	PF00069	0.632
MOD_N-GLC_1	47	52	PF02516	0.684
MOD_N-GLC_1	515	520	PF02516	0.801
MOD_NEK2_1	149	154	PF00069	0.762
MOD_NEK2_1	433	438	PF00069	0.634
MOD_NEK2_1	590	595	PF00069	0.653
MOD_NEK2_1	662	667	PF00069	0.527
MOD_NEK2_1	70	75	PF00069	0.607
MOD_PIKK_1	12	18	PF00454	0.648
MOD_PIKK_1	273	279	PF00454	0.673
MOD_PIKK_1	603	609	PF00454	0.596
MOD_PKA_2	111	117	PF00069	0.578
MOD_PKA_2	209	215	PF00069	0.613
MOD_PKA_2	261	267	PF00069	0.751
MOD_PKA_2	609	615	PF00069	0.635
MOD_PKA_2	648	654	PF00069	0.613
MOD_PKB_1	260	268	PF00069	0.653
MOD_Plk_1	250	256	PF00069	0.632
MOD_Plk_1	358	364	PF00069	0.656
MOD_Plk_1	564	570	PF00069	0.601
MOD_Plk_1	641	647	PF00069	0.673
MOD_Plk_2-3	354	360	PF00069	0.659
MOD_Plk_4	313	319	PF00069	0.635
MOD_Plk_4	361	367	PF00069	0.655
MOD_Plk_4	421	427	PF00069	0.643
MOD_Plk_4	436	442	PF00069	0.533
MOD_Plk_4	641	647	PF00069	0.631
MOD_ProDKin_1	114	120	PF00069	0.572
MOD_ProDKin_1	128	134	PF00069	0.577
MOD_ProDKin_1	162	168	PF00069	0.646
MOD_ProDKin_1	192	198	PF00069	0.625
MOD_ProDKin_1	22	28	PF00069	0.705
MOD_ProDKin_1	252	258	PF00069	0.639
MOD_ProDKin_1	266	272	PF00069	0.558
MOD_ProDKin_1	279	285	PF00069	0.582
MOD_ProDKin_1	318	324	PF00069	0.629
MOD_ProDKin_1	338	344	PF00069	0.640
MOD_ProDKin_1	34	40	PF00069	0.710
MOD_ProDKin_1	405	411	PF00069	0.643
MOD_ProDKin_1	417	423	PF00069	0.540
MOD_ProDKin_1	425	431	PF00069	0.481
MOD_ProDKin_1	503	509	PF00069	0.678
MOD_ProDKin_1	515	521	PF00069	0.544
MOD_ProDKin_1	53	59	PF00069	0.707
MOD_ProDKin_1	535	541	PF00069	0.515
MOD_ProDKin_1	543	549	PF00069	0.578
MOD_ProDKin_1	617	623	PF00069	0.657
MOD_ProDKin_1	78	84	PF00069	0.652
MOD_ProDKin_1	89	95	PF00069	0.573
MOD_ProDKin_1	98	104	PF00069	0.515
MOD_SUMO_rev_2	182	191	PF00179	0.623
MOD_SUMO_rev_2	544	554	PF00179	0.553
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.635
TRG_ENDOCYTIC_2	146	149	PF00928	0.623
TRG_ER_diArg_1	257	260	PF00400	0.646
TRG_ER_diArg_1	495	497	PF00400	0.759
TRG_ER_diArg_1	578	581	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I9Z3	Leishmania infantum	85%	70%
E9B507	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%