LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q2R8_LEIMA
TriTrypDb:
LmjF.34.2765 , LMJLV39_340033100 * , LMJSD75_340033200
Length:
343

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2R8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 197 201 PF00656 0.710
CLV_NRD_NRD_1 28 30 PF00675 0.626
CLV_NRD_NRD_1 44 46 PF00675 0.694
CLV_NRD_NRD_1 81 83 PF00675 0.743
CLV_PCSK_FUR_1 57 61 PF00082 0.716
CLV_PCSK_KEX2_1 108 110 PF00082 0.853
CLV_PCSK_KEX2_1 318 320 PF00082 0.554
CLV_PCSK_KEX2_1 59 61 PF00082 0.676
CLV_PCSK_KEX2_1 81 83 PF00082 0.716
CLV_PCSK_PC1ET2_1 108 110 PF00082 0.849
CLV_PCSK_PC1ET2_1 318 320 PF00082 0.554
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.776
CLV_PCSK_SKI1_1 325 329 PF00082 0.623
DEG_COP1_1 143 151 PF00400 0.606
DEG_SPOP_SBC_1 211 215 PF00917 0.765
DOC_CKS1_1 65 70 PF01111 0.828
DOC_CYCLIN_RxL_1 315 323 PF00134 0.652
DOC_MAPK_DCC_7 224 234 PF00069 0.568
DOC_MAPK_MEF2A_6 30 39 PF00069 0.733
DOC_MAPK_MEF2A_6 325 334 PF00069 0.700
DOC_PP2B_LxvP_1 11 14 PF13499 0.747
DOC_PP2B_LxvP_1 232 235 PF13499 0.760
DOC_USP7_MATH_1 120 124 PF00917 0.853
DOC_USP7_MATH_1 147 151 PF00917 0.761
DOC_USP7_MATH_1 169 173 PF00917 0.691
DOC_USP7_MATH_1 193 197 PF00917 0.685
DOC_USP7_MATH_1 242 246 PF00917 0.632
DOC_USP7_MATH_1 254 258 PF00917 0.635
DOC_USP7_MATH_1 300 304 PF00917 0.698
DOC_WW_Pin1_4 100 105 PF00397 0.574
DOC_WW_Pin1_4 141 146 PF00397 0.838
DOC_WW_Pin1_4 217 222 PF00397 0.617
DOC_WW_Pin1_4 225 230 PF00397 0.500
DOC_WW_Pin1_4 320 325 PF00397 0.721
DOC_WW_Pin1_4 64 69 PF00397 0.828
DOC_WW_Pin1_4 85 90 PF00397 0.778
LIG_14-3-3_CanoR_1 140 145 PF00244 0.743
LIG_14-3-3_CanoR_1 29 37 PF00244 0.576
LIG_14-3-3_CanoR_1 290 295 PF00244 0.781
LIG_14-3-3_CanoR_1 331 335 PF00244 0.663
LIG_FHA_1 133 139 PF00498 0.842
LIG_FHA_1 234 240 PF00498 0.770
LIG_FHA_2 155 161 PF00498 0.715
LIG_FHA_2 86 92 PF00498 0.855
LIG_Integrin_RGD_1 198 200 PF01839 0.746
LIG_PDZ_Class_2 338 343 PF00595 0.595
LIG_SH2_STAT5 177 180 PF00017 0.527
LIG_SH3_1 59 65 PF00018 0.791
LIG_SH3_2 313 318 PF14604 0.675
LIG_SH3_2 77 82 PF14604 0.687
LIG_SH3_3 133 139 PF00018 0.725
LIG_SH3_3 310 316 PF00018 0.719
LIG_SH3_3 59 65 PF00018 0.791
LIG_SH3_3 74 80 PF00018 0.583
LIG_SUMO_SIM_anti_2 159 165 PF11976 0.674
LIG_SUMO_SIM_anti_2 236 243 PF11976 0.705
LIG_SUMO_SIM_par_1 230 236 PF11976 0.749
LIG_SUMO_SIM_par_1 237 243 PF11976 0.549
LIG_UBA3_1 161 168 PF00899 0.608
MOD_CDK_SPK_2 320 325 PF00069 0.711
MOD_CDK_SPK_2 64 69 PF00069 0.828
MOD_CDK_SPxxK_3 100 107 PF00069 0.765
MOD_CDK_SPxxK_3 217 224 PF00069 0.603
MOD_CK1_1 201 207 PF00069 0.752
MOD_CK1_1 214 220 PF00069 0.680
MOD_CK1_1 286 292 PF00069 0.820
MOD_CK1_1 293 299 PF00069 0.706
MOD_CK1_1 333 339 PF00069 0.664
MOD_CK1_1 85 91 PF00069 0.850
MOD_CK2_1 147 153 PF00069 0.755
MOD_CK2_1 85 91 PF00069 0.856
MOD_GlcNHglycan 118 121 PF01048 0.786
MOD_GlcNHglycan 200 203 PF01048 0.714
MOD_GlcNHglycan 256 259 PF01048 0.781
MOD_GlcNHglycan 269 272 PF01048 0.590
MOD_GlcNHglycan 47 50 PF01048 0.820
MOD_GlcNHglycan 84 87 PF01048 0.820
MOD_GSK3_1 116 123 PF00069 0.805
MOD_GSK3_1 128 135 PF00069 0.693
MOD_GSK3_1 206 213 PF00069 0.699
MOD_GSK3_1 248 255 PF00069 0.695
MOD_GSK3_1 282 289 PF00069 0.828
MOD_GSK3_1 81 88 PF00069 0.790
MOD_N-GLC_1 19 24 PF02516 0.631
MOD_N-GLC_1 300 305 PF02516 0.680
MOD_NEK2_1 175 180 PF00069 0.610
MOD_NEK2_1 252 257 PF00069 0.638
MOD_NEK2_1 330 335 PF00069 0.670
MOD_NEK2_2 176 181 PF00069 0.685
MOD_PIKK_1 325 331 PF00454 0.660
MOD_PK_1 109 115 PF00069 0.854
MOD_PKA_1 29 35 PF00069 0.598
MOD_PKA_1 45 51 PF00069 0.628
MOD_PKA_1 81 87 PF00069 0.741
MOD_PKA_2 289 295 PF00069 0.782
MOD_PKA_2 330 336 PF00069 0.661
MOD_PKA_2 81 87 PF00069 0.741
MOD_PKB_1 17 25 PF00069 0.669
MOD_Plk_1 300 306 PF00069 0.699
MOD_Plk_4 300 306 PF00069 0.588
MOD_Plk_4 330 336 PF00069 0.661
MOD_ProDKin_1 100 106 PF00069 0.574
MOD_ProDKin_1 141 147 PF00069 0.838
MOD_ProDKin_1 217 223 PF00069 0.618
MOD_ProDKin_1 225 231 PF00069 0.496
MOD_ProDKin_1 320 326 PF00069 0.718
MOD_ProDKin_1 64 70 PF00069 0.829
MOD_ProDKin_1 85 91 PF00069 0.778
MOD_SUMO_rev_2 22 32 PF00179 0.688
TRG_ENDOCYTIC_2 177 180 PF00928 0.684
TRG_ER_diArg_1 266 269 PF00400 0.646
TRG_ER_diArg_1 319 322 PF00400 0.533
TRG_ER_diArg_1 80 82 PF00400 0.729
TRG_NLS_MonoExtN_4 316 322 PF00514 0.659

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H7X2 Leishmania donovani 87% 100%
A4HAZ3 Leishmania braziliensis 51% 99%
A4IA53 Leishmania infantum 87% 100%
E9B567 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS