Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2W4_LEIMA

TriTrypDb:

LmjF.34.2360 , LMJLV39_340028300 , LMJSD75_340029200

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.432
CLV_NRD_NRD_1	138	140	PF00675	0.415
CLV_NRD_NRD_1	24	26	PF00675	0.497
CLV_NRD_NRD_1	310	312	PF00675	0.525
CLV_NRD_NRD_1	45	47	PF00675	0.446
CLV_NRD_NRD_1	75	77	PF00675	0.500
CLV_PCSK_FUR_1	22	26	PF00082	0.516
CLV_PCSK_KEX2_1	24	26	PF00082	0.497
CLV_PCSK_KEX2_1	75	77	PF00082	0.500
CLV_PCSK_SKI1_1	132	136	PF00082	0.452
CLV_PCSK_SKI1_1	416	420	PF00082	0.490
CLV_PCSK_SKI1_1	57	61	PF00082	0.504
DEG_APCC_DBOX_1	365	373	PF00400	0.510
DEG_APCC_DBOX_1	415	423	PF00400	0.555
DEG_SCF_FBW7_1	292	297	PF00400	0.678
DEG_SPOP_SBC_1	171	175	PF00917	0.637
DOC_CKS1_1	211	216	PF01111	0.511
DOC_CYCLIN_RxL_1	129	136	PF00134	0.411
DOC_CYCLIN_RxL_1	412	421	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.619
DOC_MAPK_gen_1	152	160	PF00069	0.472
DOC_MAPK_gen_1	22	30	PF00069	0.503
DOC_MAPK_gen_1	259	267	PF00069	0.529
DOC_MAPK_gen_1	311	318	PF00069	0.533
DOC_MAPK_gen_1	373	382	PF00069	0.433
DOC_MAPK_MEF2A_6	152	160	PF00069	0.489
DOC_MIT_MIM_1	157	167	PF04212	0.484
DOC_PP2B_LxvP_1	199	202	PF13499	0.581
DOC_PP2B_LxvP_1	245	248	PF13499	0.608
DOC_USP7_MATH_1	294	298	PF00917	0.645
DOC_USP7_MATH_1	353	357	PF00917	0.469
DOC_USP7_MATH_1	6	10	PF00917	0.660
DOC_WW_Pin1_4	183	188	PF00397	0.679
DOC_WW_Pin1_4	210	215	PF00397	0.649
DOC_WW_Pin1_4	249	254	PF00397	0.657
DOC_WW_Pin1_4	283	288	PF00397	0.602
DOC_WW_Pin1_4	290	295	PF00397	0.640
DOC_WW_Pin1_4	380	385	PF00397	0.572
DOC_WW_Pin1_4	399	404	PF00397	0.481
DOC_WW_Pin1_4	8	13	PF00397	0.566
LIG_14-3-3_CanoR_1	109	119	PF00244	0.519
LIG_14-3-3_CanoR_1	139	148	PF00244	0.433
LIG_14-3-3_CanoR_1	271	281	PF00244	0.606
LIG_14-3-3_CanoR_1	326	336	PF00244	0.599
LIG_Actin_WH2_2	16	33	PF00022	0.505
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_FHA_1	190	196	PF00498	0.618
LIG_FHA_1	211	217	PF00498	0.653
LIG_FHA_1	283	289	PF00498	0.580
LIG_FHA_1	336	342	PF00498	0.522
LIG_FHA_1	413	419	PF00498	0.500
LIG_FHA_2	111	117	PF00498	0.521
LIG_FHA_2	140	146	PF00498	0.639
LIG_FHA_2	346	352	PF00498	0.464
LIG_FHA_2	36	42	PF00498	0.619
LIG_FHA_2	48	54	PF00498	0.499
LIG_LIR_Gen_1	124	130	PF02991	0.471
LIG_LIR_Gen_1	26	35	PF02991	0.483
LIG_LIR_Nem_3	26	30	PF02991	0.487
LIG_NRBOX	312	318	PF00104	0.482
LIG_PTB_Apo_2	68	75	PF02174	0.487
LIG_SH2_CRK	87	91	PF00017	0.530
LIG_SH2_PTP2	27	30	PF00017	0.486
LIG_SH2_SRC	155	158	PF00017	0.487
LIG_SH2_STAP1	35	39	PF00017	0.472
LIG_SH2_STAT5	125	128	PF00017	0.475
LIG_SH2_STAT5	155	158	PF00017	0.411
LIG_SH2_STAT5	27	30	PF00017	0.466
LIG_SH3_3	198	204	PF00018	0.652
LIG_SH3_3	247	253	PF00018	0.714
LIG_SH3_3	378	384	PF00018	0.545
LIG_SH3_3	419	425	PF00018	0.628
LIG_SUMO_SIM_par_1	305	310	PF11976	0.437
LIG_SUMO_SIM_par_1	401	408	PF11976	0.472
LIG_TRAF2_1	118	121	PF00917	0.461
LIG_TRAF2_1	343	346	PF00917	0.499
LIG_TRAF2_1	38	41	PF00917	0.472
LIG_TRFH_1	249	253	PF08558	0.503
LIG_UBA3_1	126	133	PF00899	0.468
LIG_UBA3_1	134	141	PF00899	0.483
LIG_Vh1_VBS_1	404	422	PF01044	0.424
MOD_CDK_SPK_2	290	295	PF00069	0.605
MOD_CDK_SPxxK_3	210	217	PF00069	0.609
MOD_CK1_1	110	116	PF00069	0.520
MOD_CK1_1	174	180	PF00069	0.619
MOD_CK1_1	183	189	PF00069	0.671
MOD_CK1_1	275	281	PF00069	0.653
MOD_CK1_1	282	288	PF00069	0.632
MOD_CK1_1	29	35	PF00069	0.480
MOD_CK1_1	296	302	PF00069	0.505
MOD_CK1_1	389	395	PF00069	0.580
MOD_CK1_1	407	413	PF00069	0.366
MOD_CK2_1	110	116	PF00069	0.346
MOD_CK2_1	139	145	PF00069	0.431
MOD_CK2_1	170	176	PF00069	0.641
MOD_CK2_1	183	189	PF00069	0.527
MOD_CK2_1	325	331	PF00069	0.510
MOD_CK2_1	35	41	PF00069	0.470
MOD_CK2_1	407	413	PF00069	0.550
MOD_CK2_1	47	53	PF00069	0.416
MOD_CK2_1	93	99	PF00069	0.522
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.632
MOD_GlcNHglycan	101	104	PF01048	0.392
MOD_GlcNHglycan	255	258	PF01048	0.588
MOD_GlcNHglycan	277	280	PF01048	0.803
MOD_GlcNHglycan	281	284	PF01048	0.754
MOD_GlcNHglycan	288	291	PF01048	0.633
MOD_GlcNHglycan	327	330	PF01048	0.502
MOD_GlcNHglycan	376	380	PF01048	0.465
MOD_GlcNHglycan	391	394	PF01048	0.651
MOD_GSK3_1	170	177	PF00069	0.590
MOD_GSK3_1	249	256	PF00069	0.602
MOD_GSK3_1	26	33	PF00069	0.461
MOD_GSK3_1	267	274	PF00069	0.696
MOD_GSK3_1	275	282	PF00069	0.577
MOD_GSK3_1	286	293	PF00069	0.495
MOD_GSK3_1	35	42	PF00069	0.411
MOD_GSK3_1	385	392	PF00069	0.682
MOD_GSK3_1	394	401	PF00069	0.623
MOD_GSK3_1	4	11	PF00069	0.677
MOD_GSK3_1	93	100	PF00069	0.523
MOD_N-GLC_1	267	272	PF02516	0.745
MOD_N-GLC_1	394	399	PF02516	0.700
MOD_NEK2_1	215	220	PF00069	0.637
MOD_NEK2_1	281	286	PF00069	0.739
MOD_NEK2_1	30	35	PF00069	0.481
MOD_NEK2_1	324	329	PF00069	0.511
MOD_NEK2_1	385	390	PF00069	0.667
MOD_NEK2_1	391	396	PF00069	0.696
MOD_NEK2_1	398	403	PF00069	0.493
MOD_NEK2_1	4	9	PF00069	0.640
MOD_NEK2_1	404	409	PF00069	0.489
MOD_NEK2_1	418	423	PF00069	0.381
MOD_PIKK_1	107	113	PF00454	0.524
MOD_PIKK_1	180	186	PF00454	0.616
MOD_PK_1	52	58	PF00069	0.481
MOD_PKA_1	139	145	PF00069	0.490
MOD_PKA_2	279	285	PF00069	0.747
MOD_PKA_2	294	300	PF00069	0.518
MOD_PKA_2	325	331	PF00069	0.510
MOD_PKA_2	353	359	PF00069	0.579
MOD_PKA_2	367	373	PF00069	0.458
MOD_Plk_1	16	22	PF00069	0.519
MOD_Plk_1	175	181	PF00069	0.605
MOD_Plk_1	345	351	PF00069	0.527
MOD_Plk_1	385	391	PF00069	0.655
MOD_Plk_1	39	45	PF00069	0.429
MOD_Plk_1	394	400	PF00069	0.643
MOD_Plk_1	52	58	PF00069	0.470
MOD_Plk_2-3	93	99	PF00069	0.506
MOD_Plk_4	345	351	PF00069	0.436
MOD_Plk_4	386	392	PF00069	0.575
MOD_ProDKin_1	183	189	PF00069	0.680
MOD_ProDKin_1	210	216	PF00069	0.650
MOD_ProDKin_1	249	255	PF00069	0.656
MOD_ProDKin_1	283	289	PF00069	0.601
MOD_ProDKin_1	290	296	PF00069	0.636
MOD_ProDKin_1	380	386	PF00069	0.574
MOD_ProDKin_1	399	405	PF00069	0.480
MOD_ProDKin_1	8	14	PF00069	0.558
MOD_SUMO_for_1	358	361	PF00179	0.523
MOD_SUMO_for_1	64	67	PF00179	0.446
MOD_SUMO_for_1	91	94	PF00179	0.461
MOD_SUMO_rev_2	370	374	PF00179	0.522
TRG_DiLeu_BaEn_1	40	45	PF01217	0.493
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.607
TRG_ENDOCYTIC_2	125	128	PF00928	0.475
TRG_ENDOCYTIC_2	155	158	PF00928	0.411
TRG_ENDOCYTIC_2	27	30	PF00928	0.486
TRG_ENDOCYTIC_2	87	90	PF00928	0.513
TRG_ER_diArg_1	166	169	PF00400	0.541
TRG_ER_diArg_1	22	25	PF00400	0.507
TRG_ER_diArg_1	366	369	PF00400	0.455
TRG_ER_diArg_1	74	76	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y4	Leptomonas seymouri	52%	99%
A0A0S4JG85	Bodo saltans	28%	83%
A0A3Q8IL47	Leishmania donovani	93%	100%
A4IA15	Leishmania infantum	93%	100%
E9AI69	Leishmania braziliensis	77%	100%
E9B522	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%