Leucine_Rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2U8_LEIMA

TriTrypDb:

LmjF.34.2485 , LMJLV39_340029900 , LMJSD75_340030100

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4Q2U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.711
CLV_NRD_NRD_1	154	156	PF00675	0.453
CLV_NRD_NRD_1	251	253	PF00675	0.491
CLV_NRD_NRD_1	279	281	PF00675	0.538
CLV_NRD_NRD_1	346	348	PF00675	0.653
CLV_NRD_NRD_1	88	90	PF00675	0.542
CLV_PCSK_KEX2_1	154	156	PF00082	0.453
CLV_PCSK_KEX2_1	251	253	PF00082	0.491
CLV_PCSK_KEX2_1	279	281	PF00082	0.538
CLV_PCSK_KEX2_1	348	350	PF00082	0.632
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.655
CLV_PCSK_SKI1_1	16	20	PF00082	0.716
CLV_PCSK_SKI1_1	298	302	PF00082	0.625
CLV_PCSK_SKI1_1	85	89	PF00082	0.525
CLV_Separin_Metazoa	107	111	PF03568	0.547
CLV_Separin_Metazoa	86	90	PF03568	0.482
DEG_APCC_DBOX_1	159	167	PF00400	0.402
DEG_SPOP_SBC_1	47	51	PF00917	0.683
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.631
DOC_PP1_RVXF_1	162	169	PF00149	0.529
DOC_PP4_FxxP_1	113	116	PF00568	0.544
DOC_USP7_MATH_1	223	227	PF00917	0.519
DOC_USP7_MATH_1	42	46	PF00917	0.730
DOC_USP7_MATH_1	47	51	PF00917	0.689
DOC_USP7_MATH_1	81	85	PF00917	0.613
DOC_USP7_UBL2_3	16	20	PF12436	0.709
LIG_14-3-3_CanoR_1	15	19	PF00244	0.704
LIG_14-3-3_CanoR_1	160	164	PF00244	0.428
LIG_14-3-3_CanoR_1	170	180	PF00244	0.381
LIG_14-3-3_CanoR_1	298	307	PF00244	0.595
LIG_Actin_WH2_2	149	166	PF00022	0.529
LIG_Actin_WH2_2	246	264	PF00022	0.476
LIG_FHA_1	160	166	PF00498	0.450
LIG_FHA_1	182	188	PF00498	0.426
LIG_FHA_1	319	325	PF00498	0.537
LIG_FHA_1	54	60	PF00498	0.623
LIG_FHA_2	27	33	PF00498	0.581
LIG_Integrin_RGD_1	11	13	PF01839	0.539
LIG_LIR_Apic_2	111	116	PF02991	0.549
LIG_LIR_Gen_1	147	158	PF02991	0.493
LIG_LIR_Gen_1	305	316	PF02991	0.411
LIG_LIR_Nem_3	147	153	PF02991	0.487
LIG_LIR_Nem_3	305	311	PF02991	0.422
LIG_REV1ctd_RIR_1	150	159	PF16727	0.467
LIG_RPA_C_Fungi	167	179	PF08784	0.455
LIG_SH2_GRB2like	308	311	PF00017	0.496
LIG_SH2_PTP2	331	334	PF00017	0.512
LIG_SH2_STAT5	124	127	PF00017	0.383
LIG_SH2_STAT5	150	153	PF00017	0.457
LIG_SH2_STAT5	308	311	PF00017	0.496
LIG_SH2_STAT5	315	318	PF00017	0.508
LIG_SH2_STAT5	331	334	PF00017	0.412
LIG_SUMO_SIM_anti_2	103	111	PF11976	0.428
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.330
LIG_SUMO_SIM_par_1	228	233	PF11976	0.338
LIG_UBA3_1	229	237	PF00899	0.486
MOD_CK1_1	211	217	PF00069	0.717
MOD_CK1_1	40	46	PF00069	0.689
MOD_CK1_1	49	55	PF00069	0.613
MOD_CK2_1	108	114	PF00069	0.595
MOD_CK2_1	222	228	PF00069	0.443
MOD_CK2_1	61	67	PF00069	0.581
MOD_GlcNHglycan	173	176	PF01048	0.469
MOD_GlcNHglycan	203	206	PF01048	0.578
MOD_GlcNHglycan	219	222	PF01048	0.659
MOD_GlcNHglycan	289	292	PF01048	0.680
MOD_GlcNHglycan	302	305	PF01048	0.605
MOD_GlcNHglycan	39	42	PF01048	0.696
MOD_GlcNHglycan	81	84	PF01048	0.621
MOD_GSK3_1	14	21	PF00069	0.717
MOD_GSK3_1	192	199	PF00069	0.608
MOD_GSK3_1	208	215	PF00069	0.554
MOD_GSK3_1	298	305	PF00069	0.623
MOD_GSK3_1	42	49	PF00069	0.675
MOD_GSK3_1	75	82	PF00069	0.557
MOD_N-GLC_1	26	31	PF02516	0.769
MOD_NEK2_1	125	130	PF00069	0.406
MOD_NEK2_1	230	235	PF00069	0.328
MOD_NEK2_2	14	19	PF00069	0.683
MOD_PK_1	252	258	PF00069	0.480
MOD_PKA_1	347	353	PF00069	0.719
MOD_PKA_2	14	20	PF00069	0.731
MOD_PKA_2	159	165	PF00069	0.462
MOD_PKA_2	171	177	PF00069	0.376
MOD_PKA_2	318	324	PF00069	0.533
MOD_PKB_1	345	353	PF00069	0.613
MOD_Plk_1	125	131	PF00069	0.431
MOD_Plk_1	209	215	PF00069	0.714
MOD_Plk_1	230	236	PF00069	0.334
MOD_Plk_4	125	131	PF00069	0.426
MOD_Plk_4	18	24	PF00069	0.672
MOD_SUMO_rev_2	342	350	PF00179	0.519
TRG_ENDOCYTIC_2	124	127	PF00928	0.472
TRG_ENDOCYTIC_2	150	153	PF00928	0.473
TRG_ENDOCYTIC_2	308	311	PF00928	0.496
TRG_ENDOCYTIC_2	331	334	PF00928	0.469
TRG_ENDOCYTIC_2	94	97	PF00928	0.402
TRG_ER_diArg_1	109	112	PF00400	0.576
TRG_ER_diArg_1	153	155	PF00400	0.544
TRG_ER_diArg_1	170	173	PF00400	0.402
TRG_ER_diArg_1	250	252	PF00400	0.478
TRG_ER_diArg_1	278	280	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC4	Leptomonas seymouri	62%	97%
A0A0S4JWU2	Bodo saltans	35%	100%
A0A1X0P9N6	Trypanosomatidae	45%	100%
A0A3Q8INF5	Leishmania donovani	91%	100%
A0A3R7NT18	Trypanosoma rangeli	42%	100%
A4HAW3	Leishmania braziliensis	77%	100%
A4IA23	Leishmania infantum	91%	100%
C9ZMJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B538	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B0E5	Trypanosoma cruzi	50%	97%