Putative GPI transamidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase subunit 16, putative

Species:

Leishmania major

UniProt:

Q4Q2S2_LEIMA

TriTrypDb:

LmjF.34.2730 , LMJLV39_340032700 , LMJSD75_340032800

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q2S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2S2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.530
CLV_NRD_NRD_1	11	13	PF00675	0.474
CLV_NRD_NRD_1	123	125	PF00675	0.541
CLV_NRD_NRD_1	150	152	PF00675	0.721
CLV_NRD_NRD_1	173	175	PF00675	0.609
CLV_NRD_NRD_1	47	49	PF00675	0.576
CLV_NRD_NRD_1	623	625	PF00675	0.623
CLV_NRD_NRD_1	720	722	PF00675	0.417
CLV_PCSK_FUR_1	171	175	PF00082	0.538
CLV_PCSK_KEX2_1	11	13	PF00082	0.506
CLV_PCSK_KEX2_1	122	124	PF00082	0.542
CLV_PCSK_KEX2_1	150	152	PF00082	0.727
CLV_PCSK_KEX2_1	173	175	PF00082	0.533
CLV_PCSK_KEX2_1	454	456	PF00082	0.773
CLV_PCSK_KEX2_1	47	49	PF00082	0.576
CLV_PCSK_KEX2_1	623	625	PF00082	0.641
CLV_PCSK_KEX2_1	658	660	PF00082	0.715
CLV_PCSK_KEX2_1	720	722	PF00082	0.398
CLV_PCSK_KEX2_1	725	727	PF00082	0.398
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.669
CLV_PCSK_PC1ET2_1	658	660	PF00082	0.623
CLV_PCSK_PC1ET2_1	725	727	PF00082	0.483
CLV_PCSK_PC7_1	721	727	PF00082	0.409
CLV_PCSK_SKI1_1	173	177	PF00082	0.639
CLV_PCSK_SKI1_1	284	288	PF00082	0.515
CLV_PCSK_SKI1_1	378	382	PF00082	0.610
CLV_PCSK_SKI1_1	393	397	PF00082	0.714
CLV_PCSK_SKI1_1	480	484	PF00082	0.576
CLV_PCSK_SKI1_1	720	724	PF00082	0.361
DEG_APCC_DBOX_1	490	498	PF00400	0.311
DEG_APCC_DBOX_1	725	733	PF00400	0.704
DOC_CYCLIN_yCln2_LP_2	483	489	PF00134	0.296
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.384
DOC_MAPK_DCC_7	480	489	PF00069	0.385
DOC_MAPK_DCC_7	589	597	PF00069	0.432
DOC_MAPK_gen_1	225	234	PF00069	0.452
DOC_MAPK_gen_1	360	368	PF00069	0.406
DOC_MAPK_gen_1	47	53	PF00069	0.316
DOC_MAPK_gen_1	556	566	PF00069	0.441
DOC_MAPK_gen_1	725	732	PF00069	0.610
DOC_MAPK_MEF2A_6	327	334	PF00069	0.371
DOC_MAPK_MEF2A_6	360	368	PF00069	0.441
DOC_MAPK_MEF2A_6	428	437	PF00069	0.415
DOC_MAPK_MEF2A_6	589	598	PF00069	0.337
DOC_PP1_RVXF_1	126	132	PF00149	0.364
DOC_PP2B_LxvP_1	78	81	PF13499	0.314
DOC_PP4_FxxP_1	298	301	PF00568	0.400
DOC_USP7_MATH_1	13	17	PF00917	0.588
DOC_USP7_MATH_1	224	228	PF00917	0.500
DOC_USP7_MATH_1	290	294	PF00917	0.405
DOC_USP7_MATH_1	315	319	PF00917	0.490
DOC_USP7_MATH_1	385	389	PF00917	0.424
DOC_USP7_MATH_1	403	407	PF00917	0.582
DOC_USP7_MATH_1	43	47	PF00917	0.406
DOC_USP7_MATH_1	610	614	PF00917	0.461
DOC_WW_Pin1_4	212	217	PF00397	0.348
DOC_WW_Pin1_4	220	225	PF00397	0.393
DOC_WW_Pin1_4	263	268	PF00397	0.431
DOC_WW_Pin1_4	386	391	PF00397	0.463
DOC_WW_Pin1_4	395	400	PF00397	0.483
DOC_WW_Pin1_4	405	410	PF00397	0.498
DOC_WW_Pin1_4	413	418	PF00397	0.386
DOC_WW_Pin1_4	524	529	PF00397	0.399
DOC_WW_Pin1_4	600	605	PF00397	0.321
DOC_WW_Pin1_4	63	68	PF00397	0.430
LIG_14-3-3_CanoR_1	196	204	PF00244	0.354
LIG_14-3-3_CanoR_1	316	324	PF00244	0.364
LIG_14-3-3_CanoR_1	333	337	PF00244	0.370
LIG_14-3-3_CanoR_1	401	409	PF00244	0.586
LIG_14-3-3_CanoR_1	47	52	PF00244	0.367
LIG_14-3-3_CanoR_1	624	630	PF00244	0.489
LIG_14-3-3_CanoR_1	680	684	PF00244	0.412
LIG_14-3-3_CanoR_1	720	729	PF00244	0.645
LIG_AP_GAE_1	110	116	PF02883	0.417
LIG_BRCT_BRCA1_1	165	169	PF00533	0.425
LIG_BRCT_BRCA1_1	185	189	PF00533	0.198
LIG_Clathr_ClatBox_1	441	445	PF01394	0.430
LIG_deltaCOP1_diTrp_1	130	138	PF00928	0.324
LIG_EH1_1	494	502	PF00400	0.417
LIG_eIF4E_1	3	9	PF01652	0.589
LIG_eIF4E_1	495	501	PF01652	0.388
LIG_FHA_1	260	266	PF00498	0.328
LIG_FHA_1	323	329	PF00498	0.405
LIG_FHA_1	381	387	PF00498	0.346
LIG_FHA_1	432	438	PF00498	0.306
LIG_FHA_1	479	485	PF00498	0.376
LIG_FHA_1	501	507	PF00498	0.417
LIG_FHA_1	515	521	PF00498	0.306
LIG_FHA_1	55	61	PF00498	0.387
LIG_FHA_1	64	70	PF00498	0.368
LIG_FHA_1	717	723	PF00498	0.601
LIG_FHA_1	737	743	PF00498	0.656
LIG_FHA_2	106	112	PF00498	0.372
LIG_FHA_2	575	581	PF00498	0.337
LIG_FHA_2	666	672	PF00498	0.347
LIG_HCF-1_HBM_1	429	432	PF13415	0.431
LIG_LIR_Apic_2	141	145	PF02991	0.451
LIG_LIR_Apic_2	651	655	PF02991	0.355
LIG_LIR_Gen_1	166	177	PF02991	0.412
LIG_LIR_Gen_1	183	192	PF02991	0.433
LIG_LIR_Gen_1	251	260	PF02991	0.414
LIG_LIR_Gen_1	429	440	PF02991	0.374
LIG_LIR_Gen_1	46	56	PF02991	0.414
LIG_LIR_Gen_1	617	626	PF02991	0.455
LIG_LIR_Nem_3	110	116	PF02991	0.335
LIG_LIR_Nem_3	166	172	PF02991	0.447
LIG_LIR_Nem_3	183	187	PF02991	0.392
LIG_LIR_Nem_3	246	252	PF02991	0.355
LIG_LIR_Nem_3	293	297	PF02991	0.330
LIG_LIR_Nem_3	429	435	PF02991	0.328
LIG_LIR_Nem_3	617	621	PF02991	0.340
LIG_NRBOX	171	177	PF00104	0.338
LIG_NRBOX	517	523	PF00104	0.346
LIG_NRBOX	728	734	PF00104	0.652
LIG_Pex14_1	204	208	PF04695	0.316
LIG_Pex14_2	109	113	PF04695	0.429
LIG_Pex14_2	287	291	PF04695	0.314
LIG_Pex14_2	294	298	PF04695	0.289
LIG_Pex14_2	569	573	PF04695	0.289
LIG_PTB_Apo_2	646	653	PF02174	0.389
LIG_PTB_Phospho_1	646	652	PF10480	0.308
LIG_SH2_CRK	184	188	PF00017	0.395
LIG_SH2_CRK	252	256	PF00017	0.396
LIG_SH2_NCK_1	184	188	PF00017	0.395
LIG_SH2_NCK_1	534	538	PF00017	0.413
LIG_SH2_SRC	538	541	PF00017	0.397
LIG_SH2_STAP1	49	53	PF00017	0.331
LIG_SH2_STAP1	534	538	PF00017	0.413
LIG_SH2_STAT5	119	122	PF00017	0.410
LIG_SH2_STAT5	297	300	PF00017	0.362
LIG_SH2_STAT5	432	435	PF00017	0.347
LIG_SH3_3	34	40	PF00018	0.424
LIG_SH3_3	384	390	PF00018	0.429
LIG_SH3_3	588	594	PF00018	0.425
LIG_SH3_3	78	84	PF00018	0.384
LIG_SUMO_SIM_anti_2	517	525	PF11976	0.384
LIG_SUMO_SIM_par_1	23	28	PF11976	0.344
LIG_SUMO_SIM_par_1	440	445	PF11976	0.466
LIG_TRAF2_1	309	312	PF00917	0.424
LIG_TRAF2_1	461	464	PF00917	0.435
LIG_TYR_ITIM	116	121	PF00017	0.498
LIG_Vh1_VBS_1	507	525	PF01044	0.410
LIG_WRC_WIRS_1	291	296	PF05994	0.471
MOD_CDK_SPK_2	220	225	PF00069	0.510
MOD_CDK_SPK_2	386	391	PF00069	0.489
MOD_CDK_SPxK_1	395	401	PF00069	0.711
MOD_CDK_SPxxK_3	386	393	PF00069	0.431
MOD_CDK_SPxxK_3	405	412	PF00069	0.724
MOD_CK1_1	185	191	PF00069	0.390
MOD_CK1_1	210	216	PF00069	0.428
MOD_CK1_1	218	224	PF00069	0.469
MOD_CK1_1	408	414	PF00069	0.644
MOD_CK1_1	628	634	PF00069	0.551
MOD_CK1_1	685	691	PF00069	0.622
MOD_CK2_1	105	111	PF00069	0.375
MOD_CK2_1	339	345	PF00069	0.481
MOD_CK2_1	386	392	PF00069	0.588
MOD_CK2_1	56	62	PF00069	0.558
MOD_CK2_1	574	580	PF00069	0.396
MOD_CK2_1	665	671	PF00069	0.517
MOD_Cter_Amidation	656	659	PF01082	0.538
MOD_DYRK1A_RPxSP_1	600	604	PF00069	0.382
MOD_GlcNHglycan	13	16	PF01048	0.603
MOD_GlcNHglycan	158	161	PF01048	0.724
MOD_GlcNHglycan	220	223	PF01048	0.512
MOD_GlcNHglycan	273	276	PF01048	0.550
MOD_GlcNHglycan	317	320	PF01048	0.572
MOD_GlcNHglycan	378	381	PF01048	0.497
MOD_GlcNHglycan	403	406	PF01048	0.749
MOD_GlcNHglycan	462	467	PF01048	0.634
MOD_GlcNHglycan	662	665	PF01048	0.586
MOD_GlcNHglycan	684	687	PF01048	0.600
MOD_GlcNHglycan	693	696	PF01048	0.547
MOD_GSK3_1	207	214	PF00069	0.419
MOD_GSK3_1	220	227	PF00069	0.501
MOD_GSK3_1	259	266	PF00069	0.420
MOD_GSK3_1	303	310	PF00069	0.426
MOD_GSK3_1	345	352	PF00069	0.447
MOD_GSK3_1	376	383	PF00069	0.461
MOD_GSK3_1	401	408	PF00069	0.754
MOD_GSK3_1	43	50	PF00069	0.463
MOD_GSK3_1	496	503	PF00069	0.520
MOD_GSK3_1	678	685	PF00069	0.516
MOD_GSK3_1	716	723	PF00069	0.620
MOD_N-GLC_1	161	166	PF02516	0.440
MOD_N-GLC_1	43	48	PF02516	0.460
MOD_N-GLC_1	648	653	PF02516	0.438
MOD_NEK2_1	208	213	PF00069	0.387
MOD_NEK2_1	217	222	PF00069	0.467
MOD_NEK2_1	467	472	PF00069	0.546
MOD_NEK2_1	500	505	PF00069	0.506
MOD_NEK2_1	521	526	PF00069	0.376
MOD_NEK2_1	573	578	PF00069	0.449
MOD_NEK2_1	648	653	PF00069	0.486
MOD_NEK2_1	74	79	PF00069	0.467
MOD_NEK2_2	665	670	PF00069	0.429
MOD_PIKK_1	197	203	PF00454	0.475
MOD_PIKK_1	259	265	PF00454	0.407
MOD_PIKK_1	307	313	PF00454	0.439
MOD_PIKK_1	371	377	PF00454	0.539
MOD_PIKK_1	611	617	PF00454	0.633
MOD_PKA_1	11	17	PF00069	0.521
MOD_PKA_1	47	53	PF00069	0.417
MOD_PKA_1	658	664	PF00069	0.545
MOD_PKA_1	720	726	PF00069	0.563
MOD_PKA_2	11	17	PF00069	0.607
MOD_PKA_2	224	230	PF00069	0.605
MOD_PKA_2	235	241	PF00069	0.616
MOD_PKA_2	315	321	PF00069	0.469
MOD_PKA_2	332	338	PF00069	0.459
MOD_PKA_2	47	53	PF00069	0.451
MOD_PKA_2	490	496	PF00069	0.374
MOD_PKA_2	62	68	PF00069	0.510
MOD_PKA_2	658	664	PF00069	0.590
MOD_PKA_2	679	685	PF00069	0.428
MOD_PKA_2	716	722	PF00069	0.449
MOD_Plk_1	140	146	PF00069	0.504
MOD_Plk_1	462	468	PF00069	0.630
MOD_Plk_1	522	528	PF00069	0.446
MOD_Plk_1	637	643	PF00069	0.567
MOD_Plk_1	648	654	PF00069	0.513
MOD_Plk_1	74	80	PF00069	0.377
MOD_Plk_4	163	169	PF00069	0.579
MOD_Plk_4	25	31	PF00069	0.419
MOD_Plk_4	290	296	PF00069	0.468
MOD_Plk_4	332	338	PF00069	0.483
MOD_Plk_4	467	473	PF00069	0.509
MOD_Plk_4	47	53	PF00069	0.479
MOD_Plk_4	490	496	PF00069	0.457
MOD_Plk_4	65	71	PF00069	0.276
MOD_Plk_4	737	743	PF00069	0.661
MOD_ProDKin_1	212	218	PF00069	0.429
MOD_ProDKin_1	220	226	PF00069	0.490
MOD_ProDKin_1	263	269	PF00069	0.544
MOD_ProDKin_1	386	392	PF00069	0.597
MOD_ProDKin_1	395	401	PF00069	0.620
MOD_ProDKin_1	405	411	PF00069	0.629
MOD_ProDKin_1	413	419	PF00069	0.472
MOD_ProDKin_1	524	530	PF00069	0.493
MOD_ProDKin_1	600	606	PF00069	0.393
MOD_ProDKin_1	63	69	PF00069	0.530
MOD_SUMO_for_1	328	331	PF00179	0.417
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.409
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.514
TRG_ENDOCYTIC_2	118	121	PF00928	0.502
TRG_ENDOCYTIC_2	184	187	PF00928	0.495
TRG_ENDOCYTIC_2	252	255	PF00928	0.484
TRG_ENDOCYTIC_2	3	6	PF00928	0.488
TRG_ENDOCYTIC_2	432	435	PF00928	0.370
TRG_ENDOCYTIC_2	49	52	PF00928	0.517
TRG_ER_diArg_1	11	13	PF00400	0.580
TRG_ER_diArg_1	121	124	PF00400	0.403
TRG_ER_diArg_1	171	174	PF00400	0.417
TRG_ER_diArg_1	47	49	PF00400	0.466
TRG_ER_diArg_1	720	722	PF00400	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I790	Leptomonas seymouri	60%	100%
A0A1X0P9R2	Trypanosomatidae	32%	100%
A0A3R7MUC6	Trypanosoma rangeli	34%	100%
A0A3S7X824	Leishmania donovani	94%	100%
A4HAY9	Leishmania braziliensis	78%	100%
A4IA49	Leishmania infantum	94%	100%
C9ZM54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B563	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BV01	Trypanosoma cruzi	34%	100%