RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit g

Species:

Leishmania major

UniProt:

Q4Q2S5_LEIMA

TriTrypDb:

LmjF.34.2700 , LMJLV39_340032400 , LMJSD75_340032500

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005852	eukaryotic translation initiation factor 3 complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2S5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.739
CLV_NRD_NRD_1	57	59	PF00675	0.607
CLV_PCSK_KEX2_1	117	119	PF00082	0.622
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.622
CLV_PCSK_PC7_1	113	119	PF00082	0.617
CLV_PCSK_SKI1_1	67	71	PF00082	0.481
CLV_Separin_Metazoa	55	59	PF03568	0.532
DOC_SPAK_OSR1_1	53	57	PF12202	0.610
DOC_USP7_MATH_1	162	166	PF00917	0.700
DOC_USP7_MATH_1	17	21	PF00917	0.805
DOC_USP7_MATH_1	32	36	PF00917	0.579
DOC_USP7_UBL2_3	238	242	PF12436	0.560
LIG_14-3-3_CanoR_1	58	64	PF00244	0.573
LIG_14-3-3_CanoR_1	67	72	PF00244	0.453
LIG_Actin_WH2_2	123	138	PF00022	0.653
LIG_APCC_ABBA_1	221	226	PF00400	0.573
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BIR_III_4	48	52	PF00653	0.628
LIG_BRCT_BRCA1_1	192	196	PF00533	0.573
LIG_FHA_1	173	179	PF00498	0.627
LIG_FHA_1	201	207	PF00498	0.546
LIG_FHA_1	42	48	PF00498	0.570
LIG_FHA_2	68	74	PF00498	0.464
LIG_Integrin_RGD_1	210	212	PF01839	0.373
LIG_LIR_Gen_1	216	227	PF02991	0.573
LIG_LIR_Nem_3	158	163	PF02991	0.674
LIG_LIR_Nem_3	216	222	PF02991	0.489
LIG_Pex14_2	224	228	PF04695	0.573
LIG_RPA_C_Fungi	48	60	PF08784	0.545
LIG_SH3_3	203	209	PF00018	0.451
LIG_SH3_3	62	68	PF00018	0.489
LIG_SUMO_SIM_par_1	244	249	PF11976	0.535
LIG_SUMO_SIM_par_1	95	101	PF11976	0.501
MOD_CK1_1	165	171	PF00069	0.683
MOD_CK1_1	35	41	PF00069	0.682
MOD_CK2_1	109	115	PF00069	0.615
MOD_CK2_1	22	28	PF00069	0.683
MOD_CK2_1	246	252	PF00069	0.565
MOD_GlcNHglycan	122	126	PF01048	0.591
MOD_GlcNHglycan	153	156	PF01048	0.697
MOD_GlcNHglycan	92	95	PF01048	0.704
MOD_GSK3_1	151	158	PF00069	0.689
MOD_GSK3_1	181	188	PF00069	0.318
MOD_GSK3_1	246	253	PF00069	0.564
MOD_GSK3_1	86	93	PF00069	0.681
MOD_N-GLC_1	181	186	PF02516	0.307
MOD_N-GLC_1	190	195	PF02516	0.307
MOD_N-GLC_1	213	218	PF02516	0.408
MOD_N-GLC_1	22	27	PF02516	0.763
MOD_NEK2_1	246	251	PF00069	0.423
MOD_PIKK_1	185	191	PF00454	0.451
MOD_PKA_2	109	115	PF00069	0.588
MOD_PKB_1	179	187	PF00069	0.451
MOD_Plk_1	190	196	PF00069	0.412
MOD_Plk_1	22	28	PF00069	0.692
MOD_Plk_1	41	47	PF00069	0.619
MOD_Plk_1	86	92	PF00069	0.661
MOD_Plk_2-3	101	107	PF00069	0.611
MOD_Plk_2-3	22	28	PF00069	0.813
MOD_Plk_4	87	93	PF00069	0.689
MOD_SUMO_for_1	130	133	PF00179	0.541
MOD_SUMO_for_1	39	42	PF00179	0.626
MOD_SUMO_rev_2	109	119	PF00179	0.603
MOD_SUMO_rev_2	140	145	PF00179	0.644
MOD_SUMO_rev_2	231	239	PF00179	0.383
MOD_SUMO_rev_2	25	35	PF00179	0.678
TRG_ER_diArg_1	178	181	PF00400	0.325
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI2	Leptomonas seymouri	72%	100%
A0A0S4JUP4	Bodo saltans	29%	85%
A0A1X0PAQ4	Trypanosomatidae	35%	95%
A0A3S5IRQ9	Trypanosoma rangeli	36%	93%
A0A3S7X829	Leishmania donovani	98%	100%
A4HAY7	Leishmania braziliensis	95%	100%
A4IA46	Leishmania infantum	98%	100%
C9ZM55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	94%
E9B560	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BV73	Trypanosoma cruzi	38%	93%