Protein phosphatase 2C-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania major

UniProt:

Q4Q2U6_LEIMA

TriTrypDb:

LmjF.34.2500 , LMJLV39_340030100 , LMJSD75_340030300

Length:

391

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2U6

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016311	dephosphorylation	5	16
GO:0019538	protein metabolic process	3	16
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043412	macromolecule modification	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004721	phosphoprotein phosphatase activity	3	16
GO:0004722	protein serine/threonine phosphatase activity	4	16
GO:0005488	binding	1	16
GO:0016787	hydrolase activity	2	16
GO:0016788	hydrolase activity, acting on ester bonds	3	16
GO:0016791	phosphatase activity	5	16
GO:0017018	myosin phosphatase activity	5	13
GO:0042578	phosphoric ester hydrolase activity	4	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0140096	catalytic activity, acting on a protein	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.310
CLV_C14_Caspase3-7	347	351	PF00656	0.265
CLV_NRD_NRD_1	178	180	PF00675	0.234
CLV_NRD_NRD_1	364	366	PF00675	0.265
CLV_PCSK_KEX2_1	364	366	PF00082	0.265
CLV_PCSK_SKI1_1	191	195	PF00082	0.368
DEG_APCC_DBOX_1	160	168	PF00400	0.417
DEG_SPOP_SBC_1	59	63	PF00917	0.715
DOC_CKS1_1	78	83	PF01111	0.652
DOC_CKS1_1	85	90	PF01111	0.664
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.516
DOC_MAPK_gen_1	161	169	PF00069	0.314
DOC_MAPK_HePTP_8	229	241	PF00069	0.306
DOC_MAPK_MEF2A_6	232	241	PF00069	0.314
DOC_PP2B_LxvP_1	72	75	PF13499	0.766
DOC_PP4_FxxP_1	85	88	PF00568	0.536
DOC_USP7_MATH_1	307	311	PF00917	0.394
DOC_USP7_MATH_1	59	63	PF00917	0.541
DOC_USP7_MATH_1	66	70	PF00917	0.566
DOC_USP7_MATH_1	98	102	PF00917	0.491
DOC_WW_Pin1_4	21	26	PF00397	0.752
DOC_WW_Pin1_4	77	82	PF00397	0.626
DOC_WW_Pin1_4	84	89	PF00397	0.573
DOC_WW_Pin1_4	94	99	PF00397	0.400
LIG_14-3-3_CanoR_1	127	131	PF00244	0.325
LIG_14-3-3_CanoR_1	179	189	PF00244	0.346
LIG_14-3-3_CanoR_1	275	280	PF00244	0.391
LIG_14-3-3_CanoR_1	8	14	PF00244	0.512
LIG_Actin_WH2_2	351	366	PF00022	0.306
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	100	104	PF00533	0.549
LIG_BRCT_BRCA1_1	182	186	PF00533	0.383
LIG_BRCT_BRCA1_1	34	38	PF00533	0.687
LIG_FHA_1	307	313	PF00498	0.358
LIG_FHA_1	52	58	PF00498	0.533
LIG_FHA_1	85	91	PF00498	0.600
LIG_FHA_2	134	140	PF00498	0.336
LIG_FHA_2	84	90	PF00498	0.534
LIG_GBD_Chelix_1	10	18	PF00786	0.521
LIG_LIR_Gen_1	101	110	PF02991	0.663
LIG_LIR_Gen_1	183	194	PF02991	0.361
LIG_LIR_Gen_1	317	328	PF02991	0.290
LIG_LIR_Gen_1	372	382	PF02991	0.346
LIG_LIR_Gen_1	68	78	PF02991	0.518
LIG_LIR_Nem_3	101	107	PF02991	0.572
LIG_LIR_Nem_3	141	147	PF02991	0.285
LIG_LIR_Nem_3	183	189	PF02991	0.323
LIG_LIR_Nem_3	317	323	PF02991	0.312
LIG_LIR_Nem_3	372	378	PF02991	0.307
LIG_LIR_Nem_3	68	73	PF02991	0.548
LIG_PTB_Apo_2	42	49	PF02174	0.517
LIG_SH2_CRK	70	74	PF00017	0.521
LIG_SH2_GRB2like	295	298	PF00017	0.265
LIG_SH2_GRB2like	42	45	PF00017	0.545
LIG_SH2_SRC	334	337	PF00017	0.417
LIG_SH2_STAP1	334	338	PF00017	0.308
LIG_SH2_STAT5	159	162	PF00017	0.368
LIG_SH2_STAT5	295	298	PF00017	0.308
LIG_SH2_STAT5	42	45	PF00017	0.545
LIG_SH3_3	134	140	PF00018	0.265
LIG_SH3_3	264	270	PF00018	0.308
LIG_SH3_3	85	91	PF00018	0.607
LIG_SUMO_SIM_anti_2	131	139	PF11976	0.265
LIG_SUMO_SIM_par_1	12	17	PF11976	0.554
LIG_SUMO_SIM_par_1	235	240	PF11976	0.289
LIG_SUMO_SIM_par_1	301	311	PF11976	0.417
MOD_CDK_SPxxK_3	21	28	PF00069	0.523
MOD_CK1_1	105	111	PF00069	0.478
MOD_CK1_1	216	222	PF00069	0.317
MOD_CK1_1	29	35	PF00069	0.730
MOD_CK1_1	58	64	PF00069	0.643
MOD_CK1_1	9	15	PF00069	0.600
MOD_CK1_1	94	100	PF00069	0.528
MOD_CK2_1	103	109	PF00069	0.389
MOD_CK2_1	111	117	PF00069	0.350
MOD_CK2_1	125	131	PF00069	0.223
MOD_CK2_1	133	139	PF00069	0.239
MOD_CK2_1	330	336	PF00069	0.355
MOD_CK2_1	83	89	PF00069	0.535
MOD_GlcNHglycan	100	103	PF01048	0.591
MOD_GlcNHglycan	202	205	PF01048	0.291
MOD_GlcNHglycan	300	303	PF01048	0.306
MOD_GlcNHglycan	31	34	PF01048	0.648
MOD_GlcNHglycan	346	349	PF01048	0.323
MOD_GlcNHglycan	380	383	PF01048	0.476
MOD_GlcNHglycan	39	42	PF01048	0.700
MOD_GlcNHglycan	57	60	PF01048	0.677
MOD_GSK3_1	195	202	PF00069	0.421
MOD_GSK3_1	275	282	PF00069	0.295
MOD_GSK3_1	29	36	PF00069	0.664
MOD_GSK3_1	51	58	PF00069	0.688
MOD_GSK3_1	94	101	PF00069	0.535
MOD_N-GLC_1	369	374	PF02516	0.329
MOD_N-GLC_1	44	49	PF02516	0.518
MOD_N-GLC_1	59	64	PF02516	0.452
MOD_NEK2_1	103	108	PF00069	0.617
MOD_NEK2_1	279	284	PF00069	0.304
MOD_NEK2_1	328	333	PF00069	0.372
MOD_NEK2_1	378	383	PF00069	0.483
MOD_NEK2_2	33	38	PF00069	0.526
MOD_PKA_1	364	370	PF00069	0.265
MOD_PKA_2	126	132	PF00069	0.314
MOD_PKA_2	29	35	PF00069	0.709
MOD_PKA_2	364	370	PF00069	0.365
MOD_Plk_1	165	171	PF00069	0.227
MOD_Plk_1	250	256	PF00069	0.265
MOD_Plk_1	369	375	PF00069	0.320
MOD_Plk_1	44	50	PF00069	0.518
MOD_Plk_2-3	133	139	PF00069	0.234
MOD_Plk_2-3	330	336	PF00069	0.289
MOD_Plk_2-3	350	356	PF00069	0.143
MOD_Plk_2-3	49	55	PF00069	0.654
MOD_Plk_4	111	117	PF00069	0.405
MOD_Plk_4	133	139	PF00069	0.424
MOD_Plk_4	213	219	PF00069	0.276
MOD_Plk_4	9	15	PF00069	0.679
MOD_ProDKin_1	21	27	PF00069	0.752
MOD_ProDKin_1	77	83	PF00069	0.627
MOD_ProDKin_1	84	90	PF00069	0.571
MOD_ProDKin_1	94	100	PF00069	0.400
MOD_SUMO_for_1	290	293	PF00179	0.265
TRG_DiLeu_BaEn_1	68	73	PF01217	0.518
TRG_ENDOCYTIC_2	70	73	PF00928	0.521
TRG_ER_diArg_1	160	163	PF00400	0.265
TRG_ER_diArg_1	363	365	PF00400	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F8	Leptomonas seymouri	29%	100%
A0A0N1I0H9	Leptomonas seymouri	32%	100%
A0A0N1I8W9	Leptomonas seymouri	49%	90%
A0A0N1IHU6	Leptomonas seymouri	31%	96%
A0A0N1PAL8	Leptomonas seymouri	31%	100%
A0A0N1PEL9	Leptomonas seymouri	63%	100%
A0A0S4ILP4	Bodo saltans	26%	75%
A0A0S4IY95	Bodo saltans	29%	100%
A0A0S4J0A6	Bodo saltans	32%	96%
A0A0S4J8Y7	Bodo saltans	30%	76%
A0A0S4JHB4	Bodo saltans	30%	100%
A0A0S4JPC3	Bodo saltans	30%	100%
A0A0S4KIS4	Bodo saltans	29%	86%
A0A0S4KJV9	Bodo saltans	31%	90%
A0A1X0NRG3	Trypanosomatidae	30%	100%
A0A1X0NVC4	Trypanosomatidae	28%	95%
A0A1X0P2A0	Trypanosomatidae	32%	100%
A0A1X0P568	Trypanosomatidae	30%	96%
A0A1X0P991	Trypanosomatidae	28%	100%
A0A1X0PAN4	Trypanosomatidae	50%	100%
A0A3Q8IEK6	Leishmania donovani	28%	100%
A0A3Q8IFG7	Leishmania donovani	30%	100%
A0A3Q8IGS1	Leishmania donovani	29%	69%
A0A3Q8IK65	Leishmania donovani	32%	100%
A0A3Q8IL63	Leishmania donovani	94%	100%
A0A3S7WZ14	Leishmania donovani	29%	96%
A0A3S7X808	Leishmania donovani	49%	87%
A0A422N8D7	Trypanosoma rangeli	46%	100%
A0A422NAJ1	Trypanosoma rangeli	29%	100%
A0A422NBV9	Trypanosoma rangeli	30%	96%
A0A422NML6	Trypanosoma rangeli	31%	100%
A0A422NS77	Trypanosoma rangeli	28%	95%
A0A422P293	Trypanosoma rangeli	27%	100%
A0BLX0	Paramecium tetraurelia	30%	100%
A0BQL0	Paramecium tetraurelia	28%	100%
A0CUB5	Paramecium tetraurelia	27%	100%
A0DSB3	Paramecium tetraurelia	26%	100%
A0DTY1	Paramecium tetraurelia	28%	100%
A3A8W2	Oryza sativa subsp. japonica	29%	100%
A4H7Y6	Leishmania braziliensis	26%	97%
A4HAW5	Leishmania braziliensis	84%	99%
A4HAW6	Leishmania braziliensis	49%	87%
A4HE10	Leishmania braziliensis	29%	96%
A4HG10	Leishmania braziliensis	28%	100%
A4HHY5	Leishmania braziliensis	29%	100%
A4HKF6	Leishmania braziliensis	28%	69%
A4HNR1	Leishmania braziliensis	32%	100%
A4I1B7	Leishmania infantum	29%	96%
A4I329	Leishmania infantum	28%	100%
A4I565	Leishmania infantum	30%	100%
A4I7Y4	Leishmania infantum	29%	69%
A4IA25	Leishmania infantum	94%	100%
A4IA26	Leishmania infantum	49%	87%
A4ICT4	Leishmania infantum	32%	100%
A5PJZ2	Bos taurus	32%	100%
C9ZJK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZMJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZNW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	92%
C9ZQJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A2L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A5L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
D0AA51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	91%
E9ACV0	Leishmania major	28%	100%
E9AQ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9ASH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AXF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
E9AZD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B2U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	69%
E9B540	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B541	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
O04719	Arabidopsis thaliana	29%	92%
O14189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	88%
O62829	Bos taurus	29%	100%
O62830	Bos taurus	31%	81%
O75688	Homo sapiens	31%	82%
O80492	Arabidopsis thaliana	30%	91%
O80871	Arabidopsis thaliana	31%	99%
O81716	Arabidopsis thaliana	28%	100%
O81760	Arabidopsis thaliana	26%	100%
P20650	Rattus norvegicus	29%	100%
P35182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P35813	Homo sapiens	29%	100%
P35814	Oryctolagus cuniculus	29%	100%
P35815	Rattus norvegicus	32%	100%
P36982	Leishmania chagasi	29%	96%
P36993	Mus musculus	31%	100%
P38089	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	99%
P40371	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P46014	Arabidopsis thaliana	25%	67%
P49443	Mus musculus	28%	100%
P49444	Paramecium tetraurelia	29%	100%
P49593	Homo sapiens	31%	86%
P49594	Caenorhabditis elegans	27%	87%
P49596	Caenorhabditis elegans	31%	100%
P49597	Arabidopsis thaliana	29%	90%
P49598	Arabidopsis thaliana	30%	98%
P49599	Arabidopsis thaliana	27%	100%
P93006	Arabidopsis thaliana	31%	100%
Q09173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	94%
Q0DBU3	Oryza sativa subsp. japonica	35%	100%
Q0IIF0	Bos taurus	28%	100%
Q0J2L7	Oryza sativa subsp. japonica	32%	100%
Q0J2R1	Oryza sativa subsp. japonica	30%	100%
Q0JL75	Oryza sativa subsp. japonica	33%	100%
Q0JLP9	Oryza sativa subsp. japonica	33%	84%
Q0V7V2	Arabidopsis thaliana	27%	100%
Q0WRB2	Arabidopsis thaliana	30%	100%
Q10MX1	Oryza sativa subsp. japonica	35%	100%
Q10S32	Oryza sativa subsp. japonica	27%	98%
Q19775	Caenorhabditis elegans	28%	84%
Q2PC20	Bos taurus	30%	100%
Q2QN36	Oryza sativa subsp. japonica	28%	100%
Q2QWE3	Oryza sativa subsp. japonica	33%	93%
Q2RBJ6	Oryza sativa subsp. japonica	27%	93%
Q3EAF9	Arabidopsis thaliana	30%	100%
Q4PSE8	Arabidopsis thaliana	36%	87%
Q4Q225	Leishmania major	32%	100%
Q4Q2U5	Leishmania major	49%	87%
Q4Q5B1	Leishmania major	29%	69%
Q4Q7S1	Leishmania major	30%	100%
Q4QA19	Leishmania major	29%	100%
Q4QFG7	Leishmania major	27%	97%
Q501F9	Arabidopsis thaliana	30%	100%
Q53Q11	Oryza sativa subsp. japonica	33%	98%
Q5JKN1	Oryza sativa subsp. japonica	30%	100%
Q5MFV5	Oryza sativa subsp. indica	30%	100%
Q5SGD2	Homo sapiens	32%	100%
Q5SMK6	Oryza sativa subsp. japonica	32%	100%
Q5SN75	Oryza sativa subsp. japonica	33%	97%
Q5Z6F5	Oryza sativa subsp. japonica	36%	100%
Q5Z8P0	Oryza sativa subsp. japonica	25%	100%
Q652Z7	Oryza sativa subsp. japonica	34%	100%
Q653S3	Oryza sativa subsp. japonica	29%	100%
Q65XG6	Oryza sativa subsp. japonica	30%	94%
Q65XK7	Oryza sativa subsp. japonica	30%	100%
Q67UP9	Oryza sativa subsp. japonica	30%	100%
Q67UX7	Oryza sativa subsp. japonica	34%	100%
Q69QZ0	Oryza sativa subsp. japonica	31%	100%
Q69VD9	Oryza sativa subsp. japonica	28%	100%
Q6AUQ4	Oryza sativa subsp. japonica	31%	100%
Q6EN45	Oryza sativa subsp. japonica	35%	100%
Q6ETK3	Oryza sativa subsp. japonica	29%	100%
Q6ING9	Xenopus laevis	29%	100%
Q6K1U4	Oryza sativa subsp. japonica	25%	75%
Q6K5I0	Oryza sativa subsp. japonica	27%	76%
Q6L482	Oryza sativa subsp. japonica	31%	100%
Q6L4R7	Oryza sativa subsp. japonica	31%	88%
Q6L5C4	Oryza sativa subsp. japonica	33%	80%
Q6L5H6	Oryza sativa subsp. japonica	30%	100%
Q6ZHC8	Oryza sativa subsp. japonica	27%	100%
Q7XCJ7	Oryza sativa subsp. japonica	23%	99%
Q7XHN8	Oryza sativa subsp. japonica	27%	100%
Q7XJ53	Arabidopsis thaliana	28%	100%
Q7XR06	Oryza sativa subsp. japonica	34%	100%
Q7XU84	Oryza sativa subsp. japonica	26%	100%
Q7Y138	Oryza sativa subsp. japonica	28%	100%
Q8BGL1	Mus musculus	30%	97%
Q8BHN0	Mus musculus	32%	100%
Q8BXN7	Mus musculus	30%	100%
Q8CGA0	Mus musculus	30%	87%
Q8H063	Oryza sativa subsp. japonica	26%	100%
Q8LAY8	Arabidopsis thaliana	35%	100%
Q8N3J5	Homo sapiens	30%	100%
Q8N819	Homo sapiens	32%	91%
Q8R0F6	Mus musculus	28%	100%
Q8RX37	Arabidopsis thaliana	31%	100%
Q8RXV3	Arabidopsis thaliana	36%	100%
Q8VZN9	Arabidopsis thaliana	36%	100%
Q94AT1	Arabidopsis thaliana	33%	93%
Q94CL8	Arabidopsis thaliana	29%	100%
Q94H98	Oryza sativa subsp. japonica	30%	100%
Q9CAJ0	Arabidopsis thaliana	30%	77%
Q9FG61	Arabidopsis thaliana	28%	87%
Q9FIF5	Arabidopsis thaliana	31%	95%
Q9FLI3	Arabidopsis thaliana	28%	94%
Q9FXE4	Arabidopsis thaliana	35%	88%
Q9FYN7	Oryza sativa subsp. japonica	31%	100%
Q9H0C8	Homo sapiens	29%	100%
Q9LHJ9	Arabidopsis thaliana	28%	100%
Q9LMT1	Arabidopsis thaliana	31%	100%
Q9LNF4	Arabidopsis thaliana	30%	100%
Q9LNP9	Arabidopsis thaliana	30%	77%
Q9LR65	Arabidopsis thaliana	25%	85%
Q9LRZ4	Arabidopsis thaliana	28%	100%
Q9LUU7	Arabidopsis thaliana	29%	93%
Q9M9W9	Arabidopsis thaliana	27%	100%
Q9SD02	Arabidopsis thaliana	30%	100%
Q9SLA1	Arabidopsis thaliana	32%	100%
Q9SZ53	Arabidopsis thaliana	29%	100%
Q9WVR7	Rattus norvegicus	31%	87%
Q9XEE8	Arabidopsis thaliana	30%	100%
Q9Z1Z6	Rattus norvegicus	28%	100%
Q9ZW21	Arabidopsis thaliana	29%	100%
V5BA03	Trypanosoma cruzi	29%	100%
V5BCX6	Trypanosoma cruzi	31%	100%
V5BH00	Trypanosoma cruzi	30%	100%
V5BSS7	Trypanosoma cruzi	30%	96%
V5DCR6	Trypanosoma cruzi	29%	95%