Dynamin-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynamin family, putative

Species:

Leishmania major

UniProt:

Q4Q2X3_LEIMA

TriTrypDb:

LmjF.34.2270 , LMJLV39_340027400 , LMJSD75_340028300

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

Q4Q2X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2X3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006897	endocytosis	5	3
GO:0009987	cellular process	1	3
GO:0016192	vesicle-mediated transport	4	3
GO:0016197	endosomal transport	4	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0005488	binding	1	22
GO:0005525	GTP binding	5	22
GO:0017076	purine nucleotide binding	4	22
GO:0019001	guanyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032561	guanyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.300
CLV_C14_Caspase3-7	364	368	PF00656	0.371
CLV_C14_Caspase3-7	470	474	PF00656	0.414
CLV_NRD_NRD_1	165	167	PF00675	0.307
CLV_NRD_NRD_1	292	294	PF00675	0.316
CLV_NRD_NRD_1	299	301	PF00675	0.314
CLV_NRD_NRD_1	412	414	PF00675	0.483
CLV_NRD_NRD_1	419	421	PF00675	0.521
CLV_PCSK_FUR_1	410	414	PF00082	0.405
CLV_PCSK_KEX2_1	165	167	PF00082	0.284
CLV_PCSK_KEX2_1	292	294	PF00082	0.334
CLV_PCSK_KEX2_1	299	301	PF00082	0.316
CLV_PCSK_KEX2_1	379	381	PF00082	0.328
CLV_PCSK_KEX2_1	412	414	PF00082	0.516
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.334
CLV_PCSK_SKI1_1	199	203	PF00082	0.293
CLV_PCSK_SKI1_1	204	208	PF00082	0.289
CLV_PCSK_SKI1_1	292	296	PF00082	0.331
CLV_PCSK_SKI1_1	360	364	PF00082	0.321
CLV_PCSK_SKI1_1	369	373	PF00082	0.323
CLV_PCSK_SKI1_1	434	438	PF00082	0.751
CLV_Separin_Metazoa	227	231	PF03568	0.372
CLV_Separin_Metazoa	247	251	PF03568	0.376
DEG_APCC_DBOX_1	314	322	PF00400	0.327
DEG_APCC_DBOX_1	359	367	PF00400	0.372
DOC_CKS1_1	150	155	PF01111	0.289
DOC_CYCLIN_RxL_1	199	211	PF00134	0.240
DOC_MAPK_DCC_7	244	253	PF00069	0.432
DOC_MAPK_gen_1	165	172	PF00069	0.333
DOC_MAPK_gen_1	299	307	PF00069	0.326
DOC_MAPK_gen_1	410	418	PF00069	0.553
DOC_MAPK_gen_1	55	63	PF00069	0.364
DOC_MAPK_MEF2A_6	244	253	PF00069	0.432
DOC_MAPK_MEF2A_6	387	394	PF00069	0.407
DOC_MAPK_MEF2A_6	55	63	PF00069	0.468
DOC_PP1_RVXF_1	143	150	PF00149	0.411
DOC_PP4_FxxP_1	63	66	PF00568	0.233
DOC_USP7_MATH_1	286	290	PF00917	0.386
DOC_USP7_MATH_1	464	468	PF00917	0.557
DOC_USP7_MATH_1	509	513	PF00917	0.691
DOC_USP7_MATH_1	66	70	PF00917	0.246
DOC_USP7_UBL2_3	324	328	PF12436	0.320
DOC_WW_Pin1_4	149	154	PF00397	0.291
DOC_WW_Pin1_4	447	452	PF00397	0.730
DOC_WW_Pin1_4	453	458	PF00397	0.742
DOC_WW_Pin1_4	494	499	PF00397	0.644
LIG_14-3-3_CanoR_1	121	130	PF00244	0.319
LIG_14-3-3_CanoR_1	145	150	PF00244	0.373
LIG_14-3-3_CanoR_1	244	248	PF00244	0.426
LIG_14-3-3_CanoR_1	250	260	PF00244	0.347
LIG_14-3-3_CanoR_1	292	298	PF00244	0.286
LIG_14-3-3_CanoR_1	299	307	PF00244	0.280
LIG_14-3-3_CanoR_1	345	354	PF00244	0.328
LIG_14-3-3_CanoR_1	380	390	PF00244	0.307
LIG_14-3-3_CanoR_1	426	432	PF00244	0.641
LIG_14-3-3_CanoR_1	434	439	PF00244	0.681
LIG_Actin_WH2_2	130	147	PF00022	0.342
LIG_AP2alpha_1	126	130	PF02296	0.342
LIG_APCC_ABBA_1	97	102	PF00400	0.259
LIG_APCC_ABBAyCdc20_2	204	210	PF00400	0.221
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_BIR_III_2	193	197	PF00653	0.398
LIG_BRCT_BRCA1_1	145	149	PF00533	0.389
LIG_BRCT_BRCA1_1	367	371	PF00533	0.374
LIG_CaM_NSCaTE_8	14	21	PF13499	0.397
LIG_CaM_NSCaTE_8	382	389	PF13499	0.240
LIG_EH1_1	517	525	PF00400	0.405
LIG_FHA_1	150	156	PF00498	0.289
LIG_FHA_1	28	34	PF00498	0.424
LIG_FHA_1	282	288	PF00498	0.361
LIG_FHA_1	293	299	PF00498	0.301
LIG_FHA_1	387	393	PF00498	0.367
LIG_FHA_1	478	484	PF00498	0.613
LIG_FHA_2	188	194	PF00498	0.284
LIG_FHA_2	362	368	PF00498	0.253
LIG_LIR_Apic_2	254	260	PF02991	0.377
LIG_LIR_Apic_2	62	66	PF02991	0.233
LIG_LIR_Gen_1	102	112	PF02991	0.291
LIG_LIR_Gen_1	128	138	PF02991	0.319
LIG_LIR_Gen_1	164	172	PF02991	0.296
LIG_LIR_Gen_1	276	287	PF02991	0.417
LIG_LIR_Gen_1	333	343	PF02991	0.278
LIG_LIR_Gen_1	368	377	PF02991	0.349
LIG_LIR_Gen_1	39	50	PF02991	0.434
LIG_LIR_Gen_1	92	100	PF02991	0.291
LIG_LIR_Nem_3	102	107	PF02991	0.288
LIG_LIR_Nem_3	128	133	PF02991	0.286
LIG_LIR_Nem_3	164	170	PF02991	0.300
LIG_LIR_Nem_3	181	187	PF02991	0.251
LIG_LIR_Nem_3	234	239	PF02991	0.411
LIG_LIR_Nem_3	276	282	PF02991	0.404
LIG_LIR_Nem_3	329	335	PF02991	0.308
LIG_LIR_Nem_3	368	374	PF02991	0.406
LIG_LIR_Nem_3	39	45	PF02991	0.443
LIG_LIR_Nem_3	72	77	PF02991	0.288
LIG_LIR_Nem_3	92	98	PF02991	0.114
LIG_Pex14_1	257	261	PF04695	0.394
LIG_Pex14_2	126	130	PF04695	0.291
LIG_Pex14_2	45	49	PF04695	0.316
LIG_Pex14_2	63	67	PF04695	0.194
LIG_Rb_pABgroove_1	181	189	PF01858	0.233
LIG_SH2_CRK	120	124	PF00017	0.441
LIG_SH2_CRK	232	236	PF00017	0.360
LIG_SH2_GRB2like	236	239	PF00017	0.473
LIG_SH2_PTP2	169	172	PF00017	0.330
LIG_SH2_SRC	167	170	PF00017	0.344
LIG_SH2_STAP1	279	283	PF00017	0.480
LIG_SH2_STAP1	29	33	PF00017	0.424
LIG_SH2_STAP1	335	339	PF00017	0.359
LIG_SH2_STAT3	100	103	PF00017	0.240
LIG_SH2_STAT3	422	425	PF00017	0.569
LIG_SH2_STAT3	77	80	PF00017	0.319
LIG_SH2_STAT5	169	172	PF00017	0.309
LIG_SH2_STAT5	252	255	PF00017	0.341
LIG_SH2_STAT5	29	32	PF00017	0.308
LIG_SH2_STAT5	77	80	PF00017	0.299
LIG_SH2_STAT5	83	86	PF00017	0.281
LIG_SH3_3	134	140	PF00018	0.347
LIG_SH3_3	280	286	PF00018	0.444
LIG_SH3_3	389	395	PF00018	0.300
LIG_SH3_3	41	47	PF00018	0.359
LIG_SH3_3	451	457	PF00018	0.761
LIG_SUMO_SIM_par_1	388	393	PF11976	0.221
LIG_TRAF2_2	286	291	PF00917	0.364
LIG_TYR_ITIM	118	123	PF00017	0.240
LIG_TYR_ITIM	277	282	PF00017	0.469
LIG_UBA3_1	397	402	PF00899	0.476
LIG_WRC_WIRS_1	253	258	PF05994	0.357
LIG_WRC_WIRS_1	60	65	PF05994	0.233
LIG_WW_3	247	251	PF00397	0.376
MOD_CDK_SPK_2	447	452	PF00069	0.566
MOD_CK1_1	313	319	PF00069	0.398
MOD_CK1_1	349	355	PF00069	0.424
MOD_CK1_1	385	391	PF00069	0.213
MOD_CK1_1	467	473	PF00069	0.597
MOD_CK1_1	496	502	PF00069	0.625
MOD_CK1_1	69	75	PF00069	0.320
MOD_CK2_1	28	34	PF00069	0.417
MOD_GlcNHglycan	157	161	PF01048	0.394
MOD_GlcNHglycan	447	450	PF01048	0.650
MOD_GlcNHglycan	68	71	PF01048	0.292
MOD_GSK3_1	145	152	PF00069	0.308
MOD_GSK3_1	23	30	PF00069	0.432
MOD_GSK3_1	341	348	PF00069	0.424
MOD_GSK3_1	361	368	PF00069	0.322
MOD_GSK3_1	381	388	PF00069	0.288
MOD_GSK3_1	464	471	PF00069	0.701
MOD_GSK3_1	496	503	PF00069	0.762
MOD_GSK3_1	65	72	PF00069	0.291
MOD_GSK3_1	89	96	PF00069	0.291
MOD_N-GLC_1	237	242	PF02516	0.382
MOD_NEK2_1	113	118	PF00069	0.341
MOD_NEK2_1	18	23	PF00069	0.367
MOD_NEK2_1	251	256	PF00069	0.396
MOD_NEK2_1	28	33	PF00069	0.234
MOD_NEK2_1	281	286	PF00069	0.430
MOD_NEK2_1	322	327	PF00069	0.412
MOD_NEK2_1	50	55	PF00069	0.259
MOD_NEK2_1	516	521	PF00069	0.530
MOD_NEK2_2	382	387	PF00069	0.182
MOD_PIKK_1	121	127	PF00454	0.322
MOD_PK_1	219	225	PF00069	0.328
MOD_PKA_1	292	298	PF00069	0.411
MOD_PKA_1	299	305	PF00069	0.411
MOD_PKA_2	243	249	PF00069	0.451
MOD_PKA_2	292	298	PF00069	0.306
MOD_PKA_2	299	305	PF00069	0.291
MOD_PKA_2	425	431	PF00069	0.648
MOD_PKA_2	45	51	PF00069	0.309
MOD_Plk_1	18	24	PF00069	0.468
MOD_Plk_1	349	355	PF00069	0.427
MOD_Plk_1	36	42	PF00069	0.309
MOD_Plk_1	402	408	PF00069	0.621
MOD_Plk_4	145	151	PF00069	0.285
MOD_Plk_4	18	24	PF00069	0.462
MOD_Plk_4	231	237	PF00069	0.407
MOD_Plk_4	252	258	PF00069	0.358
MOD_Plk_4	293	299	PF00069	0.305
MOD_Plk_4	334	340	PF00069	0.452
MOD_Plk_4	45	51	PF00069	0.305
MOD_Plk_4	477	483	PF00069	0.593
MOD_Plk_4	519	525	PF00069	0.611
MOD_Plk_4	59	65	PF00069	0.274
MOD_Plk_4	70	76	PF00069	0.300
MOD_ProDKin_1	149	155	PF00069	0.291
MOD_ProDKin_1	447	453	PF00069	0.732
MOD_ProDKin_1	494	500	PF00069	0.647
MOD_SUMO_rev_2	209	213	PF00179	0.349
MOD_SUMO_rev_2	3	13	PF00179	0.565
TRG_DiLeu_BaEn_1	178	183	PF01217	0.300
TRG_DiLeu_BaEn_1	273	278	PF01217	0.344
TRG_DiLeu_BaEn_3	333	339	PF01217	0.279
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.441
TRG_ENDOCYTIC_2	120	123	PF00928	0.273
TRG_ENDOCYTIC_2	167	170	PF00928	0.295
TRG_ENDOCYTIC_2	232	235	PF00928	0.363
TRG_ENDOCYTIC_2	236	239	PF00928	0.366
TRG_ENDOCYTIC_2	279	282	PF00928	0.431
TRG_ENDOCYTIC_2	335	338	PF00928	0.337
TRG_ENDOCYTIC_2	42	45	PF00928	0.259
TRG_ER_diArg_1	165	167	PF00400	0.258
TRG_ER_diArg_1	292	294	PF00400	0.343
TRG_ER_diArg_1	298	300	PF00400	0.332
TRG_ER_diArg_1	314	317	PF00400	0.303
TRG_NES_CRM1_1	514	530	PF08389	0.663
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.205

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	47%	91%
A0A0N0P9A4	Leptomonas seymouri	75%	98%
A0A0S4KGM0	Bodo saltans	48%	89%
A0A1X0P6D7	Trypanosomatidae	50%	99%
A0A1X0P9Q8	Trypanosomatidae	63%	97%
A0A3R7LDF3	Trypanosoma rangeli	47%	100%
A0A3S7WV81	Leishmania donovani	46%	86%
A0A3S7X801	Leishmania donovani	94%	100%
A0A422P0G8	Trypanosoma rangeli	60%	99%
A4H9Y5	Leishmania braziliensis	47%	86%
A4HAT9	Leishmania braziliensis	77%	99%
A4HY50	Leishmania infantum	46%	86%
A4IA07	Leishmania infantum	94%	100%
B3LF48	Arabidopsis thaliana	35%	99%
C9ZMM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	87%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ARX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	86%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QDJ3	Leishmania major	45%	85%
Q4V8H8	Rattus norvegicus	34%	100%
Q5E9R3	Bos taurus	34%	100%
Q5RBP4	Pongo abelii	34%	100%
Q641Z6	Rattus norvegicus	34%	100%
Q7TQ48	Mus musculus	39%	100%
Q86TD4	Homo sapiens	39%	100%
Q8BH64	Mus musculus	34%	100%
Q94CF0	Arabidopsis thaliana	36%	99%
Q9EQP2	Mus musculus	33%	100%
Q9H223	Homo sapiens	35%	100%
Q9H4M9	Homo sapiens	34%	100%
Q9NZN4	Homo sapiens	34%	100%
Q9WVK4	Mus musculus	34%	100%
V5BSA9	Trypanosoma cruzi	48%	100%
V5DGT0	Trypanosoma cruzi	61%	99%