C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil and C2 domain-containing protein

Species:

Leishmania major

UniProt:

Q4Q2U1_LEIMA

TriTrypDb:

LmjF.34.2540 , LMJLV39_340030700 , LMJSD75_340030700

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0044297	cell body	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2U1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.692
CLV_C14_Caspase3-7	342	346	PF00656	0.572
CLV_C14_Caspase3-7	486	490	PF00656	0.622
CLV_NRD_NRD_1	104	106	PF00675	0.634
CLV_NRD_NRD_1	134	136	PF00675	0.627
CLV_NRD_NRD_1	294	296	PF00675	0.585
CLV_NRD_NRD_1	524	526	PF00675	0.534
CLV_NRD_NRD_1	578	580	PF00675	0.675
CLV_NRD_NRD_1	582	584	PF00675	0.648
CLV_NRD_NRD_1	592	594	PF00675	0.537
CLV_NRD_NRD_1	619	621	PF00675	0.647
CLV_NRD_NRD_1	638	640	PF00675	0.515
CLV_NRD_NRD_1	668	670	PF00675	0.663
CLV_NRD_NRD_1	688	690	PF00675	0.429
CLV_NRD_NRD_1	810	812	PF00675	0.460
CLV_PCSK_KEX2_1	104	106	PF00082	0.612
CLV_PCSK_KEX2_1	122	124	PF00082	0.409
CLV_PCSK_KEX2_1	157	159	PF00082	0.565
CLV_PCSK_KEX2_1	192	194	PF00082	0.615
CLV_PCSK_KEX2_1	294	296	PF00082	0.608
CLV_PCSK_KEX2_1	498	500	PF00082	0.627
CLV_PCSK_KEX2_1	524	526	PF00082	0.515
CLV_PCSK_KEX2_1	582	584	PF00082	0.669
CLV_PCSK_KEX2_1	618	620	PF00082	0.609
CLV_PCSK_KEX2_1	667	669	PF00082	0.693
CLV_PCSK_KEX2_1	688	690	PF00082	0.637
CLV_PCSK_KEX2_1	810	812	PF00082	0.460
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.637
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.573
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.615
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.627
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.603
CLV_PCSK_PC7_1	663	669	PF00082	0.693
CLV_PCSK_SKI1_1	11	15	PF00082	0.571
CLV_PCSK_SKI1_1	167	171	PF00082	0.611
CLV_PCSK_SKI1_1	228	232	PF00082	0.596
CLV_PCSK_SKI1_1	32	36	PF00082	0.505
CLV_PCSK_SKI1_1	524	528	PF00082	0.560
CLV_PCSK_SKI1_1	583	587	PF00082	0.667
CLV_PCSK_SKI1_1	713	717	PF00082	0.496
CLV_PCSK_SKI1_1	726	730	PF00082	0.386
CLV_Separin_Metazoa	460	464	PF03568	0.545
CLV_Separin_Metazoa	504	508	PF03568	0.562
DEG_ODPH_VHL_1	4	17	PF01847	0.413
DOC_CKS1_1	308	313	PF01111	0.584
DOC_CYCLIN_RxL_1	347	355	PF00134	0.362
DOC_CYCLIN_RxL_1	422	432	PF00134	0.528
DOC_CYCLIN_RxL_1	504	515	PF00134	0.595
DOC_MAPK_gen_1	252	260	PF00069	0.574
DOC_MAPK_gen_1	729	738	PF00069	0.555
DOC_MAPK_gen_1	807	817	PF00069	0.452
DOC_MAPK_MEF2A_6	810	819	PF00069	0.419
DOC_PP1_RVXF_1	505	512	PF00149	0.573
DOC_PP4_FxxP_1	766	769	PF00568	0.466
DOC_USP7_MATH_1	289	293	PF00917	0.633
DOC_USP7_MATH_1	317	321	PF00917	0.721
DOC_USP7_MATH_1	380	384	PF00917	0.638
DOC_USP7_MATH_1	512	516	PF00917	0.572
DOC_USP7_MATH_1	6	10	PF00917	0.464
DOC_USP7_MATH_1	662	666	PF00917	0.694
DOC_USP7_UBL2_3	236	240	PF12436	0.603
DOC_USP7_UBL2_3	452	456	PF12436	0.594
DOC_USP7_UBL2_3	591	595	PF12436	0.572
DOC_USP7_UBL2_3	67	71	PF12436	0.646
DOC_USP7_UBL2_3	729	733	PF12436	0.407
DOC_USP7_UBL2_3	83	87	PF12436	0.612
DOC_WW_Pin1_4	307	312	PF00397	0.726
DOC_WW_Pin1_4	644	649	PF00397	0.737
DOC_WW_Pin1_4	651	656	PF00397	0.561
DOC_WW_Pin1_4	658	663	PF00397	0.668
DOC_WW_Pin1_4	667	672	PF00397	0.582
DOC_WW_Pin1_4	800	805	PF00397	0.501
DOC_WW_Pin1_4	850	855	PF00397	0.448
LIG_14-3-3_CanoR_1	295	305	PF00244	0.676
LIG_14-3-3_CanoR_1	379	388	PF00244	0.696
LIG_14-3-3_CanoR_1	395	402	PF00244	0.723
LIG_14-3-3_CanoR_1	546	552	PF00244	0.592
LIG_14-3-3_CanoR_1	582	592	PF00244	0.648
LIG_14-3-3_CanoR_1	649	657	PF00244	0.784
LIG_14-3-3_CanoR_1	713	718	PF00244	0.616
LIG_14-3-3_CanoR_1	96	106	PF00244	0.533
LIG_Actin_WH2_2	152	169	PF00022	0.582
LIG_Actin_WH2_2	216	233	PF00022	0.560
LIG_Actin_WH2_2	355	373	PF00022	0.627
LIG_Actin_WH2_2	422	439	PF00022	0.575
LIG_Actin_WH2_2	454	471	PF00022	0.574
LIG_Actin_WH2_2	672	690	PF00022	0.538
LIG_Actin_WH2_2	695	712	PF00022	0.530
LIG_Actin_WH2_2	82	98	PF00022	0.581
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_BIR_III_4	573	577	PF00653	0.596
LIG_BRCT_BRCA1_1	772	776	PF00533	0.544
LIG_FHA_1	146	152	PF00498	0.539
LIG_FHA_1	313	319	PF00498	0.708
LIG_FHA_1	630	636	PF00498	0.671
LIG_FHA_1	682	688	PF00498	0.636
LIG_FHA_1	704	710	PF00498	0.486
LIG_FHA_1	760	766	PF00498	0.390
LIG_FHA_2	227	233	PF00498	0.643
LIG_FHA_2	245	251	PF00498	0.505
LIG_FHA_2	481	487	PF00498	0.602
LIG_FHA_2	624	630	PF00498	0.628
LIG_FHA_2	699	705	PF00498	0.370
LIG_FHA_2	829	835	PF00498	0.523
LIG_FHA_2	98	104	PF00498	0.617
LIG_Integrin_isoDGR_2	711	713	PF01839	0.553
LIG_LIR_Nem_3	141	145	PF02991	0.545
LIG_LIR_Nem_3	746	752	PF02991	0.398
LIG_LIR_Nem_3	787	792	PF02991	0.447
LIG_PCNA_yPIPBox_3	177	188	PF02747	0.572
LIG_Pex14_1	326	330	PF04695	0.608
LIG_Pex14_2	745	749	PF04695	0.388
LIG_SH2_CRK	789	793	PF00017	0.496
LIG_SH2_GRB2like	528	531	PF00017	0.587
LIG_SH2_NCK_1	330	334	PF00017	0.627
LIG_SH2_SRC	528	531	PF00017	0.587
LIG_SH2_STAP1	454	458	PF00017	0.509
LIG_SH2_STAT3	454	457	PF00017	0.591
LIG_SH2_STAT3	752	755	PF00017	0.406
LIG_SH2_STAT5	752	755	PF00017	0.408
LIG_SH3_3	385	391	PF00018	0.739
LIG_SH3_3	642	648	PF00018	0.797
LIG_SH3_3	798	804	PF00018	0.530
LIG_SUMO_SIM_par_1	350	355	PF11976	0.636
LIG_SUMO_SIM_par_1	425	430	PF11976	0.518
LIG_SUMO_SIM_par_1	701	707	PF11976	0.424
LIG_TRAF2_1	322	325	PF00917	0.518
LIG_TRAF2_1	438	441	PF00917	0.527
LIG_TRAF2_1	501	504	PF00917	0.576
LIG_TRAF2_1	831	834	PF00917	0.617
LIG_UBA3_1	272	277	PF00899	0.603
LIG_UBA3_1	722	729	PF00899	0.446
LIG_UBA3_1	78	83	PF00899	0.641
MOD_CDK_SPK_2	644	649	PF00069	0.788
MOD_CDK_SPK_2	651	656	PF00069	0.584
MOD_CDK_SPK_2	658	663	PF00069	0.678
MOD_CDK_SPxxK_3	312	319	PF00069	0.679
MOD_CDK_SPxxK_3	800	807	PF00069	0.511
MOD_CK1_1	261	267	PF00069	0.640
MOD_CK1_1	306	312	PF00069	0.786
MOD_CK1_1	334	340	PF00069	0.402
MOD_CK1_1	393	399	PF00069	0.689
MOD_CK1_1	401	407	PF00069	0.734
MOD_CK1_1	651	657	PF00069	0.708
MOD_CK1_1	677	683	PF00069	0.644
MOD_CK1_1	784	790	PF00069	0.466
MOD_CK1_1	803	809	PF00069	0.573
MOD_CK2_1	107	113	PF00069	0.598
MOD_CK2_1	126	132	PF00069	0.375
MOD_CK2_1	15	21	PF00069	0.617
MOD_CK2_1	165	171	PF00069	0.618
MOD_CK2_1	226	232	PF00069	0.642
MOD_CK2_1	244	250	PF00069	0.469
MOD_CK2_1	393	399	PF00069	0.668
MOD_CK2_1	435	441	PF00069	0.596
MOD_CK2_1	498	504	PF00069	0.589
MOD_CK2_1	512	518	PF00069	0.431
MOD_CK2_1	549	555	PF00069	0.589
MOD_CK2_1	680	686	PF00069	0.712
MOD_CK2_1	698	704	PF00069	0.250
MOD_CK2_1	724	730	PF00069	0.425
MOD_CK2_1	828	834	PF00069	0.534
MOD_CK2_1	95	101	PF00069	0.586
MOD_GlcNHglycan	108	112	PF01048	0.548
MOD_GlcNHglycan	167	170	PF01048	0.612
MOD_GlcNHglycan	260	263	PF01048	0.649
MOD_GlcNHglycan	298	301	PF01048	0.738
MOD_GlcNHglycan	319	322	PF01048	0.622
MOD_GlcNHglycan	437	440	PF01048	0.640
MOD_GlcNHglycan	664	667	PF01048	0.697
MOD_GlcNHglycan	689	692	PF01048	0.680
MOD_GSK3_1	240	247	PF00069	0.550
MOD_GSK3_1	303	310	PF00069	0.750
MOD_GSK3_1	389	396	PF00069	0.722
MOD_GSK3_1	549	556	PF00069	0.589
MOD_GSK3_1	640	647	PF00069	0.720
MOD_GSK3_1	658	665	PF00069	0.686
MOD_GSK3_1	667	674	PF00069	0.672
MOD_GSK3_1	677	684	PF00069	0.555
MOD_GSK3_1	824	831	PF00069	0.609
MOD_NEK2_1	145	150	PF00069	0.548
MOD_NEK2_1	226	231	PF00069	0.620
MOD_NEK2_1	258	263	PF00069	0.624
MOD_NEK2_1	547	552	PF00069	0.554
MOD_NEK2_1	687	692	PF00069	0.661
MOD_NEK2_1	698	703	PF00069	0.375
MOD_NEK2_1	738	743	PF00069	0.436
MOD_NEK2_1	745	750	PF00069	0.371
MOD_NEK2_1	824	829	PF00069	0.563
MOD_NEK2_1	95	100	PF00069	0.545
MOD_NEK2_2	6	11	PF00069	0.461
MOD_NEK2_2	732	737	PF00069	0.409
MOD_PIKK_1	380	386	PF00454	0.640
MOD_PIKK_1	640	646	PF00454	0.720
MOD_PIKK_1	828	834	PF00454	0.543
MOD_PK_1	329	335	PF00069	0.631
MOD_PK_1	390	396	PF00069	0.732
MOD_PK_1	498	504	PF00069	0.614
MOD_PK_1	724	730	PF00069	0.425
MOD_PKA_1	294	300	PF00069	0.631
MOD_PKA_1	498	504	PF00069	0.614
MOD_PKA_2	113	119	PF00069	0.402
MOD_PKA_2	294	300	PF00069	0.641
MOD_PKA_2	378	384	PF00069	0.658
MOD_PKA_2	389	395	PF00069	0.733
MOD_PKA_2	404	410	PF00069	0.682
MOD_PKA_2	492	498	PF00069	0.599
MOD_PKA_2	648	654	PF00069	0.679
MOD_PKA_2	662	668	PF00069	0.639
MOD_PKA_2	681	687	PF00069	0.530
MOD_PKA_2	95	101	PF00069	0.542
MOD_PKB_1	105	113	PF00069	0.553
MOD_Plk_1	162	168	PF00069	0.606
MOD_Plk_1	226	232	PF00069	0.552
MOD_Plk_1	240	246	PF00069	0.495
MOD_Plk_1	398	404	PF00069	0.699
MOD_Plk_1	469	475	PF00069	0.667
MOD_Plk_1	671	677	PF00069	0.720
MOD_Plk_1	745	751	PF00069	0.400
MOD_Plk_2-3	113	119	PF00069	0.588
MOD_Plk_2-3	126	132	PF00069	0.464
MOD_Plk_4	240	246	PF00069	0.550
MOD_Plk_4	303	309	PF00069	0.791
MOD_Plk_4	480	486	PF00069	0.724
MOD_Plk_4	738	744	PF00069	0.407
MOD_Plk_4	745	751	PF00069	0.371
MOD_Plk_4	784	790	PF00069	0.433
MOD_Plk_4	824	830	PF00069	0.525
MOD_ProDKin_1	307	313	PF00069	0.727
MOD_ProDKin_1	644	650	PF00069	0.740
MOD_ProDKin_1	651	657	PF00069	0.558
MOD_ProDKin_1	658	664	PF00069	0.662
MOD_ProDKin_1	667	673	PF00069	0.580
MOD_ProDKin_1	800	806	PF00069	0.504
MOD_ProDKin_1	850	856	PF00069	0.446
MOD_SUMO_for_1	219	222	PF00179	0.631
MOD_SUMO_for_1	602	605	PF00179	0.574
MOD_SUMO_rev_2	137	145	PF00179	0.591
MOD_SUMO_rev_2	33	41	PF00179	0.503
MOD_SUMO_rev_2	353	363	PF00179	0.616
MOD_SUMO_rev_2	438	445	PF00179	0.599
MOD_SUMO_rev_2	550	558	PF00179	0.643
MOD_SUMO_rev_2	833	840	PF00179	0.392
TRG_DiLeu_BaEn_1	353	358	PF01217	0.579
TRG_DiLeu_BaEn_1	504	509	PF01217	0.600
TRG_DiLeu_BaEn_1	84	89	PF01217	0.495
TRG_DiLeu_BaEn_3	837	843	PF01217	0.360
TRG_DiLeu_BaEn_4	221	227	PF01217	0.546
TRG_DiLeu_LyEn_5	504	509	PF01217	0.600
TRG_ENDOCYTIC_2	142	145	PF00928	0.543
TRG_ENDOCYTIC_2	330	333	PF00928	0.598
TRG_ENDOCYTIC_2	789	792	PF00928	0.490
TRG_ER_diArg_1	104	107	PF00400	0.551
TRG_ER_diArg_1	251	254	PF00400	0.439
TRG_ER_diArg_1	422	425	PF00400	0.573
TRG_ER_diArg_1	523	525	PF00400	0.546
TRG_ER_diArg_1	619	621	PF00400	0.657
TRG_ER_diArg_1	667	669	PF00400	0.733
TRG_ER_diArg_1	687	689	PF00400	0.434
TRG_ER_diArg_1	793	796	PF00400	0.445
TRG_NLS_Bipartite_1	579	597	PF00514	0.559
TRG_NLS_MonoExtC_3	578	583	PF00514	0.671
TRG_NLS_MonoExtC_3	592	598	PF00514	0.562
TRG_NLS_MonoExtN_4	591	597	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	790	795	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I241	Leptomonas seymouri	57%	100%
A0A1X0P9P4	Trypanosomatidae	35%	95%
A0A3Q8IEG3	Leishmania donovani	93%	100%
A0A3R7KUQ1	Trypanosoma rangeli	35%	93%
A4HAX2	Leishmania braziliensis	80%	100%
A4IA30	Leishmania infantum	93%	100%
C9ZMJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
E9B545	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B4V3	Trypanosoma cruzi	34%	93%