CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania major

UniProt:

Q4Q2T0_LEIMA

TriTrypDb:

LmjF.34.2650 , LMJLV39_340031900 , LMJSD75_340032000

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 5
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	8
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q2T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2T0

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	12
GO:0042592	homeostatic process	3	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0072507	obsolete divalent inorganic cation homeostasis	7	12
GO:0098771	inorganic ion homeostasis	6	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.506
CLV_C14_Caspase3-7	73	77	PF00656	0.420
CLV_NRD_NRD_1	21	23	PF00675	0.394
CLV_NRD_NRD_1	347	349	PF00675	0.474
CLV_NRD_NRD_1	443	445	PF00675	0.521
CLV_NRD_NRD_1	600	602	PF00675	0.591
CLV_PCSK_KEX2_1	21	23	PF00082	0.394
CLV_PCSK_KEX2_1	347	349	PF00082	0.487
CLV_PCSK_KEX2_1	432	434	PF00082	0.627
CLV_PCSK_KEX2_1	443	445	PF00082	0.514
CLV_PCSK_KEX2_1	55	57	PF00082	0.584
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.612
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.537
CLV_PCSK_SKI1_1	240	244	PF00082	0.404
CLV_PCSK_SKI1_1	325	329	PF00082	0.514
CLV_PCSK_SKI1_1	337	341	PF00082	0.490
CLV_PCSK_SKI1_1	52	56	PF00082	0.536
DEG_APCC_DBOX_1	11	19	PF00400	0.591
DEG_APCC_DBOX_1	234	242	PF00400	0.204
DEG_COP1_1	549	557	PF00400	0.297
DOC_CKS1_1	276	281	PF01111	0.272
DOC_MAPK_gen_1	10	17	PF00069	0.675
DOC_MAPK_gen_1	21	29	PF00069	0.421
DOC_MAPK_MEF2A_6	10	17	PF00069	0.604
DOC_MAPK_MEF2A_6	198	205	PF00069	0.273
DOC_MAPK_MEF2A_6	315	323	PF00069	0.274
DOC_MAPK_MEF2A_6	337	344	PF00069	0.299
DOC_MAPK_MEF2A_6	530	537	PF00069	0.316
DOC_MAPK_NFAT4_5	10	18	PF00069	0.590
DOC_MAPK_NFAT4_5	530	538	PF00069	0.297
DOC_PP1_RVXF_1	237	244	PF00149	0.204
DOC_PP2B_LxvP_1	13	16	PF13499	0.624
DOC_PP2B_LxvP_1	552	555	PF13499	0.310
DOC_USP7_MATH_1	16	20	PF00917	0.590
DOC_USP7_MATH_1	186	190	PF00917	0.415
DOC_USP7_MATH_1	246	250	PF00917	0.253
DOC_USP7_MATH_1	490	494	PF00917	0.499
DOC_USP7_MATH_1	547	551	PF00917	0.335
DOC_USP7_MATH_1	6	10	PF00917	0.561
DOC_USP7_UBL2_3	223	227	PF12436	0.308
DOC_WW_Pin1_4	275	280	PF00397	0.296
LIG_14-3-3_CanoR_1	22	28	PF00244	0.479
LIG_14-3-3_CanoR_1	291	299	PF00244	0.367
LIG_14-3-3_CanoR_1	591	596	PF00244	0.496
LIG_14-3-3_CanoR_1	601	606	PF00244	0.388
LIG_APCC_ABBA_1	504	509	PF00400	0.378
LIG_BIR_III_4	76	80	PF00653	0.377
LIG_BRCT_BRCA1_1	405	409	PF00533	0.299
LIG_BRCT_BRCA1_1	512	516	PF00533	0.260
LIG_BRCT_BRCA1_1	549	553	PF00533	0.350
LIG_Clathr_ClatBox_1	104	108	PF01394	0.508
LIG_Clathr_ClatBox_1	393	397	PF01394	0.242
LIG_Clathr_ClatBox_1	83	87	PF01394	0.303
LIG_EH1_1	387	395	PF00400	0.250
LIG_eIF4E_1	388	394	PF01652	0.248
LIG_FHA_1	107	113	PF00498	0.445
LIG_FHA_1	141	147	PF00498	0.290
LIG_FHA_1	24	30	PF00498	0.296
LIG_FHA_1	294	300	PF00498	0.356
LIG_FHA_1	334	340	PF00498	0.273
LIG_FHA_1	354	360	PF00498	0.174
LIG_FHA_1	515	521	PF00498	0.247
LIG_FHA_1	543	549	PF00498	0.327
LIG_FHA_1	590	596	PF00498	0.326
LIG_FHA_1	99	105	PF00498	0.267
LIG_FHA_2	270	276	PF00498	0.303
LIG_FHA_2	393	399	PF00498	0.238
LIG_FHA_2	65	71	PF00498	0.386
LIG_LIR_Gen_1	513	524	PF02991	0.245
LIG_LIR_Gen_1	539	548	PF02991	0.252
LIG_LIR_Gen_1	573	581	PF02991	0.313
LIG_LIR_Gen_1	78	86	PF02991	0.300
LIG_LIR_LC3C_4	517	520	PF02991	0.332
LIG_LIR_Nem_3	385	390	PF02991	0.290
LIG_LIR_Nem_3	406	412	PF02991	0.308
LIG_LIR_Nem_3	513	519	PF02991	0.242
LIG_LIR_Nem_3	539	543	PF02991	0.253
LIG_LIR_Nem_3	78	83	PF02991	0.305
LIG_NRBOX	28	34	PF00104	0.260
LIG_PCNA_yPIPBox_3	134	145	PF02747	0.404
LIG_PDZ_Class_3	603	608	PF00595	0.429
LIG_Pex14_2	206	210	PF04695	0.239
LIG_Pex14_2	553	557	PF04695	0.299
LIG_Pex14_2	93	97	PF04695	0.254
LIG_SH2_STAP1	126	130	PF00017	0.428
LIG_SH2_STAP1	575	579	PF00017	0.226
LIG_SH2_STAT5	364	367	PF00017	0.266
LIG_SH3_3	210	216	PF00018	0.298
LIG_SH3_3	273	279	PF00018	0.268
LIG_SH3_3	484	490	PF00018	0.296
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.134
LIG_SUMO_SIM_anti_2	111	118	PF11976	0.404
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.279
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.398
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.266
LIG_SUMO_SIM_anti_2	370	377	PF11976	0.258
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.236
LIG_SUMO_SIM_par_1	108	113	PF11976	0.404
LIG_SUMO_SIM_par_1	281	287	PF11976	0.280
LIG_SUMO_SIM_par_1	516	521	PF11976	0.249
LIG_SUMO_SIM_par_1	82	88	PF11976	0.310
LIG_SxIP_EBH_1	303	314	PF03271	0.298
LIG_TRAF2_1	67	70	PF00917	0.383
LIG_TYR_ITIM	447	452	PF00017	0.286
LIG_UBA3_1	358	363	PF00899	0.275
LIG_WRC_WIRS_1	554	559	PF05994	0.277
MOD_CK1_1	249	255	PF00069	0.398
MOD_CK1_1	293	299	PF00069	0.440
MOD_CK1_1	439	445	PF00069	0.412
MOD_CK1_1	514	520	PF00069	0.347
MOD_CK1_1	587	593	PF00069	0.419
MOD_CK2_1	115	121	PF00069	0.404
MOD_CK2_1	269	275	PF00069	0.388
MOD_CK2_1	459	465	PF00069	0.337
MOD_CK2_1	64	70	PF00069	0.500
MOD_Cter_Amidation	19	22	PF01082	0.403
MOD_Cter_Amidation	599	602	PF01082	0.526
MOD_GlcNHglycan	117	120	PF01048	0.232
MOD_GlcNHglycan	18	21	PF01048	0.340
MOD_GlcNHglycan	188	191	PF01048	0.235
MOD_GlcNHglycan	198	201	PF01048	0.294
MOD_GlcNHglycan	248	251	PF01048	0.567
MOD_GlcNHglycan	4	7	PF01048	0.398
MOD_GlcNHglycan	469	474	PF01048	0.614
MOD_GlcNHglycan	520	523	PF01048	0.502
MOD_GlcNHglycan	76	80	PF01048	0.605
MOD_GSK3_1	166	173	PF00069	0.239
MOD_GSK3_1	2	9	PF00069	0.534
MOD_GSK3_1	353	360	PF00069	0.267
MOD_GSK3_1	43	50	PF00069	0.446
MOD_GSK3_1	435	442	PF00069	0.396
MOD_GSK3_1	510	517	PF00069	0.275
MOD_GSK3_1	538	545	PF00069	0.357
MOD_GSK3_1	587	594	PF00069	0.410
MOD_GSK3_1	64	71	PF00069	0.495
MOD_GSK3_1	75	82	PF00069	0.393
MOD_N-GLC_1	425	430	PF02516	0.672
MOD_NEK2_1	140	145	PF00069	0.261
MOD_NEK2_1	150	155	PF00069	0.387
MOD_NEK2_1	2	7	PF00069	0.593
MOD_NEK2_1	43	48	PF00069	0.430
MOD_NEK2_1	459	464	PF00069	0.286
MOD_NEK2_1	518	523	PF00069	0.273
MOD_NEK2_1	75	80	PF00069	0.380
MOD_NEK2_2	47	52	PF00069	0.284
MOD_NEK2_2	555	560	PF00069	0.250
MOD_PKA_1	55	61	PF00069	0.343
MOD_PKA_1	601	607	PF00069	0.393
MOD_PKA_2	290	296	PF00069	0.311
MOD_PKA_2	55	61	PF00069	0.387
MOD_Plk_1	122	128	PF00069	0.415
MOD_Plk_1	269	275	PF00069	0.262
MOD_Plk_1	293	299	PF00069	0.299
MOD_Plk_1	464	470	PF00069	0.356
MOD_Plk_1	479	485	PF00069	0.308
MOD_Plk_1	563	569	PF00069	0.261
MOD_Plk_2-3	108	114	PF00069	0.404
MOD_Plk_2-3	117	123	PF00069	0.428
MOD_Plk_2-3	290	296	PF00069	0.311
MOD_Plk_2-3	64	70	PF00069	0.486
MOD_Plk_4	140	146	PF00069	0.239
MOD_Plk_4	150	156	PF00069	0.239
MOD_Plk_4	166	172	PF00069	0.239
MOD_Plk_4	215	221	PF00069	0.225
MOD_Plk_4	25	31	PF00069	0.307
MOD_Plk_4	269	275	PF00069	0.262
MOD_Plk_4	480	486	PF00069	0.354
MOD_Plk_4	511	517	PF00069	0.362
MOD_Plk_4	563	569	PF00069	0.258
MOD_Plk_4	79	85	PF00069	0.318
MOD_ProDKin_1	275	281	PF00069	0.301
MOD_SUMO_rev_2	234	241	PF00179	0.204
MOD_SUMO_rev_2	354	359	PF00179	0.250
MOD_SUMO_rev_2	385	393	PF00179	0.266
MOD_SUMO_rev_2	58	67	PF00179	0.364
TRG_DiLeu_BaEn_1	237	242	PF01217	0.204
TRG_DiLeu_BaEn_1	295	300	PF01217	0.294
TRG_DiLeu_BaEn_1	389	394	PF01217	0.239
TRG_ENDOCYTIC_2	387	390	PF00928	0.279
TRG_ENDOCYTIC_2	449	452	PF00928	0.394
TRG_ENDOCYTIC_2	575	578	PF00928	0.299
TRG_ER_diArg_1	10	13	PF00400	0.695
TRG_ER_diArg_1	443	445	PF00400	0.314
TRG_ER_diArg_1	485	488	PF00400	0.410
TRG_NES_CRM1_1	275	290	PF08389	0.304
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.204
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B7P9G0	Drosophila melanogaster	33%	73%
A0A0N1IK76	Leptomonas seymouri	30%	80%
A0A0N1PDI6	Leptomonas seymouri	82%	100%
A0A0S4JSF9	Bodo saltans	69%	100%
A0A131MCZ8	Caenorhabditis elegans	32%	76%
A0A1X0PAL3	Trypanosomatidae	69%	100%
A0A3Q8IC75	Leishmania donovani	24%	100%
A0A3Q8IL77	Leishmania donovani	96%	100%
A0A3Q8ITK0	Leishmania donovani	23%	100%
A0A3S7WUR9	Leishmania donovani	31%	82%
A0A422NS01	Trypanosoma rangeli	73%	100%
A0JPA0	Xenopus tropicalis	36%	79%
A3QM97	Caenorhabditis elegans	31%	75%
A4HAY2	Leishmania braziliensis	90%	100%
A4HIN7	Leishmania braziliensis	23%	100%
A4HKU5	Leishmania braziliensis	24%	100%
A4HXP0	Leishmania infantum	31%	82%
A4I5Y4	Leishmania infantum	24%	100%
A4I8C4	Leishmania infantum	23%	100%
A4IA41	Leishmania infantum	96%	100%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	82%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	82%
E9B177	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P0C588	Rattus norvegicus	36%	79%
Q32NY4	Mus musculus	29%	85%
Q3TWN3	Mus musculus	35%	69%
Q4Q4X2	Leishmania major	22%	100%
Q4Q6Y7	Leishmania major	24%	100%
Q4QE28	Leishmania major	30%	82%
Q4QE29	Leishmania major	32%	88%
Q5U2P1	Rattus norvegicus	35%	69%
Q69ZF7	Mus musculus	36%	79%
Q6P4Q7	Homo sapiens	36%	78%
Q8NE01	Homo sapiens	28%	86%
Q9GYL2	Caenorhabditis elegans	30%	80%
Q9H8M5	Homo sapiens	35%	69%
V5B9W6	Trypanosoma cruzi	35%	83%
V5BKR5	Trypanosoma cruzi	71%	100%