LeishMANIAdb
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Protein phosphatase 2C-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein phosphatase 2C-like protein
Gene product:
protein phosphatase 2C-like protein
Species:
Leishmania major
UniProt:
Q4Q2U5_LEIMA
TriTrypDb:
LmjF.34.2510 , LMJLV39_340030200 , LMJSD75_340030400 *
Length:
451

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2U5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2U5

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016311 dephosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004721 phosphoprotein phosphatase activity 3 11
GO:0004722 protein serine/threonine phosphatase activity 4 11
GO:0005488 binding 1 11
GO:0016787 hydrolase activity 2 11
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0016791 phosphatase activity 5 11
GO:0017018 myosin phosphatase activity 5 10
GO:0042578 phosphoric ester hydrolase activity 4 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0140096 catalytic activity, acting on a protein 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.653
CLV_NRD_NRD_1 153 155 PF00675 0.556
CLV_NRD_NRD_1 171 173 PF00675 0.331
CLV_NRD_NRD_1 424 426 PF00675 0.524
CLV_PCSK_KEX2_1 424 426 PF00082 0.524
CLV_PCSK_SKI1_1 155 159 PF00082 0.462
CLV_PCSK_SKI1_1 235 239 PF00082 0.496
CLV_PCSK_SKI1_1 335 339 PF00082 0.277
CLV_PCSK_SKI1_1 39 43 PF00082 0.814
DEG_APCC_DBOX_1 204 212 PF00400 0.496
DEG_COP1_1 430 438 PF00400 0.604
DEG_SPOP_SBC_1 439 443 PF00917 0.574
DOC_MAPK_DCC_7 43 53 PF00069 0.630
DOC_MAPK_gen_1 154 161 PF00069 0.469
DOC_MAPK_gen_1 45 53 PF00069 0.650
DOC_MAPK_JIP1_4 279 285 PF00069 0.353
DOC_MAPK_MEF2A_6 45 53 PF00069 0.621
DOC_PP1_SILK_1 39 44 PF00149 0.599
DOC_PP4_FxxP_1 71 74 PF00568 0.641
DOC_USP7_MATH_1 134 138 PF00917 0.655
DOC_USP7_MATH_1 319 323 PF00917 0.276
DOC_USP7_MATH_1 32 36 PF00917 0.812
DOC_USP7_MATH_1 351 355 PF00917 0.496
DOC_USP7_MATH_1 438 442 PF00917 0.580
DOC_USP7_MATH_1 83 87 PF00917 0.593
DOC_USP7_MATH_2 2 8 PF00917 0.585
DOC_WW_Pin1_4 14 19 PF00397 0.653
DOC_WW_Pin1_4 20 25 PF00397 0.620
DOC_WW_Pin1_4 70 75 PF00397 0.786
DOC_WW_Pin1_4 76 81 PF00397 0.655
DOC_WW_Pin1_4 93 98 PF00397 0.600
LIG_14-3-3_CanoR_1 138 147 PF00244 0.632
LIG_14-3-3_CanoR_1 149 154 PF00244 0.582
LIG_14-3-3_CanoR_1 172 176 PF00244 0.500
LIG_14-3-3_CanoR_1 298 303 PF00244 0.321
LIG_14-3-3_CanoR_1 357 365 PF00244 0.321
LIG_FHA_1 154 160 PF00498 0.460
LIG_FHA_1 324 330 PF00498 0.305
LIG_FHA_1 410 416 PF00498 0.331
LIG_FHA_1 442 448 PF00498 0.613
LIG_FHA_1 48 54 PF00498 0.650
LIG_FHA_2 172 178 PF00498 0.369
LIG_FHA_2 218 224 PF00498 0.321
LIG_FHA_2 357 363 PF00498 0.323
LIG_FHA_2 375 381 PF00498 0.193
LIG_FHA_2 421 427 PF00498 0.477
LIG_GBD_Chelix_1 254 262 PF00786 0.331
LIG_LIR_Gen_1 156 165 PF02991 0.469
LIG_LIR_Gen_1 361 372 PF02991 0.396
LIG_LIR_Gen_1 377 384 PF02991 0.396
LIG_LIR_LC3C_4 259 264 PF02991 0.321
LIG_LIR_Nem_3 156 161 PF02991 0.482
LIG_LIR_Nem_3 361 367 PF02991 0.337
LIG_LIR_Nem_3 377 381 PF02991 0.337
LIG_SH2_SRC 378 381 PF00017 0.496
LIG_SH2_STAP1 378 382 PF00017 0.496
LIG_SH2_STAT5 203 206 PF00017 0.396
LIG_SH2_STAT5 339 342 PF00017 0.396
LIG_SH3_3 12 18 PF00018 0.600
LIG_SH3_3 122 128 PF00018 0.650
LIG_SH3_3 308 314 PF00018 0.396
LIG_SH3_3 46 52 PF00018 0.707
LIG_SH3_3 77 83 PF00018 0.642
LIG_SH3_3 94 100 PF00018 0.593
LIG_SUMO_SIM_par_1 279 284 PF11976 0.374
LIG_SUMO_SIM_par_1 345 354 PF11976 0.396
LIG_TRAF2_1 293 296 PF00917 0.331
MOD_CDC14_SPxK_1 79 82 PF00782 0.639
MOD_CDK_SPK_2 17 22 PF00069 0.654
MOD_CDK_SPxK_1 76 82 PF00069 0.655
MOD_CK1_1 129 135 PF00069 0.659
MOD_CK1_1 17 23 PF00069 0.523
MOD_CK1_1 291 297 PF00069 0.327
MOD_CK1_1 441 447 PF00069 0.606
MOD_CK1_1 56 62 PF00069 0.688
MOD_CK1_1 7 13 PF00069 0.601
MOD_CK1_1 78 84 PF00069 0.641
MOD_CK1_1 86 92 PF00069 0.597
MOD_CK1_1 96 102 PF00069 0.604
MOD_CK2_1 217 223 PF00069 0.321
MOD_CK2_1 238 244 PF00069 0.331
MOD_CK2_1 291 297 PF00069 0.276
MOD_CK2_1 374 380 PF00069 0.337
MOD_CK2_1 420 426 PF00069 0.457
MOD_CK2_1 427 433 PF00069 0.577
MOD_GlcNHglycan 103 108 PF01048 0.777
MOD_GlcNHglycan 132 135 PF01048 0.628
MOD_GlcNHglycan 247 250 PF01048 0.394
MOD_GlcNHglycan 25 28 PF01048 0.752
MOD_GlcNHglycan 34 37 PF01048 0.561
MOD_GlcNHglycan 344 347 PF01048 0.396
MOD_GlcNHglycan 85 88 PF01048 0.700
MOD_GSK3_1 126 133 PF00069 0.651
MOD_GSK3_1 134 141 PF00069 0.709
MOD_GSK3_1 149 156 PF00069 0.596
MOD_GSK3_1 23 30 PF00069 0.684
MOD_GSK3_1 238 245 PF00069 0.339
MOD_GSK3_1 319 326 PF00069 0.396
MOD_GSK3_1 405 412 PF00069 0.345
MOD_GSK3_1 441 448 PF00069 0.607
MOD_GSK3_1 53 60 PF00069 0.684
MOD_N-GLC_1 129 134 PF02516 0.727
MOD_N-GLC_1 139 144 PF02516 0.525
MOD_N-GLC_1 245 250 PF02516 0.348
MOD_N-GLC_1 413 418 PF02516 0.447
MOD_N-GLC_1 445 450 PF02516 0.635
MOD_N-GLC_1 53 58 PF02516 0.647
MOD_NEK2_1 153 158 PF00069 0.620
MOD_NEK2_1 323 328 PF00069 0.396
MOD_PIKK_1 195 201 PF00454 0.331
MOD_PIKK_1 383 389 PF00454 0.277
MOD_PK_1 298 304 PF00069 0.399
MOD_PK_1 37 43 PF00069 0.645
MOD_PKA_1 37 43 PF00069 0.645
MOD_PKA_2 148 154 PF00069 0.622
MOD_PKA_2 171 177 PF00069 0.497
MOD_PKA_2 356 362 PF00069 0.498
MOD_PKA_2 83 89 PF00069 0.709
MOD_Plk_1 139 145 PF00069 0.583
MOD_Plk_1 351 357 PF00069 0.331
MOD_Plk_1 413 419 PF00069 0.448
MOD_Plk_2-3 374 380 PF00069 0.396
MOD_Plk_4 177 183 PF00069 0.382
MOD_Plk_4 37 43 PF00069 0.704
MOD_ProDKin_1 14 20 PF00069 0.652
MOD_ProDKin_1 70 76 PF00069 0.784
MOD_ProDKin_1 93 99 PF00069 0.600
TRG_DiLeu_BaEn_1 361 366 PF01217 0.375
TRG_ENDOCYTIC_2 378 381 PF00928 0.331
TRG_NES_CRM1_1 202 217 PF08389 0.331
TRG_Pf-PMV_PEXEL_1 327 331 PF00026 0.331
TRG_Pf-PMV_PEXEL_1 445 449 PF00026 0.633

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8W9 Leptomonas seymouri 75% 100%
A0A0S4ILP4 Bodo saltans 24% 86%
A0A3Q8IEK6 Leishmania donovani 32% 100%
A0A3Q8IFG7 Leishmania donovani 28% 100%
A0A3Q8IK65 Leishmania donovani 31% 100%
A0A3Q8IL63 Leishmania donovani 45% 100%
A0A3S7WTA2 Leishmania donovani 29% 100%
A0A3S7X808 Leishmania donovani 97% 100%
A3A8W6 Oryza sativa subsp. japonica 25% 78%
A3CCP9 Oryza sativa subsp. japonica 24% 90%
A4H7Y6 Leishmania braziliensis 31% 100%
A4HAW5 Leishmania braziliensis 46% 100%
A4HAW6 Leishmania braziliensis 88% 100%
A4HG10 Leishmania braziliensis 30% 100%
A4HHY5 Leishmania braziliensis 28% 100%
A4HNR1 Leishmania braziliensis 31% 100%
A4HWB4 Leishmania infantum 29% 100%
A4I329 Leishmania infantum 32% 100%
A4I565 Leishmania infantum 28% 100%
A4IA25 Leishmania infantum 45% 100%
A4IA26 Leishmania infantum 97% 100%
A4ICT4 Leishmania infantum 30% 100%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9ACV0 Leishmania major 32% 100%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ASH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AZD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
O04719 Arabidopsis thaliana 32% 100%
O81716 Arabidopsis thaliana 30% 100%
O81760 Arabidopsis thaliana 22% 100%
P38089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
P39966 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 97%
P49597 Arabidopsis thaliana 30% 100%
P49599 Arabidopsis thaliana 28% 100%
Q0IIF0 Bos taurus 29% 100%
Q0J2L7 Oryza sativa subsp. japonica 31% 100%
Q3EAF9 Arabidopsis thaliana 33% 100%
Q4Q225 Leishmania major 31% 100%
Q4Q2U6 Leishmania major 49% 100%
Q4Q7S1 Leishmania major 28% 100%
Q4QFG7 Leishmania major 28% 100%
Q5JKN1 Oryza sativa subsp. japonica 28% 100%
Q5MFV5 Oryza sativa subsp. indica 26% 100%
Q5N9N2 Oryza sativa subsp. japonica 30% 100%
Q653S3 Oryza sativa subsp. japonica 30% 100%
Q65XK7 Oryza sativa subsp. japonica 30% 100%
Q67UP9 Oryza sativa subsp. japonica 28% 100%
Q6AUQ4 Oryza sativa subsp. japonica 32% 100%
Q6ETK3 Oryza sativa subsp. japonica 28% 100%
Q6K1U4 Oryza sativa subsp. japonica 27% 87%
Q6K5I0 Oryza sativa subsp. japonica 30% 87%
Q6NKS1 Arabidopsis thaliana 26% 100%
Q7XU84 Oryza sativa subsp. japonica 34% 100%
Q94H98 Oryza sativa subsp. japonica 26% 100%
Q9CAJ0 Arabidopsis thaliana 32% 88%
Q9FG61 Arabidopsis thaliana 25% 100%
Q9FLI3 Arabidopsis thaliana 27% 100%
Q9LNP9 Arabidopsis thaliana 29% 88%
Q9SLA1 Arabidopsis thaliana 36% 100%
Q9SZ53 Arabidopsis thaliana 30% 100%
Q9ZW21 Arabidopsis thaliana 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS