Alpha-1,3/1,6-mannosyltransferase ALG2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q2V8_LEIMA

TriTrypDb:

LmjF.34.2420 , LMJLV39_340028900

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q2V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2V8

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	11
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	2
GO:0006629	lipid metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043413	macromolecule glycosylation	3	11
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	2
GO:0070085	glycosylation	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	11
GO:0000033	alpha-1,3-mannosyltransferase activity	6	2
GO:0003824	catalytic activity	1	11
GO:0004376	glycolipid mannosyltransferase activity	6	11
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	7	11
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016758	hexosyltransferase activity	4	11
GO:0102704	GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.526
CLV_MEL_PAP_1	496	502	PF00089	0.418
CLV_NRD_NRD_1	325	327	PF00675	0.272
CLV_NRD_NRD_1	36	38	PF00675	0.340
CLV_PCSK_FUR_1	36	40	PF00082	0.382
CLV_PCSK_KEX2_1	107	109	PF00082	0.351
CLV_PCSK_KEX2_1	36	38	PF00082	0.322
CLV_PCSK_KEX2_1	522	524	PF00082	0.349
CLV_PCSK_KEX2_1	548	550	PF00082	0.371
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.351
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.386
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.281
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.371
CLV_PCSK_SKI1_1	127	131	PF00082	0.350
CLV_PCSK_SKI1_1	237	241	PF00082	0.290
CLV_PCSK_SKI1_1	249	253	PF00082	0.300
CLV_PCSK_SKI1_1	292	296	PF00082	0.430
CLV_PCSK_SKI1_1	306	310	PF00082	0.404
CLV_PCSK_SKI1_1	393	397	PF00082	0.313
CLV_PCSK_SKI1_1	403	407	PF00082	0.235
CLV_PCSK_SKI1_1	522	526	PF00082	0.367
CLV_PCSK_SKI1_1	81	85	PF00082	0.302
CLV_Separin_Metazoa	78	82	PF03568	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.405
DEG_SCF_FBW7_2	413	420	PF00400	0.458
DOC_ANK_TNKS_1	522	529	PF00023	0.453
DOC_CKS1_1	414	419	PF01111	0.458
DOC_MAPK_gen_1	107	113	PF00069	0.586
DOC_MAPK_gen_1	26	34	PF00069	0.532
DOC_MAPK_gen_1	323	332	PF00069	0.468
DOC_MAPK_gen_1	352	359	PF00069	0.538
DOC_MAPK_JIP1_4	353	359	PF00069	0.561
DOC_MAPK_MEF2A_6	326	334	PF00069	0.458
DOC_MAPK_MEF2A_6	352	359	PF00069	0.538
DOC_MAPK_MEF2A_6	77	84	PF00069	0.499
DOC_MAPK_NFAT4_5	327	335	PF00069	0.458
DOC_MAPK_RevD_3	23	38	PF00069	0.454
DOC_PIKK_1	369	377	PF02985	0.534
DOC_PP1_RVXF_1	79	85	PF00149	0.530
DOC_PP2B_LxvP_1	385	388	PF13499	0.538
DOC_PP4_FxxP_1	283	286	PF00568	0.499
DOC_PP4_FxxP_1	84	87	PF00568	0.508
DOC_USP7_MATH_1	311	315	PF00917	0.423
DOC_USP7_MATH_1	444	448	PF00917	0.458
DOC_USP7_MATH_1	540	544	PF00917	0.675
DOC_USP7_UBL2_3	542	546	PF12436	0.702
DOC_WW_Pin1_4	196	201	PF00397	0.354
DOC_WW_Pin1_4	413	418	PF00397	0.450
DOC_WW_Pin1_4	462	467	PF00397	0.495
LIG_14-3-3_CanoR_1	26	34	PF00244	0.587
LIG_14-3-3_CanoR_1	386	395	PF00244	0.506
LIG_14-3-3_CanoR_1	499	505	PF00244	0.540
LIG_14-3-3_CanoR_1	515	524	PF00244	0.481
LIG_BRCT_BRCA1_1	125	129	PF00533	0.629
LIG_BRCT_BRCA1_1	246	250	PF00533	0.554
LIG_CaM_IQ_9	504	519	PF13499	0.605
LIG_CtBP_PxDLS_1	528	533	PF00389	0.550
LIG_FHA_1	134	140	PF00498	0.525
LIG_FHA_1	197	203	PF00498	0.423
LIG_FHA_1	250	256	PF00498	0.521
LIG_FHA_1	277	283	PF00498	0.503
LIG_FHA_1	380	386	PF00498	0.522
LIG_FHA_1	505	511	PF00498	0.550
LIG_FHA_2	269	275	PF00498	0.590
LIG_LIR_Apic_2	170	175	PF02991	0.383
LIG_LIR_Apic_2	280	286	PF02991	0.504
LIG_LIR_Gen_1	317	324	PF02991	0.532
LIG_LIR_Gen_1	335	341	PF02991	0.393
LIG_LIR_Gen_1	42	51	PF02991	0.644
LIG_LIR_Nem_3	267	272	PF02991	0.545
LIG_LIR_Nem_3	281	287	PF02991	0.444
LIG_LIR_Nem_3	317	321	PF02991	0.532
LIG_LIR_Nem_3	335	340	PF02991	0.393
LIG_LIR_Nem_3	42	47	PF02991	0.638
LIG_LIR_Nem_3	420	425	PF02991	0.452
LIG_LYPXL_S_1	283	287	PF13949	0.300
LIG_LYPXL_yS_3	284	287	PF13949	0.503
LIG_Pex14_1	232	236	PF04695	0.620
LIG_Pex14_2	168	172	PF04695	0.384
LIG_Pex14_2	203	207	PF04695	0.482
LIG_Pex14_2	8	12	PF04695	0.445
LIG_PTB_Apo_2	254	261	PF02174	0.492
LIG_SH2_CRK	432	436	PF00017	0.514
LIG_SH2_STAP1	373	377	PF00017	0.482
LIG_SH2_STAP1	484	488	PF00017	0.538
LIG_SH2_STAT5	20	23	PF00017	0.409
LIG_SH2_STAT5	33	36	PF00017	0.583
LIG_SH2_STAT5	415	418	PF00017	0.472
LIG_SH3_3	411	417	PF00018	0.464
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.541
LIG_SUMO_SIM_anti_2	2	7	PF11976	0.330
LIG_SUMO_SIM_par_1	115	121	PF11976	0.514
LIG_SUMO_SIM_par_1	435	441	PF11976	0.519
LIG_TRAF2_1	55	58	PF00917	0.684
LIG_TYR_ITIM	282	287	PF00017	0.498
MOD_CDK_SPxK_1	413	419	PF00069	0.561
MOD_CK1_1	224	230	PF00069	0.625
MOD_CK1_1	258	264	PF00069	0.495
MOD_CK1_1	314	320	PF00069	0.385
MOD_CK1_1	447	453	PF00069	0.473
MOD_CK2_1	339	345	PF00069	0.552
MOD_CK2_1	396	402	PF00069	0.538
MOD_CK2_1	461	467	PF00069	0.521
MOD_GlcNHglycan	143	146	PF01048	0.352
MOD_GlcNHglycan	223	226	PF01048	0.438
MOD_GlcNHglycan	301	304	PF01048	0.419
MOD_GlcNHglycan	313	316	PF01048	0.384
MOD_GlcNHglycan	70	73	PF01048	0.455
MOD_GSK3_1	129	136	PF00069	0.538
MOD_GSK3_1	170	177	PF00069	0.468
MOD_GSK3_1	310	317	PF00069	0.519
MOD_GSK3_1	499	506	PF00069	0.523
MOD_N-GLC_1	396	401	PF02516	0.310
MOD_NEK2_1	157	162	PF00069	0.315
MOD_NEK2_1	202	207	PF00069	0.413
MOD_NEK2_1	250	255	PF00069	0.513
MOD_NEK2_1	299	304	PF00069	0.605
MOD_NEK2_1	339	344	PF00069	0.473
MOD_NEK2_1	430	435	PF00069	0.561
MOD_NEK2_2	218	223	PF00069	0.662
MOD_NEK2_2	541	546	PF00069	0.691
MOD_PIKK_1	387	393	PF00454	0.535
MOD_PIKK_1	504	510	PF00454	0.510
MOD_PK_1	107	113	PF00069	0.619
MOD_PKA_1	107	113	PF00069	0.560
MOD_PKA_2	107	113	PF00069	0.565
MOD_PKA_2	141	147	PF00069	0.591
MOD_PKA_2	27	33	PF00069	0.590
MOD_PKA_2	498	504	PF00069	0.558
MOD_Plk_1	243	249	PF00069	0.604
MOD_Plk_4	146	152	PF00069	0.543
MOD_Plk_4	250	256	PF00069	0.485
MOD_Plk_4	314	320	PF00069	0.561
MOD_ProDKin_1	196	202	PF00069	0.354
MOD_ProDKin_1	413	419	PF00069	0.450
MOD_ProDKin_1	462	468	PF00069	0.495
MOD_SUMO_for_1	532	535	PF00179	0.653
MOD_SUMO_rev_2	302	311	PF00179	0.616
MOD_SUMO_rev_2	342	349	PF00179	0.541
MOD_SUMO_rev_2	399	405	PF00179	0.540
TRG_DiLeu_BaEn_1	335	340	PF01217	0.538
TRG_DiLeu_BaEn_1	402	407	PF01217	0.510
TRG_DiLeu_BaEn_1	409	414	PF01217	0.510
TRG_DiLeu_BaLyEn_6	520	525	PF01217	0.534
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.529
TRG_ENDOCYTIC_2	20	23	PF00928	0.371
TRG_ENDOCYTIC_2	204	207	PF00928	0.485
TRG_ENDOCYTIC_2	236	239	PF00928	0.499
TRG_ENDOCYTIC_2	284	287	PF00928	0.503
TRG_ENDOCYTIC_2	44	47	PF00928	0.644
TRG_ER_diArg_1	25	28	PF00400	0.567
TRG_ER_diArg_1	36	39	PF00400	0.574
TRG_ER_diArg_1	493	496	PF00400	0.558
TRG_ER_diArg_1	514	517	PF00400	0.550
TRG_ER_diLys_1	546	550	PF00400	0.706
TRG_NLS_MonoExtC_3	36	42	PF00514	0.559
TRG_NLS_MonoExtN_4	36	41	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8W1	Leptomonas seymouri	63%	97%
A0A0S4INF7	Bodo saltans	46%	100%
A0A1X0P9N2	Trypanosomatidae	48%	100%
A0A3Q8IEF0	Leishmania donovani	93%	100%
A0A3R7N194	Trypanosoma rangeli	44%	100%
A4HAV3	Leishmania braziliensis	82%	100%
A4IA00	Leishmania infantum	93%	100%
C9ZML3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B528	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O94738	Rhizomucor pusillus	38%	100%
P43636	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P53954	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q08B22	Xenopus laevis	26%	100%
Q2TAA5	Homo sapiens	24%	100%
Q3TZM9	Mus musculus	24%	100%
Q59LF2	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	100%
Q5R7Z6	Pongo abelii	24%	100%
Q6BVA4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	34%	100%
Q6C3V7	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	100%
Q6CWQ0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	41%	100%
Q6FJJ9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q755C1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q7KWM5	Dictyostelium discoideum	34%	100%
Q8X0H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
Q96WW6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9DBE8	Mus musculus	37%	100%
Q9H553	Homo sapiens	37%	100%