LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania major
UniProt:
Q4Q2S3_LEIMA
TriTrypDb:
LmjF.34.2720 , LMJLV39_340032600 , LMJSD75_340032700 *
Length:
684

Annotations

LeishMANIAdb annotations

A family with high similarity to plant sugar transporters.. Might be an extensive family that already diverged in free-living Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4Q2S3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2S3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 11
GO:0022857 transmembrane transporter activity 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 375 379 PF00656 0.625
CLV_NRD_NRD_1 240 242 PF00675 0.283
CLV_NRD_NRD_1 275 277 PF00675 0.477
CLV_NRD_NRD_1 421 423 PF00675 0.362
CLV_NRD_NRD_1 657 659 PF00675 0.620
CLV_NRD_NRD_1 671 673 PF00675 0.460
CLV_PCSK_KEX2_1 240 242 PF00082 0.283
CLV_PCSK_KEX2_1 275 277 PF00082 0.518
CLV_PCSK_KEX2_1 420 422 PF00082 0.375
CLV_PCSK_KEX2_1 492 494 PF00082 0.319
CLV_PCSK_KEX2_1 671 673 PF00082 0.446
CLV_PCSK_PC1ET2_1 240 242 PF00082 0.283
CLV_PCSK_PC1ET2_1 492 494 PF00082 0.319
CLV_PCSK_SKI1_1 136 140 PF00082 0.420
CLV_PCSK_SKI1_1 242 246 PF00082 0.318
CLV_PCSK_SKI1_1 535 539 PF00082 0.534
DEG_APCC_DBOX_1 169 177 PF00400 0.519
DEG_Nend_UBRbox_2 1 3 PF02207 0.662
DOC_CDC14_PxL_1 33 41 PF14671 0.582
DOC_CYCLIN_yCln2_LP_2 618 624 PF00134 0.635
DOC_MAPK_gen_1 134 141 PF00069 0.220
DOC_MAPK_gen_1 170 178 PF00069 0.519
DOC_MAPK_gen_1 420 429 PF00069 0.664
DOC_MAPK_MEF2A_6 123 131 PF00069 0.384
DOC_MAPK_MEF2A_6 422 431 PF00069 0.580
DOC_PP1_RVXF_1 109 116 PF00149 0.480
DOC_PP2B_LxvP_1 34 37 PF13499 0.512
DOC_PP4_FxxP_1 230 233 PF00568 0.420
DOC_USP7_MATH_1 323 327 PF00917 0.814
DOC_USP7_MATH_1 334 338 PF00917 0.719
DOC_USP7_MATH_1 564 568 PF00917 0.325
DOC_USP7_MATH_1 96 100 PF00917 0.323
DOC_WW_Pin1_4 289 294 PF00397 0.730
DOC_WW_Pin1_4 318 323 PF00397 0.691
DOC_WW_Pin1_4 641 646 PF00397 0.822
LIG_14-3-3_CanoR_1 172 177 PF00244 0.527
LIG_14-3-3_CanoR_1 24 33 PF00244 0.645
LIG_14-3-3_CanoR_1 241 251 PF00244 0.653
LIG_14-3-3_CanoR_1 336 343 PF00244 0.719
LIG_14-3-3_CanoR_1 344 354 PF00244 0.712
LIG_14-3-3_CanoR_1 521 529 PF00244 0.371
LIG_14-3-3_CanoR_1 671 679 PF00244 0.644
LIG_Actin_WH2_2 150 168 PF00022 0.373
LIG_BIR_III_4 279 283 PF00653 0.686
LIG_BRCT_BRCA1_1 174 178 PF00533 0.519
LIG_BRCT_BRCA1_1 190 194 PF00533 0.373
LIG_BRCT_BRCA1_1 226 230 PF00533 0.373
LIG_BRCT_BRCA1_1 522 526 PF00533 0.220
LIG_CSL_BTD_1 65 68 PF09270 0.319
LIG_DLG_GKlike_1 172 180 PF00625 0.483
LIG_EH1_1 218 226 PF00400 0.314
LIG_eIF4E_1 453 459 PF01652 0.283
LIG_FHA_1 211 217 PF00498 0.399
LIG_FHA_1 245 251 PF00498 0.611
LIG_FHA_1 25 31 PF00498 0.616
LIG_FHA_1 267 273 PF00498 0.796
LIG_FHA_1 449 455 PF00498 0.422
LIG_FHA_1 466 472 PF00498 0.226
LIG_FHA_1 506 512 PF00498 0.439
LIG_FHA_1 540 546 PF00498 0.328
LIG_FHA_1 602 608 PF00498 0.421
LIG_FHA_1 655 661 PF00498 0.806
LIG_FHA_1 665 671 PF00498 0.613
LIG_FHA_2 153 159 PF00498 0.386
LIG_FHA_2 243 249 PF00498 0.605
LIG_GBD_Chelix_1 189 197 PF00786 0.236
LIG_GBD_Chelix_1 441 449 PF00786 0.301
LIG_GBD_Chelix_1 478 486 PF00786 0.236
LIG_HCF-1_HBM_1 410 413 PF13415 0.553
LIG_LIR_Apic_2 227 233 PF02991 0.420
LIG_LIR_Gen_1 191 199 PF02991 0.444
LIG_LIR_Gen_1 508 517 PF02991 0.517
LIG_LIR_Gen_1 524 534 PF02991 0.237
LIG_LIR_Gen_1 560 568 PF02991 0.281
LIG_LIR_Gen_1 596 607 PF02991 0.371
LIG_LIR_Nem_3 146 152 PF02991 0.414
LIG_LIR_Nem_3 191 197 PF02991 0.448
LIG_LIR_Nem_3 451 456 PF02991 0.329
LIG_LIR_Nem_3 508 512 PF02991 0.453
LIG_LIR_Nem_3 523 529 PF02991 0.250
LIG_LIR_Nem_3 560 565 PF02991 0.281
LIG_LIR_Nem_3 596 602 PF02991 0.371
LIG_LIR_Nem_3 63 69 PF02991 0.304
LIG_Pex14_2 226 230 PF04695 0.373
LIG_Pex14_2 593 597 PF04695 0.314
LIG_Pex14_2 598 602 PF04695 0.314
LIG_PTAP_UEV_1 262 267 PF05743 0.692
LIG_Rb_LxCxE_1 153 171 PF01857 0.236
LIG_SH2_CRK 149 153 PF00017 0.435
LIG_SH2_CRK 494 498 PF00017 0.484
LIG_SH2_CRK 513 517 PF00017 0.323
LIG_SH2_CRK 625 629 PF00017 0.644
LIG_SH2_NCK_1 413 417 PF00017 0.570
LIG_SH2_SRC 196 199 PF00017 0.301
LIG_SH2_SRC 408 411 PF00017 0.581
LIG_SH2_SRC 413 416 PF00017 0.548
LIG_SH2_STAP1 174 178 PF00017 0.519
LIG_SH2_STAP1 26 30 PF00017 0.589
LIG_SH2_STAT5 196 199 PF00017 0.412
LIG_SH2_STAT5 26 29 PF00017 0.590
LIG_SH2_STAT5 33 36 PF00017 0.547
LIG_SH2_STAT5 408 411 PF00017 0.621
LIG_SH2_STAT5 453 456 PF00017 0.354
LIG_SH2_STAT5 529 532 PF00017 0.323
LIG_SH2_STAT5 71 74 PF00017 0.283
LIG_SH3_2 263 268 PF14604 0.695
LIG_SH3_3 103 109 PF00018 0.484
LIG_SH3_3 228 234 PF00018 0.472
LIG_SH3_3 260 266 PF00018 0.769
LIG_SH3_3 646 652 PF00018 0.813
LIG_SH3_3 657 663 PF00018 0.657
LIG_SUMO_SIM_anti_2 247 254 PF11976 0.618
LIG_SUMO_SIM_anti_2 440 447 PF11976 0.393
LIG_SUMO_SIM_par_1 247 254 PF11976 0.699
LIG_SUMO_SIM_par_1 440 447 PF11976 0.399
LIG_SUMO_SIM_par_1 620 626 PF11976 0.698
LIG_TYR_ITIM 511 516 PF00017 0.323
LIG_TYR_ITIM 623 628 PF00017 0.572
LIG_UBA3_1 220 228 PF00899 0.338
LIG_UBA3_1 456 460 PF00899 0.319
LIG_UBA3_1 510 519 PF00899 0.323
LIG_UBA3_1 578 586 PF00899 0.283
LIG_WRC_WIRS_1 506 511 PF05994 0.323
LIG_WRC_WIRS_1 594 599 PF05994 0.373
MOD_CK1_1 179 185 PF00069 0.373
MOD_CK1_1 299 305 PF00069 0.718
MOD_CK1_1 465 471 PF00069 0.387
MOD_CK1_1 55 61 PF00069 0.351
MOD_CK1_1 567 573 PF00069 0.324
MOD_CK1_1 630 636 PF00069 0.766
MOD_CK2_1 152 158 PF00069 0.370
MOD_CK2_1 359 365 PF00069 0.740
MOD_CK2_1 630 636 PF00069 0.680
MOD_Cter_Amidation 490 493 PF01082 0.319
MOD_GlcNHglycan 263 266 PF01048 0.491
MOD_GlcNHglycan 361 364 PF01048 0.516
MOD_GlcNHglycan 375 378 PF01048 0.538
MOD_GlcNHglycan 401 404 PF01048 0.409
MOD_GlcNHglycan 414 419 PF01048 0.452
MOD_GlcNHglycan 446 449 PF01048 0.433
MOD_GlcNHglycan 569 572 PF01048 0.501
MOD_GlcNHglycan 573 576 PF01048 0.489
MOD_GlcNHglycan 604 607 PF01048 0.340
MOD_GlcNHglycan 98 101 PF01048 0.432
MOD_GSK3_1 152 159 PF00069 0.382
MOD_GSK3_1 172 179 PF00069 0.519
MOD_GSK3_1 335 342 PF00069 0.718
MOD_GSK3_1 379 386 PF00069 0.699
MOD_GSK3_1 444 451 PF00069 0.373
MOD_GSK3_1 517 524 PF00069 0.426
MOD_GSK3_1 52 59 PF00069 0.350
MOD_GSK3_1 539 546 PF00069 0.282
MOD_GSK3_1 567 574 PF00069 0.301
MOD_GSK3_1 641 648 PF00069 0.726
MOD_GSK3_1 7 14 PF00069 0.662
MOD_N-GLC_1 318 323 PF02516 0.486
MOD_N-GLC_1 462 467 PF02516 0.514
MOD_N-GLC_1 539 544 PF02516 0.482
MOD_N-GLC_1 74 79 PF02516 0.494
MOD_NEK2_1 12 17 PF00069 0.612
MOD_NEK2_1 150 155 PF00069 0.344
MOD_NEK2_1 189 194 PF00069 0.422
MOD_NEK2_1 39 44 PF00069 0.684
MOD_NEK2_1 474 479 PF00069 0.350
MOD_NEK2_1 52 57 PF00069 0.420
MOD_NEK2_1 539 544 PF00069 0.288
MOD_NEK2_1 593 598 PF00069 0.394
MOD_NEK2_1 601 606 PF00069 0.372
MOD_NEK2_1 654 659 PF00069 0.806
MOD_NEK2_1 74 79 PF00069 0.380
MOD_NEK2_1 91 96 PF00069 0.312
MOD_NEK2_2 156 161 PF00069 0.373
MOD_PIKK_1 627 633 PF00454 0.625
MOD_PIKK_1 643 649 PF00454 0.629
MOD_PKA_2 335 341 PF00069 0.714
MOD_PKA_2 520 526 PF00069 0.287
MOD_PKA_2 557 563 PF00069 0.319
MOD_PKA_2 7 13 PF00069 0.612
MOD_PKB_1 170 178 PF00069 0.519
MOD_Plk_1 462 468 PF00069 0.412
MOD_Plk_1 539 545 PF00069 0.332
MOD_Plk_4 156 162 PF00069 0.335
MOD_Plk_4 189 195 PF00069 0.336
MOD_Plk_4 379 385 PF00069 0.788
MOD_Plk_4 390 396 PF00069 0.661
MOD_Plk_4 432 438 PF00069 0.364
MOD_Plk_4 474 480 PF00069 0.457
MOD_Plk_4 505 511 PF00069 0.323
MOD_Plk_4 56 62 PF00069 0.386
MOD_Plk_4 674 680 PF00069 0.596
MOD_ProDKin_1 289 295 PF00069 0.732
MOD_ProDKin_1 318 324 PF00069 0.692
MOD_ProDKin_1 641 647 PF00069 0.822
MOD_SUMO_rev_2 6 12 PF00179 0.580
TRG_ENDOCYTIC_2 149 152 PF00928 0.415
TRG_ENDOCYTIC_2 196 199 PF00928 0.373
TRG_ENDOCYTIC_2 33 36 PF00928 0.520
TRG_ENDOCYTIC_2 453 456 PF00928 0.327
TRG_ENDOCYTIC_2 494 497 PF00928 0.484
TRG_ENDOCYTIC_2 513 516 PF00928 0.323
TRG_ENDOCYTIC_2 625 628 PF00928 0.590
TRG_ENDOCYTIC_2 71 74 PF00928 0.283
TRG_ER_diArg_1 420 422 PF00400 0.580
TRG_ER_diArg_1 670 672 PF00400 0.642
TRG_Pf-PMV_PEXEL_1 547 552 PF00026 0.519

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5K5 Leptomonas seymouri 57% 100%
A0A1X0NVK4 Trypanosomatidae 24% 100%
A0A3Q8IIA5 Leishmania donovani 87% 100%
A0A3S7WTH9 Leishmania donovani 26% 100%
A4H859 Leishmania braziliensis 26% 100%
A4HWI5 Leishmania infantum 26% 100%
A4IA48 Leishmania infantum 87% 100%
E9AQ86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B562 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QF97 Leishmania major 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS