Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2W0_LEIMA

TriTrypDb:

LmjF.34.2400 , LMJLV39_340028700

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2W0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.606
CLV_NRD_NRD_1	125	127	PF00675	0.686
CLV_NRD_NRD_1	2	4	PF00675	0.622
CLV_NRD_NRD_1	219	221	PF00675	0.378
CLV_NRD_NRD_1	225	227	PF00675	0.406
CLV_NRD_NRD_1	328	330	PF00675	0.632
CLV_NRD_NRD_1	7	9	PF00675	0.580
CLV_PCSK_KEX2_1	125	127	PF00082	0.647
CLV_PCSK_KEX2_1	207	209	PF00082	0.491
CLV_PCSK_KEX2_1	219	221	PF00082	0.376
CLV_PCSK_KEX2_1	225	227	PF00082	0.396
CLV_PCSK_KEX2_1	328	330	PF00082	0.578
CLV_PCSK_KEX2_1	7	9	PF00082	0.597
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.505
CLV_PCSK_PC7_1	3	9	PF00082	0.663
CLV_PCSK_SKI1_1	15	19	PF00082	0.648
CLV_PCSK_SKI1_1	210	214	PF00082	0.486
CLV_PCSK_SKI1_1	219	223	PF00082	0.441
CLV_PCSK_SKI1_1	299	303	PF00082	0.517
CLV_PCSK_SKI1_1	8	12	PF00082	0.623
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DOC_MAPK_DCC_7	126	136	PF00069	0.593
DOC_MAPK_gen_1	207	215	PF00069	0.466
DOC_MAPK_gen_1	3	11	PF00069	0.701
DOC_PP1_RVXF_1	194	201	PF00149	0.507
DOC_PP4_FxxP_1	17	20	PF00568	0.654
DOC_USP7_MATH_1	24	28	PF00917	0.648
DOC_USP7_MATH_1	307	311	PF00917	0.641
DOC_WW_Pin1_4	20	25	PF00397	0.631
DOC_WW_Pin1_4	253	258	PF00397	0.499
DOC_WW_Pin1_4	99	104	PF00397	0.652
LIG_14-3-3_CanoR_1	133	139	PF00244	0.634
LIG_14-3-3_CanoR_1	299	304	PF00244	0.522
LIG_14-3-3_CanoR_1	315	321	PF00244	0.344
LIG_APCC_ABBA_1	151	156	PF00400	0.599
LIG_Clathr_ClatBox_1	148	152	PF01394	0.558
LIG_Clathr_ClatBox_1	57	61	PF01394	0.736
LIG_eIF4E_1	138	144	PF01652	0.475
LIG_eIF4E_1	95	101	PF01652	0.581
LIG_FHA_1	26	32	PF00498	0.610
LIG_FHA_1	315	321	PF00498	0.463
LIG_FHA_2	243	249	PF00498	0.476
LIG_FHA_2	276	282	PF00498	0.496
LIG_FHA_2	300	306	PF00498	0.545
LIG_FHA_2	322	328	PF00498	0.603
LIG_KLC1_Yacidic_2	92	97	PF13176	0.668
LIG_LIR_Apic_2	14	20	PF02991	0.631
LIG_LIR_Apic_2	181	187	PF02991	0.536
LIG_LIR_Apic_2	44	50	PF02991	0.581
LIG_LIR_Apic_2	63	68	PF02991	0.670
LIG_LIR_Apic_2	92	98	PF02991	0.546
LIG_LIR_Gen_1	118	128	PF02991	0.696
LIG_LIR_Gen_1	209	218	PF02991	0.362
LIG_LIR_Gen_1	248	257	PF02991	0.552
LIG_LIR_Gen_1	266	274	PF02991	0.512
LIG_LIR_Gen_1	283	294	PF02991	0.287
LIG_LIR_Nem_3	118	123	PF02991	0.534
LIG_LIR_Nem_3	199	203	PF02991	0.554
LIG_LIR_Nem_3	209	215	PF02991	0.414
LIG_LIR_Nem_3	248	252	PF02991	0.462
LIG_LIR_Nem_3	266	270	PF02991	0.360
LIG_LIR_Nem_3	282	288	PF02991	0.382
LIG_LIR_Nem_3	76	82	PF02991	0.635
LIG_MAD2	196	204	PF02301	0.629
LIG_PCNA_yPIPBox_3	261	275	PF02747	0.533
LIG_Pex14_1	180	184	PF04695	0.526
LIG_SH2_CRK	34	38	PF00017	0.602
LIG_SH2_PTP2	267	270	PF00017	0.557
LIG_SH2_PTP2	47	50	PF00017	0.623
LIG_SH2_SRC	184	187	PF00017	0.539
LIG_SH2_SRC	265	268	PF00017	0.557
LIG_SH2_SRC	47	50	PF00017	0.625
LIG_SH2_SRC	95	98	PF00017	0.565
LIG_SH2_STAP1	316	320	PF00017	0.452
LIG_SH2_STAT3	258	261	PF00017	0.486
LIG_SH2_STAT5	184	187	PF00017	0.536
LIG_SH2_STAT5	267	270	PF00017	0.547
LIG_SH2_STAT5	285	288	PF00017	0.284
LIG_SH2_STAT5	316	319	PF00017	0.452
LIG_SH2_STAT5	47	50	PF00017	0.606
LIG_SH2_STAT5	79	82	PF00017	0.553
LIG_SH2_STAT5	95	98	PF00017	0.500
LIG_SH3_3	200	206	PF00018	0.626
LIG_SH3_CIN85_PxpxPR_1	128	133	PF14604	0.660
LIG_Sin3_3	211	218	PF02671	0.434
LIG_SUMO_SIM_anti_2	231	239	PF11976	0.558
LIG_SUMO_SIM_par_1	107	113	PF11976	0.537
LIG_SUMO_SIM_par_1	316	321	PF11976	0.449
LIG_SUMO_SIM_par_1	55	61	PF11976	0.734
LIG_TRAF2_1	102	105	PF00917	0.535
LIG_UBA3_1	214	222	PF00899	0.538
LIG_WW_3	48	52	PF00397	0.709
MOD_CK1_1	310	316	PF00069	0.620
MOD_CK2_1	99	105	PF00069	0.547
MOD_Cter_Amidation	5	8	PF01082	0.746
MOD_GlcNHglycan	181	184	PF01048	0.549
MOD_GlcNHglycan	193	196	PF01048	0.435
MOD_GlcNHglycan	258	261	PF01048	0.564
MOD_GlcNHglycan	299	302	PF01048	0.614
MOD_GlcNHglycan	4	7	PF01048	0.617
MOD_GlcNHglycan	54	57	PF01048	0.589
MOD_GSK3_1	134	141	PF00069	0.638
MOD_GSK3_1	20	27	PF00069	0.634
MOD_GSK3_1	297	304	PF00069	0.630
MOD_GSK3_1	310	317	PF00069	0.504
MOD_NEK2_1	110	115	PF00069	0.529
MOD_NEK2_1	134	139	PF00069	0.655
MOD_NEK2_1	179	184	PF00069	0.607
MOD_NEK2_1	2	7	PF00069	0.662
MOD_NEK2_1	25	30	PF00069	0.729
MOD_NEK2_1	270	275	PF00069	0.521
MOD_NEK2_2	242	247	PF00069	0.543
MOD_PIKK_1	41	47	PF00454	0.622
MOD_PKA_2	134	140	PF00069	0.647
MOD_PKA_2	2	8	PF00069	0.627
MOD_PKA_2	314	320	PF00069	0.463
MOD_Plk_1	167	173	PF00069	0.512
MOD_Plk_1	281	287	PF00069	0.497
MOD_Plk_1	60	66	PF00069	0.623
MOD_Plk_2-3	281	287	PF00069	0.497
MOD_Plk_4	168	174	PF00069	0.532
MOD_Plk_4	242	248	PF00069	0.509
MOD_Plk_4	281	287	PF00069	0.482
MOD_Plk_4	60	66	PF00069	0.653
MOD_ProDKin_1	20	26	PF00069	0.631
MOD_ProDKin_1	253	259	PF00069	0.505
MOD_ProDKin_1	99	105	PF00069	0.650
MOD_SUMO_for_1	161	164	PF00179	0.583
MOD_SUMO_for_1	279	282	PF00179	0.512
MOD_SUMO_rev_2	199	209	PF00179	0.378
TRG_DiLeu_BaEn_1	104	109	PF01217	0.528
TRG_DiLeu_BaEn_1	146	151	PF01217	0.476
TRG_ENDOCYTIC_2	265	268	PF00928	0.573
TRG_ENDOCYTIC_2	34	37	PF00928	0.604
TRG_ENDOCYTIC_2	79	82	PF00928	0.559
TRG_ER_diArg_1	125	127	PF00400	0.588
TRG_ER_diArg_1	132	135	PF00400	0.527
TRG_ER_diArg_1	218	220	PF00400	0.426
TRG_ER_diArg_1	328	330	PF00400	0.671
TRG_ER_diArg_1	7	9	PF00400	0.597
TRG_NLS_MonoExtN_4	204	211	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3R0	Leptomonas seymouri	81%	100%
A0A0S4INW7	Bodo saltans	53%	99%
A0A1X0P9M5	Trypanosomatidae	62%	100%
A0A3S7X7Z6	Leishmania donovani	98%	100%
A4HAV1	Leishmania braziliensis	93%	100%
A4I9Z8	Leishmania infantum	98%	100%
C9ZML5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B526	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5DGS2	Trypanosoma cruzi	61%	100%