Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2V1_LEIMA

TriTrypDb:

LmjF.34.2476 , LMJLV39_340029600 , LMJSD75_340029800

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q2V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.707
CLV_MEL_PAP_1	328	334	PF00089	0.496
CLV_NRD_NRD_1	168	170	PF00675	0.645
CLV_NRD_NRD_1	207	209	PF00675	0.453
CLV_NRD_NRD_1	281	283	PF00675	0.495
CLV_NRD_NRD_1	360	362	PF00675	0.516
CLV_NRD_NRD_1	374	376	PF00675	0.421
CLV_NRD_NRD_1	65	67	PF00675	0.719
CLV_NRD_NRD_1	81	83	PF00675	0.649
CLV_PCSK_KEX2_1	168	170	PF00082	0.645
CLV_PCSK_KEX2_1	206	208	PF00082	0.443
CLV_PCSK_KEX2_1	281	283	PF00082	0.495
CLV_PCSK_KEX2_1	360	362	PF00082	0.516
CLV_PCSK_KEX2_1	373	375	PF00082	0.429
CLV_PCSK_KEX2_1	65	67	PF00082	0.719
CLV_PCSK_KEX2_1	81	83	PF00082	0.649
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.443
CLV_PCSK_SKI1_1	257	261	PF00082	0.292
CLV_PCSK_SKI1_1	27	31	PF00082	0.731
DEG_APCC_DBOX_1	256	264	PF00400	0.292
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_CYCLIN_RxL_1	257	268	PF00134	0.269
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.488
DOC_MAPK_gen_1	168	175	PF00069	0.429
DOC_MAPK_gen_1	250	260	PF00069	0.250
DOC_MAPK_gen_1	281	289	PF00069	0.571
DOC_MAPK_gen_1	305	314	PF00069	0.633
DOC_MAPK_HePTP_8	233	245	PF00069	0.413
DOC_MAPK_MEF2A_6	168	175	PF00069	0.429
DOC_MAPK_MEF2A_6	236	245	PF00069	0.354
DOC_MAPK_MEF2A_6	281	289	PF00069	0.571
DOC_MAPK_MEF2A_6	56	64	PF00069	0.456
DOC_PP1_RVXF_1	259	266	PF00149	0.370
DOC_PP2B_LxvP_1	100	103	PF13499	0.453
DOC_PP2B_LxvP_1	109	112	PF13499	0.523
DOC_USP7_MATH_1	103	107	PF00917	0.453
DOC_USP7_MATH_1	115	119	PF00917	0.587
DOC_USP7_MATH_1	164	168	PF00917	0.501
DOC_USP7_MATH_1	288	292	PF00917	0.705
DOC_USP7_MATH_1	306	310	PF00917	0.606
DOC_USP7_MATH_1	37	41	PF00917	0.548
DOC_USP7_MATH_1	6	10	PF00917	0.650
DOC_USP7_MATH_1	83	87	PF00917	0.556
DOC_WW_Pin1_4	110	115	PF00397	0.512
DOC_WW_Pin1_4	119	124	PF00397	0.474
DOC_WW_Pin1_4	160	165	PF00397	0.496
DOC_WW_Pin1_4	47	52	PF00397	0.545
DOC_WW_Pin1_4	56	61	PF00397	0.478
DOC_WW_Pin1_4	85	90	PF00397	0.546
DOC_WW_Pin1_4	98	103	PF00397	0.452
LIG_14-3-3_CanoR_1	104	112	PF00244	0.538
LIG_14-3-3_CanoR_1	155	164	PF00244	0.440
LIG_14-3-3_CanoR_1	168	172	PF00244	0.357
LIG_14-3-3_CanoR_1	214	224	PF00244	0.530
LIG_14-3-3_CanoR_1	236	245	PF00244	0.414
LIG_14-3-3_CanoR_1	300	307	PF00244	0.697
LIG_14-3-3_CanoR_1	308	313	PF00244	0.694
LIG_14-3-3_CanoR_1	331	341	PF00244	0.758
LIG_14-3-3_CanoR_1	360	370	PF00244	0.719
LIG_14-3-3_CanoR_1	45	50	PF00244	0.553
LIG_14-3-3_CanoR_1	82	92	PF00244	0.467
LIG_CSL_BTD_1	33	36	PF09270	0.507
LIG_EH1_1	224	232	PF00400	0.382
LIG_eIF4E_1	225	231	PF01652	0.382
LIG_FHA_1	218	224	PF00498	0.382
LIG_FHA_1	238	244	PF00498	0.287
LIG_FHA_1	48	54	PF00498	0.540
LIG_Integrin_RGD_1	76	78	PF01839	0.675
LIG_NRBOX	259	265	PF00104	0.298
LIG_Pex14_2	187	191	PF04695	0.390
LIG_PTB_Apo_2	92	99	PF02174	0.543
LIG_SH2_CRK	130	134	PF00017	0.458
LIG_SH2_SRC	225	228	PF00017	0.382
LIG_SH2_STAT3	121	124	PF00017	0.510
LIG_SH2_STAT5	225	228	PF00017	0.382
LIG_SH3_3	109	115	PF00018	0.590
LIG_SH3_3	120	126	PF00018	0.487
LIG_SH3_3	272	278	PF00018	0.698
LIG_SH3_3	309	315	PF00018	0.690
LIG_SH3_3	324	330	PF00018	0.618
LIG_SH3_3	90	96	PF00018	0.506
LIG_SUMO_SIM_anti_2	238	245	PF11976	0.397
LIG_SUMO_SIM_par_1	229	235	PF11976	0.382
LIG_TRFH_1	98	102	PF08558	0.674
LIG_TYR_ITIM	223	228	PF00017	0.382
LIG_WRC_WIRS_1	139	144	PF05994	0.620
LIG_WW_3	101	105	PF00397	0.556
MOD_CDC14_SPxK_1	101	104	PF00782	0.667
MOD_CDC14_SPxK_1	165	168	PF00782	0.569
MOD_CDK_SPxK_1	162	168	PF00069	0.586
MOD_CDK_SPxK_1	98	104	PF00069	0.673
MOD_CDK_SPxxK_3	162	169	PF00069	0.610
MOD_CK1_1	131	137	PF00069	0.656
MOD_CK1_1	141	147	PF00069	0.579
MOD_CK1_1	167	173	PF00069	0.497
MOD_CK1_1	215	221	PF00069	0.392
MOD_CK1_1	5	11	PF00069	0.745
MOD_CK1_1	67	73	PF00069	0.704
MOD_CK2_1	345	351	PF00069	0.657
MOD_CMANNOS	262	265	PF00535	0.382
MOD_GlcNHglycan	130	133	PF01048	0.653
MOD_GlcNHglycan	158	161	PF01048	0.653
MOD_GlcNHglycan	215	218	PF01048	0.379
MOD_GlcNHglycan	27	30	PF01048	0.663
MOD_GlcNHglycan	290	293	PF01048	0.485
MOD_GlcNHglycan	302	305	PF01048	0.563
MOD_GlcNHglycan	323	326	PF01048	0.640
MOD_GlcNHglycan	363	366	PF01048	0.650
MOD_GlcNHglycan	4	7	PF01048	0.715
MOD_GlcNHglycan	45	48	PF01048	0.532
MOD_GlcNHglycan	85	88	PF01048	0.690
MOD_GSK3_1	110	117	PF00069	0.722
MOD_GSK3_1	131	138	PF00069	0.677
MOD_GSK3_1	140	147	PF00069	0.611
MOD_GSK3_1	156	163	PF00069	0.480
MOD_GSK3_1	167	174	PF00069	0.432
MOD_GSK3_1	2	9	PF00069	0.714
MOD_GSK3_1	213	220	PF00069	0.305
MOD_GSK3_1	332	339	PF00069	0.641
MOD_GSK3_1	341	348	PF00069	0.574
MOD_GSK3_1	349	356	PF00069	0.520
MOD_GSK3_1	43	50	PF00069	0.693
MOD_GSK3_1	52	59	PF00069	0.590
MOD_LATS_1	43	49	PF00433	0.667
MOD_N-GLC_1	67	72	PF02516	0.624
MOD_NEK2_1	142	147	PF00069	0.658
MOD_NEK2_1	156	161	PF00069	0.499
MOD_NEK2_1	187	192	PF00069	0.426
MOD_NEK2_1	2	7	PF00069	0.688
MOD_NEK2_1	20	25	PF00069	0.513
MOD_NEK2_1	200	205	PF00069	0.429
MOD_NEK2_1	237	242	PF00069	0.473
MOD_NEK2_1	298	303	PF00069	0.602
MOD_NEK2_1	307	312	PF00069	0.559
MOD_NEK2_1	332	337	PF00069	0.621
MOD_NEK2_1	341	346	PF00069	0.565
MOD_NEK2_1	349	354	PF00069	0.511
MOD_NEK2_2	115	120	PF00069	0.668
MOD_NEK2_2	368	373	PF00069	0.643
MOD_PIKK_1	192	198	PF00454	0.501
MOD_PIKK_1	332	338	PF00454	0.621
MOD_PIKK_1	341	347	PF00454	0.565
MOD_PIKK_1	6	12	PF00454	0.691
MOD_PK_1	308	314	PF00069	0.546
MOD_PKA_2	103	109	PF00069	0.673
MOD_PKA_2	167	173	PF00069	0.422
MOD_PKA_2	2	8	PF00069	0.687
MOD_PKA_2	213	219	PF00069	0.298
MOD_PKA_2	235	241	PF00069	0.494
MOD_PKA_2	307	313	PF00069	0.678
MOD_PKA_2	330	336	PF00069	0.693
MOD_PKA_2	349	355	PF00069	0.495
MOD_PKA_2	64	70	PF00069	0.648
MOD_Plk_1	37	43	PF00069	0.754
MOD_ProDKin_1	110	116	PF00069	0.637
MOD_ProDKin_1	119	125	PF00069	0.578
MOD_ProDKin_1	160	166	PF00069	0.612
MOD_ProDKin_1	47	53	PF00069	0.680
MOD_ProDKin_1	56	62	PF00069	0.588
MOD_ProDKin_1	85	91	PF00069	0.680
MOD_ProDKin_1	98	104	PF00069	0.555
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.498
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.269
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.533
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.668
TRG_ENDOCYTIC_2	130	133	PF00928	0.562
TRG_ENDOCYTIC_2	224	227	PF00928	0.382
TRG_ER_diArg_1	207	209	PF00400	0.530
TRG_ER_diArg_1	280	282	PF00400	0.535
TRG_ER_diArg_1	360	362	PF00400	0.642
TRG_ER_diArg_1	372	375	PF00400	0.528
TRG_ER_diArg_1	64	66	PF00400	0.647
TRG_ER_diArg_1	80	82	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7Z9	Leishmania donovani	88%	100%
A4IA20	Leishmania infantum	88%	100%
E9B535	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%