Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2X2_LEIMA

TriTrypDb:

LmjF.34.2280 , LMJLV39_340027500 , LMJSD75_340028400

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2X2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.580
CLV_C14_Caspase3-7	206	210	PF00656	0.557
CLV_C14_Caspase3-7	283	287	PF00656	0.749
CLV_C14_Caspase3-7	60	64	PF00656	0.705
CLV_C14_Caspase3-7	690	694	PF00656	0.718
CLV_NRD_NRD_1	182	184	PF00675	0.551
CLV_NRD_NRD_1	215	217	PF00675	0.622
CLV_NRD_NRD_1	249	251	PF00675	0.707
CLV_NRD_NRD_1	511	513	PF00675	0.771
CLV_NRD_NRD_1	514	516	PF00675	0.731
CLV_NRD_NRD_1	673	675	PF00675	0.769
CLV_NRD_NRD_1	728	730	PF00675	0.574
CLV_PCSK_FUR_1	512	516	PF00082	0.779
CLV_PCSK_KEX2_1	182	184	PF00082	0.551
CLV_PCSK_KEX2_1	301	303	PF00082	0.725
CLV_PCSK_KEX2_1	511	513	PF00082	0.771
CLV_PCSK_KEX2_1	514	516	PF00082	0.731
CLV_PCSK_KEX2_1	673	675	PF00082	0.810
CLV_PCSK_KEX2_1	728	730	PF00082	0.574
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.706
CLV_PCSK_PC7_1	669	675	PF00082	0.727
CLV_PCSK_SKI1_1	168	172	PF00082	0.556
CLV_PCSK_SKI1_1	201	205	PF00082	0.615
CLV_PCSK_SKI1_1	276	280	PF00082	0.753
CLV_PCSK_SKI1_1	402	406	PF00082	0.418
CLV_PCSK_SKI1_1	502	506	PF00082	0.619
CLV_PCSK_SKI1_1	620	624	PF00082	0.615
CLV_PCSK_SKI1_1	669	673	PF00082	0.726
CLV_Separin_Metazoa	106	110	PF03568	0.541
CLV_Separin_Metazoa	491	495	PF03568	0.551
DEG_COP1_1	6	16	PF00400	0.621
DEG_SPOP_SBC_1	475	479	PF00917	0.633
DEG_SPOP_SBC_1	590	594	PF00917	0.765
DEG_SPOP_SBC_1	655	659	PF00917	0.738
DEG_SPOP_SBC_1	88	92	PF00917	0.513
DOC_ANK_TNKS_1	642	649	PF00023	0.578
DOC_CKS1_1	613	618	PF01111	0.556
DOC_CYCLIN_RxL_1	398	407	PF00134	0.514
DOC_CYCLIN_RxL_1	497	507	PF00134	0.617
DOC_MAPK_gen_1	728	735	PF00069	0.602
DOC_MAPK_MEF2A_6	109	118	PF00069	0.530
DOC_MAPK_MEF2A_6	355	362	PF00069	0.469
DOC_PP1_RVXF_1	400	406	PF00149	0.430
DOC_PP4_FxxP_1	606	609	PF00568	0.664
DOC_PP4_FxxP_1	613	616	PF00568	0.573
DOC_USP7_MATH_1	232	236	PF00917	0.530
DOC_USP7_MATH_1	291	295	PF00917	0.745
DOC_USP7_MATH_1	335	339	PF00917	0.580
DOC_USP7_MATH_1	384	388	PF00917	0.653
DOC_USP7_MATH_1	655	659	PF00917	0.678
DOC_USP7_MATH_1	70	74	PF00917	0.699
DOC_USP7_MATH_1	718	722	PF00917	0.724
DOC_USP7_MATH_1	88	92	PF00917	0.481
DOC_WW_Pin1_4	251	256	PF00397	0.731
DOC_WW_Pin1_4	265	270	PF00397	0.653
DOC_WW_Pin1_4	295	300	PF00397	0.797
DOC_WW_Pin1_4	313	318	PF00397	0.400
DOC_WW_Pin1_4	41	46	PF00397	0.692
DOC_WW_Pin1_4	576	581	PF00397	0.720
DOC_WW_Pin1_4	595	600	PF00397	0.461
DOC_WW_Pin1_4	612	617	PF00397	0.458
DOC_WW_Pin1_4	66	71	PF00397	0.780
DOC_WW_Pin1_4	694	699	PF00397	0.671
DOC_WW_Pin1_4	707	712	PF00397	0.519
DOC_WW_Pin1_4	78	83	PF00397	0.591
LIG_14-3-3_CanoR_1	201	211	PF00244	0.578
LIG_14-3-3_CanoR_1	216	222	PF00244	0.477
LIG_14-3-3_CanoR_1	259	267	PF00244	0.710
LIG_14-3-3_CanoR_1	355	359	PF00244	0.497
LIG_14-3-3_CanoR_1	402	410	PF00244	0.488
LIG_14-3-3_CanoR_1	47	57	PF00244	0.674
LIG_14-3-3_CanoR_1	497	501	PF00244	0.429
LIG_Actin_WH2_2	93	111	PF00022	0.580
LIG_BIR_III_2	52	56	PF00653	0.675
LIG_BRCT_BRCA1_1	478	482	PF00533	0.685
LIG_BRCT_BRCA1_1	591	595	PF00533	0.756
LIG_FHA_1	155	161	PF00498	0.656
LIG_FHA_1	164	170	PF00498	0.466
LIG_FHA_1	275	281	PF00498	0.667
LIG_FHA_1	404	410	PF00498	0.549
LIG_FHA_1	499	505	PF00498	0.579
LIG_FHA_1	8	14	PF00498	0.602
LIG_FHA_2	56	62	PF00498	0.750
LIG_FHA_2	677	683	PF00498	0.763
LIG_FHA_2	79	85	PF00498	0.706
LIG_Integrin_RGD_1	582	584	PF01839	0.708
LIG_IRF3_LxIS_1	310	316	PF10401	0.709
LIG_LIR_Apic_2	604	609	PF02991	0.642
LIG_LIR_Apic_2	612	616	PF02991	0.604
LIG_LIR_Apic_2	9	14	PF02991	0.642
LIG_LIR_Gen_1	244	253	PF02991	0.681
LIG_LIR_Nem_3	198	203	PF02991	0.534
LIG_LIR_Nem_3	244	249	PF02991	0.693
LIG_LIR_Nem_3	390	395	PF02991	0.560
LIG_LIR_Nem_3	6	11	PF02991	0.600
LIG_NRBOX	143	149	PF00104	0.524
LIG_NRBOX	93	99	PF00104	0.694
LIG_PCNA_yPIPBox_3	137	148	PF02747	0.559
LIG_PCNA_yPIPBox_3	391	404	PF02747	0.606
LIG_PDZ_Class_3	745	750	PF00595	0.647
LIG_Pex14_2	118	122	PF04695	0.528
LIG_SH2_STAP1	442	446	PF00017	0.534
LIG_SH2_STAT3	548	551	PF00017	0.716
LIG_SH2_STAT5	11	14	PF00017	0.765
LIG_SH2_STAT5	548	551	PF00017	0.671
LIG_SH2_STAT5	629	632	PF00017	0.671
LIG_SH3_2	266	271	PF14604	0.678
LIG_SH3_3	263	269	PF00018	0.720
LIG_SH3_3	596	602	PF00018	0.728
LIG_Sin3_3	430	437	PF02671	0.498
LIG_SUMO_SIM_anti_2	450	455	PF11976	0.476
LIG_SUMO_SIM_anti_2	586	594	PF11976	0.539
LIG_SUMO_SIM_par_1	145	152	PF11976	0.583
LIG_SUMO_SIM_par_1	309	314	PF11976	0.600
LIG_SUMO_SIM_par_1	586	594	PF11976	0.753
LIG_SUMO_SIM_par_1	96	102	PF11976	0.588
LIG_TRAF2_1	343	346	PF00917	0.583
LIG_TRAF2_1	553	556	PF00917	0.787
MOD_CDC14_SPxK_1	268	271	PF00782	0.673
MOD_CDC14_SPxK_1	298	301	PF00782	0.799
MOD_CDC14_SPxK_1	44	47	PF00782	0.671
MOD_CDC14_SPxK_1	579	582	PF00782	0.759
MOD_CDK_SPxK_1	265	271	PF00069	0.679
MOD_CDK_SPxK_1	295	301	PF00069	0.801
MOD_CDK_SPxK_1	41	47	PF00069	0.675
MOD_CDK_SPxK_1	576	582	PF00069	0.765
MOD_CDK_SPxxK_3	295	302	PF00069	0.801
MOD_CK1_1	163	169	PF00069	0.507
MOD_CK1_1	300	306	PF00069	0.734
MOD_CK1_1	316	322	PF00069	0.473
MOD_CK1_1	338	344	PF00069	0.579
MOD_CK1_1	41	47	PF00069	0.753
MOD_CK1_1	476	482	PF00069	0.678
MOD_CK1_1	572	578	PF00069	0.706
MOD_CK1_1	586	592	PF00069	0.710
MOD_CK1_1	598	604	PF00069	0.587
MOD_CK1_1	657	663	PF00069	0.806
MOD_CK1_1	687	693	PF00069	0.768
MOD_CK1_1	69	75	PF00069	0.805
MOD_CK1_1	697	703	PF00069	0.703
MOD_CK1_1	7	13	PF00069	0.616
MOD_CK1_1	90	96	PF00069	0.583
MOD_CK2_1	143	149	PF00069	0.578
MOD_CK2_1	339	345	PF00069	0.524
MOD_CK2_1	55	61	PF00069	0.726
MOD_CK2_1	676	682	PF00069	0.764
MOD_CK2_1	718	724	PF00069	0.779
MOD_GlcNHglycan	162	165	PF01048	0.628
MOD_GlcNHglycan	205	208	PF01048	0.517
MOD_GlcNHglycan	286	290	PF01048	0.685
MOD_GlcNHglycan	305	308	PF01048	0.565
MOD_GlcNHglycan	318	321	PF01048	0.459
MOD_GlcNHglycan	328	331	PF01048	0.567
MOD_GlcNHglycan	341	344	PF01048	0.607
MOD_GlcNHglycan	365	368	PF01048	0.536
MOD_GlcNHglycan	468	471	PF01048	0.701
MOD_GlcNHglycan	478	481	PF01048	0.528
MOD_GlcNHglycan	528	531	PF01048	0.644
MOD_GlcNHglycan	551	554	PF01048	0.765
MOD_GlcNHglycan	603	606	PF01048	0.711
MOD_GlcNHglycan	676	679	PF01048	0.800
MOD_GlcNHglycan	701	704	PF01048	0.775
MOD_GlcNHglycan	718	721	PF01048	0.698
MOD_GlcNHglycan	72	75	PF01048	0.821
MOD_GSK3_1	125	132	PF00069	0.504
MOD_GSK3_1	18	25	PF00069	0.670
MOD_GSK3_1	274	281	PF00069	0.642
MOD_GSK3_1	291	298	PF00069	0.763
MOD_GSK3_1	335	342	PF00069	0.586
MOD_GSK3_1	466	473	PF00069	0.641
MOD_GSK3_1	482	489	PF00069	0.454
MOD_GSK3_1	564	571	PF00069	0.744
MOD_GSK3_1	57	64	PF00069	0.748
MOD_GSK3_1	572	579	PF00069	0.716
MOD_GSK3_1	586	593	PF00069	0.649
MOD_GSK3_1	597	604	PF00069	0.590
MOD_GSK3_1	650	657	PF00069	0.805
MOD_GSK3_1	66	73	PF00069	0.702
MOD_GSK3_1	672	679	PF00069	0.721
MOD_GSK3_1	697	704	PF00069	0.769
MOD_GSK3_1	74	81	PF00069	0.576
MOD_N-GLC_1	75	80	PF02516	0.685
MOD_NEK2_1	125	130	PF00069	0.601
MOD_NEK2_1	18	23	PF00069	0.736
MOD_NEK2_1	195	200	PF00069	0.453
MOD_NEK2_1	202	207	PF00069	0.467
MOD_NEK2_1	351	356	PF00069	0.518
MOD_NEK2_1	404	409	PF00069	0.487
MOD_NEK2_1	482	487	PF00069	0.655
MOD_NEK2_1	496	501	PF00069	0.510
MOD_NEK2_1	504	509	PF00069	0.616
MOD_NEK2_1	547	552	PF00069	0.700
MOD_NEK2_1	591	596	PF00069	0.550
MOD_NEK2_1	672	677	PF00069	0.569
MOD_NEK2_1	701	706	PF00069	0.745
MOD_NEK2_1	89	94	PF00069	0.623
MOD_NEK2_2	232	237	PF00069	0.601
MOD_NEK2_2	274	279	PF00069	0.682
MOD_NEK2_2	384	389	PF00069	0.654
MOD_PIKK_1	293	299	PF00454	0.740
MOD_PIKK_1	300	306	PF00454	0.695
MOD_PIKK_1	328	334	PF00454	0.700
MOD_PIKK_1	482	488	PF00454	0.574
MOD_PIKK_1	547	553	PF00454	0.712
MOD_PKA_2	354	360	PF00069	0.495
MOD_PKA_2	496	502	PF00069	0.427
MOD_PKA_2	638	644	PF00069	0.706
MOD_PKA_2	672	678	PF00069	0.566
MOD_PKA_2	716	722	PF00069	0.711
MOD_Plk_1	232	238	PF00069	0.726
MOD_Plk_1	241	247	PF00069	0.661
MOD_Plk_1	583	589	PF00069	0.755
MOD_Plk_1	684	690	PF00069	0.761
MOD_Plk_1	731	737	PF00069	0.657
MOD_Plk_4	143	149	PF00069	0.578
MOD_Plk_4	195	201	PF00069	0.459
MOD_Plk_4	232	238	PF00069	0.683
MOD_Plk_4	354	360	PF00069	0.490
MOD_Plk_4	518	524	PF00069	0.777
MOD_Plk_4	583	589	PF00069	0.755
MOD_Plk_4	591	597	PF00069	0.618
MOD_Plk_4	633	639	PF00069	0.694
MOD_Plk_4	7	13	PF00069	0.669
MOD_Plk_4	734	740	PF00069	0.668
MOD_Plk_4	90	96	PF00069	0.576
MOD_ProDKin_1	251	257	PF00069	0.728
MOD_ProDKin_1	265	271	PF00069	0.654
MOD_ProDKin_1	295	301	PF00069	0.798
MOD_ProDKin_1	313	319	PF00069	0.400
MOD_ProDKin_1	41	47	PF00069	0.692
MOD_ProDKin_1	576	582	PF00069	0.723
MOD_ProDKin_1	595	601	PF00069	0.459
MOD_ProDKin_1	612	618	PF00069	0.450
MOD_ProDKin_1	66	72	PF00069	0.781
MOD_ProDKin_1	694	700	PF00069	0.672
MOD_ProDKin_1	707	713	PF00069	0.522
MOD_ProDKin_1	78	84	PF00069	0.590
TRG_DiLeu_BaEn_1	633	638	PF01217	0.698
TRG_ER_diArg_1	136	139	PF00400	0.492
TRG_ER_diArg_1	510	512	PF00400	0.757
TRG_ER_diArg_1	514	516	PF00400	0.726
TRG_ER_diArg_1	672	674	PF00400	0.792
TRG_ER_diArg_1	727	729	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8V5	Leptomonas seymouri	53%	99%
A0A1X0PAK4	Trypanosomatidae	31%	100%
A0A3S7X7X6	Leishmania donovani	92%	100%
A4HAU0	Leishmania braziliensis	74%	100%
A4IA08	Leishmania infantum	92%	100%
E9B514	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%