Coiled-coil domain-containing protein 146

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2U9_LEIMA

TriTrypDb:

LmjF.34.2480 , LMJLV39_340029800 , LMJSD75_340030000

Length:

1069

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005856	cytoskeleton	5	3
GO:0005930	axoneme	2	3
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	5
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q2U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2U9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.568
CLV_C14_Caspase3-7	754	758	PF00656	0.549
CLV_C14_Caspase3-7	838	842	PF00656	0.408
CLV_MEL_PAP_1	832	838	PF00089	0.514
CLV_NRD_NRD_1	1067	1069	PF00675	0.678
CLV_NRD_NRD_1	135	137	PF00675	0.353
CLV_NRD_NRD_1	288	290	PF00675	0.554
CLV_NRD_NRD_1	359	361	PF00675	0.527
CLV_NRD_NRD_1	393	395	PF00675	0.487
CLV_NRD_NRD_1	443	445	PF00675	0.480
CLV_NRD_NRD_1	486	488	PF00675	0.433
CLV_NRD_NRD_1	493	495	PF00675	0.417
CLV_NRD_NRD_1	50	52	PF00675	0.549
CLV_NRD_NRD_1	575	577	PF00675	0.429
CLV_NRD_NRD_1	594	596	PF00675	0.368
CLV_NRD_NRD_1	611	613	PF00675	0.405
CLV_NRD_NRD_1	65	67	PF00675	0.351
CLV_PCSK_KEX2_1	106	108	PF00082	0.508
CLV_PCSK_KEX2_1	1066	1068	PF00082	0.665
CLV_PCSK_KEX2_1	135	137	PF00082	0.496
CLV_PCSK_KEX2_1	276	278	PF00082	0.513
CLV_PCSK_KEX2_1	288	290	PF00082	0.422
CLV_PCSK_KEX2_1	359	361	PF00082	0.634
CLV_PCSK_KEX2_1	442	444	PF00082	0.457
CLV_PCSK_KEX2_1	452	454	PF00082	0.414
CLV_PCSK_KEX2_1	486	488	PF00082	0.415
CLV_PCSK_KEX2_1	493	495	PF00082	0.434
CLV_PCSK_KEX2_1	50	52	PF00082	0.448
CLV_PCSK_KEX2_1	594	596	PF00082	0.409
CLV_PCSK_KEX2_1	611	613	PF00082	0.365
CLV_PCSK_KEX2_1	65	67	PF00082	0.310
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.508
CLV_PCSK_PC1ET2_1	1066	1068	PF00082	0.521
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.465
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.396
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.423
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.400
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.460
CLV_PCSK_SKI1_1	306	310	PF00082	0.581
CLV_PCSK_SKI1_1	324	328	PF00082	0.499
CLV_PCSK_SKI1_1	402	406	PF00082	0.528
CLV_PCSK_SKI1_1	477	481	PF00082	0.564
CLV_PCSK_SKI1_1	51	55	PF00082	0.570
CLV_PCSK_SKI1_1	587	591	PF00082	0.402
CLV_PCSK_SKI1_1	664	668	PF00082	0.472
CLV_PCSK_SKI1_1	987	991	PF00082	0.673
DEG_APCC_DBOX_1	211	219	PF00400	0.609
DEG_APCC_DBOX_1	288	296	PF00400	0.466
DEG_APCC_DBOX_1	442	450	PF00400	0.550
DEG_SPOP_SBC_1	1059	1063	PF00917	0.639
DOC_CKS1_1	1043	1048	PF01111	0.540
DOC_CYCLIN_RxL_1	224	235	PF00134	0.494
DOC_CYCLIN_RxL_1	399	407	PF00134	0.605
DOC_CYCLIN_RxL_1	818	830	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	970	976	PF00134	0.644
DOC_MAPK_gen_1	135	142	PF00069	0.367
DOC_MAPK_gen_1	224	231	PF00069	0.485
DOC_MAPK_gen_1	339	347	PF00069	0.524
DOC_MAPK_gen_1	442	451	PF00069	0.405
DOC_MAPK_gen_1	493	501	PF00069	0.533
DOC_MAPK_gen_1	723	731	PF00069	0.654
DOC_MAPK_gen_1	75	83	PF00069	0.472
DOC_MAPK_gen_1	818	826	PF00069	0.399
DOC_MAPK_MEF2A_6	122	130	PF00069	0.396
DOC_MAPK_MEF2A_6	686	694	PF00069	0.554
DOC_MAPK_MEF2A_6	723	731	PF00069	0.654
DOC_MAPK_MEF2A_6	981	990	PF00069	0.559
DOC_MIT_MIM_1	807	815	PF04212	0.323
DOC_PP2B_LxvP_1	1023	1026	PF13499	0.526
DOC_PP2B_LxvP_1	729	732	PF13499	0.518
DOC_PP2B_LxvP_1	968	971	PF13499	0.532
DOC_PP2B_LxvP_1	990	993	PF13499	0.490
DOC_USP7_MATH_1	1030	1034	PF00917	0.780
DOC_USP7_MATH_1	1048	1052	PF00917	0.612
DOC_USP7_MATH_1	1059	1063	PF00917	0.721
DOC_USP7_MATH_1	582	586	PF00917	0.514
DOC_USP7_MATH_1	685	689	PF00917	0.552
DOC_USP7_MATH_1	738	742	PF00917	0.601
DOC_USP7_MATH_1	775	779	PF00917	0.598
DOC_USP7_MATH_1	8	12	PF00917	0.713
DOC_USP7_MATH_1	938	942	PF00917	0.593
DOC_USP7_MATH_1	979	983	PF00917	0.701
DOC_USP7_MATH_1	995	999	PF00917	0.678
DOC_USP7_UBL2_3	412	416	PF12436	0.589
DOC_USP7_UBL2_3	50	54	PF12436	0.346
DOC_USP7_UBL2_3	531	535	PF12436	0.389
DOC_USP7_UBL2_3	577	581	PF12436	0.421
DOC_USP7_UBL2_3	814	818	PF12436	0.532
DOC_WW_Pin1_4	1004	1009	PF00397	0.771
DOC_WW_Pin1_4	1025	1030	PF00397	0.684
DOC_WW_Pin1_4	1042	1047	PF00397	0.469
DOC_WW_Pin1_4	765	770	PF00397	0.619
LIG_14-3-3_CanoR_1	1017	1022	PF00244	0.633
LIG_14-3-3_CanoR_1	256	261	PF00244	0.560
LIG_14-3-3_CanoR_1	277	282	PF00244	0.520
LIG_14-3-3_CanoR_1	289	293	PF00244	0.430
LIG_14-3-3_CanoR_1	306	313	PF00244	0.556
LIG_14-3-3_CanoR_1	466	470	PF00244	0.481
LIG_14-3-3_CanoR_1	486	495	PF00244	0.444
LIG_14-3-3_CanoR_1	611	615	PF00244	0.543
LIG_14-3-3_CanoR_1	87	92	PF00244	0.391
LIG_Actin_WH2_2	56	74	PF00022	0.345
LIG_BRCT_BRCA1_1	410	414	PF00533	0.620
LIG_BRCT_BRCA1_2	410	416	PF00533	0.504
LIG_FHA_1	25	31	PF00498	0.424
LIG_FHA_1	320	326	PF00498	0.444
LIG_FHA_1	381	387	PF00498	0.552
LIG_FHA_1	399	405	PF00498	0.532
LIG_FHA_1	429	435	PF00498	0.583
LIG_FHA_1	528	534	PF00498	0.552
LIG_FHA_1	633	639	PF00498	0.325
LIG_FHA_1	706	712	PF00498	0.492
LIG_FHA_1	845	851	PF00498	0.361
LIG_FHA_1	950	956	PF00498	0.636
LIG_FHA_2	295	301	PF00498	0.470
LIG_FHA_2	604	610	PF00498	0.396
LIG_FHA_2	752	758	PF00498	0.659
LIG_FHA_2	869	875	PF00498	0.327
LIG_FHA_2	88	94	PF00498	0.520
LIG_HP1_1	986	990	PF01393	0.490
LIG_LIR_Gen_1	26	36	PF02991	0.442
LIG_LIR_Gen_1	500	510	PF02991	0.356
LIG_LIR_Gen_1	795	803	PF02991	0.471
LIG_LIR_Nem_3	26	32	PF02991	0.479
LIG_LIR_Nem_3	500	505	PF02991	0.353
LIG_LIR_Nem_3	795	801	PF02991	0.413
LIG_NRBOX	669	675	PF00104	0.373
LIG_RPA_C_Fungi	636	648	PF08784	0.455
LIG_SH2_NCK_1	910	914	PF00017	0.410
LIG_SH2_PTP2	29	32	PF00017	0.337
LIG_SH2_PTP2	798	801	PF00017	0.533
LIG_SH2_SRC	910	913	PF00017	0.417
LIG_SH2_STAP1	614	618	PF00017	0.439
LIG_SH2_STAT3	961	964	PF00017	0.693
LIG_SH2_STAT5	29	32	PF00017	0.366
LIG_SH2_STAT5	48	51	PF00017	0.363
LIG_SH2_STAT5	798	801	PF00017	0.533
LIG_SH2_STAT5	89	92	PF00017	0.393
LIG_SH2_STAT5	927	930	PF00017	0.459
LIG_SH2_STAT5	961	964	PF00017	0.516
LIG_SH3_2	718	723	PF14604	0.497
LIG_SH3_2	976	981	PF14604	0.525
LIG_SH3_3	1023	1029	PF00018	0.570
LIG_SH3_3	1040	1046	PF00018	0.585
LIG_SH3_3	715	721	PF00018	0.489
LIG_SH3_3	732	738	PF00018	0.461
LIG_SH3_3	788	794	PF00018	0.520
LIG_SH3_3	952	958	PF00018	0.654
LIG_SH3_3	970	976	PF00018	0.512
LIG_SH3_CIN85_PxpxPR_1	1006	1011	PF14604	0.549
LIG_SUMO_SIM_anti_2	536	541	PF11976	0.354
LIG_TRAF2_1	149	152	PF00917	0.380
LIG_TRAF2_1	245	248	PF00917	0.537
LIG_TRAF2_1	308	311	PF00917	0.546
LIG_TRAF2_1	436	439	PF00917	0.415
LIG_TRAF2_1	461	464	PF00917	0.481
LIG_WRC_WIRS_1	88	93	PF05994	0.389
LIG_WW_2	1047	1050	PF00397	0.499
LIG_WW_3	991	995	PF00397	0.541
MOD_CDK_SPxxK_3	1004	1011	PF00069	0.548
MOD_CK1_1	1024	1030	PF00069	0.755
MOD_CK1_1	1051	1057	PF00069	0.604
MOD_CK1_1	12	18	PF00069	0.611
MOD_CK1_1	21	27	PF00069	0.380
MOD_CK1_1	457	463	PF00069	0.571
MOD_CK1_1	941	947	PF00069	0.611
MOD_CK1_1	998	1004	PF00069	0.600
MOD_CK2_1	241	247	PF00069	0.539
MOD_CK2_1	263	269	PF00069	0.529
MOD_CK2_1	294	300	PF00069	0.457
MOD_CK2_1	346	352	PF00069	0.496
MOD_CK2_1	355	361	PF00069	0.428
MOD_CK2_1	457	463	PF00069	0.561
MOD_CK2_1	486	492	PF00069	0.424
MOD_CK2_1	582	588	PF00069	0.484
MOD_CK2_1	685	691	PF00069	0.571
MOD_CK2_1	76	82	PF00069	0.423
MOD_CK2_1	868	874	PF00069	0.346
MOD_CK2_1	891	897	PF00069	0.510
MOD_GlcNHglycan	1000	1003	PF01048	0.761
MOD_GlcNHglycan	1023	1026	PF01048	0.749
MOD_GlcNHglycan	1032	1035	PF01048	0.552
MOD_GlcNHglycan	1050	1053	PF01048	0.574
MOD_GlcNHglycan	11	14	PF01048	0.719
MOD_GlcNHglycan	250	253	PF01048	0.475
MOD_GlcNHglycan	348	351	PF01048	0.467
MOD_GlcNHglycan	459	462	PF01048	0.566
MOD_GlcNHglycan	543	546	PF01048	0.382
MOD_GlcNHglycan	757	760	PF01048	0.691
MOD_GlcNHglycan	776	780	PF01048	0.604
MOD_GlcNHglycan	981	984	PF01048	0.593
MOD_GSK3_1	1017	1024	PF00069	0.697
MOD_GSK3_1	1025	1032	PF00069	0.631
MOD_GSK3_1	1051	1058	PF00069	0.650
MOD_GSK3_1	164	171	PF00069	0.567
MOD_GSK3_1	291	298	PF00069	0.486
MOD_GSK3_1	302	309	PF00069	0.508
MOD_GSK3_1	665	672	PF00069	0.504
MOD_GSK3_1	751	758	PF00069	0.648
MOD_GSK3_1	8	15	PF00069	0.708
MOD_N-GLC_1	1055	1060	PF02516	0.533
MOD_N-GLC_1	295	300	PF02516	0.467
MOD_N-GLC_1	763	768	PF02516	0.653
MOD_N-GLC_1	862	867	PF02516	0.469
MOD_NEK2_1	1055	1060	PF00069	0.666
MOD_NEK2_1	204	209	PF00069	0.555
MOD_NEK2_1	319	324	PF00069	0.384
MOD_NEK2_1	541	546	PF00069	0.301
MOD_NEK2_1	610	615	PF00069	0.496
MOD_NEK2_1	692	697	PF00069	0.435
MOD_NEK2_1	763	768	PF00069	0.573
MOD_NEK2_1	868	873	PF00069	0.395
MOD_NEK2_1	878	883	PF00069	0.415
MOD_NEK2_1	949	954	PF00069	0.746
MOD_NEK2_2	857	862	PF00069	0.386
MOD_NEK2_2	873	878	PF00069	0.281
MOD_PIKK_1	306	312	PF00454	0.433
MOD_PIKK_1	511	517	PF00454	0.393
MOD_PIKK_1	685	691	PF00454	0.535
MOD_PIKK_1	705	711	PF00454	0.327
MOD_PIKK_1	751	757	PF00454	0.520
MOD_PK_1	1017	1023	PF00069	0.543
MOD_PK_1	535	541	PF00069	0.481
MOD_PK_1	891	897	PF00069	0.369
MOD_PKA_1	288	294	PF00069	0.429
MOD_PKA_1	486	492	PF00069	0.542
MOD_PKA_2	1016	1022	PF00069	0.775
MOD_PKA_2	121	127	PF00069	0.356
MOD_PKA_2	263	269	PF00069	0.496
MOD_PKA_2	288	294	PF00069	0.432
MOD_PKA_2	352	358	PF00069	0.526
MOD_PKA_2	380	386	PF00069	0.481
MOD_PKA_2	457	463	PF00069	0.495
MOD_PKA_2	465	471	PF00069	0.522
MOD_PKA_2	486	492	PF00069	0.449
MOD_PKA_2	541	547	PF00069	0.354
MOD_PKA_2	610	616	PF00069	0.599
MOD_PKA_2	653	659	PF00069	0.389
MOD_PKB_1	85	93	PF00069	0.531
MOD_Plk_1	1055	1061	PF00069	0.553
MOD_Plk_1	295	301	PF00069	0.466
MOD_Plk_1	361	367	PF00069	0.518
MOD_Plk_1	428	434	PF00069	0.556
MOD_Plk_1	462	468	PF00069	0.444
MOD_Plk_1	535	541	PF00069	0.461
MOD_Plk_1	559	565	PF00069	0.600
MOD_Plk_1	603	609	PF00069	0.493
MOD_Plk_1	632	638	PF00069	0.304
MOD_Plk_1	66	72	PF00069	0.351
MOD_Plk_1	692	698	PF00069	0.436
MOD_Plk_1	844	850	PF00069	0.358
MOD_Plk_1	873	879	PF00069	0.348
MOD_Plk_1	941	947	PF00069	0.653
MOD_Plk_1	995	1001	PF00069	0.773
MOD_Plk_2-3	361	367	PF00069	0.522
MOD_Plk_4	121	127	PF00069	0.350
MOD_Plk_4	535	541	PF00069	0.387
MOD_Plk_4	66	72	PF00069	0.351
MOD_Plk_4	669	675	PF00069	0.463
MOD_Plk_4	873	879	PF00069	0.348
MOD_Plk_4	891	897	PF00069	0.384
MOD_ProDKin_1	1004	1010	PF00069	0.765
MOD_ProDKin_1	1025	1031	PF00069	0.684
MOD_ProDKin_1	1042	1048	PF00069	0.503
MOD_ProDKin_1	765	771	PF00069	0.622
MOD_SUMO_for_1	157	160	PF00179	0.525
MOD_SUMO_for_1	191	194	PF00179	0.407
MOD_SUMO_for_1	436	439	PF00179	0.518
MOD_SUMO_for_1	505	508	PF00179	0.397
MOD_SUMO_rev_2	242	251	PF00179	0.423
MOD_SUMO_rev_2	584	591	PF00179	0.556
MOD_SUMO_rev_2	712	721	PF00179	0.616
TRG_DiLeu_BaEn_1	186	191	PF01217	0.405
TRG_DiLeu_BaEn_1	315	320	PF01217	0.465
TRG_DiLeu_BaEn_1	367	372	PF01217	0.533
TRG_DiLeu_BaEn_1	528	533	PF01217	0.500
TRG_DiLeu_BaEn_1	536	541	PF01217	0.501
TRG_DiLeu_BaEn_4	827	833	PF01217	0.376
TRG_ENDOCYTIC_2	29	32	PF00928	0.366
TRG_ENDOCYTIC_2	798	801	PF00928	0.492
TRG_ENDOCYTIC_2	974	977	PF00928	0.502
TRG_ER_diArg_1	154	157	PF00400	0.424
TRG_ER_diArg_1	493	495	PF00400	0.431
TRG_ER_diArg_1	593	595	PF00400	0.382
TRG_ER_diArg_1	610	612	PF00400	0.375
TRG_ER_diArg_1	64	66	PF00400	0.484
TRG_ER_diArg_1	77	80	PF00400	0.397
TRG_ER_diArg_1	85	88	PF00400	0.500
TRG_NES_CRM1_1	560	571	PF08389	0.404
TRG_NLS_Bipartite_1	275	292	PF00514	0.527
TRG_NLS_MonoExtC_3	49	54	PF00514	0.337
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	594	599	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC41	Leptomonas seymouri	64%	92%
A0A0S4JNC8	Bodo saltans	41%	100%
A0A1X0P9Q4	Trypanosomatidae	44%	100%
A0A3Q8IGJ9	Leishmania donovani	23%	100%
A0A3S7X809	Leishmania donovani	94%	100%
A0A422P0B4	Trypanosoma rangeli	43%	100%
A4HAW2	Leishmania braziliensis	80%	96%
A4IA22	Leishmania infantum	95%	100%
A4IDS5	Leishmania infantum	23%	100%
C9ZMK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ATT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B537	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0R0	Leishmania major	23%	100%
Q8IYE0	Homo sapiens	22%	100%
V5DGR4	Trypanosoma cruzi	44%	100%