Putative 40S ribosomal protein S19 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S19 protein, putative

Species:

Leishmania major

UniProt:

Q4Q2R6_LEIMA

TriTrypDb:

LmjF.34.2780 , LMJLV39_340033300 , LMJSD75_340033400

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	3
GO:0022627	cytosolic small ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	18
GO:0044391	ribosomal subunit	3	3
GO:1990904	ribonucleoprotein complex	2	18
GO:0005840	ribosome	5	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

Q4Q2R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R6

Function

Biological processes
Term	Name	Level	Count
GO:0000028	ribosomal small subunit assembly	7	3
GO:0006412	translation	4	18
GO:0006518	peptide metabolic process	4	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0009058	biosynthetic process	2	18
GO:0009059	macromolecule biosynthetic process	4	18
GO:0009987	cellular process	1	18
GO:0016043	cellular component organization	3	3
GO:0019538	protein metabolic process	3	18
GO:0022607	cellular component assembly	4	3
GO:0022618	ribonucleoprotein complex assembly	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	18
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	18
GO:0043043	peptide biosynthetic process	5	18
GO:0043170	macromolecule metabolic process	3	18
GO:0043603	amide metabolic process	3	18
GO:0043604	amide biosynthetic process	4	18
GO:0043933	protein-containing complex organization	4	3
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0044249	cellular biosynthetic process	3	18
GO:0044260	obsolete cellular macromolecule metabolic process	3	18
GO:0044271	cellular nitrogen compound biosynthetic process	4	18
GO:0065003	protein-containing complex assembly	5	3
GO:0071704	organic substance metabolic process	2	18
GO:0071826	ribonucleoprotein complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:1901564	organonitrogen compound metabolic process	3	18
GO:1901566	organonitrogen compound biosynthetic process	4	18
GO:1901576	organic substance biosynthetic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003735	structural constituent of ribosome	2	18
GO:0005198	structural molecule activity	1	18
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	100	106	PF00089	0.312
CLV_NRD_NRD_1	149	151	PF00675	0.449
CLV_NRD_NRD_1	165	167	PF00675	0.433
CLV_NRD_NRD_1	25	27	PF00675	0.617
CLV_NRD_NRD_1	4	6	PF00675	0.463
CLV_PCSK_KEX2_1	102	104	PF00082	0.315
CLV_PCSK_KEX2_1	25	27	PF00082	0.584
CLV_PCSK_KEX2_1	4	6	PF00082	0.472
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.315
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.581
CLV_PCSK_SKI1_1	130	134	PF00082	0.402
CLV_PCSK_SKI1_1	27	31	PF00082	0.413
CLV_PCSK_SKI1_1	38	42	PF00082	0.322
CLV_PCSK_SKI1_1	4	8	PF00082	0.450
CLV_PCSK_SKI1_1	45	49	PF00082	0.344
DEG_Nend_Nbox_1	1	3	PF02207	0.444
DEG_SPOP_SBC_1	118	122	PF00917	0.419
DOC_MAPK_gen_1	150	161	PF00069	0.344
DOC_MAPK_gen_1	45	55	PF00069	0.395
DOC_USP7_MATH_1	128	132	PF00917	0.385
DOC_USP7_UBL2_3	130	134	PF12436	0.331
DOC_USP7_UBL2_3	48	52	PF12436	0.347
LIG_14-3-3_CanoR_1	26	32	PF00244	0.516
LIG_14-3-3_CanoR_1	38	47	PF00244	0.348
LIG_Actin_WH2_2	16	34	PF00022	0.521
LIG_BRCT_BRCA1_1	100	104	PF00533	0.312
LIG_BRCT_BRCA1_1	157	161	PF00533	0.416
LIG_FHA_1	120	126	PF00498	0.428
LIG_FHA_2	28	34	PF00498	0.306
LIG_LIR_Nem_3	35	40	PF02991	0.457
LIG_LIR_Nem_3	76	80	PF02991	0.327
LIG_SH2_CRK	97	101	PF00017	0.337
LIG_SH2_STAT5	79	82	PF00017	0.312
LIG_SH2_STAT5	90	93	PF00017	0.312
LIG_SH3_3	3	9	PF00018	0.470
LIG_SH3_3	69	75	PF00018	0.325
LIG_TYR_ITIM	95	100	PF00017	0.341
LIG_UBA3_1	12	19	PF00899	0.441
MOD_CK2_1	109	115	PF00069	0.312
MOD_Cter_Amidation	23	26	PF01082	0.465
MOD_GlcNHglycan	143	146	PF01048	0.333
MOD_GlcNHglycan	33	37	PF01048	0.457
MOD_GSK3_1	114	121	PF00069	0.479
MOD_N-GLC_1	56	61	PF02516	0.385
MOD_NEK2_1	155	160	PF00069	0.419
MOD_NEK2_1	62	67	PF00069	0.416
MOD_PKA_1	4	10	PF00069	0.444
MOD_PKA_2	146	152	PF00069	0.325
MOD_PKA_2	4	10	PF00069	0.391
MOD_Plk_1	114	120	PF00069	0.457
MOD_Plk_1	32	38	PF00069	0.457
MOD_SUMO_for_1	47	50	PF00179	0.325
TRG_DiLeu_BaEn_2	49	55	PF01217	0.416
TRG_ENDOCYTIC_2	97	100	PF00928	0.318
TRG_ER_diArg_1	3	5	PF00400	0.459
TRG_NLS_MonoExtN_4	22	29	PF00514	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IY51	Bodo saltans	67%	100%
A0A1D8PK61	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	100%
A0A1X0P9W6	Trypanosomatidae	70%	100%
A0A1X0P9X9	Trypanosomatidae	72%	100%
A0A3Q8IFE1	Leishmania donovani	97%	100%
A0A3Q8INI0	Leishmania donovani	98%	96%
A0A3R7KIF6	Trypanosoma rangeli	70%	100%
A0A422NEU2	Trypanosoma rangeli	73%	100%
A4H3R3	Leishmania braziliensis	96%	75%
A4HAZ5	Leishmania braziliensis	97%	100%
A4I4Y2	Leishmania infantum	97%	100%
A4IA55	Leishmania infantum	99%	96%
C9ZM47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AEE8	Leishmania major	97%	100%
E9ALD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B569	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	99%
O15631	Entamoeba histolytica	37%	100%
O18650	Caenorhabditis elegans	34%	100%
O27653	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	100%
O28210	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	30%	100%
O59041	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	29%	100%
P07280	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P07281	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P17074	Rattus norvegicus	33%	100%
P19952	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	29%	100%
P24494	Ascaris suum	31%	100%
P27073	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	41%	100%
P39018	Drosophila melanogaster	33%	100%
P39019	Homo sapiens	32%	100%
P39698	Ascaris suum	32%	100%
P40978	Oryza sativa subsp. japonica	35%	100%
P54057	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	40%	100%
P58234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P61155	Pagrus major	33%	100%
P79016	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
Q29308	Sus scrofa	32%	100%
Q32PD5	Bos taurus	32%	100%
Q54X51	Dictyostelium discoideum	35%	100%
Q5R8M9	Pongo abelii	32%	100%
Q7KS38	Drosophila melanogaster	35%	100%
Q8ITC3	Argopecten irradians	35%	100%
Q8T5Z4	Branchiostoma belcheri	36%	100%
Q90YQ4	Ictalurus punctatus	36%	100%
Q94613	Mya arenaria	33%	100%
Q9CZX8	Mus musculus	33%	100%
Q9DFR5	Gillichthys mirabilis	33%	100%
Q9FNP8	Arabidopsis thaliana	38%	100%
Q9HM21	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	29%	100%
Q9LF30	Arabidopsis thaliana	40%	100%
Q9SGA6	Arabidopsis thaliana	39%	100%
Q9V0G8	Pyrococcus abyssi (strain GE5 / Orsay)	31%	100%
Q9Y0H3	Myxine glutinosa	38%	100%
Q9YD22	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	27%	100%
V5DM12	Trypanosoma cruzi	71%	100%