Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2W9_LEIMA

TriTrypDb:

LmjF.34.2310 , LMJLV39_340027800 , LMJSD75_340028700

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2W9

PDB structure(s): 7aih_T , 7am2_T , 7ane_T

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	30	32	PF00675	0.549
CLV_NRD_NRD_1	39	41	PF00675	0.493
CLV_NRD_NRD_1	74	76	PF00675	0.466
CLV_PCSK_KEX2_1	30	32	PF00082	0.549
CLV_PCSK_KEX2_1	39	41	PF00082	0.493
CLV_PCSK_KEX2_1	74	76	PF00082	0.491
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.549
CLV_PCSK_SKI1_1	50	54	PF00082	0.487
CLV_PCSK_SKI1_1	79	83	PF00082	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DOC_CKS1_1	16	21	PF01111	0.641
DOC_CYCLIN_RxL_1	46	56	PF00134	0.514
DOC_MAPK_gen_1	30	38	PF00069	0.533
DOC_MAPK_gen_1	39	47	PF00069	0.445
DOC_WW_Pin1_4	15	20	PF00397	0.576
DOC_WW_Pin1_4	25	30	PF00397	0.545
LIG_14-3-3_CanoR_1	39	44	PF00244	0.512
LIG_14-3-3_CanoR_1	4	8	PF00244	0.573
LIG_deltaCOP1_diTrp_1	55	59	PF00928	0.510
LIG_FHA_1	16	22	PF00498	0.548
LIG_FHA_1	40	46	PF00498	0.519
LIG_LIR_Apic_2	55	61	PF02991	0.436
LIG_LIR_Gen_1	49	59	PF02991	0.481
LIG_LIR_Nem_3	49	54	PF02991	0.436
LIG_LIR_Nem_3	56	62	PF02991	0.400
LIG_SH2_CRK	10	14	PF00017	0.650
LIG_SH2_STAP1	10	14	PF00017	0.703
LIG_SH2_STAT5	51	54	PF00017	0.444
LIG_SH2_STAT5	58	61	PF00017	0.387
LIG_SUMO_SIM_par_1	18	24	PF11976	0.650
MOD_CDK_SPK_2	25	30	PF00069	0.566
MOD_CDK_SPxK_1	25	31	PF00069	0.562
MOD_CDK_SPxxK_3	25	32	PF00069	0.560
MOD_GlcNHglycan	10	13	PF01048	0.650
MOD_GSK3_1	21	28	PF00069	0.723
MOD_NEK2_1	2	7	PF00069	0.568
MOD_NEK2_1	21	26	PF00069	0.665
MOD_PKA_1	39	45	PF00069	0.554
MOD_PKA_2	3	9	PF00069	0.571
MOD_PKA_2	39	45	PF00069	0.512
MOD_ProDKin_1	15	21	PF00069	0.579
MOD_ProDKin_1	25	31	PF00069	0.542
MOD_SUMO_for_1	52	55	PF00179	0.486
TRG_ENDOCYTIC_2	10	13	PF00928	0.602
TRG_ENDOCYTIC_2	51	54	PF00928	0.485
TRG_ER_diArg_1	38	40	PF00400	0.492
TRG_NLS_MonoCore_2	29	34	PF00514	0.535
TRG_NLS_MonoExtC_3	30	35	PF00514	0.531
TRG_NLS_MonoExtN_4	29	35	PF00514	0.533
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I230	Leptomonas seymouri	88%	100%
A0A0S4JJA2	Bodo saltans	67%	100%
A0A3S7X7Y9	Leishmania donovani	99%	100%
A4HAU3	Leishmania braziliensis	93%	100%
A4IA10	Leishmania infantum	99%	100%
C9ZMM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9B517	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%