Putative adaptor complex subunit medium chain 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AP-3 complex subunit mu, putative

Species:

Leishmania major

UniProt:

Q4Q2T6_LEIMA

TriTrypDb:

LmjF.34.2590 , LMJLV39_340031300 , LMJSD75_340031400

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	12
GO:0030131	clathrin adaptor complex	4	12
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098796	membrane protein complex	2	12
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2T6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.330
CLV_PCSK_SKI1_1	146	150	PF00082	0.493
CLV_PCSK_SKI1_1	26	30	PF00082	0.287
CLV_PCSK_SKI1_1	335	339	PF00082	0.396
CLV_PCSK_SKI1_1	452	456	PF00082	0.292
CLV_PCSK_SKI1_1	90	94	PF00082	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.329
DEG_SCF_FBW7_1	148	155	PF00400	0.457
DEG_SCF_FBW7_1	293	298	PF00400	0.292
DEG_SPOP_SBC_1	340	344	PF00917	0.339
DOC_CKS1_1	149	154	PF01111	0.634
DOC_CKS1_1	292	297	PF01111	0.292
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	337	340	PF00134	0.411
DOC_MAPK_gen_1	325	334	PF00069	0.411
DOC_MAPK_HePTP_8	223	235	PF00069	0.253
DOC_MAPK_MEF2A_6	226	235	PF00069	0.253
DOC_MAPK_MEF2A_6	327	336	PF00069	0.307
DOC_PP1_RVXF_1	260	267	PF00149	0.276
DOC_PP2B_LxvP_1	284	287	PF13499	0.301
DOC_PP2B_LxvP_1	336	339	PF13499	0.276
DOC_PP4_FxxP_1	266	269	PF00568	0.292
DOC_PP4_FxxP_1	426	429	PF00568	0.276
DOC_USP7_MATH_1	152	156	PF00917	0.581
DOC_USP7_MATH_1	159	163	PF00917	0.608
DOC_USP7_MATH_1	340	344	PF00917	0.411
DOC_USP7_MATH_1	375	379	PF00917	0.368
DOC_USP7_MATH_1	401	405	PF00917	0.295
DOC_USP7_MATH_1	422	426	PF00917	0.330
DOC_USP7_UBL2_3	277	281	PF12436	0.394
DOC_WW_Pin1_4	148	153	PF00397	0.627
DOC_WW_Pin1_4	291	296	PF00397	0.300
DOC_WW_Pin1_4	373	378	PF00397	0.369
LIG_14-3-3_CanoR_1	171	177	PF00244	0.695
LIG_14-3-3_CanoR_1	331	335	PF00244	0.394
LIG_14-3-3_CanoR_1	359	365	PF00244	0.335
LIG_14-3-3_CanoR_1	408	416	PF00244	0.413
LIG_14-3-3_CanoR_1	431	437	PF00244	0.411
LIG_14-3-3_CanoR_1	90	96	PF00244	0.455
LIG_Actin_WH2_2	223	240	PF00022	0.405
LIG_BRCT_BRCA1_1	173	177	PF00533	0.621
LIG_BRCT_BRCA1_1	2	6	PF00533	0.305
LIG_Clathr_ClatBox_1	79	83	PF01394	0.364
LIG_FHA_1	124	130	PF00498	0.474
LIG_FHA_1	149	155	PF00498	0.636
LIG_FHA_1	189	195	PF00498	0.411
LIG_FHA_1	292	298	PF00498	0.279
LIG_FHA_1	340	346	PF00498	0.292
LIG_FHA_1	363	369	PF00498	0.292
LIG_FHA_1	374	380	PF00498	0.272
LIG_FHA_1	75	81	PF00498	0.427
LIG_FHA_1	91	97	PF00498	0.474
LIG_FHA_2	101	107	PF00498	0.373
LIG_FHA_2	145	151	PF00498	0.569
LIG_FHA_2	240	246	PF00498	0.250
LIG_FHA_2	353	359	PF00498	0.404
LIG_GBD_Chelix_1	198	206	PF00786	0.411
LIG_GBD_Chelix_1	88	96	PF00786	0.385
LIG_LIR_Apic_2	120	124	PF02991	0.498
LIG_LIR_Apic_2	263	269	PF02991	0.311
LIG_LIR_Apic_2	35	39	PF02991	0.390
LIG_LIR_Apic_2	425	429	PF02991	0.275
LIG_LIR_Gen_1	106	115	PF02991	0.362
LIG_LIR_Gen_1	193	204	PF02991	0.253
LIG_LIR_Gen_1	270	278	PF02991	0.276
LIG_LIR_Gen_1	56	66	PF02991	0.345
LIG_LIR_LC3C_4	76	81	PF02991	0.467
LIG_LIR_Nem_3	106	111	PF02991	0.372
LIG_LIR_Nem_3	174	180	PF02991	0.642
LIG_LIR_Nem_3	193	199	PF02991	0.259
LIG_LIR_Nem_3	30	36	PF02991	0.372
LIG_LIR_Nem_3	56	61	PF02991	0.333
LIG_LRP6_Inhibitor_1	99	105	PF00058	0.433
LIG_MLH1_MIPbox_1	173	177	PF16413	0.526
LIG_PCNA_yPIPBox_3	188	199	PF02747	0.411
LIG_Rb_pABgroove_1	113	121	PF01858	0.474
LIG_SH2_CRK	112	116	PF00017	0.430
LIG_SH2_CRK	121	125	PF00017	0.456
LIG_SH2_CRK	36	40	PF00017	0.409
LIG_SH2_CRK	451	455	PF00017	0.288
LIG_SH2_PTP2	292	295	PF00017	0.276
LIG_SH2_STAT3	456	459	PF00017	0.330
LIG_SH2_STAT5	204	207	PF00017	0.382
LIG_SH2_STAT5	278	281	PF00017	0.313
LIG_SH2_STAT5	292	295	PF00017	0.215
LIG_SH2_STAT5	456	459	PF00017	0.277
LIG_SH2_STAT5	463	466	PF00017	0.273
LIG_SH2_STAT5	95	98	PF00017	0.359
LIG_SH3_3	133	139	PF00018	0.398
LIG_SH3_3	284	290	PF00018	0.339
LIG_SUMO_SIM_anti_2	74	83	PF11976	0.413
LIG_SUMO_SIM_par_1	74	83	PF11976	0.385
LIG_TRAF2_1	131	134	PF00917	0.508
LIG_TRFH_1	383	387	PF08558	0.330
LIG_WW_1	289	292	PF00397	0.411
MOD_CK1_1	343	349	PF00069	0.371
MOD_CK1_1	351	357	PF00069	0.294
MOD_CK1_1	360	366	PF00069	0.190
MOD_CK1_1	74	80	PF00069	0.483
MOD_CK1_1	97	103	PF00069	0.391
MOD_CK2_1	100	106	PF00069	0.375
MOD_CK2_1	128	134	PF00069	0.528
MOD_CK2_1	24	30	PF00069	0.358
MOD_CK2_1	318	324	PF00069	0.411
MOD_CK2_1	389	395	PF00069	0.383
MOD_GlcNHglycan	227	230	PF01048	0.304
MOD_GlcNHglycan	351	354	PF01048	0.411
MOD_GlcNHglycan	373	376	PF01048	0.264
MOD_GlcNHglycan	391	395	PF01048	0.310
MOD_GlcNHglycan	405	408	PF01048	0.196
MOD_GlcNHglycan	459	462	PF01048	0.325
MOD_GSK3_1	124	131	PF00069	0.292
MOD_GSK3_1	144	151	PF00069	0.570
MOD_GSK3_1	167	174	PF00069	0.668
MOD_GSK3_1	184	191	PF00069	0.276
MOD_GSK3_1	276	283	PF00069	0.368
MOD_GSK3_1	291	298	PF00069	0.198
MOD_GSK3_1	339	346	PF00069	0.319
MOD_GSK3_1	348	355	PF00069	0.239
MOD_GSK3_1	360	367	PF00069	0.286
MOD_GSK3_1	369	376	PF00069	0.255
MOD_GSK3_1	403	410	PF00069	0.330
MOD_GSK3_1	455	462	PF00069	0.462
MOD_GSK3_1	90	97	PF00069	0.515
MOD_N-GLC_1	106	111	PF02516	0.353
MOD_N-GLC_1	299	304	PF02516	0.368
MOD_N-GLC_1	340	345	PF02516	0.388
MOD_N-GLC_1	348	353	PF02516	0.289
MOD_N-GLC_1	369	374	PF02516	0.401
MOD_N-GLC_1	417	422	PF02516	0.388
MOD_NEK2_1	276	281	PF00069	0.411
MOD_NEK2_1	299	304	PF00069	0.311
MOD_NEK2_1	32	37	PF00069	0.357
MOD_NEK2_1	345	350	PF00069	0.347
MOD_NEK2_1	357	362	PF00069	0.227
MOD_NEK2_1	364	369	PF00069	0.151
MOD_NEK2_1	371	376	PF00069	0.292
MOD_NEK2_1	457	462	PF00069	0.396
MOD_NEK2_1	68	73	PF00069	0.415
MOD_NEK2_2	53	58	PF00069	0.521
MOD_PIKK_1	455	461	PF00454	0.330
MOD_PK_1	437	443	PF00069	0.268
MOD_PKA_2	137	143	PF00069	0.566
MOD_PKA_2	225	231	PF00069	0.282
MOD_PKA_2	330	336	PF00069	0.394
MOD_PKA_2	407	413	PF00069	0.394
MOD_Plk_1	100	106	PF00069	0.363
MOD_Plk_1	260	266	PF00069	0.329
MOD_Plk_1	340	346	PF00069	0.394
MOD_Plk_1	417	423	PF00069	0.321
MOD_Plk_1	74	80	PF00069	0.501
MOD_Plk_2-3	128	134	PF00069	0.302
MOD_Plk_2-3	239	245	PF00069	0.203
MOD_Plk_4	107	113	PF00069	0.501
MOD_Plk_4	172	178	PF00069	0.557
MOD_Plk_4	239	245	PF00069	0.203
MOD_Plk_4	280	286	PF00069	0.449
MOD_Plk_4	32	38	PF00069	0.367
MOD_Plk_4	352	358	PF00069	0.419
MOD_Plk_4	459	465	PF00069	0.298
MOD_Plk_4	53	59	PF00069	0.457
MOD_Plk_4	91	97	PF00069	0.380
MOD_ProDKin_1	148	154	PF00069	0.630
MOD_ProDKin_1	291	297	PF00069	0.300
MOD_ProDKin_1	373	379	PF00069	0.369
TRG_DiLeu_BaEn_1	83	88	PF01217	0.346
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.330
TRG_ENDOCYTIC_2	112	115	PF00928	0.403
TRG_ENDOCYTIC_2	451	454	PF00928	0.288
TRG_ER_diArg_1	235	238	PF00400	0.445
TRG_NES_CRM1_1	427	439	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F2	Leptomonas seymouri	74%	99%
A0A0N1I7F0	Leptomonas seymouri	27%	100%
A0A0N1ILY9	Leptomonas seymouri	23%	100%
A0A0N1PAY6	Leptomonas seymouri	23%	100%
A0A0S4INT9	Bodo saltans	24%	100%
A0A0S4JHW9	Bodo saltans	24%	100%
A0A0S4JX54	Bodo saltans	47%	97%
A0A1X0NL86	Trypanosomatidae	24%	100%
A0A1X0NTD3	Trypanosomatidae	28%	100%
A0A1X0P9U6	Trypanosomatidae	50%	100%
A0A3Q8IB94	Leishmania donovani	24%	100%
A0A3Q8IKF7	Leishmania donovani	25%	100%
A0A3R7KIH0	Trypanosoma rangeli	49%	100%
A0A3S7X806	Leishmania donovani	96%	100%
A0A422NHS3	Trypanosoma rangeli	29%	100%
A0A422NLU9	Trypanosoma rangeli	25%	96%
A4HAX6	Leishmania braziliensis	87%	100%
A4HCF3	Leishmania braziliensis	24%	100%
A4HPG9	Leishmania braziliensis	24%	100%
A4HZY5	Leishmania infantum	24%	100%
A4IA35	Leishmania infantum	96%	100%
A4ID91	Leishmania infantum	25%	100%
C9ZM64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZSM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D3ZRP6	Rattus norvegicus	26%	100%
E2RED8	Canis lupus familiaris	26%	100%
E9AT81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AVU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B550	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F4I562	Arabidopsis thaliana	30%	100%
O00189	Homo sapiens	26%	100%
O22715	Arabidopsis thaliana	26%	100%
O23140	Arabidopsis thaliana	25%	100%
O94669	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P35585	Mus musculus	26%	100%
P35602	Caenorhabditis elegans	25%	100%
P35603	Caenorhabditis elegans	24%	100%
P47795	Diplobatis ommata	30%	100%
P53676	Rattus norvegicus	30%	100%
P53677	Homo sapiens	28%	100%
P53678	Rattus norvegicus	29%	100%
P54672	Dictyostelium discoideum	27%	100%
P84091	Mus musculus	25%	100%
P84092	Rattus norvegicus	25%	100%
Q00776	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	99%
Q09718	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q24K11	Bos taurus	30%	100%
Q29RY8	Bos taurus	26%	100%
Q2KJ81	Bos taurus	26%	100%
Q2PWT8	Rattus norvegicus	26%	100%
Q32Q06	Rattus norvegicus	26%	100%
Q3SYW1	Bos taurus	26%	100%
Q3ZC13	Bos taurus	25%	100%
Q4Q1B6	Leishmania major	24%	100%
Q4QBN3	Leishmania major	23%	100%
Q4R706	Macaca fascicularis	25%	100%
Q54HS9	Dictyostelium discoideum	26%	100%
Q5NVF7	Pongo abelii	25%	100%
Q5R478	Pongo abelii	30%	100%
Q5ZMP6	Gallus gallus	25%	100%
Q5ZMP7	Gallus gallus	30%	100%
Q6NWK2	Danio rerio	25%	100%
Q6P856	Xenopus tropicalis	25%	100%
Q7ZW98	Danio rerio	25%	100%
Q801Q8	Xenopus laevis	25%	100%
Q8R2R9	Mus musculus	29%	100%
Q96CW1	Homo sapiens	25%	100%
Q99186	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	95%
Q9BXS5	Homo sapiens	26%	100%
Q9GPF0	Dictyostelium discoideum	22%	88%
Q9GPF1	Dictyostelium discoideum	30%	100%
Q9HFE5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9JKC7	Mus musculus	26%	100%
Q9JKC8	Mus musculus	30%	100%
Q9SAC9	Arabidopsis thaliana	26%	100%
Q9SB50	Arabidopsis thaliana	26%	100%
Q9WVP1	Mus musculus	26%	100%
Q9Y2T2	Homo sapiens	30%	100%
Q9Y6Q5	Homo sapiens	26%	100%
V5BKQ8	Trypanosoma cruzi	50%	100%
V5BLL2	Trypanosoma cruzi	28%	100%
V5D569	Trypanosoma cruzi	27%	94%
V5DGM7	Trypanosoma cruzi	25%	100%