Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2U7_LEIMA

TriTrypDb:

LmjF.34.2490 , LMJLV39_340030000 , LMJSD75_340030200

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2U7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0008104	protein localization	4	4
GO:0009966	regulation of signal transduction	4	4
GO:0009967	positive regulation of signal transduction	5	4
GO:0009987	cellular process	1	4
GO:0010646	regulation of cell communication	4	4
GO:0010647	positive regulation of cell communication	5	4
GO:0015031	protein transport	4	4
GO:0023051	regulation of signaling	3	4
GO:0023056	positive regulation of signaling	4	4
GO:0032006	regulation of TOR signaling	6	4
GO:0032008	positive regulation of TOR signaling	7	4
GO:0033036	macromolecule localization	2	4
GO:0045184	establishment of protein localization	3	4
GO:0048518	positive regulation of biological process	3	4
GO:0048522	positive regulation of cellular process	4	4
GO:0048583	regulation of response to stimulus	3	4
GO:0048584	positive regulation of response to stimulus	4	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0051641	cellular localization	2	4
GO:0065007	biological regulation	1	4
GO:0070727	cellular macromolecule localization	3	4
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4
GO:1902531	regulation of intracellular signal transduction	5	4
GO:1902533	positive regulation of intracellular signal transduction	6	4
GO:1903432	regulation of TORC1 signaling	7	4
GO:1904263	positive regulation of TORC1 signaling	8	4

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.796
CLV_C14_Caspase3-7	25	29	PF00656	0.756
CLV_NRD_NRD_1	219	221	PF00675	0.360
CLV_NRD_NRD_1	305	307	PF00675	0.419
CLV_NRD_NRD_1	387	389	PF00675	0.479
CLV_PCSK_FUR_1	302	306	PF00082	0.500
CLV_PCSK_KEX2_1	219	221	PF00082	0.360
CLV_PCSK_KEX2_1	304	306	PF00082	0.466
CLV_PCSK_KEX2_1	387	389	PF00082	0.365
CLV_PCSK_SKI1_1	268	272	PF00082	0.509
CLV_PCSK_SKI1_1	306	310	PF00082	0.324
CLV_PCSK_SKI1_1	368	372	PF00082	0.322
CLV_PCSK_SKI1_1	382	386	PF00082	0.293
CLV_PCSK_SKI1_1	451	455	PF00082	0.382
DEG_SPOP_SBC_1	13	17	PF00917	0.588
DOC_CKS1_1	132	137	PF01111	0.502
DOC_CKS1_1	68	73	PF01111	0.580
DOC_CYCLIN_RxL_1	265	276	PF00134	0.416
DOC_MAPK_gen_1	219	227	PF00069	0.452
DOC_MAPK_gen_1	302	311	PF00069	0.535
DOC_MAPK_MEF2A_6	219	227	PF00069	0.452
DOC_MAPK_MEF2A_6	368	375	PF00069	0.327
DOC_MAPK_MEF2A_6	515	522	PF00069	0.497
DOC_MAPK_NFAT4_5	368	376	PF00069	0.324
DOC_PP1_RVXF_1	137	144	PF00149	0.592
DOC_PP1_RVXF_1	356	363	PF00149	0.329
DOC_PP1_RVXF_1	380	387	PF00149	0.414
DOC_PP1_RVXF_1	440	446	PF00149	0.492
DOC_PP2B_LxvP_1	120	123	PF13499	0.530
DOC_PP2B_LxvP_1	270	273	PF13499	0.469
DOC_PP4_FxxP_1	386	389	PF00568	0.378
DOC_USP7_MATH_1	12	16	PF00917	0.586
DOC_USP7_MATH_1	146	150	PF00917	0.467
DOC_USP7_MATH_1	241	245	PF00917	0.602
DOC_USP7_MATH_1	247	251	PF00917	0.562
DOC_USP7_MATH_1	400	404	PF00917	0.554
DOC_USP7_MATH_1	415	419	PF00917	0.581
DOC_USP7_MATH_1	423	427	PF00917	0.494
DOC_USP7_MATH_1	64	68	PF00917	0.589
DOC_WW_Pin1_4	131	136	PF00397	0.669
DOC_WW_Pin1_4	239	244	PF00397	0.715
DOC_WW_Pin1_4	292	297	PF00397	0.532
DOC_WW_Pin1_4	360	365	PF00397	0.350
DOC_WW_Pin1_4	67	72	PF00397	0.538
LIG_14-3-3_CanoR_1	186	194	PF00244	0.376
LIG_14-3-3_CanoR_1	21	30	PF00244	0.599
LIG_14-3-3_CanoR_1	228	237	PF00244	0.627
LIG_14-3-3_CanoR_1	268	273	PF00244	0.548
LIG_AP2alpha_1	4	8	PF02296	0.463
LIG_BRCT_BRCA1_1	208	212	PF00533	0.358
LIG_CSL_BTD_1	361	364	PF09270	0.400
LIG_deltaCOP1_diTrp_1	161	167	PF00928	0.453
LIG_FHA_1	145	151	PF00498	0.409
LIG_FHA_1	199	205	PF00498	0.354
LIG_FHA_1	260	266	PF00498	0.476
LIG_FHA_1	376	382	PF00498	0.376
LIG_FHA_1	448	454	PF00498	0.340
LIG_FHA_1	523	529	PF00498	0.570
LIG_FHA_2	132	138	PF00498	0.647
LIG_FHA_2	156	162	PF00498	0.438
LIG_FHA_2	35	41	PF00498	0.584
LIG_FHA_2	74	80	PF00498	0.474
LIG_LIR_Apic_2	467	473	PF02991	0.518
LIG_LIR_Apic_2	67	71	PF02991	0.629
LIG_LIR_Gen_1	106	114	PF02991	0.549
LIG_LIR_Gen_1	343	353	PF02991	0.562
LIG_LIR_Gen_1	369	377	PF02991	0.300
LIG_LIR_Nem_3	106	110	PF02991	0.526
LIG_LIR_Nem_3	343	349	PF02991	0.543
LIG_LIR_Nem_3	369	373	PF02991	0.312
LIG_LIR_Nem_3	40	44	PF02991	0.595
LIG_LIR_Nem_3	6	11	PF02991	0.480
LIG_Pex14_1	41	45	PF04695	0.638
LIG_Pex14_1	464	468	PF04695	0.416
LIG_Pex14_2	4	8	PF04695	0.475
LIG_SH2_CRK	346	350	PF00017	0.431
LIG_SH2_CRK	531	535	PF00017	0.602
LIG_SH2_CRK	68	72	PF00017	0.548
LIG_SH2_STAT5	157	160	PF00017	0.487
LIG_SH2_STAT5	172	175	PF00017	0.302
LIG_SH2_STAT5	330	333	PF00017	0.466
LIG_SUMO_SIM_anti_2	425	431	PF11976	0.426
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.552
LIG_TRAF2_1	436	439	PF00917	0.383
LIG_TRAF2_1	511	514	PF00917	0.427
LIG_TYR_ITIM	344	349	PF00017	0.381
LIG_UBA3_1	93	100	PF00899	0.411
MOD_CK1_1	200	206	PF00069	0.411
MOD_CK1_1	207	213	PF00069	0.324
MOD_CK1_1	230	236	PF00069	0.643
MOD_CK1_1	250	256	PF00069	0.686
MOD_CK1_1	260	266	PF00069	0.397
MOD_CK1_1	363	369	PF00069	0.501
MOD_CK1_1	493	499	PF00069	0.595
MOD_CK1_1	67	73	PF00069	0.531
MOD_CK2_1	155	161	PF00069	0.456
MOD_CK2_1	34	40	PF00069	0.445
MOD_CK2_1	422	428	PF00069	0.487
MOD_CK2_1	480	486	PF00069	0.523
MOD_CMANNOS	164	167	PF00535	0.329
MOD_GlcNHglycan	232	235	PF01048	0.648
MOD_GlcNHglycan	245	248	PF01048	0.707
MOD_GlcNHglycan	288	292	PF01048	0.740
MOD_GlcNHglycan	296	299	PF01048	0.648
MOD_GlcNHglycan	315	318	PF01048	0.255
MOD_GlcNHglycan	350	353	PF01048	0.530
MOD_GlcNHglycan	365	368	PF01048	0.525
MOD_GlcNHglycan	406	409	PF01048	0.647
MOD_GlcNHglycan	47	50	PF01048	0.598
MOD_GlcNHglycan	482	485	PF01048	0.600
MOD_GlcNHglycan	495	498	PF01048	0.649
MOD_GlcNHglycan	525	528	PF01048	0.477
MOD_GSK3_1	13	20	PF00069	0.603
MOD_GSK3_1	198	205	PF00069	0.394
MOD_GSK3_1	206	213	PF00069	0.359
MOD_GSK3_1	228	235	PF00069	0.560
MOD_GSK3_1	239	246	PF00069	0.644
MOD_GSK3_1	268	275	PF00069	0.424
MOD_GSK3_1	30	37	PF00069	0.605
MOD_GSK3_1	332	339	PF00069	0.496
MOD_GSK3_1	362	369	PF00069	0.442
MOD_GSK3_1	400	407	PF00069	0.466
MOD_GSK3_1	441	448	PF00069	0.419
MOD_GSK3_1	51	58	PF00069	0.557
MOD_GSK3_1	518	525	PF00069	0.476
MOD_N-GLC_1	210	215	PF02516	0.500
MOD_N-GLC_1	445	450	PF02516	0.422
MOD_N-GLC_1	479	484	PF02516	0.681
MOD_N-GLC_1	52	57	PF02516	0.683
MOD_N-GLC_2	89	91	PF02516	0.513
MOD_NEK2_1	375	380	PF00069	0.480
MOD_NEK2_1	4	9	PF00069	0.660
MOD_NEK2_1	430	435	PF00069	0.312
MOD_NEK2_1	457	462	PF00069	0.527
MOD_NEK2_1	51	56	PF00069	0.666
MOD_NEK2_1	73	78	PF00069	0.436
MOD_PIKK_1	105	111	PF00454	0.445
MOD_PIKK_1	23	29	PF00454	0.750
MOD_PIKK_1	332	338	PF00454	0.512
MOD_PIKK_1	430	436	PF00454	0.420
MOD_PKA_1	387	393	PF00069	0.413
MOD_PKA_2	185	191	PF00069	0.371
MOD_PKA_2	198	204	PF00069	0.370
MOD_PKA_2	20	26	PF00069	0.728
MOD_PKA_2	227	233	PF00069	0.507
MOD_PKA_2	387	393	PF00069	0.413
MOD_Plk_1	160	166	PF00069	0.416
MOD_Plk_1	210	216	PF00069	0.387
MOD_Plk_1	336	342	PF00069	0.463
MOD_Plk_1	457	463	PF00069	0.482
MOD_Plk_1	503	509	PF00069	0.648
MOD_Plk_1	78	84	PF00069	0.550
MOD_Plk_4	14	20	PF00069	0.684
MOD_Plk_4	146	152	PF00069	0.462
MOD_Plk_4	260	266	PF00069	0.531
MOD_Plk_4	325	331	PF00069	0.416
MOD_Plk_4	387	393	PF00069	0.367
MOD_Plk_4	503	509	PF00069	0.542
MOD_Plk_4	64	70	PF00069	0.578
MOD_Plk_4	78	84	PF00069	0.381
MOD_ProDKin_1	131	137	PF00069	0.663
MOD_ProDKin_1	239	245	PF00069	0.719
MOD_ProDKin_1	292	298	PF00069	0.532
MOD_ProDKin_1	360	366	PF00069	0.361
MOD_ProDKin_1	67	73	PF00069	0.529
TRG_DiLeu_BaEn_1	315	320	PF01217	0.345
TRG_DiLeu_BaEn_3	513	519	PF01217	0.344
TRG_DiLeu_BaEn_4	438	444	PF01217	0.371
TRG_DiLeu_BaEn_4	486	492	PF01217	0.525
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.614
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.390
TRG_ENDOCYTIC_2	346	349	PF00928	0.382
TRG_ENDOCYTIC_2	531	534	PF00928	0.738
TRG_ER_diArg_1	219	222	PF00400	0.459
TRG_ER_diArg_1	302	305	PF00400	0.612
TRG_ER_diArg_1	386	388	PF00400	0.414
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3R7	Leptomonas seymouri	60%	90%
A0A1X0P9T6	Trypanosomatidae	34%	100%
A0A3Q8IHB0	Leishmania donovani	93%	100%
A0A3R7N181	Trypanosoma rangeli	33%	100%
A4HAW4	Leishmania braziliensis	78%	100%
A4IA24	Leishmania infantum	93%	100%
C9ZMJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B539	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BFU9	Trypanosoma cruzi	32%	100%