Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 8

Species:

Leishmania major

UniProt:

Q4Q2T8_LEIMA

TriTrypDb:

LmjF.34.2570 , LMJLV39_340031100 , LMJSD75_340031200

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.525
CLV_NRD_NRD_1	130	132	PF00675	0.572
CLV_NRD_NRD_1	144	146	PF00675	0.419
CLV_NRD_NRD_1	303	305	PF00675	0.570
CLV_PCSK_KEX2_1	303	305	PF00082	0.545
CLV_PCSK_SKI1_1	146	150	PF00082	0.496
CLV_PCSK_SKI1_1	181	185	PF00082	0.618
CLV_PCSK_SKI1_1	303	307	PF00082	0.650
CLV_PCSK_SKI1_1	367	371	PF00082	0.467
CLV_PCSK_SKI1_1	453	457	PF00082	0.500
DEG_APCC_DBOX_1	452	460	PF00400	0.573
DEG_APCC_KENBOX_2	320	324	PF00400	0.606
DOC_CYCLIN_RxL_1	450	458	PF00134	0.523
DOC_MAPK_gen_1	131	140	PF00069	0.632
DOC_MAPK_gen_1	69	77	PF00069	0.593
DOC_MAPK_MEF2A_6	16	24	PF00069	0.491
DOC_MAPK_MEF2A_6	419	428	PF00069	0.452
DOC_PP1_RVXF_1	391	397	PF00149	0.482
DOC_PP2B_LxvP_1	3	6	PF13499	0.578
DOC_USP7_MATH_1	216	220	PF00917	0.740
DOC_USP7_MATH_1	361	365	PF00917	0.587
DOC_USP7_MATH_1	412	416	PF00917	0.462
DOC_USP7_MATH_1	417	421	PF00917	0.419
DOC_WW_Pin1_4	212	217	PF00397	0.710
LIG_14-3-3_CanoR_1	328	338	PF00244	0.570
LIG_14-3-3_CanoR_1	381	385	PF00244	0.477
LIG_BIR_II_1	1	5	PF00653	0.322
LIG_BIR_III_3	1	5	PF00653	0.322
LIG_CaM_IQ_9	171	186	PF13499	0.517
LIG_FHA_1	21	27	PF00498	0.475
LIG_FHA_1	284	290	PF00498	0.580
LIG_FHA_1	329	335	PF00498	0.579
LIG_FHA_2	25	31	PF00498	0.613
LIG_FHA_2	330	336	PF00498	0.468
LIG_FHA_2	355	361	PF00498	0.571
LIG_FXI_DFP_1	220	224	PF00024	0.517
LIG_Integrin_RGD_1	88	90	PF01839	0.637
LIG_LIR_Gen_1	19	26	PF02991	0.461
LIG_LIR_Gen_1	226	236	PF02991	0.522
LIG_LIR_Nem_3	19	24	PF02991	0.466
LIG_LIR_Nem_3	226	232	PF02991	0.527
LIG_LIR_Nem_3	349	355	PF02991	0.468
LIG_LIR_Nem_3	48	53	PF02991	0.631
LIG_NRBOX	259	265	PF00104	0.635
LIG_PCNA_PIPBox_1	14	23	PF02747	0.608
LIG_PCNA_yPIPBox_3	184	198	PF02747	0.608
LIG_PCNA_yPIPBox_3	442	456	PF02747	0.373
LIG_PDZ_Class_1	476	481	PF00595	0.631
LIG_Pex14_2	46	50	PF04695	0.620
LIG_SH2_GRB2like	278	281	PF00017	0.492
LIG_SH2_STAP1	278	282	PF00017	0.505
LIG_SH2_STAP1	330	334	PF00017	0.462
LIG_SH2_STAT5	197	200	PF00017	0.596
LIG_SH2_STAT5	21	24	PF00017	0.475
LIG_SH2_STAT5	330	333	PF00017	0.561
LIG_SH2_STAT5	355	358	PF00017	0.569
LIG_SUMO_SIM_par_1	337	343	PF11976	0.590
LIG_TRAF2_1	104	107	PF00917	0.595
LIG_TRAF2_1	33	36	PF00917	0.638
LIG_UBA3_1	120	126	PF00899	0.582
LIG_UBA3_1	169	178	PF00899	0.533
LIG_UBA3_1	198	203	PF00899	0.627
LIG_WRC_WIRS_1	21	26	PF05994	0.471
MOD_CDK_SPK_2	212	217	PF00069	0.734
MOD_CK1_1	377	383	PF00069	0.538
MOD_CK2_1	24	30	PF00069	0.596
MOD_CK2_1	312	318	PF00069	0.587
MOD_CK2_1	329	335	PF00069	0.484
MOD_CK2_1	354	360	PF00069	0.467
MOD_CK2_1	412	418	PF00069	0.598
MOD_GlcNHglycan	160	164	PF01048	0.550
MOD_GlcNHglycan	212	215	PF01048	0.685
MOD_GlcNHglycan	420	423	PF01048	0.501
MOD_GSK3_1	16	23	PF00069	0.500
MOD_GSK3_1	201	208	PF00069	0.551
MOD_GSK3_1	212	219	PF00069	0.626
MOD_GSK3_1	288	295	PF00069	0.589
MOD_GSK3_1	380	387	PF00069	0.495
MOD_N-GLC_1	210	215	PF02516	0.760
MOD_N-GLC_1	322	327	PF02516	0.502
MOD_NEK2_1	20	25	PF00069	0.482
MOD_NEK2_1	337	342	PF00069	0.568
MOD_NEK2_1	384	389	PF00069	0.523
MOD_NEK2_1	430	435	PF00069	0.431
MOD_NEK2_1	455	460	PF00069	0.471
MOD_PIKK_1	133	139	PF00454	0.609
MOD_PIKK_1	201	207	PF00454	0.616
MOD_PIKK_1	243	249	PF00454	0.507
MOD_PIKK_1	283	289	PF00454	0.611
MOD_PIKK_1	30	36	PF00454	0.643
MOD_PK_1	385	391	PF00069	0.587
MOD_PKA_2	216	222	PF00069	0.735
MOD_PKA_2	258	264	PF00069	0.502
MOD_PKA_2	292	298	PF00069	0.541
MOD_PKA_2	312	318	PF00069	0.381
MOD_PKA_2	380	386	PF00069	0.490
MOD_Plk_1	116	122	PF00069	0.622
MOD_Plk_1	322	328	PF00069	0.491
MOD_Plk_2-3	274	280	PF00069	0.613
MOD_Plk_4	116	122	PF00069	0.558
MOD_Plk_4	16	22	PF00069	0.489
MOD_Plk_4	216	222	PF00069	0.735
MOD_Plk_4	322	328	PF00069	0.482
MOD_ProDKin_1	212	218	PF00069	0.712
MOD_SUMO_for_1	152	155	PF00179	0.531
MOD_SUMO_rev_2	142	148	PF00179	0.491
MOD_SUMO_rev_2	291	298	PF00179	0.574
MOD_SUMO_rev_2	372	380	PF00179	0.611
MOD_SUMO_rev_2	87	95	PF00179	0.592
TRG_DiLeu_BaEn_1	144	149	PF01217	0.622
TRG_DiLeu_BaEn_1	228	233	PF01217	0.513
TRG_ENDOCYTIC_2	21	24	PF00928	0.459
TRG_ER_diArg_1	206	209	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P612	Leptomonas seymouri	74%	85%
A0A1X0P9R7	Trypanosomatidae	48%	83%
A0A3S7X860	Leishmania donovani	97%	86%
A0A422N8F5	Trypanosoma rangeli	48%	83%
A4HAX4	Leishmania braziliensis	86%	86%
A4IA33	Leishmania infantum	97%	86%
C9ZMJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	82%
E9B548	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	86%
V5BUY7	Trypanosoma cruzi	48%	83%