Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2W2_LEIMA

TriTrypDb:

LmjF.34.2380 , LMJLV39_340028500 , LMJSD75_340029400

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.706
CLV_C14_Caspase3-7	243	247	PF00656	0.712
CLV_C14_Caspase3-7	283	287	PF00656	0.746
CLV_NRD_NRD_1	296	298	PF00675	0.806
CLV_NRD_NRD_1	314	316	PF00675	0.526
CLV_PCSK_KEX2_1	296	298	PF00082	0.806
CLV_PCSK_KEX2_1	313	315	PF00082	0.554
CLV_PCSK_KEX2_1	337	339	PF00082	0.687
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.687
CLV_PCSK_PC7_1	292	298	PF00082	0.728
CLV_PCSK_SKI1_1	131	135	PF00082	0.635
CLV_PCSK_SKI1_1	16	20	PF00082	0.630
CLV_PCSK_SKI1_1	337	341	PF00082	0.727
CLV_PCSK_SKI1_1	352	356	PF00082	0.542
CLV_PCSK_SKI1_1	6	10	PF00082	0.717
DEG_Nend_UBRbox_3	1	3	PF02207	0.774
DOC_CKS1_1	7	12	PF01111	0.768
DOC_MAPK_gen_1	184	192	PF00069	0.707
DOC_MAPK_gen_1	296	303	PF00069	0.811
DOC_USP7_MATH_1	120	124	PF00917	0.591
DOC_USP7_MATH_1	282	286	PF00917	0.744
DOC_USP7_MATH_1	48	52	PF00917	0.730
DOC_USP7_MATH_1	71	75	PF00917	0.697
DOC_USP7_MATH_1	83	87	PF00917	0.658
DOC_WW_Pin1_4	303	308	PF00397	0.706
DOC_WW_Pin1_4	324	329	PF00397	0.633
DOC_WW_Pin1_4	6	11	PF00397	0.669
LIG_14-3-3_CanoR_1	166	176	PF00244	0.628
LIG_14-3-3_CanoR_1	194	200	PF00244	0.811
LIG_14-3-3_CanoR_1	28	36	PF00244	0.810
LIG_14-3-3_CanoR_1	296	300	PF00244	0.810
LIG_14-3-3_CanoR_1	61	66	PF00244	0.674
LIG_14-3-3_CanoR_1	99	105	PF00244	0.718
LIG_APCC_ABBAyCdc20_2	16	22	PF00400	0.801
LIG_BRCT_BRCA1_1	139	143	PF00533	0.795
LIG_Clathr_ClatBox_1	264	268	PF01394	0.559
LIG_FHA_1	116	122	PF00498	0.698
LIG_FHA_1	159	165	PF00498	0.651
LIG_FHA_1	187	193	PF00498	0.633
LIG_FHA_1	330	336	PF00498	0.789
LIG_FHA_1	338	344	PF00498	0.678
LIG_FHA_2	196	202	PF00498	0.779
LIG_FHA_2	278	284	PF00498	0.749
LIG_LIR_Nem_3	132	137	PF02991	0.669
LIG_NRP_CendR_1	358	361	PF00754	0.726
LIG_SH2_SRC	251	254	PF00017	0.745
LIG_SH2_STAP1	251	255	PF00017	0.742
LIG_SH2_STAT3	197	200	PF00017	0.809
LIG_SH2_STAT5	197	200	PF00017	0.710
LIG_SH3_3	272	278	PF00018	0.711
LIG_SH3_3	301	307	PF00018	0.731
LIG_SH3_3	351	357	PF00018	0.652
LIG_SH3_3	65	71	PF00018	0.711
LIG_TRAF2_1	198	201	PF00917	0.694
LIG_TRAF2_1	257	260	PF00917	0.802
MOD_CDK_SPxxK_3	6	13	PF00069	0.692
MOD_CK1_1	105	111	PF00069	0.536
MOD_CK1_1	123	129	PF00069	0.551
MOD_CK1_1	139	145	PF00069	0.532
MOD_CK1_1	14	20	PF00069	0.691
MOD_CK1_1	151	157	PF00069	0.651
MOD_CK1_1	193	199	PF00069	0.759
MOD_CK1_1	30	36	PF00069	0.658
MOD_CK1_1	302	308	PF00069	0.746
MOD_CK1_1	324	330	PF00069	0.797
MOD_CK1_1	44	50	PF00069	0.593
MOD_CK1_1	75	81	PF00069	0.681
MOD_CK1_1	86	92	PF00069	0.632
MOD_CK1_1	94	100	PF00069	0.557
MOD_CK2_1	195	201	PF00069	0.757
MOD_CK2_1	219	225	PF00069	0.745
MOD_CK2_1	277	283	PF00069	0.719
MOD_CK2_1	284	290	PF00069	0.670
MOD_GlcNHglycan	139	142	PF01048	0.794
MOD_GlcNHglycan	150	153	PF01048	0.613
MOD_GlcNHglycan	252	256	PF01048	0.710
MOD_GlcNHglycan	272	275	PF01048	0.460
MOD_GlcNHglycan	323	326	PF01048	0.732
MOD_GlcNHglycan	96	99	PF01048	0.763
MOD_GSK3_1	186	193	PF00069	0.688
MOD_GSK3_1	195	202	PF00069	0.624
MOD_GSK3_1	217	224	PF00069	0.700
MOD_GSK3_1	229	236	PF00069	0.660
MOD_GSK3_1	251	258	PF00069	0.697
MOD_GSK3_1	266	273	PF00069	0.718
MOD_GSK3_1	27	34	PF00069	0.773
MOD_GSK3_1	295	302	PF00069	0.773
MOD_GSK3_1	303	310	PF00069	0.748
MOD_GSK3_1	327	334	PF00069	0.764
MOD_GSK3_1	44	51	PF00069	0.656
MOD_GSK3_1	59	66	PF00069	0.557
MOD_GSK3_1	71	78	PF00069	0.601
MOD_N-GLC_1	105	110	PF02516	0.805
MOD_N-GLC_1	78	83	PF02516	0.655
MOD_NEK2_1	100	105	PF00069	0.756
MOD_NEK2_1	121	126	PF00069	0.755
MOD_NEK2_1	190	195	PF00069	0.713
MOD_NEK2_1	199	204	PF00069	0.579
MOD_NEK2_1	231	236	PF00069	0.700
MOD_NEK2_1	59	64	PF00069	0.684
MOD_PIKK_1	167	173	PF00454	0.629
MOD_PIKK_1	266	272	PF00454	0.787
MOD_PIKK_1	86	92	PF00454	0.814
MOD_PKA_1	337	343	PF00069	0.689
MOD_PKA_2	193	199	PF00069	0.755
MOD_PKA_2	27	33	PF00069	0.712
MOD_PKA_2	295	301	PF00069	0.809
MOD_PKA_2	337	343	PF00069	0.689
MOD_PKA_2	86	92	PF00069	0.739
MOD_PKB_1	184	192	PF00069	0.727
MOD_Plk_1	146	152	PF00069	0.754
MOD_Plk_1	186	192	PF00069	0.678
MOD_Plk_1	200	206	PF00069	0.528
MOD_Plk_1	217	223	PF00069	0.611
MOD_Plk_1	78	84	PF00069	0.721
MOD_Plk_2-3	217	223	PF00069	0.756
MOD_Plk_4	14	20	PF00069	0.784
MOD_Plk_4	299	305	PF00069	0.812
MOD_Plk_4	63	69	PF00069	0.792
MOD_ProDKin_1	303	309	PF00069	0.706
MOD_ProDKin_1	324	330	PF00069	0.631
MOD_ProDKin_1	6	12	PF00069	0.668
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.592
TRG_ER_diArg_1	183	186	PF00400	0.717
TRG_ER_diArg_1	295	297	PF00400	0.737
TRG_ER_diArg_1	312	315	PF00400	0.618
TRG_ER_diLys_1	356	361	PF00400	0.688
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAB5	Leptomonas seymouri	36%	100%
A0A3S7X7Y4	Leishmania donovani	92%	100%
A4HAU9	Leishmania braziliensis	66%	99%
A4IAM0	Leishmania infantum	92%	100%
E9B524	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%