Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2S6_LEIMA

TriTrypDb:

LmjF.34.2690 , LMJLV39_340032300 , LMJSD75_340032400

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.699
CLV_NRD_NRD_1	119	121	PF00675	0.645
CLV_NRD_NRD_1	160	162	PF00675	0.569
CLV_NRD_NRD_1	211	213	PF00675	0.688
CLV_NRD_NRD_1	341	343	PF00675	0.802
CLV_NRD_NRD_1	446	448	PF00675	0.618
CLV_NRD_NRD_1	92	94	PF00675	0.716
CLV_PCSK_FUR_1	323	327	PF00082	0.662
CLV_PCSK_FUR_1	329	333	PF00082	0.690
CLV_PCSK_KEX2_1	119	121	PF00082	0.723
CLV_PCSK_KEX2_1	160	162	PF00082	0.621
CLV_PCSK_KEX2_1	211	213	PF00082	0.686
CLV_PCSK_KEX2_1	325	327	PF00082	0.623
CLV_PCSK_KEX2_1	331	333	PF00082	0.649
CLV_PCSK_KEX2_1	341	343	PF00082	0.684
CLV_PCSK_KEX2_1	446	448	PF00082	0.645
CLV_PCSK_KEX2_1	92	94	PF00082	0.719
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.681
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.697
CLV_PCSK_PC7_1	156	162	PF00082	0.580
CLV_PCSK_PC7_1	321	327	PF00082	0.656
CLV_PCSK_PC7_1	442	448	PF00082	0.627
DEG_APCC_DBOX_1	174	182	PF00400	0.709
DEG_APCC_DBOX_1	441	449	PF00400	0.594
DEG_SCF_FBW7_1	65	72	PF00400	0.704
DEG_SPOP_SBC_1	106	110	PF00917	0.625
DEG_SPOP_SBC_1	167	171	PF00917	0.583
DEG_SPOP_SBC_1	454	458	PF00917	0.549
DOC_CKS1_1	421	426	PF01111	0.595
DOC_CKS1_1	66	71	PF01111	0.679
DOC_PP2B_LxvP_1	146	149	PF13499	0.738
DOC_PP4_FxxP_1	53	56	PF00568	0.780
DOC_USP7_MATH_1	159	163	PF00917	0.682
DOC_USP7_MATH_1	183	187	PF00917	0.811
DOC_USP7_MATH_1	280	284	PF00917	0.781
DOC_USP7_MATH_1	347	351	PF00917	0.725
DOC_USP7_MATH_1	352	356	PF00917	0.741
DOC_USP7_MATH_1	394	398	PF00917	0.707
DOC_USP7_MATH_1	412	416	PF00917	0.535
DOC_USP7_MATH_1	424	428	PF00917	0.508
DOC_USP7_MATH_1	481	485	PF00917	0.805
DOC_USP7_MATH_1	7	11	PF00917	0.561
DOC_WW_Pin1_4	102	107	PF00397	0.758
DOC_WW_Pin1_4	222	227	PF00397	0.826
DOC_WW_Pin1_4	256	261	PF00397	0.767
DOC_WW_Pin1_4	407	412	PF00397	0.760
DOC_WW_Pin1_4	420	425	PF00397	0.614
DOC_WW_Pin1_4	495	500	PF00397	0.646
DOC_WW_Pin1_4	61	66	PF00397	0.659
DOC_WW_Pin1_4	79	84	PF00397	0.563
LIG_14-3-3_CanoR_1	104	113	PF00244	0.651
LIG_14-3-3_CanoR_1	182	188	PF00244	0.619
LIG_14-3-3_CanoR_1	240	250	PF00244	0.614
LIG_14-3-3_CanoR_1	555	562	PF00244	0.677
LIG_CaM_IQ_9	313	328	PF13499	0.675
LIG_CSL_BTD_1	496	499	PF09270	0.649
LIG_FHA_1	107	113	PF00498	0.790
LIG_FHA_1	182	188	PF00498	0.736
LIG_FHA_1	284	290	PF00498	0.786
LIG_FHA_1	300	306	PF00498	0.451
LIG_FHA_1	421	427	PF00498	0.749
LIG_FHA_2	168	174	PF00498	0.684
LIG_FHA_2	430	436	PF00498	0.670
LIG_FHA_2	469	475	PF00498	0.805
LIG_LIR_Apic_2	244	250	PF02991	0.728
LIG_LIR_Apic_2	418	424	PF02991	0.594
LIG_LIR_Apic_2	63	69	PF02991	0.686
LIG_LIR_Gen_1	298	307	PF02991	0.584
LIG_LIR_Gen_1	449	460	PF02991	0.631
LIG_LIR_Gen_1	531	538	PF02991	0.677
LIG_LIR_Gen_1	544	551	PF02991	0.696
LIG_LIR_Gen_1	68	78	PF02991	0.664
LIG_LIR_Nem_3	293	299	PF02991	0.634
LIG_LIR_Nem_3	302	306	PF02991	0.491
LIG_LIR_Nem_3	449	455	PF02991	0.612
LIG_LIR_Nem_3	531	536	PF02991	0.674
LIG_LIR_Nem_3	68	74	PF02991	0.664
LIG_Pex14_1	296	300	PF04695	0.600
LIG_Pex14_1	303	307	PF04695	0.578
LIG_SH2_CRK	115	119	PF00017	0.724
LIG_SH2_CRK	307	311	PF00017	0.597
LIG_SH2_CRK	452	456	PF00017	0.727
LIG_SH2_CRK	66	70	PF00017	0.779
LIG_SH2_STAP1	297	301	PF00017	0.592
LIG_SH2_STAP1	311	315	PF00017	0.611
LIG_SH2_STAT3	306	309	PF00017	0.593
LIG_SH2_STAT3	311	314	PF00017	0.616
LIG_SH2_STAT5	301	304	PF00017	0.523
LIG_SH3_2	408	413	PF14604	0.787
LIG_SH3_3	257	263	PF00018	0.751
LIG_SH3_3	286	292	PF00018	0.661
LIG_SH3_3	405	411	PF00018	0.826
LIG_SH3_3	498	504	PF00018	0.776
LIG_SUMO_SIM_par_1	143	151	PF11976	0.533
LIG_TYR_ITIM	305	310	PF00017	0.553
LIG_WW_3	261	265	PF00397	0.763
MOD_CDC14_SPxK_1	410	413	PF00782	0.824
MOD_CDC14_SPxK_1	64	67	PF00782	0.712
MOD_CDK_SPK_2	420	425	PF00069	0.817
MOD_CDK_SPxK_1	407	413	PF00069	0.827
MOD_CDK_SPxK_1	61	67	PF00069	0.721
MOD_CK1_1	105	111	PF00069	0.791
MOD_CK1_1	125	131	PF00069	0.672
MOD_CK1_1	186	192	PF00069	0.722
MOD_CK1_1	243	249	PF00069	0.712
MOD_CK1_1	283	289	PF00069	0.803
MOD_CK1_1	334	340	PF00069	0.738
MOD_CK1_1	392	398	PF00069	0.836
MOD_CK1_1	415	421	PF00069	0.719
MOD_CK1_1	558	564	PF00069	0.722
MOD_CK2_1	167	173	PF00069	0.754
MOD_CK2_1	347	353	PF00069	0.769
MOD_CK2_1	94	100	PF00069	0.765
MOD_Cter_Amidation	329	332	PF01082	0.755
MOD_Cter_Amidation	339	342	PF01082	0.639
MOD_DYRK1A_RPxSP_1	222	226	PF00069	0.739
MOD_GlcNHglycan	161	164	PF01048	0.815
MOD_GlcNHglycan	189	192	PF01048	0.801
MOD_GlcNHglycan	2	5	PF01048	0.711
MOD_GlcNHglycan	232	235	PF01048	0.814
MOD_GlcNHglycan	256	259	PF01048	0.783
MOD_GlcNHglycan	349	352	PF01048	0.833
MOD_GlcNHglycan	398	401	PF01048	0.794
MOD_GlcNHglycan	426	429	PF01048	0.648
MOD_GlcNHglycan	483	486	PF01048	0.754
MOD_GlcNHglycan	525	528	PF01048	0.823
MOD_GlcNHglycan	9	12	PF01048	0.691
MOD_GSK3_1	100	107	PF00069	0.749
MOD_GSK3_1	182	189	PF00069	0.727
MOD_GSK3_1	236	243	PF00069	0.714
MOD_GSK3_1	342	349	PF00069	0.739
MOD_GSK3_1	392	399	PF00069	0.751
MOD_GSK3_1	420	427	PF00069	0.642
MOD_GSK3_1	519	526	PF00069	0.838
MOD_GSK3_1	551	558	PF00069	0.776
MOD_GSK3_1	61	68	PF00069	0.785
MOD_LATS_1	102	108	PF00433	0.600
MOD_N-GLC_1	541	546	PF02516	0.706
MOD_NEK2_1	17	22	PF00069	0.726
MOD_NEK2_1	241	246	PF00069	0.719
MOD_NEK2_1	455	460	PF00069	0.679
MOD_PIKK_1	122	128	PF00454	0.633
MOD_PIKK_1	555	561	PF00454	0.590
MOD_PKA_1	331	337	PF00069	0.797
MOD_PKA_2	159	165	PF00069	0.714
MOD_PKA_2	181	187	PF00069	0.636
MOD_PKA_2	331	337	PF00069	0.797
MOD_PKA_2	424	430	PF00069	0.626
MOD_PKA_2	523	529	PF00069	0.724
MOD_PKB_1	180	188	PF00069	0.739
MOD_PKB_1	539	547	PF00069	0.660
MOD_Plk_1	352	358	PF00069	0.741
MOD_Plk_2-3	168	174	PF00069	0.690
MOD_Plk_4	299	305	PF00069	0.451
MOD_ProDKin_1	102	108	PF00069	0.756
MOD_ProDKin_1	222	228	PF00069	0.826
MOD_ProDKin_1	256	262	PF00069	0.768
MOD_ProDKin_1	407	413	PF00069	0.761
MOD_ProDKin_1	420	426	PF00069	0.612
MOD_ProDKin_1	495	501	PF00069	0.646
MOD_ProDKin_1	61	67	PF00069	0.654
MOD_ProDKin_1	79	85	PF00069	0.562
TRG_DiLeu_BaEn_4	450	456	PF01217	0.691
TRG_ENDOCYTIC_2	115	118	PF00928	0.718
TRG_ENDOCYTIC_2	301	304	PF00928	0.537
TRG_ENDOCYTIC_2	307	310	PF00928	0.512
TRG_ENDOCYTIC_2	452	455	PF00928	0.725
TRG_ER_diArg_1	118	120	PF00400	0.663
TRG_ER_diArg_1	445	447	PF00400	0.707
TRG_ER_diArg_1	564	567	PF00400	0.759
TRG_ER_diArg_1	91	93	PF00400	0.703
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P607	Leptomonas seymouri	31%	100%
A0A3Q8IEH1	Leishmania donovani	86%	100%
A4HAY6	Leishmania braziliensis	57%	100%
A4IA45	Leishmania infantum	86%	100%
E9B559	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%