Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2V6_LEIMA

TriTrypDb:

LmjF.34.2440 , LMJLV39_340029100

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.617
CLV_NRD_NRD_1	180	182	PF00675	0.625
CLV_NRD_NRD_1	31	33	PF00675	0.495
CLV_PCSK_KEX2_1	182	184	PF00082	0.627
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.652
CLV_PCSK_SKI1_1	33	37	PF00082	0.495
DOC_ANK_TNKS_1	145	152	PF00023	0.475
DOC_CKS1_1	15	20	PF01111	0.483
DOC_MAPK_MEF2A_6	80	89	PF00069	0.439
DOC_PP4_FxxP_1	100	103	PF00568	0.622
DOC_PP4_FxxP_1	147	150	PF00568	0.458
DOC_PP4_FxxP_1	15	18	PF00568	0.518
DOC_PP4_FxxP_1	91	94	PF00568	0.452
DOC_SPAK_OSR1_1	146	150	PF12202	0.481
DOC_USP7_MATH_1	18	22	PF00917	0.459
DOC_WW_Pin1_4	14	19	PF00397	0.501
DOC_WW_Pin1_4	72	77	PF00397	0.525
LIG_14-3-3_CanoR_1	129	137	PF00244	0.679
LIG_14-3-3_CanoR_1	32	40	PF00244	0.528
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_eIF4E_1	59	65	PF01652	0.447
LIG_FHA_1	103	109	PF00498	0.699
LIG_FHA_2	15	21	PF00498	0.454
LIG_FHA_2	165	171	PF00498	0.574
LIG_LIR_Apic_2	90	94	PF02991	0.367
LIG_LIR_Apic_2	97	103	PF02991	0.512
LIG_LIR_Gen_1	20	29	PF02991	0.505
LIG_LIR_Nem_3	20	25	PF02991	0.382
LIG_SH2_CRK	79	83	PF00017	0.496
LIG_SH2_STAT5	22	25	PF00017	0.482
LIG_SH2_STAT5	59	62	PF00017	0.458
LIG_UBA3_1	152	160	PF00899	0.445
MOD_CK1_1	111	117	PF00069	0.618
MOD_CK1_1	119	125	PF00069	0.660
MOD_CK1_1	27	33	PF00069	0.503
MOD_CK2_1	121	127	PF00069	0.734
MOD_CK2_1	14	20	PF00069	0.483
MOD_GlcNHglycan	27	30	PF01048	0.492
MOD_GSK3_1	119	126	PF00069	0.664
MOD_GSK3_1	129	136	PF00069	0.576
MOD_GSK3_1	14	21	PF00069	0.459
MOD_LATS_1	121	127	PF00433	0.692
MOD_N-GLC_1	72	77	PF02516	0.649
MOD_NEK2_1	108	113	PF00069	0.549
MOD_NEK2_1	25	30	PF00069	0.534
MOD_NEK2_1	35	40	PF00069	0.463
MOD_NEK2_1	83	88	PF00069	0.460
MOD_NEK2_1	95	100	PF00069	0.489
MOD_PKA_2	122	128	PF00069	0.758
MOD_PKA_2	57	63	PF00069	0.437
MOD_Plk_4	18	24	PF00069	0.457
MOD_Plk_4	35	41	PF00069	0.473
MOD_Plk_4	95	101	PF00069	0.382
MOD_ProDKin_1	14	20	PF00069	0.493
MOD_ProDKin_1	72	78	PF00069	0.524
TRG_ENDOCYTIC_2	22	25	PF00928	0.389
TRG_ENDOCYTIC_2	81	84	PF00928	0.553
TRG_ER_diArg_1	180	183	PF00400	0.605
TRG_NLS_MonoExtC_3	180	185	PF00514	0.642
TRG_NLS_MonoExtN_4	179	186	PF00514	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I235	Leptomonas seymouri	70%	100%
A0A0S4INZ5	Bodo saltans	42%	94%
A0A1X0P9P7	Trypanosomatidae	58%	100%
A0A3R7KWP6	Trypanosoma rangeli	54%	100%
A0A3S7X7Y8	Leishmania donovani	94%	100%
A4HAV5	Leishmania braziliensis	87%	100%
A4IA02	Leishmania infantum	96%	100%
C9ZMK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B530	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%