Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2X0_LEIMA

TriTrypDb:

LmjF.34.2300 , LMJLV39_340027700 , LMJSD75_340028600

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q2X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.550
CLV_C14_Caspase3-7	222	226	PF00656	0.397
CLV_C14_Caspase3-7	237	241	PF00656	0.483
CLV_C14_Caspase3-7	347	351	PF00656	0.672
CLV_C14_Caspase3-7	509	513	PF00656	0.675
CLV_NRD_NRD_1	444	446	PF00675	0.473
CLV_NRD_NRD_1	55	57	PF00675	0.690
CLV_NRD_NRD_1	582	584	PF00675	0.500
CLV_PCSK_KEX2_1	444	446	PF00082	0.434
CLV_PCSK_KEX2_1	57	59	PF00082	0.674
CLV_PCSK_KEX2_1	586	588	PF00082	0.528
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.674
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.428
CLV_PCSK_SKI1_1	128	132	PF00082	0.651
CLV_PCSK_SKI1_1	338	342	PF00082	0.539
CLV_PCSK_SKI1_1	370	374	PF00082	0.550
CLV_PCSK_SKI1_1	416	420	PF00082	0.561
CLV_PCSK_SKI1_1	427	431	PF00082	0.483
CLV_PCSK_SKI1_1	444	448	PF00082	0.259
CLV_PCSK_SKI1_1	539	543	PF00082	0.392
CLV_PCSK_SKI1_1	86	90	PF00082	0.589
DEG_APCC_DBOX_1	538	546	PF00400	0.427
DEG_APCC_DBOX_1	621	629	PF00400	0.464
DEG_Nend_UBRbox_2	1	3	PF02207	0.436
DEG_SPOP_SBC_1	327	331	PF00917	0.679
DEG_SPOP_SBC_1	49	53	PF00917	0.591
DEG_SPOP_SBC_1	69	73	PF00917	0.543
DOC_CDC14_PxL_1	278	286	PF14671	0.469
DOC_CKS1_1	113	118	PF01111	0.518
DOC_CKS1_1	77	82	PF01111	0.580
DOC_CYCLIN_RxL_1	335	344	PF00134	0.543
DOC_CYCLIN_RxL_1	367	374	PF00134	0.472
DOC_MAPK_gen_1	444	452	PF00069	0.345
DOC_MAPK_MEF2A_6	203	211	PF00069	0.418
DOC_MAPK_MEF2A_6	445	454	PF00069	0.343
DOC_MIT_MIM_1	199	207	PF04212	0.441
DOC_PP1_RVXF_1	442	449	PF00149	0.430
DOC_PP4_FxxP_1	26	29	PF00568	0.643
DOC_PP4_FxxP_1	42	45	PF00568	0.543
DOC_PP4_FxxP_1	557	560	PF00568	0.347
DOC_USP7_MATH_1	12	16	PF00917	0.672
DOC_USP7_MATH_1	126	130	PF00917	0.662
DOC_USP7_MATH_1	252	256	PF00917	0.493
DOC_USP7_MATH_1	327	331	PF00917	0.661
DOC_USP7_MATH_1	351	355	PF00917	0.515
DOC_USP7_MATH_1	363	367	PF00917	0.437
DOC_USP7_MATH_1	368	372	PF00917	0.414
DOC_USP7_MATH_1	405	409	PF00917	0.726
DOC_USP7_MATH_1	45	49	PF00917	0.657
DOC_USP7_MATH_1	582	586	PF00917	0.477
DOC_USP7_MATH_1	589	593	PF00917	0.457
DOC_USP7_MATH_1	68	72	PF00917	0.589
DOC_WW_Pin1_4	109	114	PF00397	0.646
DOC_WW_Pin1_4	163	168	PF00397	0.560
DOC_WW_Pin1_4	341	346	PF00397	0.670
DOC_WW_Pin1_4	387	392	PF00397	0.584
DOC_WW_Pin1_4	43	48	PF00397	0.683
DOC_WW_Pin1_4	575	580	PF00397	0.385
DOC_WW_Pin1_4	58	63	PF00397	0.663
DOC_WW_Pin1_4	73	78	PF00397	0.565
DOC_WW_Pin1_4	97	102	PF00397	0.670
LIG_14-3-3_CanoR_1	108	116	PF00244	0.535
LIG_14-3-3_CanoR_1	163	167	PF00244	0.471
LIG_14-3-3_CanoR_1	194	199	PF00244	0.462
LIG_14-3-3_CanoR_1	487	491	PF00244	0.420
LIG_14-3-3_CanoR_1	573	579	PF00244	0.371
LIG_Actin_WH2_2	148	165	PF00022	0.402
LIG_Actin_WH2_2	204	219	PF00022	0.265
LIG_Actin_WH2_2	527	545	PF00022	0.441
LIG_BIR_III_2	225	229	PF00653	0.451
LIG_BIR_III_4	552	556	PF00653	0.382
LIG_BRCT_BRCA1_1	102	106	PF00533	0.537
LIG_BRCT_BRCA1_1	493	497	PF00533	0.441
LIG_BRCT_BRCA1_1	577	581	PF00533	0.365
LIG_Clathr_ClatBox_1	564	568	PF01394	0.469
LIG_deltaCOP1_diTrp_1	301	307	PF00928	0.500
LIG_deltaCOP1_diTrp_1	481	486	PF00928	0.296
LIG_EVH1_1	26	30	PF00568	0.518
LIG_FHA_1	190	196	PF00498	0.531
LIG_FHA_1	303	309	PF00498	0.458
LIG_FHA_1	362	368	PF00498	0.413
LIG_FHA_1	387	393	PF00498	0.532
LIG_FHA_1	505	511	PF00498	0.492
LIG_FHA_1	77	83	PF00498	0.532
LIG_FHA_2	168	174	PF00498	0.704
LIG_FHA_2	194	200	PF00498	0.479
LIG_FHA_2	220	226	PF00498	0.410
LIG_FHA_2	473	479	PF00498	0.440
LIG_LIR_Gen_1	199	209	PF02991	0.315
LIG_LIR_Gen_1	264	273	PF02991	0.526
LIG_LIR_Gen_1	379	388	PF02991	0.542
LIG_LIR_Gen_1	568	576	PF02991	0.435
LIG_LIR_Gen_1	6	14	PF02991	0.570
LIG_LIR_Gen_1	611	621	PF02991	0.356
LIG_LIR_Nem_3	199	204	PF02991	0.327
LIG_LIR_Nem_3	264	268	PF02991	0.481
LIG_LIR_Nem_3	379	384	PF02991	0.482
LIG_LIR_Nem_3	423	429	PF02991	0.521
LIG_LIR_Nem_3	568	572	PF02991	0.400
LIG_LIR_Nem_3	588	593	PF02991	0.211
LIG_LIR_Nem_3	6	11	PF02991	0.573
LIG_LIR_Nem_3	611	617	PF02991	0.369
LIG_Pex14_1	303	307	PF04695	0.506
LIG_Pex14_1	434	438	PF04695	0.509
LIG_Pex14_1	493	497	PF04695	0.374
LIG_PTB_Apo_2	563	570	PF02174	0.466
LIG_Rb_pABgroove_1	367	375	PF01858	0.475
LIG_SH2_CRK	438	442	PF00017	0.449
LIG_SH2_CRK	590	594	PF00017	0.462
LIG_SH2_STAP1	457	461	PF00017	0.469
LIG_SH2_STAT3	95	98	PF00017	0.634
LIG_SH2_STAT5	161	164	PF00017	0.522
LIG_SH2_STAT5	201	204	PF00017	0.307
LIG_SH2_STAT5	286	289	PF00017	0.348
LIG_SH2_STAT5	41	44	PF00017	0.504
LIG_SH3_2	27	32	PF14604	0.593
LIG_SH3_3	110	116	PF00018	0.476
LIG_SH3_3	24	30	PF00018	0.784
LIG_SH3_3	273	279	PF00018	0.464
LIG_SH3_3	411	417	PF00018	0.640
LIG_SH3_3	74	80	PF00018	0.620
LIG_SH3_3	8	14	PF00018	0.482
LIG_SUMO_SIM_par_1	79	84	PF11976	0.463
LIG_WRC_WIRS_1	262	267	PF05994	0.451
MOD_CDK_SPxxK_3	387	394	PF00069	0.535
MOD_CK1_1	100	106	PF00069	0.640
MOD_CK1_1	107	113	PF00069	0.627
MOD_CK1_1	330	336	PF00069	0.556
MOD_CK1_1	344	350	PF00069	0.479
MOD_CK1_1	390	396	PF00069	0.523
MOD_CK1_1	465	471	PF00069	0.490
MOD_CK1_1	48	54	PF00069	0.600
MOD_CK1_1	72	78	PF00069	0.665
MOD_CK2_1	193	199	PF00069	0.496
MOD_CK2_1	315	321	PF00069	0.498
MOD_CK2_1	331	337	PF00069	0.497
MOD_CK2_1	582	588	PF00069	0.454
MOD_CMANNOS	483	486	PF00535	0.475
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.508
MOD_DYRK1A_RPxSP_1	58	62	PF00069	0.702
MOD_GlcNHglycan	128	131	PF01048	0.540
MOD_GlcNHglycan	156	160	PF01048	0.501
MOD_GlcNHglycan	315	318	PF01048	0.624
MOD_GlcNHglycan	346	349	PF01048	0.534
MOD_GlcNHglycan	407	410	PF01048	0.740
MOD_GlcNHglycan	47	50	PF01048	0.712
MOD_GlcNHglycan	493	496	PF01048	0.492
MOD_GlcNHglycan	531	534	PF01048	0.442
MOD_GSK3_1	100	107	PF00069	0.616
MOD_GSK3_1	163	170	PF00069	0.519
MOD_GSK3_1	189	196	PF00069	0.457
MOD_GSK3_1	313	320	PF00069	0.642
MOD_GSK3_1	326	333	PF00069	0.700
MOD_GSK3_1	386	393	PF00069	0.433
MOD_GSK3_1	43	50	PF00069	0.650
MOD_GSK3_1	461	468	PF00069	0.476
MOD_GSK3_1	500	507	PF00069	0.555
MOD_GSK3_1	52	59	PF00069	0.666
MOD_GSK3_1	543	550	PF00069	0.421
MOD_GSK3_1	589	596	PF00069	0.477
MOD_GSK3_1	608	615	PF00069	0.381
MOD_GSK3_1	68	75	PF00069	0.714
MOD_N-GLC_1	121	126	PF02516	0.672
MOD_N-GLC_1	405	410	PF02516	0.555
MOD_NEK2_1	104	109	PF00069	0.637
MOD_NEK2_1	155	160	PF00069	0.422
MOD_NEK2_1	162	167	PF00069	0.538
MOD_NEK2_1	253	258	PF00069	0.360
MOD_NEK2_1	261	266	PF00069	0.376
MOD_NEK2_1	315	320	PF00069	0.495
MOD_NEK2_1	336	341	PF00069	0.531
MOD_NEK2_1	511	516	PF00069	0.644
MOD_NEK2_1	600	605	PF00069	0.462
MOD_NEK2_2	368	373	PF00069	0.546
MOD_PIKK_1	12	18	PF00454	0.739
MOD_PIKK_1	219	225	PF00454	0.477
MOD_PIKK_1	302	308	PF00454	0.574
MOD_PIKK_1	351	357	PF00454	0.526
MOD_PKA_1	56	62	PF00069	0.739
MOD_PKA_2	107	113	PF00069	0.559
MOD_PKA_2	162	168	PF00069	0.507
MOD_PKA_2	193	199	PF00069	0.496
MOD_PKA_2	486	492	PF00069	0.490
MOD_PKA_2	582	588	PF00069	0.454
MOD_Plk_1	172	178	PF00069	0.624
MOD_Plk_1	239	245	PF00069	0.407
MOD_Plk_1	246	252	PF00069	0.362
MOD_Plk_1	253	259	PF00069	0.299
MOD_Plk_1	266	272	PF00069	0.446
MOD_Plk_1	336	342	PF00069	0.535
MOD_Plk_1	511	517	PF00069	0.468
MOD_Plk_1	567	573	PF00069	0.374
MOD_Plk_2-3	420	426	PF00069	0.447
MOD_Plk_4	100	106	PF00069	0.734
MOD_Plk_4	253	259	PF00069	0.416
MOD_Plk_4	293	299	PF00069	0.454
MOD_Plk_4	3	9	PF00069	0.538
MOD_Plk_4	331	337	PF00069	0.508
MOD_ProDKin_1	109	115	PF00069	0.646
MOD_ProDKin_1	163	169	PF00069	0.569
MOD_ProDKin_1	341	347	PF00069	0.670
MOD_ProDKin_1	387	393	PF00069	0.582
MOD_ProDKin_1	43	49	PF00069	0.683
MOD_ProDKin_1	575	581	PF00069	0.384
MOD_ProDKin_1	58	64	PF00069	0.662
MOD_ProDKin_1	73	79	PF00069	0.564
MOD_ProDKin_1	97	103	PF00069	0.694
MOD_SUMO_rev_2	420	429	PF00179	0.445
TRG_DiLeu_BaEn_2	34	40	PF01217	0.543
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.535
TRG_ENDOCYTIC_2	201	204	PF00928	0.307
TRG_ENDOCYTIC_2	41	44	PF00928	0.504
TRG_ENDOCYTIC_2	438	441	PF00928	0.434
TRG_ENDOCYTIC_2	590	593	PF00928	0.523
TRG_ER_diArg_1	443	445	PF00400	0.404
TRG_NES_CRM1_1	144	156	PF08389	0.408
TRG_NES_CRM1_1	199	213	PF08389	0.327
TRG_NES_CRM1_1	481	491	PF08389	0.296
TRG_NLS_MonoExtC_3	55	60	PF00514	0.672
TRG_NLS_MonoExtC_3	582	587	PF00514	0.400
TRG_NLS_MonoExtN_4	56	61	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH4	Leptomonas seymouri	47%	98%
A0A1X0P9M0	Trypanosomatidae	25%	100%
A0A3Q8IFL4	Leishmania donovani	90%	100%
A0A422P0J6	Trypanosoma rangeli	25%	100%
A4HAU2	Leishmania braziliensis	73%	100%
C9ZMM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AHT6	Leishmania infantum	89%	100%
E9B516	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BKG8	Trypanosoma cruzi	25%	100%