Methyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase-like protein

Species:

Leishmania major

UniProt:

Q4Q2S0_LEIMA

TriTrypDb:

LmjF.34.2750 , LMJLV39_340032900 , LMJSD75_340033000

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10
GO:0005634	nucleus	5	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

Q4Q2S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2S0

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	11
GO:0001510	RNA methylation	4	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0031167	rRNA methylation	5	11
GO:0032259	methylation	2	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0036265	RNA (guanine-N7)-methylation	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043414	macromolecule methylation	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0070475	rRNA base methylation	6	11
GO:0070476	rRNA (guanine-N7)-methylation	6	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008649	rRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016435	rRNA (guanine) methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140102	catalytic activity, acting on a rRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.449
CLV_NRD_NRD_1	22	24	PF00675	0.462
CLV_NRD_NRD_1	232	234	PF00675	0.371
CLV_NRD_NRD_1	246	248	PF00675	0.370
CLV_NRD_NRD_1	30	32	PF00675	0.428
CLV_NRD_NRD_1	356	358	PF00675	0.692
CLV_NRD_NRD_1	384	386	PF00675	0.231
CLV_NRD_NRD_1	407	409	PF00675	0.206
CLV_NRD_NRD_1	422	424	PF00675	0.224
CLV_PCSK_FUR_1	405	409	PF00082	0.264
CLV_PCSK_KEX2_1	22	24	PF00082	0.548
CLV_PCSK_KEX2_1	232	234	PF00082	0.369
CLV_PCSK_KEX2_1	246	248	PF00082	0.370
CLV_PCSK_KEX2_1	358	360	PF00082	0.300
CLV_PCSK_KEX2_1	371	373	PF00082	0.215
CLV_PCSK_KEX2_1	382	384	PF00082	0.253
CLV_PCSK_KEX2_1	405	407	PF00082	0.202
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.300
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.164
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.199
CLV_PCSK_SKI1_1	247	251	PF00082	0.335
CLV_PCSK_SKI1_1	35	39	PF00082	0.306
CLV_PCSK_SKI1_1	389	393	PF00082	0.215
CLV_PCSK_SKI1_1	92	96	PF00082	0.384
DOC_MAPK_gen_1	288	296	PF00069	0.305
DOC_MAPK_gen_1	29	39	PF00069	0.425
DOC_PP2B_LxvP_1	45	48	PF13499	0.393
DOC_PP4_FxxP_1	305	308	PF00568	0.418
DOC_USP7_MATH_1	111	115	PF00917	0.524
DOC_USP7_MATH_1	175	179	PF00917	0.628
DOC_USP7_MATH_1	373	377	PF00917	0.475
DOC_USP7_UBL2_3	382	386	PF12436	0.398
LIG_14-3-3_CanoR_1	22	27	PF00244	0.358
LIG_14-3-3_CanoR_1	408	418	PF00244	0.497
LIG_Actin_WH2_2	230	248	PF00022	0.344
LIG_Actin_WH2_2	81	98	PF00022	0.453
LIG_EVH1_2	11	15	PF00568	0.442
LIG_FHA_1	130	136	PF00498	0.630
LIG_FHA_1	310	316	PF00498	0.582
LIG_FHA_2	139	145	PF00498	0.544
LIG_FHA_2	164	170	PF00498	0.714
LIG_FHA_2	410	416	PF00498	0.402
LIG_LIR_Gen_1	240	249	PF02991	0.334
LIG_LIR_Gen_1	394	404	PF02991	0.402
LIG_LIR_Nem_3	102	108	PF02991	0.566
LIG_LIR_Nem_3	240	245	PF02991	0.320
LIG_LIR_Nem_3	394	400	PF02991	0.402
LIG_PCNA_PIPBox_1	231	240	PF02747	0.306
LIG_PCNA_yPIPBox_3	225	238	PF02747	0.327
LIG_SH2_CRK	242	246	PF00017	0.285
LIG_SH2_STAT5	121	124	PF00017	0.388
LIG_SH2_STAT5	24	27	PF00017	0.331
LIG_SH2_STAT5	293	296	PF00017	0.278
LIG_SH2_STAT5	418	421	PF00017	0.402
LIG_SH3_3	146	152	PF00018	0.534
LIG_SH3_3	199	205	PF00018	0.343
LIG_SH3_3	254	260	PF00018	0.453
LIG_SH3_3	278	284	PF00018	0.320
LIG_SH3_3	303	309	PF00018	0.370
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.395
LIG_SUMO_SIM_par_1	63	69	PF11976	0.348
LIG_TYR_ITIM	103	108	PF00017	0.422
LIG_UBA3_1	44	49	PF00899	0.488
LIG_UBA3_1	94	99	PF00899	0.307
MOD_CK1_1	416	422	PF00069	0.398
MOD_CK1_1	71	77	PF00069	0.305
MOD_CK2_1	147	153	PF00069	0.693
MOD_CK2_1	255	261	PF00069	0.409
MOD_GlcNHglycan	113	116	PF01048	0.418
MOD_GlcNHglycan	166	169	PF01048	0.551
MOD_GlcNHglycan	177	180	PF01048	0.497
MOD_GlcNHglycan	184	187	PF01048	0.560
MOD_GlcNHglycan	285	288	PF01048	0.453
MOD_GlcNHglycan	339	342	PF01048	0.590
MOD_GlcNHglycan	376	379	PF01048	0.243
MOD_GlcNHglycan	60	63	PF01048	0.407
MOD_GlcNHglycan	68	71	PF01048	0.350
MOD_GlcNHglycan	73	76	PF01048	0.261
MOD_GSK3_1	409	416	PF00069	0.402
MOD_GSK3_1	49	56	PF00069	0.404
MOD_N-GLC_1	16	21	PF02516	0.354
MOD_N-GLC_1	58	63	PF02516	0.520
MOD_NEK2_1	122	127	PF00069	0.577
MOD_NEK2_1	130	135	PF00069	0.638
MOD_NEK2_1	220	225	PF00069	0.438
MOD_NEK2_1	237	242	PF00069	0.219
MOD_PKA_1	22	28	PF00069	0.476
MOD_PKA_2	22	28	PF00069	0.362
MOD_PKA_2	373	379	PF00069	0.507
MOD_PKB_1	372	380	PF00069	0.462
MOD_Plk_1	130	136	PF00069	0.699
MOD_Plk_1	35	41	PF00069	0.433
MOD_Plk_1	58	64	PF00069	0.505
MOD_Plk_2-3	147	153	PF00069	0.691
MOD_Plk_4	237	243	PF00069	0.332
MOD_SUMO_for_1	400	403	PF00179	0.457
TRG_ENDOCYTIC_2	105	108	PF00928	0.548
TRG_ENDOCYTIC_2	242	245	PF00928	0.279
TRG_ENDOCYTIC_2	292	295	PF00928	0.290
TRG_ER_diArg_1	22	24	PF00400	0.398
TRG_ER_diArg_1	232	234	PF00400	0.315
TRG_ER_diArg_1	245	247	PF00400	0.351
TRG_ER_diArg_1	357	360	PF00400	0.599
TRG_ER_diArg_1	383	385	PF00400	0.446
TRG_ER_diArg_1	405	408	PF00400	0.457
TRG_ER_diArg_1	420	423	PF00400	0.349
TRG_NLS_Bipartite_1	371	386	PF00514	0.414
TRG_NLS_Bipartite_1	405	427	PF00514	0.415
TRG_NLS_MonoCore_2	381	386	PF00514	0.399
TRG_NLS_MonoCore_2	422	427	PF00514	0.601
TRG_NLS_MonoExtC_3	356	361	PF00514	0.622
TRG_NLS_MonoExtC_3	381	386	PF00514	0.399
TRG_NLS_MonoExtN_4	354	361	PF00514	0.664
TRG_NLS_MonoExtN_4	421	427	PF00514	0.415
TRG_PTS1	424	427	PF00515	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC68	Leptomonas seymouri	73%	100%
A0A1X0P9R3	Trypanosomatidae	53%	100%
A0A3Q8IFP3	Leishmania donovani	93%	100%
A0A3R7KRG3	Trypanosoma rangeli	53%	100%
A4HAZ1	Leishmania braziliensis	83%	100%
A4IA51	Leishmania infantum	93%	100%
C9ZM51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B565	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q55DA6	Dictyostelium discoideum	33%	100%
V5B593	Trypanosoma cruzi	54%	100%