Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2R9_LEIMA

TriTrypDb:

LmjF.34.2760 , LMJLV39_340033000 , LMJSD75_340033100

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.534
CLV_C14_Caspase3-7	82	86	PF00656	0.641
CLV_C14_Caspase3-7	98	102	PF00656	0.709
CLV_NRD_NRD_1	131	133	PF00675	0.440
CLV_NRD_NRD_1	275	277	PF00675	0.507
CLV_NRD_NRD_1	279	281	PF00675	0.518
CLV_NRD_NRD_1	57	59	PF00675	0.567
CLV_PCSK_KEX2_1	131	133	PF00082	0.440
CLV_PCSK_KEX2_1	275	277	PF00082	0.507
CLV_PCSK_KEX2_1	279	281	PF00082	0.518
CLV_PCSK_KEX2_1	57	59	PF00082	0.567
CLV_PCSK_PC7_1	271	277	PF00082	0.507
CLV_PCSK_SKI1_1	183	187	PF00082	0.441
CLV_PCSK_SKI1_1	22	26	PF00082	0.383
CLV_PCSK_SKI1_1	222	226	PF00082	0.688
CLV_Separin_Metazoa	254	258	PF03568	0.609
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DOC_CYCLIN_RxL_1	177	190	PF00134	0.441
DOC_CYCLIN_RxL_1	19	29	PF00134	0.399
DOC_USP7_MATH_1	104	108	PF00917	0.758
DOC_WW_Pin1_4	191	196	PF00397	0.430
LIG_Actin_WH2_2	194	209	PF00022	0.420
LIG_BIR_III_4	85	89	PF00653	0.634
LIG_BRCT_BRCA1_1	195	199	PF00533	0.424
LIG_FHA_1	117	123	PF00498	0.387
LIG_FHA_1	226	232	PF00498	0.549
LIG_FHA_1	45	51	PF00498	0.422
LIG_FHA_2	145	151	PF00498	0.419
LIG_FHA_2	165	171	PF00498	0.340
LIG_LIR_Gen_1	156	166	PF02991	0.482
LIG_LIR_Nem_3	134	139	PF02991	0.461
LIG_LIR_Nem_3	156	162	PF02991	0.474
LIG_NRBOX	181	187	PF00104	0.430
LIG_PALB2_WD40_1	237	245	PF16756	0.559
LIG_Pex14_1	238	242	PF04695	0.563
LIG_RPA_C_Fungi	120	132	PF08784	0.509
LIG_RPA_C_Insects	120	135	PF08784	0.497
LIG_SH2_CRK	159	163	PF00017	0.505
LIG_SH2_STAP1	208	212	PF00017	0.543
LIG_SH2_STAT5	200	203	PF00017	0.427
LIG_SUMO_SIM_par_1	187	194	PF11976	0.441
MOD_CDK_SPxxK_3	191	198	PF00069	0.558
MOD_CK1_1	193	199	PF00069	0.543
MOD_CK1_1	258	264	PF00069	0.560
MOD_CK2_1	164	170	PF00069	0.492
MOD_CK2_1	69	75	PF00069	0.794
MOD_CK2_1	76	82	PF00069	0.668
MOD_CK2_1	8	14	PF00069	0.655
MOD_CMANNOS	238	241	PF00535	0.567
MOD_GlcNHglycan	208	211	PF01048	0.536
MOD_GlcNHglycan	233	236	PF01048	0.591
MOD_GSK3_1	206	213	PF00069	0.482
MOD_GSK3_1	4	11	PF00069	0.661
MOD_LATS_1	68	74	PF00433	0.705
MOD_N-GLC_2	40	42	PF02516	0.389
MOD_NEK2_1	206	211	PF00069	0.450
MOD_NEK2_1	231	236	PF00069	0.569
MOD_NEK2_2	104	109	PF00069	0.532
MOD_OFUCOSY	142	148	PF10250	0.419
MOD_PIKK_1	95	101	PF00454	0.789
MOD_PKA_1	131	137	PF00069	0.483
MOD_PKA_2	124	130	PF00069	0.620
MOD_PKA_2	131	137	PF00069	0.461
MOD_PKA_2	206	212	PF00069	0.464
MOD_Plk_1	144	150	PF00069	0.419
MOD_Plk_2-3	76	82	PF00069	0.754
MOD_Plk_2-3	8	14	PF00069	0.655
MOD_Plk_4	157	163	PF00069	0.623
MOD_ProDKin_1	191	197	PF00069	0.424
TRG_DiLeu_BaEn_1	184	189	PF01217	0.411
TRG_ENDOCYTIC_2	114	117	PF00928	0.461
TRG_ENDOCYTIC_2	159	162	PF00928	0.486
TRG_ENDOCYTIC_2	208	211	PF00928	0.473
TRG_ER_diArg_1	279	282	PF00400	0.468
TRG_ER_diArg_1	56	58	PF00400	0.563
TRG_NLS_MonoExtN_4	279	286	PF00514	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P606	Leptomonas seymouri	58%	100%
A0A3S7X837	Leishmania donovani	95%	100%
A4HAZ2	Leishmania braziliensis	83%	100%
A4IA52	Leishmania infantum	95%	100%
E9B566	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%