Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2W5_LEIMA

TriTrypDb:

LmjF.34.2350 , LMJLV39_340028200 , LMJSD75_340029100

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.405
CLV_NRD_NRD_1	182	184	PF00675	0.492
CLV_NRD_NRD_1	48	50	PF00675	0.664
CLV_NRD_NRD_1	80	82	PF00675	0.570
CLV_PCSK_FUR_1	46	50	PF00082	0.493
CLV_PCSK_KEX2_1	182	184	PF00082	0.492
CLV_PCSK_KEX2_1	48	50	PF00082	0.598
CLV_PCSK_SKI1_1	38	42	PF00082	0.502
DEG_SPOP_SBC_1	12	16	PF00917	0.514
DOC_CYCLIN_RxL_1	164	178	PF00134	0.470
DOC_MAPK_gen_1	43	52	PF00069	0.388
DOC_MAPK_gen_1	99	108	PF00069	0.630
DOC_USP7_MATH_1	104	108	PF00917	0.502
DOC_USP7_MATH_1	26	30	PF00917	0.522
DOC_USP7_MATH_1	80	84	PF00917	0.556
LIG_14-3-3_CanoR_1	101	107	PF00244	0.709
LIG_14-3-3_CanoR_1	11	19	PF00244	0.492
LIG_14-3-3_CanoR_1	95	99	PF00244	0.670
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_eIF4E_1	199	205	PF01652	0.555
LIG_FHA_1	103	109	PF00498	0.654
LIG_FHA_1	113	119	PF00498	0.563
LIG_FHA_1	14	20	PF00498	0.512
LIG_FHA_1	186	192	PF00498	0.553
LIG_FHA_2	166	172	PF00498	0.444
LIG_LIR_Gen_1	58	68	PF02991	0.458
LIG_LIR_Nem_3	194	199	PF02991	0.532
LIG_LIR_Nem_3	44	50	PF02991	0.469
LIG_LIR_Nem_3	58	63	PF02991	0.391
LIG_SH2_CRK	47	51	PF00017	0.396
LIG_SH2_NCK_1	199	203	PF00017	0.571
LIG_SH2_STAP1	96	100	PF00017	0.580
LIG_SH2_STAT5	96	99	PF00017	0.587
LIG_SH3_3	85	91	PF00018	0.706
LIG_SUMO_SIM_anti_2	105	110	PF11976	0.627
LIG_SUMO_SIM_par_1	104	110	PF11976	0.486
LIG_WW_1	93	96	PF00397	0.509
LIG_WW_3	92	96	PF00397	0.511
MOD_CK1_1	107	113	PF00069	0.486
MOD_CK1_1	14	20	PF00069	0.681
MOD_CK2_1	165	171	PF00069	0.403
MOD_GSK3_1	107	114	PF00069	0.550
MOD_GSK3_1	11	18	PF00069	0.685
MOD_LATS_1	9	15	PF00433	0.593
MOD_N-GLC_1	118	123	PF02516	0.548
MOD_N-GLC_1	185	190	PF02516	0.522
MOD_N-GLC_1	191	196	PF02516	0.502
MOD_NEK2_1	118	123	PF00069	0.518
MOD_NEK2_1	185	190	PF00069	0.599
MOD_NEK2_1	19	24	PF00069	0.650
MOD_NEK2_1	191	196	PF00069	0.614
MOD_PIKK_1	165	171	PF00454	0.385
MOD_PK_1	48	54	PF00069	0.558
MOD_PKA_1	48	54	PF00069	0.486
MOD_PKA_2	48	54	PF00069	0.507
MOD_PKA_2	80	86	PF00069	0.550
MOD_PKA_2	94	100	PF00069	0.491
MOD_PKB_1	46	54	PF00069	0.487
MOD_Plk_1	191	197	PF00069	0.655
MOD_Plk_4	104	110	PF00069	0.670
MOD_SUMO_rev_2	149	158	PF00179	0.376
TRG_ENDOCYTIC_2	47	50	PF00928	0.396
TRG_ER_diArg_1	182	184	PF00400	0.588
TRG_ER_diArg_1	47	49	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC33	Leptomonas seymouri	32%	100%
A0A3Q8IHA0	Leishmania donovani	90%	100%
A4HAU7	Leishmania braziliensis	56%	100%
A4IA14	Leishmania infantum	89%	100%
E9B521	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%