Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q2S7_LEIMA

TriTrypDb:

LmjF.34.2680 , LMJLV39_340032200 , LMJSD75_340032300

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q2S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	234	240	PF00089	0.467
CLV_NRD_NRD_1	278	280	PF00675	0.505
CLV_NRD_NRD_1	412	414	PF00675	0.626
CLV_NRD_NRD_1	467	469	PF00675	0.425
CLV_NRD_NRD_1	514	516	PF00675	0.572
CLV_PCSK_KEX2_1	278	280	PF00082	0.645
CLV_PCSK_KEX2_1	467	469	PF00082	0.425
CLV_PCSK_KEX2_1	514	516	PF00082	0.572
CLV_PCSK_SKI1_1	199	203	PF00082	0.541
CLV_PCSK_SKI1_1	22	26	PF00082	0.546
CLV_PCSK_SKI1_1	27	31	PF00082	0.511
CLV_PCSK_SKI1_1	423	427	PF00082	0.524
CLV_PCSK_SKI1_1	467	471	PF00082	0.448
DEG_APCC_DBOX_1	39	47	PF00400	0.488
DEG_APCC_DBOX_1	422	430	PF00400	0.522
DOC_ANK_TNKS_1	412	419	PF00023	0.521
DOC_CKS1_1	64	69	PF01111	0.521
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.498
DOC_MAPK_gen_1	228	236	PF00069	0.383
DOC_MAPK_gen_1	413	421	PF00069	0.585
DOC_MAPK_gen_1	442	452	PF00069	0.591
DOC_MAPK_MEF2A_6	230	238	PF00069	0.398
DOC_MAPK_MEF2A_6	413	421	PF00069	0.501
DOC_MAPK_MEF2A_6	445	454	PF00069	0.601
DOC_MAPK_MEF2A_6	56	64	PF00069	0.537
DOC_MAPK_NFAT4_5	414	422	PF00069	0.488
DOC_USP7_MATH_1	15	19	PF00917	0.475
DOC_USP7_MATH_1	2	6	PF00917	0.551
DOC_USP7_MATH_1	287	291	PF00917	0.585
DOC_USP7_MATH_1	296	300	PF00917	0.616
DOC_USP7_MATH_1	346	350	PF00917	0.655
DOC_USP7_MATH_1	522	526	PF00917	0.489
DOC_WW_Pin1_4	319	324	PF00397	0.707
DOC_WW_Pin1_4	334	339	PF00397	0.546
DOC_WW_Pin1_4	369	374	PF00397	0.480
DOC_WW_Pin1_4	63	68	PF00397	0.546
DOC_WW_Pin1_4	93	98	PF00397	0.672
DOC_WW_Pin1_4	99	104	PF00397	0.660
LIG_14-3-3_CanoR_1	228	236	PF00244	0.394
LIG_14-3-3_CanoR_1	250	255	PF00244	0.418
LIG_14-3-3_CanoR_1	358	365	PF00244	0.530
LIG_14-3-3_CanoR_1	371	377	PF00244	0.479
LIG_14-3-3_CanoR_1	467	476	PF00244	0.414
LIG_APCC_ABBA_1	450	455	PF00400	0.581
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BIR_III_2	320	324	PF00653	0.636
LIG_BRCT_BRCA1_1	450	454	PF00533	0.469
LIG_CSL_BTD_1	532	535	PF09270	0.394
LIG_EH1_1	43	51	PF00400	0.553
LIG_eIF4E_1	44	50	PF01652	0.447
LIG_FHA_1	119	125	PF00498	0.457
LIG_FHA_1	184	190	PF00498	0.447
LIG_FHA_1	229	235	PF00498	0.391
LIG_FHA_1	335	341	PF00498	0.678
LIG_FHA_1	384	390	PF00498	0.482
LIG_FHA_1	481	487	PF00498	0.401
LIG_FHA_1	527	533	PF00498	0.445
LIG_FHA_1	57	63	PF00498	0.548
LIG_FHA_1	73	79	PF00498	0.631
LIG_FHA_2	159	165	PF00498	0.426
LIG_FHA_2	195	201	PF00498	0.559
LIG_FHA_2	323	329	PF00498	0.687
LIG_FHA_2	361	367	PF00498	0.639
LIG_FHA_2	46	52	PF00498	0.548
LIG_FHA_2	468	474	PF00498	0.433
LIG_FHA_2	64	70	PF00498	0.597
LIG_HCF-1_HBM_1	246	249	PF13415	0.559
LIG_MLH1_MIPbox_1	450	454	PF16413	0.467
LIG_Pex14_2	376	380	PF04695	0.464
LIG_SH2_CRK	90	94	PF00017	0.667
LIG_SH2_GRB2like	183	186	PF00017	0.546
LIG_SH2_NCK_1	256	260	PF00017	0.495
LIG_SH2_NCK_1	90	94	PF00017	0.709
LIG_SH2_SRC	256	259	PF00017	0.485
LIG_SH2_STAP1	183	187	PF00017	0.546
LIG_SH2_STAP1	256	260	PF00017	0.534
LIG_SH2_STAT5	151	154	PF00017	0.465
LIG_SH2_STAT5	205	208	PF00017	0.513
LIG_SH2_STAT5	420	423	PF00017	0.535
LIG_SH3_3	213	219	PF00018	0.488
LIG_SH3_3	350	356	PF00018	0.640
LIG_SH3_3	459	465	PF00018	0.616
LIG_SUMO_SIM_par_1	270	276	PF11976	0.407
LIG_TRAF2_1	162	165	PF00917	0.547
LIG_UBA3_1	49	56	PF00899	0.435
LIG_WW_3	355	359	PF00397	0.624
LIG_WW_3	464	468	PF00397	0.592
MOD_CK1_1	285	291	PF00069	0.552
MOD_CK1_1	349	355	PF00069	0.667
MOD_CK1_1	372	378	PF00069	0.377
MOD_CK1_1	406	412	PF00069	0.609
MOD_CK1_1	5	11	PF00069	0.607
MOD_CK1_1	525	531	PF00069	0.493
MOD_CK1_1	63	69	PF00069	0.640
MOD_CK1_1	96	102	PF00069	0.623
MOD_CK2_1	127	133	PF00069	0.553
MOD_CK2_1	158	164	PF00069	0.401
MOD_CK2_1	252	258	PF00069	0.483
MOD_CK2_1	322	328	PF00069	0.722
MOD_CK2_1	360	366	PF00069	0.519
MOD_Cter_Amidation	411	414	PF01082	0.634
MOD_GlcNHglycan	15	18	PF01048	0.507
MOD_GlcNHglycan	152	155	PF01048	0.556
MOD_GlcNHglycan	179	182	PF01048	0.260
MOD_GlcNHglycan	212	215	PF01048	0.426
MOD_GlcNHglycan	3	7	PF01048	0.602
MOD_GlcNHglycan	341	344	PF01048	0.655
MOD_GlcNHglycan	392	395	PF01048	0.422
MOD_GlcNHglycan	405	408	PF01048	0.580
MOD_GlcNHglycan	524	527	PF01048	0.371
MOD_GlcNHglycan	98	101	PF01048	0.675
MOD_GSK3_1	179	186	PF00069	0.459
MOD_GSK3_1	224	231	PF00069	0.383
MOD_GSK3_1	282	289	PF00069	0.564
MOD_GSK3_1	319	326	PF00069	0.672
MOD_GSK3_1	379	386	PF00069	0.547
MOD_GSK3_1	509	516	PF00069	0.461
MOD_GSK3_1	52	59	PF00069	0.449
MOD_GSK3_1	522	529	PF00069	0.332
MOD_LATS_1	305	311	PF00433	0.634
MOD_N-GLC_1	403	408	PF02516	0.571
MOD_NEK2_1	136	141	PF00069	0.501
MOD_NEK2_1	210	215	PF00069	0.370
MOD_NEK2_1	265	270	PF00069	0.498
MOD_NEK2_1	474	479	PF00069	0.458
MOD_NEK2_2	183	188	PF00069	0.546
MOD_NEK2_2	526	531	PF00069	0.370
MOD_PIKK_1	15	21	PF00454	0.539
MOD_PIKK_1	8	14	PF00454	0.582
MOD_PKA_1	467	473	PF00069	0.439
MOD_PKA_2	357	363	PF00069	0.591
MOD_PKA_2	467	473	PF00069	0.446
MOD_PKA_2	506	512	PF00069	0.528
MOD_PKA_2	513	519	PF00069	0.562
MOD_Plk_1	183	189	PF00069	0.491
MOD_Plk_1	403	409	PF00069	0.558
MOD_Plk_1	448	454	PF00069	0.507
MOD_Plk_1	526	532	PF00069	0.354
MOD_Plk_4	217	223	PF00069	0.418
MOD_Plk_4	270	276	PF00069	0.484
MOD_Plk_4	448	454	PF00069	0.571
MOD_Plk_4	45	51	PF00069	0.564
MOD_ProDKin_1	319	325	PF00069	0.710
MOD_ProDKin_1	334	340	PF00069	0.547
MOD_ProDKin_1	369	375	PF00069	0.473
MOD_ProDKin_1	63	69	PF00069	0.543
MOD_ProDKin_1	93	99	PF00069	0.673
TRG_DiLeu_BaEn_1	471	476	PF01217	0.431
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.546
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.450
TRG_ENDOCYTIC_2	90	93	PF00928	0.727
TRG_ER_diArg_1	277	279	PF00400	0.606
TRG_ER_diArg_1	466	468	PF00400	0.458
TRG_ER_diArg_1	513	515	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E9	Leptomonas seymouri	68%	94%
A0A0S4JQH6	Bodo saltans	33%	100%
A0A1X0P9Q5	Trypanosomatidae	43%	100%
A0A3Q8IUQ4	Leishmania donovani	93%	99%
A0A3R7L5W7	Trypanosoma rangeli	42%	100%
A4HAY5	Leishmania braziliensis	85%	99%
A4IA44	Leishmania infantum	94%	98%
C9ZM56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B558	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BKS0	Trypanosoma cruzi	43%	100%