Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2U0_LEIMA

TriTrypDb:

LmjF.34.2550 , LMJLV39_340030800 , LMJSD75_340030800

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2U0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.578
CLV_C14_Caspase3-7	396	400	PF00656	0.807
CLV_C14_Caspase3-7	57	61	PF00656	0.444
CLV_C14_Caspase3-7	79	83	PF00656	0.587
CLV_NRD_NRD_1	101	103	PF00675	0.585
CLV_NRD_NRD_1	243	245	PF00675	0.478
CLV_NRD_NRD_1	28	30	PF00675	0.432
CLV_NRD_NRD_1	372	374	PF00675	0.709
CLV_NRD_NRD_1	418	420	PF00675	0.750
CLV_PCSK_FUR_1	241	245	PF00082	0.478
CLV_PCSK_KEX2_1	101	103	PF00082	0.496
CLV_PCSK_KEX2_1	243	245	PF00082	0.478
CLV_PCSK_KEX2_1	28	30	PF00082	0.390
CLV_PCSK_KEX2_1	372	374	PF00082	0.709
CLV_PCSK_KEX2_1	93	95	PF00082	0.572
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.506
CLV_PCSK_SKI1_1	205	209	PF00082	0.530
CLV_PCSK_SKI1_1	35	39	PF00082	0.534
CLV_PCSK_SKI1_1	412	416	PF00082	0.836
CLV_PCSK_SKI1_1	435	439	PF00082	0.592
CLV_PCSK_SKI1_1	50	54	PF00082	0.373
CLV_PCSK_SKI1_1	519	523	PF00082	0.493
CLV_PCSK_SKI1_1	545	549	PF00082	0.653
CLV_PCSK_SKI1_1	93	97	PF00082	0.571
DEG_APCC_DBOX_1	292	300	PF00400	0.592
DEG_APCC_DBOX_1	49	57	PF00400	0.522
DEG_Kelch_Keap1_1	458	463	PF01344	0.600
DEG_Nend_UBRbox_3	1	3	PF02207	0.534
DEG_SPOP_SBC_1	436	440	PF00917	0.655
DOC_CYCLIN_RxL_1	516	526	PF00134	0.490
DOC_MAPK_gen_1	150	160	PF00069	0.508
DOC_MAPK_gen_1	28	36	PF00069	0.425
DOC_MAPK_MEF2A_6	153	162	PF00069	0.511
DOC_MAPK_MEF2A_6	29	38	PF00069	0.443
DOC_MIT_MIM_1	65	74	PF04212	0.534
DOC_PP1_RVXF_1	92	99	PF00149	0.487
DOC_USP7_MATH_1	118	122	PF00917	0.519
DOC_USP7_MATH_1	136	140	PF00917	0.416
DOC_USP7_MATH_1	374	378	PF00917	0.733
DOC_USP7_MATH_1	392	396	PF00917	0.567
DOC_USP7_MATH_1	425	429	PF00917	0.626
DOC_USP7_MATH_1	473	477	PF00917	0.768
DOC_USP7_MATH_1	48	52	PF00917	0.518
DOC_USP7_MATH_1	61	65	PF00917	0.306
DOC_USP7_UBL2_3	487	491	PF12436	0.659
DOC_WW_Pin1_4	326	331	PF00397	0.634
DOC_WW_Pin1_4	342	347	PF00397	0.682
DOC_WW_Pin1_4	351	356	PF00397	0.646
DOC_WW_Pin1_4	421	426	PF00397	0.591
LIG_14-3-3_CanoR_1	243	248	PF00244	0.445
LIG_14-3-3_CanoR_1	323	328	PF00244	0.796
LIG_14-3-3_CanoR_1	340	347	PF00244	0.570
LIG_14-3-3_CanoR_1	47	53	PF00244	0.492
LIG_14-3-3_CanoR_1	551	556	PF00244	0.556
LIG_14-3-3_CanoR_1	69	74	PF00244	0.446
LIG_Actin_WH2_2	59	76	PF00022	0.378
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.440
LIG_FHA_1	261	267	PF00498	0.465
LIG_FHA_1	3	9	PF00498	0.620
LIG_FHA_1	31	37	PF00498	0.441
LIG_FHA_1	396	402	PF00498	0.654
LIG_FHA_1	406	412	PF00498	0.699
LIG_FHA_1	442	448	PF00498	0.675
LIG_FHA_2	142	148	PF00498	0.585
LIG_FHA_2	453	459	PF00498	0.735
LIG_FHA_2	522	528	PF00498	0.658
LIG_LIR_Apic_2	42	48	PF02991	0.520
LIG_LIR_Gen_1	108	118	PF02991	0.369
LIG_LIR_Gen_1	173	183	PF02991	0.514
LIG_LIR_Gen_1	187	198	PF02991	0.335
LIG_LIR_Gen_1	502	511	PF02991	0.482
LIG_LIR_Gen_1	67	78	PF02991	0.412
LIG_LIR_Nem_3	108	114	PF02991	0.450
LIG_LIR_Nem_3	173	178	PF02991	0.505
LIG_LIR_Nem_3	187	193	PF02991	0.335
LIG_LIR_Nem_3	208	213	PF02991	0.532
LIG_LIR_Nem_3	502	507	PF02991	0.484
LIG_LIR_Nem_3	67	73	PF02991	0.436
LIG_Pex14_1	206	210	PF04695	0.521
LIG_PTAP_UEV_1	469	474	PF05743	0.611
LIG_Rb_LxCxE_1	495	516	PF01857	0.647
LIG_SH2_CRK	11	15	PF00017	0.601
LIG_SH2_CRK	190	194	PF00017	0.407
LIG_SH2_GRB2like	511	514	PF00017	0.660
LIG_SH2_NCK_1	175	179	PF00017	0.533
LIG_SH2_NCK_1	190	194	PF00017	0.332
LIG_SH2_STAP1	511	515	PF00017	0.505
LIG_SH2_STAT5	182	185	PF00017	0.446
LIG_SH2_STAT5	273	276	PF00017	0.562
LIG_SH2_STAT5	288	291	PF00017	0.444
LIG_SH2_STAT5	600	603	PF00017	0.679
LIG_SH3_3	368	374	PF00018	0.782
LIG_SH3_3	467	473	PF00018	0.770
LIG_TRAF2_1	177	180	PF00917	0.491
LIG_TRAF2_1	18	21	PF00917	0.629
LIG_TRAF2_1	298	301	PF00917	0.602
LIG_TRAF2_1	524	527	PF00917	0.656
LIG_TYR_ITIM	188	193	PF00017	0.418
MOD_CDK_SPK_2	326	331	PF00069	0.586
MOD_CDK_SPK_2	351	356	PF00069	0.716
MOD_CK1_1	139	145	PF00069	0.488
MOD_CK1_1	184	190	PF00069	0.461
MOD_CK1_1	191	197	PF00069	0.433
MOD_CK1_1	232	238	PF00069	0.565
MOD_CK1_1	359	365	PF00069	0.647
MOD_CK1_1	395	401	PF00069	0.750
MOD_CK1_1	424	430	PF00069	0.750
MOD_CK1_1	450	456	PF00069	0.726
MOD_CK1_1	464	470	PF00069	0.506
MOD_CK1_1	471	477	PF00069	0.619
MOD_CK1_1	72	78	PF00069	0.636
MOD_CK2_1	151	157	PF00069	0.411
MOD_CK2_1	174	180	PF00069	0.436
MOD_CK2_1	232	238	PF00069	0.463
MOD_CK2_1	295	301	PF00069	0.607
MOD_CK2_1	332	338	PF00069	0.639
MOD_CK2_1	397	403	PF00069	0.798
MOD_CK2_1	521	527	PF00069	0.666
MOD_CK2_1	61	67	PF00069	0.506
MOD_CK2_1	73	79	PF00069	0.548
MOD_GlcNHglycan	120	123	PF01048	0.441
MOD_GlcNHglycan	124	127	PF01048	0.418
MOD_GlcNHglycan	153	156	PF01048	0.512
MOD_GlcNHglycan	238	241	PF01048	0.453
MOD_GlcNHglycan	358	361	PF01048	0.655
MOD_GlcNHglycan	366	369	PF01048	0.651
MOD_GlcNHglycan	421	424	PF01048	0.695
MOD_GlcNHglycan	427	430	PF01048	0.695
MOD_GlcNHglycan	469	473	PF01048	0.663
MOD_GlcNHglycan	475	478	PF01048	0.653
MOD_GlcNHglycan	564	567	PF01048	0.689
MOD_GlcNHglycan	586	589	PF01048	0.732
MOD_GSK3_1	118	125	PF00069	0.600
MOD_GSK3_1	136	143	PF00069	0.334
MOD_GSK3_1	170	177	PF00069	0.537
MOD_GSK3_1	184	191	PF00069	0.441
MOD_GSK3_1	229	236	PF00069	0.581
MOD_GSK3_1	258	265	PF00069	0.612
MOD_GSK3_1	277	284	PF00069	0.496
MOD_GSK3_1	322	329	PF00069	0.748
MOD_GSK3_1	347	354	PF00069	0.760
MOD_GSK3_1	393	400	PF00069	0.732
MOD_GSK3_1	415	422	PF00069	0.686
MOD_GSK3_1	431	438	PF00069	0.669
MOD_GSK3_1	447	454	PF00069	0.633
MOD_GSK3_1	464	471	PF00069	0.794
MOD_GSK3_1	511	518	PF00069	0.507
MOD_GSK3_1	69	76	PF00069	0.465
MOD_N-GLC_1	573	578	PF02516	0.735
MOD_NEK2_1	140	145	PF00069	0.445
MOD_NEK2_1	151	156	PF00069	0.428
MOD_NEK2_1	170	175	PF00069	0.443
MOD_NEK2_1	183	188	PF00069	0.421
MOD_NEK2_1	303	308	PF00069	0.586
MOD_NEK2_1	397	402	PF00069	0.594
MOD_NEK2_1	437	442	PF00069	0.640
MOD_NEK2_1	451	456	PF00069	0.619
MOD_NEK2_1	561	566	PF00069	0.563
MOD_NEK2_1	581	586	PF00069	0.636
MOD_NEK2_1	73	78	PF00069	0.667
MOD_PIKK_1	112	118	PF00454	0.605
MOD_PIKK_1	191	197	PF00454	0.546
MOD_PIKK_1	260	266	PF00454	0.462
MOD_PIKK_1	452	458	PF00454	0.696
MOD_PKA_1	243	249	PF00069	0.472
MOD_PKA_1	419	425	PF00069	0.724
MOD_PKA_2	118	124	PF00069	0.418
MOD_PKA_2	242	248	PF00069	0.469
MOD_PKA_2	322	328	PF00069	0.737
MOD_PKA_2	339	345	PF00069	0.573
MOD_PKA_2	458	464	PF00069	0.710
MOD_PKA_2	73	79	PF00069	0.438
MOD_PKB_1	241	249	PF00069	0.474
MOD_Plk_1	170	176	PF00069	0.528
MOD_Plk_1	178	184	PF00069	0.433
MOD_Plk_1	332	338	PF00069	0.735
MOD_Plk_1	405	411	PF00069	0.638
MOD_Plk_1	602	608	PF00069	0.681
MOD_Plk_2-3	220	226	PF00069	0.413
MOD_Plk_4	136	142	PF00069	0.620
MOD_Plk_4	178	184	PF00069	0.517
MOD_Plk_4	303	309	PF00069	0.535
MOD_Plk_4	361	367	PF00069	0.613
MOD_Plk_4	493	499	PF00069	0.637
MOD_ProDKin_1	326	332	PF00069	0.633
MOD_ProDKin_1	342	348	PF00069	0.683
MOD_ProDKin_1	351	357	PF00069	0.643
MOD_ProDKin_1	421	427	PF00069	0.591
MOD_SUMO_for_1	355	358	PF00179	0.664
MOD_SUMO_rev_2	502	512	PF00179	0.506
TRG_AP2beta_CARGO_1	67	77	PF09066	0.404
TRG_DiLeu_BaEn_4	20	26	PF01217	0.590
TRG_DiLeu_BaEn_4	502	508	PF01217	0.649
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.490
TRG_ENDOCYTIC_2	175	178	PF00928	0.419
TRG_ENDOCYTIC_2	190	193	PF00928	0.438
TRG_ENDOCYTIC_2	504	507	PF00928	0.502
TRG_ER_diArg_1	100	102	PF00400	0.590
TRG_ER_diArg_1	27	29	PF00400	0.387
TRG_ER_diArg_1	371	373	PF00400	0.745
TRG_NLS_MonoExtN_4	85	91	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ7	Leptomonas seymouri	44%	99%
A0A3Q8IIM3	Leishmania donovani	86%	100%
A4HBI7	Leishmania braziliensis	66%	100%
A4IA31	Leishmania infantum	86%	100%
E9B546	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%