Putative acyl-CoA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q2T5_LEIMA

TriTrypDb:

LmjF.34.2600 , LMJLV39_340031400 , LMJSD75_340031500

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2T5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	10
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0008289	lipid binding	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0033218	amide binding	2	10
GO:0036094	small molecule binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0120227	acyl-CoA binding	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:1901567	fatty acid derivative binding	3	10
GO:1901681	sulfur compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	71	75	PF00082	0.363
DOC_CYCLIN_RxL_1	68	76	PF00134	0.424
DOC_PP2B_LxvP_1	20	23	PF13499	0.413
DOC_USP7_UBL2_3	39	43	PF12436	0.455
DOC_USP7_UBL2_3	84	88	PF12436	0.527
LIG_14-3-3_CanoR_1	37	43	PF00244	0.465
LIG_14-3-3_CanoR_1	8	14	PF00244	0.312
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_FHA_1	8	14	PF00498	0.394
LIG_LIR_Nem_3	4	9	PF02991	0.315
LIG_PDZ_Class_1	84	89	PF00595	0.490
LIG_SH2_STAP1	9	13	PF00017	0.406
LIG_SH2_STAT5	9	12	PF00017	0.338
LIG_TRAF2_1	2	5	PF00917	0.521
MOD_CK1_1	18	24	PF00069	0.370
MOD_CMANNOS	56	59	PF00535	0.338
MOD_GlcNHglycan	1	4	PF01048	0.598
MOD_GSK3_1	7	14	PF00069	0.433
MOD_N-GLC_1	18	23	PF02516	0.404
MOD_NEK2_2	38	43	PF00069	0.416
MOD_PKA_2	7	13	PF00069	0.377
MOD_Plk_1	18	24	PF00069	0.447
MOD_Plk_4	77	83	PF00069	0.430
TRG_ENDOCYTIC_2	62	65	PF00928	0.338
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.455
TRG_PTS1	86	89	PF00515	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P610	Leptomonas seymouri	70%	100%
A0A0S4JQG1	Bodo saltans	35%	99%
A0A3Q8II94	Leishmania donovani	93%	100%
A4HAX7	Leishmania braziliensis	74%	100%
A4IA36	Leishmania infantum	93%	100%
C9ZM63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	96%
E9B551	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O04066	Ricinus communis	31%	99%
P0C8L7	Hypsibius exemplaris	35%	100%
P31787	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P61867	Saccharomyces pastorianus	32%	100%
P61868	Saccharomyces pastorianus (strain ATCC 76670 / Carlsberg bottom yeast no.2 / CBS 1503 / CLIB 180 / NBRC 10610 / NRRL Y-1525)	32%	100%
Q39315	Brassica napus	33%	97%
V5DM18	Trypanosoma cruzi	39%	96%