Tr-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongation factor Tu GTP binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2V4_LEIMA

TriTrypDb:

LmjF.34.2460 , LMJLV39_340029300 , LMJSD75_340029500

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2V4

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0008135	translation factor activity, RNA binding	3	3
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	501	505	PF00656	0.522
CLV_C14_Caspase3-7	587	591	PF00656	0.558
CLV_C14_Caspase3-7	819	823	PF00656	0.614
CLV_C14_Caspase3-7	847	851	PF00656	0.446
CLV_NRD_NRD_1	10	12	PF00675	0.619
CLV_NRD_NRD_1	118	120	PF00675	0.726
CLV_NRD_NRD_1	286	288	PF00675	0.548
CLV_NRD_NRD_1	315	317	PF00675	0.651
CLV_NRD_NRD_1	370	372	PF00675	0.541
CLV_NRD_NRD_1	519	521	PF00675	0.274
CLV_PCSK_KEX2_1	118	120	PF00082	0.726
CLV_PCSK_KEX2_1	286	288	PF00082	0.548
CLV_PCSK_KEX2_1	370	372	PF00082	0.541
CLV_PCSK_PC7_1	282	288	PF00082	0.539
CLV_PCSK_SKI1_1	282	286	PF00082	0.437
CLV_PCSK_SKI1_1	498	502	PF00082	0.273
CLV_PCSK_SKI1_1	511	515	PF00082	0.211
CLV_PCSK_SKI1_1	838	842	PF00082	0.480
DEG_APCC_DBOX_1	655	663	PF00400	0.505
DEG_APCC_KENBOX_2	354	358	PF00400	0.578
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SCF_FBW7_1	620	627	PF00400	0.503
DEG_SPOP_SBC_1	615	619	PF00917	0.587
DEG_SPOP_SBC_1	74	78	PF00917	0.614
DOC_CKS1_1	549	554	PF01111	0.543
DOC_CKS1_1	621	626	PF01111	0.503
DOC_CYCLIN_RxL_1	835	844	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	202	205	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.503
DOC_MAPK_gen_1	520	527	PF00069	0.543
DOC_MAPK_gen_1	632	640	PF00069	0.469
DOC_MAPK_gen_1	702	710	PF00069	0.487
DOC_MAPK_HePTP_8	517	529	PF00069	0.543
DOC_MAPK_MEF2A_6	392	400	PF00069	0.449
DOC_MAPK_MEF2A_6	520	529	PF00069	0.543
DOC_MAPK_MEF2A_6	632	640	PF00069	0.469
DOC_PP1_RVXF_1	217	223	PF00149	0.499
DOC_PP1_RVXF_1	331	337	PF00149	0.507
DOC_PP2B_LxvP_1	202	205	PF13499	0.708
DOC_PP2B_LxvP_1	42	45	PF13499	0.546
DOC_PP2B_LxvP_1	48	51	PF13499	0.571
DOC_PP2B_LxvP_1	636	639	PF13499	0.543
DOC_PP2B_LxvP_1	72	75	PF13499	0.594
DOC_USP7_MATH_1	110	114	PF00917	0.683
DOC_USP7_MATH_1	132	136	PF00917	0.741
DOC_USP7_MATH_1	16	20	PF00917	0.618
DOC_USP7_MATH_1	224	228	PF00917	0.542
DOC_USP7_MATH_1	323	327	PF00917	0.594
DOC_USP7_MATH_1	338	342	PF00917	0.498
DOC_USP7_MATH_1	387	391	PF00917	0.467
DOC_USP7_MATH_1	448	452	PF00917	0.592
DOC_USP7_MATH_1	534	538	PF00917	0.550
DOC_USP7_MATH_1	66	70	PF00917	0.643
DOC_USP7_MATH_1	75	79	PF00917	0.591
DOC_USP7_MATH_1	781	785	PF00917	0.413
DOC_USP7_UBL2_3	870	874	PF12436	0.398
DOC_WW_Pin1_4	134	139	PF00397	0.754
DOC_WW_Pin1_4	144	149	PF00397	0.606
DOC_WW_Pin1_4	195	200	PF00397	0.749
DOC_WW_Pin1_4	212	217	PF00397	0.714
DOC_WW_Pin1_4	244	249	PF00397	0.517
DOC_WW_Pin1_4	277	282	PF00397	0.436
DOC_WW_Pin1_4	30	35	PF00397	0.542
DOC_WW_Pin1_4	318	323	PF00397	0.596
DOC_WW_Pin1_4	326	331	PF00397	0.622
DOC_WW_Pin1_4	442	447	PF00397	0.517
DOC_WW_Pin1_4	456	461	PF00397	0.447
DOC_WW_Pin1_4	477	482	PF00397	0.553
DOC_WW_Pin1_4	493	498	PF00397	0.386
DOC_WW_Pin1_4	548	553	PF00397	0.543
DOC_WW_Pin1_4	616	621	PF00397	0.538
DOC_WW_Pin1_4	665	670	PF00397	0.522
DOC_WW_Pin1_4	70	75	PF00397	0.799
DOC_WW_Pin1_4	811	816	PF00397	0.459
LIG_14-3-3_CanoR_1	109	115	PF00244	0.632
LIG_14-3-3_CanoR_1	11	20	PF00244	0.701
LIG_14-3-3_CanoR_1	316	322	PF00244	0.726
LIG_14-3-3_CanoR_1	324	330	PF00244	0.529
LIG_14-3-3_CanoR_1	412	416	PF00244	0.529
LIG_14-3-3_CanoR_1	426	431	PF00244	0.567
LIG_14-3-3_CanoR_1	433	438	PF00244	0.543
LIG_14-3-3_CanoR_1	450	458	PF00244	0.543
LIG_14-3-3_CanoR_1	498	503	PF00244	0.479
LIG_14-3-3_CanoR_1	656	666	PF00244	0.498
LIG_14-3-3_CanoR_1	830	834	PF00244	0.325
LIG_14-3-3_CanoR_1	865	870	PF00244	0.456
LIG_APCC_ABBA_1	539	544	PF00400	0.537
LIG_BIR_III_4	504	508	PF00653	0.543
LIG_BRCT_BRCA1_1	380	384	PF00533	0.417
LIG_CSL_BTD_1	601	604	PF09270	0.469
LIG_FHA_1	128	134	PF00498	0.649
LIG_FHA_1	15	21	PF00498	0.593
LIG_FHA_1	37	43	PF00498	0.569
LIG_FHA_1	399	405	PF00498	0.480
LIG_FHA_1	425	431	PF00498	0.449
LIG_FHA_1	447	453	PF00498	0.507
LIG_FHA_1	531	537	PF00498	0.513
LIG_FHA_1	549	555	PF00498	0.543
LIG_FHA_1	55	61	PF00498	0.717
LIG_FHA_1	616	622	PF00498	0.594
LIG_FHA_1	747	753	PF00498	0.364
LIG_FHA_2	227	233	PF00498	0.523
LIG_FHA_2	283	289	PF00498	0.471
LIG_FHA_2	335	341	PF00498	0.545
LIG_FHA_2	442	448	PF00498	0.524
LIG_FHA_2	499	505	PF00498	0.480
LIG_FHA_2	556	562	PF00498	0.449
LIG_FHA_2	93	99	PF00498	0.666
LIG_GSK3_LRP6_1	665	670	PF00069	0.572
LIG_LIR_Apic_2	713	718	PF02991	0.470
LIG_LIR_Gen_1	147	158	PF02991	0.697
LIG_LIR_Gen_1	190	200	PF02991	0.506
LIG_LIR_Gen_1	249	258	PF02991	0.436
LIG_LIR_Gen_1	328	339	PF02991	0.648
LIG_LIR_Gen_1	512	522	PF02991	0.569
LIG_LIR_Gen_1	523	531	PF02991	0.498
LIG_LIR_Gen_1	540	549	PF02991	0.399
LIG_LIR_Gen_1	687	695	PF02991	0.355
LIG_LIR_LC3C_4	551	555	PF02991	0.400
LIG_LIR_Nem_3	147	153	PF02991	0.642
LIG_LIR_Nem_3	249	254	PF02991	0.441
LIG_LIR_Nem_3	328	334	PF02991	0.640
LIG_LIR_Nem_3	523	527	PF02991	0.460
LIG_LIR_Nem_3	540	545	PF02991	0.410
LIG_LIR_Nem_3	687	691	PF02991	0.335
LIG_LIR_Nem_3	721	727	PF02991	0.362
LIG_MYND_1	200	204	PF01753	0.617
LIG_MYND_1	669	673	PF01753	0.679
LIG_PDZ_Class_2	870	875	PF00595	0.582
LIG_Rb_LxCxE_1	356	369	PF01857	0.417
LIG_SH2_CRK	225	229	PF00017	0.550
LIG_SH2_CRK	331	335	PF00017	0.648
LIG_SH2_CRK	688	692	PF00017	0.297
LIG_SH2_CRK	725	729	PF00017	0.482
LIG_SH2_PTP2	524	527	PF00017	0.543
LIG_SH2_PTP2	715	718	PF00017	0.460
LIG_SH2_SRC	542	545	PF00017	0.537
LIG_SH2_STAP1	688	692	PF00017	0.406
LIG_SH2_STAP1	725	729	PF00017	0.429
LIG_SH2_STAP1	799	803	PF00017	0.422
LIG_SH2_STAT5	524	527	PF00017	0.538
LIG_SH2_STAT5	598	601	PF00017	0.543
LIG_SH2_STAT5	657	660	PF00017	0.503
LIG_SH2_STAT5	715	718	PF00017	0.460
LIG_SH2_STAT5	799	802	PF00017	0.386
LIG_SH3_3	135	141	PF00018	0.677
LIG_SH3_3	148	154	PF00018	0.521
LIG_SH3_3	324	330	PF00018	0.568
LIG_SH3_3	478	484	PF00018	0.598
LIG_SH3_3	663	669	PF00018	0.472
LIG_SH3_3	766	772	PF00018	0.488
LIG_SH3_3	809	815	PF00018	0.553
LIG_SH3_3	866	872	PF00018	0.402
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.505
LIG_SUMO_SIM_anti_2	551	558	PF11976	0.400
LIG_SUMO_SIM_par_1	551	558	PF11976	0.602
LIG_TRAF2_1	817	820	PF00917	0.606
LIG_TYR_ITIM	223	228	PF00017	0.575
LIG_TYR_ITIM	686	691	PF00017	0.279
LIG_UBA3_1	513	521	PF00899	0.543
LIG_WRC_WIRS_1	776	781	PF05994	0.363
LIG_WW_3	629	633	PF00397	0.469
MOD_CDC14_SPxK_1	247	250	PF00782	0.438
MOD_CDK_SPK_2	277	282	PF00069	0.415
MOD_CDK_SPK_2	456	461	PF00069	0.503
MOD_CDK_SPK_2	493	498	PF00069	0.543
MOD_CDK_SPxK_1	244	250	PF00069	0.519
MOD_CDK_SPxK_1	318	324	PF00069	0.606
MOD_CDK_SPxxK_3	212	219	PF00069	0.542
MOD_CDK_SPxxK_3	326	333	PF00069	0.639
MOD_CK1_1	14	20	PF00069	0.781
MOD_CK1_1	161	167	PF00069	0.657
MOD_CK1_1	190	196	PF00069	0.653
MOD_CK1_1	206	212	PF00069	0.752
MOD_CK1_1	292	298	PF00069	0.384
MOD_CK1_1	326	332	PF00069	0.590
MOD_CK1_1	35	41	PF00069	0.702
MOD_CK1_1	390	396	PF00069	0.483
MOD_CK1_1	429	435	PF00069	0.475
MOD_CK1_1	471	477	PF00069	0.602
MOD_CK1_1	496	502	PF00069	0.548
MOD_CK1_1	537	543	PF00069	0.503
MOD_CK1_1	55	61	PF00069	0.718
MOD_CK1_1	672	678	PF00069	0.671
MOD_CK1_1	70	76	PF00069	0.670
MOD_CK1_1	784	790	PF00069	0.449
MOD_CK1_1	811	817	PF00069	0.563
MOD_CK1_1	87	93	PF00069	0.670
MOD_CK2_1	334	340	PF00069	0.661
MOD_CK2_1	441	447	PF00069	0.541
MOD_CK2_1	606	612	PF00069	0.417
MOD_CK2_1	814	820	PF00069	0.666
MOD_CK2_1	92	98	PF00069	0.669
MOD_GlcNHglycan	205	208	PF01048	0.813
MOD_GlcNHglycan	212	215	PF01048	0.691
MOD_GlcNHglycan	340	343	PF01048	0.564
MOD_GlcNHglycan	389	392	PF01048	0.242
MOD_GlcNHglycan	452	455	PF01048	0.324
MOD_GlcNHglycan	470	473	PF01048	0.270
MOD_GlcNHglycan	608	611	PF01048	0.272
MOD_GlcNHglycan	78	81	PF01048	0.795
MOD_GlcNHglycan	790	793	PF01048	0.450
MOD_GlcNHglycan	846	849	PF01048	0.551
MOD_GSK3_1	10	17	PF00069	0.733
MOD_GSK3_1	133	140	PF00069	0.666
MOD_GSK3_1	161	168	PF00069	0.680
MOD_GSK3_1	178	185	PF00069	0.513
MOD_GSK3_1	190	197	PF00069	0.685
MOD_GSK3_1	206	213	PF00069	0.717
MOD_GSK3_1	273	280	PF00069	0.535
MOD_GSK3_1	28	35	PF00069	0.461
MOD_GSK3_1	334	341	PF00069	0.519
MOD_GSK3_1	387	394	PF00069	0.462
MOD_GSK3_1	421	428	PF00069	0.450
MOD_GSK3_1	429	436	PF00069	0.451
MOD_GSK3_1	442	449	PF00069	0.452
MOD_GSK3_1	456	463	PF00069	0.511
MOD_GSK3_1	473	480	PF00069	0.460
MOD_GSK3_1	530	537	PF00069	0.503
MOD_GSK3_1	615	622	PF00069	0.511
MOD_GSK3_1	66	73	PF00069	0.715
MOD_GSK3_1	665	672	PF00069	0.639
MOD_GSK3_1	771	778	PF00069	0.489
MOD_GSK3_1	784	791	PF00069	0.319
MOD_GSK3_1	807	814	PF00069	0.485
MOD_GSK3_1	92	99	PF00069	0.673
MOD_N-GLC_1	195	200	PF02516	0.576
MOD_N-GLC_1	289	294	PF02516	0.574
MOD_N-GLC_1	624	629	PF02516	0.269
MOD_N-GLC_2	52	54	PF02516	0.598
MOD_NEK2_1	133	138	PF00069	0.615
MOD_NEK2_1	188	193	PF00069	0.715
MOD_NEK2_1	289	294	PF00069	0.466
MOD_NEK2_1	305	310	PF00069	0.302
MOD_NEK2_1	334	339	PF00069	0.611
MOD_NEK2_1	399	404	PF00069	0.570
MOD_NEK2_1	468	473	PF00069	0.591
MOD_NEK2_1	641	646	PF00069	0.449
MOD_NEK2_1	786	791	PF00069	0.452
MOD_NEK2_1	829	834	PF00069	0.435
MOD_NEK2_2	110	115	PF00069	0.687
MOD_PIKK_1	253	259	PF00454	0.401
MOD_PIKK_1	759	765	PF00454	0.347
MOD_PIKK_1	784	790	PF00454	0.452
MOD_PIKK_1	98	104	PF00454	0.681
MOD_PK_1	865	871	PF00069	0.395
MOD_PKA_1	11	17	PF00069	0.614
MOD_PKA_2	10	16	PF00069	0.613
MOD_PKA_2	127	133	PF00069	0.685
MOD_PKA_2	182	188	PF00069	0.594
MOD_PKA_2	241	247	PF00069	0.390
MOD_PKA_2	260	266	PF00069	0.558
MOD_PKA_2	315	321	PF00069	0.688
MOD_PKA_2	323	329	PF00069	0.682
MOD_PKA_2	411	417	PF00069	0.529
MOD_PKA_2	425	431	PF00069	0.547
MOD_PKA_2	468	474	PF00069	0.538
MOD_PKA_2	606	612	PF00069	0.509
MOD_PKA_2	829	835	PF00069	0.403
MOD_PKA_2	864	870	PF00069	0.507
MOD_Plk_1	289	295	PF00069	0.452
MOD_Plk_1	305	311	PF00069	0.309
MOD_Plk_1	378	384	PF00069	0.417
MOD_Plk_1	537	543	PF00069	0.487
MOD_Plk_1	589	595	PF00069	0.522
MOD_Plk_1	746	752	PF00069	0.373
MOD_Plk_4	153	159	PF00069	0.709
MOD_Plk_4	165	171	PF00069	0.716
MOD_Plk_4	305	311	PF00069	0.420
MOD_Plk_4	391	397	PF00069	0.449
MOD_Plk_4	411	417	PF00069	0.357
MOD_Plk_4	44	50	PF00069	0.505
MOD_Plk_4	509	515	PF00069	0.515
MOD_Plk_4	537	543	PF00069	0.543
MOD_Plk_4	589	595	PF00069	0.533
MOD_Plk_4	67	73	PF00069	0.622
MOD_Plk_4	781	787	PF00069	0.424
MOD_Plk_4	829	835	PF00069	0.592
MOD_Plk_4	87	93	PF00069	0.469
MOD_ProDKin_1	134	140	PF00069	0.752
MOD_ProDKin_1	144	150	PF00069	0.607
MOD_ProDKin_1	195	201	PF00069	0.752
MOD_ProDKin_1	212	218	PF00069	0.709
MOD_ProDKin_1	244	250	PF00069	0.519
MOD_ProDKin_1	277	283	PF00069	0.431
MOD_ProDKin_1	30	36	PF00069	0.544
MOD_ProDKin_1	318	324	PF00069	0.601
MOD_ProDKin_1	326	332	PF00069	0.621
MOD_ProDKin_1	442	448	PF00069	0.517
MOD_ProDKin_1	456	462	PF00069	0.447
MOD_ProDKin_1	477	483	PF00069	0.553
MOD_ProDKin_1	493	499	PF00069	0.386
MOD_ProDKin_1	548	554	PF00069	0.543
MOD_ProDKin_1	616	622	PF00069	0.538
MOD_ProDKin_1	665	671	PF00069	0.527
MOD_ProDKin_1	70	76	PF00069	0.801
MOD_ProDKin_1	811	817	PF00069	0.466
MOD_SUMO_for_1	437	440	PF00179	0.400
MOD_SUMO_rev_2	94	101	PF00179	0.483
TRG_DiLeu_BaEn_1	567	572	PF01217	0.543
TRG_DiLeu_BaLyEn_6	666	671	PF01217	0.593
TRG_ENDOCYTIC_2	225	228	PF00928	0.555
TRG_ENDOCYTIC_2	331	334	PF00928	0.645
TRG_ENDOCYTIC_2	524	527	PF00928	0.497
TRG_ENDOCYTIC_2	542	545	PF00928	0.377
TRG_ENDOCYTIC_2	688	691	PF00928	0.299
TRG_ENDOCYTIC_2	725	728	PF00928	0.435
TRG_ER_diArg_1	118	120	PF00400	0.694
TRG_ER_diArg_1	604	607	PF00400	0.543
TRG_ER_diArg_1	635	638	PF00400	0.543
TRG_NES_CRM1_1	294	306	PF08389	0.406
TRG_NES_CRM1_1	567	580	PF08389	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y7	Leptomonas seymouri	65%	100%
A0A0S4JNB2	Bodo saltans	35%	100%
A0A1X0PAM4	Trypanosomatidae	39%	100%
A0A3R7MTY6	Trypanosoma rangeli	39%	100%
A0A3S7X814	Leishmania donovani	92%	100%
A4HAV7	Leishmania braziliensis	77%	100%
A4IA17	Leishmania infantum	92%	100%
C9ZJA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZMK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D2XV59	Rattus norvegicus	27%	100%
E9B532	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O00178	Homo sapiens	26%	100%
O08582	Mus musculus	26%	100%
Q3UJK4	Mus musculus	26%	100%
Q58DC5	Bos taurus	26%	100%
Q5R8Q7	Pongo abelii	27%	100%
Q5XGS8	Xenopus laevis	26%	100%
Q9BX10	Homo sapiens	26%	100%