Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminotransferase class IV, putative

Species:

Leishmania major

UniProt:

Q4Q2V9_LEIMA

TriTrypDb:

LmjF.34.2410 , LMJLV39_340028800

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q2V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2V9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008483	transaminase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016769	transferase activity, transferring nitrogenous groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.597
CLV_C14_Caspase3-7	93	97	PF00656	0.290
CLV_NRD_NRD_1	371	373	PF00675	0.527
CLV_NRD_NRD_1	76	78	PF00675	0.491
CLV_PCSK_KEX2_1	371	373	PF00082	0.527
CLV_PCSK_KEX2_1	76	78	PF00082	0.469
CLV_PCSK_SKI1_1	191	195	PF00082	0.321
CLV_PCSK_SKI1_1	339	343	PF00082	0.334
CLV_PCSK_SKI1_1	345	349	PF00082	0.324
CLV_PCSK_SKI1_1	44	48	PF00082	0.515
DEG_SPOP_SBC_1	203	207	PF00917	0.408
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.460
DOC_MAPK_DCC_7	395	404	PF00069	0.458
DOC_MAPK_gen_1	133	141	PF00069	0.513
DOC_MAPK_MEF2A_6	232	241	PF00069	0.526
DOC_PP1_RVXF_1	192	199	PF00149	0.482
DOC_PP2B_LxvP_1	155	158	PF13499	0.534
DOC_PP4_FxxP_1	14	17	PF00568	0.404
DOC_PP4_FxxP_1	212	215	PF00568	0.522
DOC_USP7_MATH_1	108	112	PF00917	0.498
DOC_USP7_MATH_1	226	230	PF00917	0.543
DOC_USP7_MATH_1	286	290	PF00917	0.493
DOC_USP7_MATH_1	358	362	PF00917	0.562
DOC_USP7_MATH_1	40	44	PF00917	0.769
DOC_USP7_MATH_1	81	85	PF00917	0.309
DOC_USP7_MATH_1	95	99	PF00917	0.549
DOC_USP7_UBL2_3	335	339	PF12436	0.562
DOC_WW_Pin1_4	13	18	PF00397	0.561
DOC_WW_Pin1_4	177	182	PF00397	0.526
DOC_WW_Pin1_4	22	27	PF00397	0.561
DOC_WW_Pin1_4	350	355	PF00397	0.496
DOC_WW_Pin1_4	97	102	PF00397	0.392
LIG_14-3-3_CanoR_1	148	154	PF00244	0.534
LIG_14-3-3_CanoR_1	22	26	PF00244	0.473
LIG_14-3-3_CanoR_1	56	61	PF00244	0.653
LIG_14-3-3_CanoR_1	63	69	PF00244	0.579
LIG_Actin_WH2_2	324	341	PF00022	0.562
LIG_APCC_ABBA_1	362	367	PF00400	0.428
LIG_BIR_II_1	1	5	PF00653	0.483
LIG_BIR_III_2	120	124	PF00653	0.636
LIG_BRCT_BRCA1_1	15	19	PF00533	0.471
LIG_BRCT_BRCA1_1	83	87	PF00533	0.471
LIG_FHA_1	122	128	PF00498	0.350
LIG_FHA_1	148	154	PF00498	0.544
LIG_FHA_1	317	323	PF00498	0.480
LIG_FHA_1	368	374	PF00498	0.474
LIG_FHA_1	98	104	PF00498	0.483
LIG_FHA_2	204	210	PF00498	0.502
LIG_FHA_2	335	341	PF00498	0.585
LIG_LIR_Apic_2	13	17	PF02991	0.404
LIG_LIR_Apic_2	209	215	PF02991	0.552
LIG_LIR_Apic_2	281	286	PF02991	0.516
LIG_LIR_Gen_1	124	132	PF02991	0.390
LIG_LIR_Gen_1	269	279	PF02991	0.406
LIG_LIR_Gen_1	84	95	PF02991	0.456
LIG_LIR_Nem_3	124	128	PF02991	0.446
LIG_LIR_Nem_3	269	274	PF02991	0.406
LIG_LIR_Nem_3	318	323	PF02991	0.563
LIG_LIR_Nem_3	84	90	PF02991	0.418
LIG_MLH1_MIPbox_1	15	19	PF16413	0.480
LIG_PCNA_yPIPBox_3	167	178	PF02747	0.408
LIG_PCNA_yPIPBox_3	191	199	PF02747	0.563
LIG_Pex14_2	14	18	PF04695	0.477
LIG_Pex14_2	87	91	PF04695	0.502
LIG_REV1ctd_RIR_1	16	25	PF16727	0.521
LIG_SH2_CRK	125	129	PF00017	0.485
LIG_SH2_CRK	320	324	PF00017	0.585
LIG_SH2_SRC	177	180	PF00017	0.534
LIG_SH2_SRC	184	187	PF00017	0.534
LIG_SH2_SRC	374	377	PF00017	0.531
LIG_SH2_STAP1	145	149	PF00017	0.538
LIG_SH2_STAP1	271	275	PF00017	0.562
LIG_SH2_STAP1	374	378	PF00017	0.511
LIG_SH2_STAT3	293	296	PF00017	0.562
LIG_SH2_STAT5	177	180	PF00017	0.504
LIG_SH2_STAT5	184	187	PF00017	0.432
LIG_SH2_STAT5	264	267	PF00017	0.575
LIG_SH2_STAT5	283	286	PF00017	0.513
LIG_SH2_STAT5	293	296	PF00017	0.471
LIG_SH2_STAT5	414	417	PF00017	0.489
LIG_SH3_3	1	7	PF00018	0.544
LIG_SH3_3	23	29	PF00018	0.630
LIG_SUMO_SIM_anti_2	272	278	PF11976	0.513
LIG_SUMO_SIM_par_1	100	105	PF11976	0.554
LIG_SUMO_SIM_par_1	272	278	PF11976	0.513
LIG_SxIP_EBH_1	191	205	PF03271	0.526
LIG_TRAF2_1	206	209	PF00917	0.408
LIG_TRAF2_1	305	308	PF00917	0.513
LIG_TYR_ITSM	316	323	PF00017	0.467
LIG_UBA3_1	310	317	PF00899	0.585
MOD_CDK_SPK_2	22	27	PF00069	0.442
MOD_CK1_1	224	230	PF00069	0.524
MOD_CK1_1	298	304	PF00069	0.574
MOD_CK2_1	141	147	PF00069	0.570
MOD_CK2_1	203	209	PF00069	0.459
MOD_CK2_1	302	308	PF00069	0.525
MOD_GlcNHglycan	110	113	PF01048	0.439
MOD_GlcNHglycan	304	307	PF01048	0.348
MOD_GlcNHglycan	53	56	PF01048	0.648
MOD_GlcNHglycan	60	63	PF01048	0.567
MOD_GlcNHglycan	96	100	PF01048	0.493
MOD_GSK3_1	165	172	PF00069	0.556
MOD_GSK3_1	199	206	PF00069	0.487
MOD_GSK3_1	220	227	PF00069	0.525
MOD_GSK3_1	298	305	PF00069	0.539
MOD_GSK3_1	312	319	PF00069	0.562
MOD_GSK3_1	380	387	PF00069	0.633
MOD_NEK2_1	10	15	PF00069	0.575
MOD_NEK2_1	141	146	PF00069	0.559
MOD_NEK2_1	149	154	PF00069	0.502
MOD_NEK2_1	169	174	PF00069	0.590
MOD_NEK2_1	220	225	PF00069	0.505
MOD_NEK2_1	316	321	PF00069	0.501
MOD_NEK2_1	381	386	PF00069	0.616
MOD_NEK2_1	51	56	PF00069	0.515
MOD_NEK2_1	90	95	PF00069	0.394
MOD_NEK2_2	226	231	PF00069	0.542
MOD_NEK2_2	334	339	PF00069	0.585
MOD_PIKK_1	204	210	PF00454	0.513
MOD_PKA_2	147	153	PF00069	0.542
MOD_PKA_2	21	27	PF00069	0.474
MOD_PKA_2	33	39	PF00069	0.485
MOD_PKA_2	365	371	PF00069	0.350
MOD_PKA_2	51	57	PF00069	0.517
MOD_Plk_4	194	200	PF00069	0.513
MOD_Plk_4	226	232	PF00069	0.511
MOD_Plk_4	298	304	PF00069	0.523
MOD_Plk_4	343	349	PF00069	0.567
MOD_Plk_4	352	358	PF00069	0.526
MOD_ProDKin_1	13	19	PF00069	0.564
MOD_ProDKin_1	177	183	PF00069	0.526
MOD_ProDKin_1	22	28	PF00069	0.563
MOD_ProDKin_1	350	356	PF00069	0.496
MOD_ProDKin_1	97	103	PF00069	0.393
MOD_SUMO_rev_2	340	347	PF00179	0.585
MOD_SUMO_rev_2	392	396	PF00179	0.539
TRG_DiLeu_BaEn_1	307	312	PF01217	0.534
TRG_ENDOCYTIC_2	125	128	PF00928	0.424
TRG_ENDOCYTIC_2	129	132	PF00928	0.471
TRG_ENDOCYTIC_2	271	274	PF00928	0.548
TRG_ENDOCYTIC_2	320	323	PF00928	0.546
TRG_ER_diArg_1	132	135	PF00400	0.504
TRG_ER_diArg_1	32	35	PF00400	0.494
TRG_ER_diArg_1	371	373	PF00400	0.508
TRG_ER_diArg_1	75	77	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK5	Leptomonas seymouri	63%	100%
A0A0S4INR1	Bodo saltans	26%	99%
A0A3Q8IUN5	Leishmania donovani	88%	100%
A0A3R7NT31	Trypanosoma rangeli	36%	100%
A4HAV2	Leishmania braziliensis	83%	100%
A4I9Z9	Leishmania infantum	90%	100%
C9ZML4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B527	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5B0F3	Trypanosoma cruzi	33%	90%