Histone-fold-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2W3_LEIMA

TriTrypDb:

LmjF.34.2370 , LMJLV39_340028400 , LMJSD75_340029300

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2W3

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0046982	protein heterodimerization activity	4	8
GO:0046983	protein dimerization activity	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.721
CLV_C14_Caspase3-7	158	162	PF00656	0.654
CLV_MEL_PAP_1	252	258	PF00089	0.443
CLV_NRD_NRD_1	235	237	PF00675	0.426
CLV_PCSK_KEX2_1	235	237	PF00082	0.429
CLV_PCSK_KEX2_1	299	301	PF00082	0.696
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.594
CLV_PCSK_SKI1_1	194	198	PF00082	0.393
CLV_PCSK_SKI1_1	239	243	PF00082	0.413
CLV_PCSK_SKI1_1	317	321	PF00082	0.698
CLV_PCSK_SKI1_1	359	363	PF00082	0.580
CLV_PCSK_SKI1_1	36	40	PF00082	0.683
DEG_APCC_DBOX_1	316	324	PF00400	0.594
DEG_SCF_TRCP1_1	83	88	PF00400	0.634
DEG_SPOP_SBC_1	267	271	PF00917	0.558
DEG_SPOP_SBC_1	292	296	PF00917	0.587
DEG_SPOP_SBC_1	46	50	PF00917	0.647
DOC_CYCLIN_RxL_1	190	200	PF00134	0.411
DOC_MAPK_gen_1	332	340	PF00069	0.592
DOC_USP7_MATH_1	11	15	PF00917	0.557
DOC_USP7_MATH_1	110	114	PF00917	0.670
DOC_USP7_MATH_1	267	271	PF00917	0.516
DOC_USP7_MATH_1	276	280	PF00917	0.559
DOC_USP7_MATH_1	292	296	PF00917	0.528
DOC_USP7_MATH_1	345	349	PF00917	0.568
DOC_USP7_MATH_1	46	50	PF00917	0.665
DOC_USP7_MATH_1	81	85	PF00917	0.616
DOC_USP7_UBL2_3	194	198	PF12436	0.452
DOC_WW_Pin1_4	113	118	PF00397	0.589
DOC_WW_Pin1_4	288	293	PF00397	0.577
DOC_WW_Pin1_4	323	328	PF00397	0.648
DOC_WW_Pin1_4	42	47	PF00397	0.624
LIG_14-3-3_CanoR_1	104	110	PF00244	0.651
LIG_14-3-3_CanoR_1	236	242	PF00244	0.425
LIG_14-3-3_CanoR_1	255	259	PF00244	0.370
LIG_14-3-3_CanoR_1	307	315	PF00244	0.699
LIG_14-3-3_CanoR_1	332	341	PF00244	0.732
LIG_14-3-3_CanoR_1	359	364	PF00244	0.574
LIG_14-3-3_CanoR_1	36	41	PF00244	0.636
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BIR_III_2	164	168	PF00653	0.613
LIG_FHA_1	220	226	PF00498	0.458
LIG_FHA_1	333	339	PF00498	0.599
LIG_FHA_2	132	138	PF00498	0.611
LIG_FHA_2	240	246	PF00498	0.446
LIG_LIR_Apic_2	31	35	PF02991	0.611
LIG_LIR_Gen_1	240	250	PF02991	0.380
LIG_LIR_Gen_1	254	264	PF02991	0.359
LIG_LIR_Nem_3	240	246	PF02991	0.399
LIG_LIR_Nem_3	254	259	PF02991	0.348
LIG_PDZ_Class_2	360	365	PF00595	0.544
LIG_SH2_GRB2like	184	187	PF00017	0.520
LIG_SH2_NCK_1	243	247	PF00017	0.372
LIG_SH2_SRC	184	187	PF00017	0.520
LIG_SH2_SRC	243	246	PF00017	0.383
LIG_SH2_SRC	40	43	PF00017	0.608
LIG_SH2_STAP1	12	16	PF00017	0.645
LIG_SH2_STAP1	243	247	PF00017	0.372
LIG_SH2_STAT5	132	135	PF00017	0.529
LIG_SH2_STAT5	184	187	PF00017	0.520
LIG_SH2_STAT5	32	35	PF00017	0.602
LIG_SH3_3	259	265	PF00018	0.457
LIG_SUMO_SIM_anti_2	215	222	PF11976	0.423
LIG_TRAF2_1	117	120	PF00917	0.602
LIG_TRAF2_1	61	64	PF00917	0.801
LIG_TYR_ITIM	241	246	PF00017	0.389
MOD_CK1_1	113	119	PF00069	0.654
MOD_CK1_1	204	210	PF00069	0.422
MOD_CK1_1	212	218	PF00069	0.396
MOD_CK1_1	285	291	PF00069	0.588
MOD_CK1_1	295	301	PF00069	0.612
MOD_CK1_1	305	311	PF00069	0.486
MOD_CK1_1	330	336	PF00069	0.660
MOD_CK1_1	45	51	PF00069	0.681
MOD_CK2_1	113	119	PF00069	0.685
MOD_CK2_1	133	139	PF00069	0.438
MOD_GlcNHglycan	1	4	PF01048	0.649
MOD_GlcNHglycan	113	116	PF01048	0.689
MOD_GlcNHglycan	126	129	PF01048	0.555
MOD_GlcNHglycan	170	173	PF01048	0.801
MOD_GlcNHglycan	211	214	PF01048	0.445
MOD_GlcNHglycan	295	298	PF01048	0.716
MOD_GlcNHglycan	309	312	PF01048	0.596
MOD_GlcNHglycan	329	332	PF01048	0.454
MOD_GlcNHglycan	347	350	PF01048	0.555
MOD_GlcNHglycan	42	45	PF01048	0.606
MOD_GlcNHglycan	76	79	PF01048	0.686
MOD_GlcNHglycan	83	86	PF01048	0.597
MOD_GlcNHglycan	87	90	PF01048	0.584
MOD_GSK3_1	12	19	PF00069	0.677
MOD_GSK3_1	166	173	PF00069	0.646
MOD_GSK3_1	200	207	PF00069	0.499
MOD_GSK3_1	281	288	PF00069	0.697
MOD_GSK3_1	291	298	PF00069	0.576
MOD_GSK3_1	323	330	PF00069	0.640
MOD_GSK3_1	36	43	PF00069	0.622
MOD_GSK3_1	46	53	PF00069	0.617
MOD_GSK3_1	81	88	PF00069	0.631
MOD_LATS_1	237	243	PF00433	0.488
MOD_NEK2_1	103	108	PF00069	0.613
MOD_NEK2_1	188	193	PF00069	0.438
MOD_NEK2_1	47	52	PF00069	0.670
MOD_PIKK_1	50	56	PF00454	0.735
MOD_PIKK_1	76	82	PF00454	0.726
MOD_PKA_2	103	109	PF00069	0.658
MOD_PKA_2	111	117	PF00069	0.650
MOD_PKA_2	254	260	PF00069	0.434
MOD_PKA_2	81	87	PF00069	0.659
MOD_PKB_1	72	80	PF00069	0.561
MOD_Plk_1	12	18	PF00069	0.571
MOD_Plk_4	201	207	PF00069	0.483
MOD_Plk_4	276	282	PF00069	0.525
MOD_Plk_4	28	34	PF00069	0.648
MOD_ProDKin_1	113	119	PF00069	0.588
MOD_ProDKin_1	288	294	PF00069	0.580
MOD_ProDKin_1	323	329	PF00069	0.648
MOD_ProDKin_1	42	48	PF00069	0.628
MOD_SUMO_for_1	197	200	PF00179	0.471
TRG_DiLeu_BaEn_1	216	221	PF01217	0.387
TRG_ENDOCYTIC_2	243	246	PF00928	0.383
TRG_ER_diArg_1	306	309	PF00400	0.699
TRG_NES_CRM1_1	209	224	PF08389	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A7	Leptomonas seymouri	45%	100%
A0A3S7X811	Leishmania donovani	91%	100%
A0A422P0E4	Trypanosoma rangeli	28%	100%
A4HAU8	Leishmania braziliensis	72%	100%
A4IA16	Leishmania infantum	90%	100%
E9B523	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%