Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2V0_LEIMA

TriTrypDb:

LmjF.34.2479 , LMJLV39_340029700 , LMJSD75_340029900

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.718
CLV_C14_Caspase3-7	324	328	PF00656	0.630
CLV_NRD_NRD_1	184	186	PF00675	0.462
CLV_NRD_NRD_1	306	308	PF00675	0.650
CLV_PCSK_KEX2_1	306	308	PF00082	0.644
DEG_APCC_DBOX_1	233	241	PF00400	0.502
DEG_Nend_UBRbox_1	1	4	PF02207	0.657
DEG_SPOP_SBC_1	100	104	PF00917	0.706
DOC_CKS1_1	197	202	PF01111	0.554
DOC_MAPK_gen_1	140	147	PF00069	0.521
DOC_MAPK_MEF2A_6	140	147	PF00069	0.514
DOC_PP4_FxxP_1	268	271	PF00568	0.557
DOC_SPAK_OSR1_1	2	6	PF12202	0.778
DOC_USP7_MATH_1	134	138	PF00917	0.775
DOC_USP7_MATH_1	188	192	PF00917	0.667
DOC_USP7_MATH_1	223	227	PF00917	0.805
DOC_USP7_MATH_1	245	249	PF00917	0.605
DOC_USP7_MATH_1	314	318	PF00917	0.681
DOC_USP7_MATH_1	325	329	PF00917	0.563
DOC_USP7_MATH_1	42	46	PF00917	0.712
DOC_USP7_MATH_1	64	68	PF00917	0.724
DOC_WW_Pin1_4	196	201	PF00397	0.545
DOC_WW_Pin1_4	212	217	PF00397	0.691
DOC_WW_Pin1_4	51	56	PF00397	0.735
LIG_14-3-3_CanoR_1	133	143	PF00244	0.779
LIG_14-3-3_CanoR_1	256	264	PF00244	0.559
LIG_14-3-3_CanoR_1	295	300	PF00244	0.681
LIG_14-3-3_CanoR_1	347	355	PF00244	0.608
LIG_BRCT_BRCA1_1	160	164	PF00533	0.639
LIG_BRCT_BRCA1_1	327	331	PF00533	0.719
LIG_eIF4E_1	79	85	PF01652	0.627
LIG_FHA_1	105	111	PF00498	0.711
LIG_FHA_1	179	185	PF00498	0.585
LIG_FHA_1	213	219	PF00498	0.809
LIG_FHA_1	55	61	PF00498	0.703
LIG_FHA_1	79	85	PF00498	0.627
LIG_FHA_2	113	119	PF00498	0.617
LIG_LIR_Apic_2	265	271	PF02991	0.557
LIG_LIR_Gen_1	161	172	PF02991	0.738
LIG_LIR_Nem_3	161	167	PF02991	0.734
LIG_LIR_Nem_3	297	302	PF02991	0.617
LIG_Pex14_1	156	160	PF04695	0.623
LIG_Pex14_2	268	272	PF04695	0.559
LIG_PTAP_UEV_1	229	234	PF05743	0.563
LIG_PTB_Apo_2	258	265	PF02174	0.674
LIG_PTB_Phospho_1	258	264	PF10480	0.556
LIG_SH2_NCK_1	264	268	PF00017	0.719
LIG_SH2_STAP1	106	110	PF00017	0.663
LIG_SH2_STAP1	160	164	PF00017	0.710
LIG_SH2_STAP1	264	268	PF00017	0.719
LIG_SH2_STAT5	106	109	PF00017	0.652
LIG_SH2_STAT5	192	195	PF00017	0.619
LIG_SH2_STAT5	264	267	PF00017	0.715
LIG_SH3_1	227	233	PF00018	0.573
LIG_SH3_3	194	200	PF00018	0.527
LIG_SH3_3	227	233	PF00018	0.742
LIG_SH3_3	308	314	PF00018	0.649
LIG_SUMO_SIM_par_1	81	88	PF11976	0.626
LIG_TRAF2_1	136	139	PF00917	0.784
LIG_UBA3_1	146	155	PF00899	0.524
MOD_CDK_SPxxK_3	212	219	PF00069	0.576
MOD_CK1_1	175	181	PF00069	0.688
MOD_CK1_1	20	26	PF00069	0.732
MOD_CK1_1	248	254	PF00069	0.656
MOD_CK1_1	263	269	PF00069	0.682
MOD_CK1_1	44	50	PF00069	0.677
MOD_CK1_1	54	60	PF00069	0.662
MOD_CK1_1	78	84	PF00069	0.622
MOD_CK2_1	132	138	PF00069	0.805
MOD_CK2_1	145	151	PF00069	0.507
MOD_CK2_1	270	276	PF00069	0.764
MOD_CK2_1	346	352	PF00069	0.716
MOD_GlcNHglycan	115	118	PF01048	0.740
MOD_GlcNHglycan	134	137	PF01048	0.479
MOD_GlcNHglycan	24	28	PF01048	0.714
MOD_GlcNHglycan	247	250	PF01048	0.587
MOD_GlcNHglycan	265	268	PF01048	0.728
MOD_GlcNHglycan	348	351	PF01048	0.634
MOD_GlcNHglycan	44	47	PF01048	0.474
MOD_GSK3_1	100	107	PF00069	0.658
MOD_GSK3_1	158	165	PF00069	0.731
MOD_GSK3_1	16	23	PF00069	0.739
MOD_GSK3_1	188	195	PF00069	0.609
MOD_GSK3_1	244	251	PF00069	0.625
MOD_GSK3_1	256	263	PF00069	0.587
MOD_GSK3_1	54	61	PF00069	0.720
MOD_N-GLC_1	175	180	PF02516	0.691
MOD_N-GLC_2	308	310	PF02516	0.525
MOD_NEK2_1	255	260	PF00069	0.629
MOD_NEK2_1	294	299	PF00069	0.513
MOD_PKA_2	132	138	PF00069	0.805
MOD_PKA_2	162	168	PF00069	0.657
MOD_PKA_2	255	261	PF00069	0.558
MOD_PKA_2	294	300	PF00069	0.686
MOD_PKA_2	325	331	PF00069	0.641
MOD_PKA_2	346	352	PF00069	0.716
MOD_Plk_1	23	29	PF00069	0.750
MOD_Plk_1	32	38	PF00069	0.607
MOD_Plk_1	65	71	PF00069	0.677
MOD_Plk_1	90	96	PF00069	0.630
MOD_Plk_2-3	32	38	PF00069	0.678
MOD_Plk_4	188	194	PF00069	0.650
MOD_ProDKin_1	196	202	PF00069	0.550
MOD_ProDKin_1	212	218	PF00069	0.693
MOD_ProDKin_1	51	57	PF00069	0.731
TRG_DiLeu_BaEn_1	24	29	PF01217	0.680
TRG_DiLeu_BaEn_4	138	144	PF01217	0.762
TRG_ER_diArg_1	142	145	PF00400	0.668
TRG_ER_diArg_1	69	72	PF00400	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMR5	Leptomonas seymouri	32%	95%
A0A3S5H7X0	Leishmania donovani	80%	89%
A4HAW1	Leishmania braziliensis	61%	93%
A4IA21	Leishmania infantum	80%	89%
E9B536	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	93%