Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcineurin-like phosphoesterase-like protein

Species:

Leishmania major

UniProt:

Q4Q2R7_LEIMA

TriTrypDb:

LmjF.34.2770 , LMJLV39_340033200 , LMJSD75_340033300

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0004722	protein serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0017018	myosin phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.553
CLV_NRD_NRD_1	116	118	PF00675	0.408
CLV_NRD_NRD_1	363	365	PF00675	0.573
CLV_NRD_NRD_1	451	453	PF00675	0.467
CLV_PCSK_FUR_1	370	374	PF00082	0.536
CLV_PCSK_KEX2_1	363	365	PF00082	0.573
CLV_PCSK_KEX2_1	372	374	PF00082	0.457
CLV_PCSK_KEX2_1	412	414	PF00082	0.665
CLV_PCSK_KEX2_1	451	453	PF00082	0.505
CLV_PCSK_KEX2_1	480	482	PF00082	0.729
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.569
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.665
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.729
CLV_PCSK_SKI1_1	121	125	PF00082	0.466
CLV_PCSK_SKI1_1	183	187	PF00082	0.444
CLV_PCSK_SKI1_1	363	367	PF00082	0.596
CLV_PCSK_SKI1_1	451	455	PF00082	0.438
CLV_PCSK_SKI1_1	67	71	PF00082	0.466
DEG_SCF_FBW7_1	145	152	PF00400	0.408
DEG_SCF_FBW7_1	384	389	PF00400	0.697
DEG_SPOP_SBC_1	387	391	PF00917	0.711
DOC_CKS1_1	146	151	PF01111	0.369
DOC_CYCLIN_RxL_1	180	189	PF00134	0.444
DOC_CYCLIN_yClb3_PxF_3	598	606	PF00134	0.688
DOC_CYCLIN_yCln2_LP_2	18	21	PF00134	0.512
DOC_MAPK_gen_1	136	145	PF00069	0.252
DOC_MAPK_gen_1	193	203	PF00069	0.370
DOC_MAPK_HePTP_8	69	81	PF00069	0.496
DOC_MAPK_MEF2A_6	193	202	PF00069	0.405
DOC_MAPK_MEF2A_6	72	81	PF00069	0.495
DOC_PP1_RVXF_1	178	185	PF00149	0.444
DOC_PP1_RVXF_1	554	560	PF00149	0.510
DOC_PP2B_LxvP_1	18	21	PF13499	0.512
DOC_PP2B_LxvP_1	358	361	PF13499	0.416
DOC_PP4_FxxP_1	526	529	PF00568	0.374
DOC_USP7_MATH_1	157	161	PF00917	0.386
DOC_USP7_MATH_1	261	265	PF00917	0.664
DOC_USP7_MATH_1	277	281	PF00917	0.476
DOC_USP7_MATH_1	327	331	PF00917	0.518
DOC_USP7_MATH_1	387	391	PF00917	0.654
DOC_USP7_MATH_1	470	474	PF00917	0.775
DOC_USP7_MATH_1	548	552	PF00917	0.572
DOC_USP7_UBL2_3	580	584	PF12436	0.778
DOC_WW_Pin1_4	138	143	PF00397	0.367
DOC_WW_Pin1_4	145	150	PF00397	0.360
DOC_WW_Pin1_4	266	271	PF00397	0.668
DOC_WW_Pin1_4	356	361	PF00397	0.380
DOC_WW_Pin1_4	382	387	PF00397	0.699
DOC_WW_Pin1_4	394	399	PF00397	0.612
DOC_WW_Pin1_4	405	410	PF00397	0.735
DOC_WW_Pin1_4	462	467	PF00397	0.566
DOC_WW_Pin1_4	484	489	PF00397	0.658
LIG_14-3-3_CanoR_1	308	316	PF00244	0.710
LIG_14-3-3_CanoR_1	363	371	PF00244	0.554
LIG_Actin_WH2_2	285	303	PF00022	0.522
LIG_Actin_WH2_2	39	55	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	170	174	PF00533	0.444
LIG_deltaCOP1_diTrp_1	326	335	PF00928	0.524
LIG_FHA_1	146	152	PF00498	0.396
LIG_FHA_1	225	231	PF00498	0.444
LIG_FHA_1	383	389	PF00498	0.751
LIG_FHA_1	463	469	PF00498	0.653
LIG_FHA_2	321	327	PF00498	0.654
LIG_FHA_2	548	554	PF00498	0.384
LIG_LIR_Apic_2	252	256	PF02991	0.727
LIG_LIR_Apic_2	524	529	PF02991	0.372
LIG_LIR_Gen_1	24	34	PF02991	0.486
LIG_LIR_Gen_1	259	270	PF02991	0.574
LIG_LIR_Gen_1	326	335	PF02991	0.451
LIG_LIR_Gen_1	85	93	PF02991	0.482
LIG_LIR_Nem_3	24	29	PF02991	0.499
LIG_LIR_Nem_3	259	265	PF02991	0.576
LIG_LIR_Nem_3	326	331	PF02991	0.438
LIG_LIR_Nem_3	334	340	PF02991	0.299
LIG_LIR_Nem_3	558	562	PF02991	0.495
LIG_LIR_Nem_3	617	623	PF02991	0.729
LIG_LIR_Nem_3	8	14	PF02991	0.489
LIG_LIR_Nem_3	85	90	PF02991	0.482
LIG_MYND_1	16	20	PF01753	0.526
LIG_PCNA_yPIPBox_3	412	423	PF02747	0.595
LIG_PCNA_yPIPBox_3	606	620	PF02747	0.685
LIG_PCNA_yPIPBox_3	98	111	PF02747	0.444
LIG_Pex14_2	331	335	PF04695	0.464
LIG_Rb_pABgroove_1	8	16	PF01858	0.467
LIG_SH2_CRK	262	266	PF00017	0.676
LIG_SH2_CRK	406	410	PF00017	0.770
LIG_SH2_PTP2	253	256	PF00017	0.571
LIG_SH2_PTP2	26	29	PF00017	0.472
LIG_SH2_SRC	253	256	PF00017	0.688
LIG_SH2_STAP1	262	266	PF00017	0.509
LIG_SH2_STAP1	38	42	PF00017	0.518
LIG_SH2_STAT5	12	15	PF00017	0.485
LIG_SH2_STAT5	190	193	PF00017	0.356
LIG_SH2_STAT5	253	256	PF00017	0.688
LIG_SH2_STAT5	26	29	PF00017	0.479
LIG_SH2_STAT5	42	45	PF00017	0.256
LIG_SH2_STAT5	531	534	PF00017	0.454
LIG_SH2_STAT5	619	622	PF00017	0.694
LIG_SH3_2	601	606	PF14604	0.768
LIG_SH3_3	143	149	PF00018	0.457
LIG_SH3_3	595	601	PF00018	0.779
LIG_SH3_3	608	614	PF00018	0.700
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.449
LIG_SUMO_SIM_par_1	521	527	PF11976	0.370
LIG_TRAF2_2	415	420	PF00917	0.525
LIG_UBA3_1	203	208	PF00899	0.444
LIG_WRC_WIRS_1	562	567	PF05994	0.515
LIG_WW_3	487	491	PF00397	0.730
MOD_CDC14_SPxK_1	397	400	PF00782	0.775
MOD_CDK_SPK_2	398	403	PF00069	0.701
MOD_CDK_SPxK_1	394	400	PF00069	0.777
MOD_CDK_SPxK_1	484	490	PF00069	0.578
MOD_CDK_SPxxK_3	356	363	PF00069	0.529
MOD_CDK_SPxxK_3	405	412	PF00069	0.721
MOD_CDK_SPxxK_3	462	469	PF00069	0.588
MOD_CK1_1	103	109	PF00069	0.444
MOD_CK1_1	304	310	PF00069	0.785
MOD_CK1_1	390	396	PF00069	0.677
MOD_CK1_1	408	414	PF00069	0.652
MOD_CK1_1	425	431	PF00069	0.513
MOD_CK1_1	551	557	PF00069	0.590
MOD_CK1_1	574	580	PF00069	0.768
MOD_CK1_1	68	74	PF00069	0.507
MOD_CK2_1	249	255	PF00069	0.681
MOD_CK2_1	309	315	PF00069	0.761
MOD_CK2_1	316	322	PF00069	0.736
MOD_CK2_1	393	399	PF00069	0.721
MOD_CK2_1	408	414	PF00069	0.663
MOD_CK2_1	547	553	PF00069	0.387
MOD_GlcNHglycan	1	4	PF01048	0.692
MOD_GlcNHglycan	111	114	PF01048	0.429
MOD_GlcNHglycan	303	306	PF01048	0.718
MOD_GlcNHglycan	312	315	PF01048	0.674
MOD_GlcNHglycan	526	529	PF01048	0.374
MOD_GlcNHglycan	550	553	PF01048	0.508
MOD_GlcNHglycan	585	588	PF01048	0.741
MOD_GSK3_1	103	110	PF00069	0.418
MOD_GSK3_1	113	120	PF00069	0.398
MOD_GSK3_1	145	152	PF00069	0.411
MOD_GSK3_1	300	307	PF00069	0.775
MOD_GSK3_1	316	323	PF00069	0.587
MOD_GSK3_1	327	334	PF00069	0.450
MOD_GSK3_1	347	354	PF00069	0.463
MOD_GSK3_1	382	389	PF00069	0.626
MOD_GSK3_1	390	397	PF00069	0.650
MOD_GSK3_1	460	467	PF00069	0.679
MOD_GSK3_1	479	486	PF00069	0.533
MOD_GSK3_1	547	554	PF00069	0.386
MOD_GSK3_1	619	626	PF00069	0.632
MOD_GSK3_1	68	75	PF00069	0.517
MOD_LATS_1	299	305	PF00433	0.539
MOD_LATS_1	583	589	PF00433	0.585
MOD_N-GLC_1	309	314	PF02516	0.760
MOD_N-GLC_1	331	336	PF02516	0.424
MOD_N-GLC_2	530	532	PF02516	0.419
MOD_NEK2_1	100	105	PF00069	0.369
MOD_NEK2_1	109	114	PF00069	0.369
MOD_NEK2_1	151	156	PF00069	0.408
MOD_NEK2_1	300	305	PF00069	0.716
MOD_NEK2_1	331	336	PF00069	0.438
MOD_NEK2_1	351	356	PF00069	0.446
MOD_NEK2_1	380	385	PF00069	0.679
MOD_NEK2_1	388	393	PF00069	0.714
MOD_NEK2_1	521	526	PF00069	0.469
MOD_NEK2_1	590	595	PF00069	0.662
MOD_NEK2_2	347	352	PF00069	0.430
MOD_PIKK_1	121	127	PF00454	0.446
MOD_PIKK_1	363	369	PF00454	0.539
MOD_PIKK_1	460	466	PF00454	0.654
MOD_PIKK_1	494	500	PF00454	0.662
MOD_PIKK_1	514	520	PF00454	0.224
MOD_PKA_1	117	123	PF00069	0.408
MOD_PKA_1	363	369	PF00069	0.576
MOD_PKA_1	372	378	PF00069	0.476
MOD_PKA_2	300	306	PF00069	0.735
MOD_PKA_2	363	369	PF00069	0.539
MOD_PKA_2	372	378	PF00069	0.546
MOD_PKB_1	166	174	PF00069	0.252
MOD_Plk_1	331	337	PF00069	0.427
MOD_Plk_1	38	44	PF00069	0.480
MOD_Plk_2-3	249	255	PF00069	0.734
MOD_Plk_4	100	106	PF00069	0.369
MOD_Plk_4	249	255	PF00069	0.672
MOD_Plk_4	261	267	PF00069	0.627
MOD_Plk_4	316	322	PF00069	0.727
MOD_Plk_4	347	353	PF00069	0.475
MOD_Plk_4	38	44	PF00069	0.542
MOD_Plk_4	521	527	PF00069	0.370
MOD_Plk_4	65	71	PF00069	0.541
MOD_Plk_4	72	78	PF00069	0.498
MOD_ProDKin_1	138	144	PF00069	0.367
MOD_ProDKin_1	145	151	PF00069	0.360
MOD_ProDKin_1	266	272	PF00069	0.668
MOD_ProDKin_1	356	362	PF00069	0.381
MOD_ProDKin_1	382	388	PF00069	0.701
MOD_ProDKin_1	394	400	PF00069	0.613
MOD_ProDKin_1	405	411	PF00069	0.727
MOD_ProDKin_1	462	468	PF00069	0.578
MOD_ProDKin_1	484	490	PF00069	0.656
MOD_SUMO_for_1	207	210	PF00179	0.444
MOD_SUMO_for_1	371	374	PF00179	0.562
MOD_SUMO_for_1	624	627	PF00179	0.475
MOD_SUMO_rev_2	473	482	PF00179	0.711
MOD_SUMO_rev_2	553	561	PF00179	0.482
MOD_SUMO_rev_2	61	69	PF00179	0.550
TRG_DiLeu_BaEn_1	199	204	PF01217	0.408
TRG_ENDOCYTIC_2	231	234	PF00928	0.369
TRG_ENDOCYTIC_2	26	29	PF00928	0.479
TRG_ENDOCYTIC_2	262	265	PF00928	0.560
TRG_ENDOCYTIC_2	531	534	PF00928	0.478
TRG_ENDOCYTIC_2	562	565	PF00928	0.488
TRG_ER_diArg_1	165	168	PF00400	0.382
TRG_ER_diArg_1	362	364	PF00400	0.562
TRG_ER_diArg_1	451	453	PF00400	0.505
TRG_NES_CRM1_1	199	210	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E6	Leptomonas seymouri	55%	100%
A0A3S7X863	Leishmania donovani	91%	100%
A0A422N1U7	Trypanosoma rangeli	25%	100%
A4HAZ4	Leishmania braziliensis	71%	100%
A4IA54	Leishmania infantum	91%	100%
D0A366	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
E9B568	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BBS3	Trypanosoma cruzi	27%	100%