Signal recognition particle subunit SRP68

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2R5_LEIMA

TriTrypDb:

LmjF.34.2790 , LMJLV39_340033400 , LMJSD75_340033500

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0048500	signal recognition particle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4Q2R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R5

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006612	protein targeting to membrane	5	11
GO:0006613	cotranslational protein targeting to membrane	6	11
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045047	protein targeting to ER	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051668	localization within membrane	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0070972	protein localization to endoplasmic reticulum	6	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	11
GO:0072657	protein localization to membrane	4	11
GO:0090150	establishment of protein localization to membrane	4	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005047	signal recognition particle binding	4	11
GO:0005048	signal sequence binding	4	11
GO:0005488	binding	1	11
GO:0008312	7S RNA binding	5	11
GO:0030942	endoplasmic reticulum signal peptide binding	5	11
GO:0033218	amide binding	2	11
GO:0042277	peptide binding	3	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0044877	protein-containing complex binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	561	565	PF00656	0.736
CLV_NRD_NRD_1	113	115	PF00675	0.245
CLV_NRD_NRD_1	297	299	PF00675	0.260
CLV_NRD_NRD_1	342	344	PF00675	0.294
CLV_NRD_NRD_1	353	355	PF00675	0.218
CLV_NRD_NRD_1	384	386	PF00675	0.308
CLV_NRD_NRD_1	40	42	PF00675	0.306
CLV_NRD_NRD_1	506	508	PF00675	0.636
CLV_PCSK_KEX2_1	115	117	PF00082	0.232
CLV_PCSK_KEX2_1	297	299	PF00082	0.260
CLV_PCSK_KEX2_1	342	344	PF00082	0.294
CLV_PCSK_KEX2_1	353	355	PF00082	0.218
CLV_PCSK_KEX2_1	384	386	PF00082	0.221
CLV_PCSK_KEX2_1	40	42	PF00082	0.306
CLV_PCSK_KEX2_1	506	508	PF00082	0.670
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.248
CLV_PCSK_SKI1_1	119	123	PF00082	0.261
CLV_PCSK_SKI1_1	162	166	PF00082	0.285
CLV_PCSK_SKI1_1	258	262	PF00082	0.266
CLV_PCSK_SKI1_1	343	347	PF00082	0.254
CLV_PCSK_SKI1_1	35	39	PF00082	0.324
CLV_PCSK_SKI1_1	360	364	PF00082	0.283
CLV_PCSK_SKI1_1	438	442	PF00082	0.196
CLV_PCSK_SKI1_1	467	471	PF00082	0.309
CLV_PCSK_SKI1_1	50	54	PF00082	0.195
CLV_PCSK_SKI1_1	542	546	PF00082	0.469
CLV_PCSK_SKI1_1	55	59	PF00082	0.127
CLV_PCSK_SKI1_1	572	576	PF00082	0.648
CLV_Separin_Metazoa	400	404	PF03568	0.473
DEG_SPOP_SBC_1	366	370	PF00917	0.544
DOC_ANK_TNKS_1	313	320	PF00023	0.563
DOC_CYCLIN_RxL_1	340	349	PF00134	0.464
DOC_CYCLIN_RxL_1	35	48	PF00134	0.523
DOC_MAPK_MEF2A_6	66	73	PF00069	0.463
DOC_MAPK_NFAT4_5	66	74	PF00069	0.539
DOC_PP1_RVXF_1	117	124	PF00149	0.459
DOC_PP1_RVXF_1	436	442	PF00149	0.396
DOC_USP7_MATH_1	366	370	PF00917	0.511
DOC_USP7_MATH_1	408	412	PF00917	0.514
DOC_USP7_MATH_1	432	436	PF00917	0.502
DOC_USP7_MATH_1	495	499	PF00917	0.511
DOC_USP7_MATH_1	505	509	PF00917	0.697
DOC_USP7_MATH_1	556	560	PF00917	0.633
DOC_USP7_UBL2_3	115	119	PF12436	0.459
DOC_USP7_UBL2_3	122	126	PF12436	0.459
DOC_USP7_UBL2_3	51	55	PF12436	0.511
DOC_WW_Pin1_4	368	373	PF00397	0.502
DOC_WW_Pin1_4	394	399	PF00397	0.467
DOC_WW_Pin1_4	506	511	PF00397	0.673
DOC_WW_Pin1_4	55	60	PF00397	0.505
LIG_14-3-3_CanoR_1	116	122	PF00244	0.452
LIG_14-3-3_CanoR_1	153	161	PF00244	0.490
LIG_14-3-3_CanoR_1	179	189	PF00244	0.509
LIG_14-3-3_CanoR_1	200	204	PF00244	0.539
LIG_14-3-3_CanoR_1	239	245	PF00244	0.515
LIG_14-3-3_CanoR_1	342	346	PF00244	0.491
LIG_14-3-3_CanoR_1	35	40	PF00244	0.487
LIG_14-3-3_CanoR_1	41	46	PF00244	0.494
LIG_14-3-3_CanoR_1	506	510	PF00244	0.648
LIG_14-3-3_CanoR_1	96	103	PF00244	0.396
LIG_Actin_WH2_2	326	344	PF00022	0.539
LIG_APCC_ABBA_1	71	76	PF00400	0.490
LIG_APCC_ABBAyCdc20_2	50	56	PF00400	0.488
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BRCT_BRCA1_1	351	355	PF00533	0.438
LIG_BRCT_BRCA1_1	370	374	PF00533	0.567
LIG_deltaCOP1_diTrp_1	444	452	PF00928	0.539
LIG_deltaCOP1_diTrp_1	593	598	PF00928	0.589
LIG_FHA_1	247	253	PF00498	0.518
LIG_FHA_1	277	283	PF00498	0.569
LIG_FHA_1	31	37	PF00498	0.473
LIG_FHA_1	342	348	PF00498	0.526
LIG_FHA_1	391	397	PF00498	0.522
LIG_FHA_1	511	517	PF00498	0.629
LIG_FHA_1	520	526	PF00498	0.593
LIG_FHA_1	571	577	PF00498	0.754
LIG_FHA_1	6	12	PF00498	0.470
LIG_FHA_2	549	555	PF00498	0.459
LIG_Integrin_isoDGR_2	246	248	PF01839	0.273
LIG_LIR_Apic_2	393	398	PF02991	0.457
LIG_LIR_Gen_1	173	181	PF02991	0.504
LIG_LIR_Gen_1	184	194	PF02991	0.441
LIG_LIR_Gen_1	323	333	PF02991	0.541
LIG_LIR_Nem_3	173	178	PF02991	0.449
LIG_LIR_Nem_3	184	190	PF02991	0.451
LIG_LIR_Nem_3	23	28	PF02991	0.457
LIG_LIR_Nem_3	323	328	PF02991	0.541
LIG_LIR_Nem_3	550	555	PF02991	0.541
LIG_SH2_CRK	175	179	PF00017	0.539
LIG_SH2_CRK	325	329	PF00017	0.479
LIG_SH2_GRB2like	301	304	PF00017	0.539
LIG_SH2_PTP2	395	398	PF00017	0.424
LIG_SH2_STAP1	253	257	PF00017	0.563
LIG_SH2_STAP1	351	355	PF00017	0.438
LIG_SH2_STAT3	203	206	PF00017	0.539
LIG_SH2_STAT5	146	149	PF00017	0.504
LIG_SH2_STAT5	203	206	PF00017	0.459
LIG_SH2_STAT5	25	28	PF00017	0.464
LIG_SH2_STAT5	31	34	PF00017	0.455
LIG_SH2_STAT5	395	398	PF00017	0.424
LIG_SH2_STAT5	459	462	PF00017	0.527
LIG_SH2_STAT5	514	517	PF00017	0.559
LIG_SH3_1	537	543	PF00018	0.408
LIG_SH3_3	369	375	PF00018	0.479
LIG_SH3_3	527	533	PF00018	0.591
LIG_SH3_3	537	543	PF00018	0.437
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.473
LIG_SUMO_SIM_anti_2	461	468	PF11976	0.532
LIG_SUMO_SIM_par_1	290	296	PF11976	0.473
LIG_TRAF2_1	411	414	PF00917	0.479
LIG_TRAF2_1	476	479	PF00917	0.523
LIG_TRAF2_1	518	521	PF00917	0.589
LIG_TYR_ITSM	321	328	PF00017	0.479
LIG_WW_1	533	536	PF00397	0.487
MOD_CK1_1	180	186	PF00069	0.495
MOD_CK1_1	241	247	PF00069	0.541
MOD_CK1_1	368	374	PF00069	0.480
MOD_CK1_1	95	101	PF00069	0.507
MOD_CK2_1	394	400	PF00069	0.475
MOD_CK2_1	408	414	PF00069	0.459
MOD_CK2_1	473	479	PF00069	0.539
MOD_CK2_1	556	562	PF00069	0.684
MOD_GlcNHglycan	142	146	PF01048	0.280
MOD_GlcNHglycan	184	187	PF01048	0.196
MOD_GlcNHglycan	224	227	PF01048	0.339
MOD_GlcNHglycan	434	437	PF01048	0.306
MOD_GlcNHglycan	558	561	PF01048	0.679
MOD_GlcNHglycan	566	571	PF01048	0.709
MOD_GlcNHglycan	582	585	PF01048	0.517
MOD_GSK3_1	133	140	PF00069	0.396
MOD_GSK3_1	337	344	PF00069	0.459
MOD_GSK3_1	358	365	PF00069	0.509
MOD_GSK3_1	366	373	PF00069	0.476
MOD_GSK3_1	390	397	PF00069	0.448
MOD_GSK3_1	442	449	PF00069	0.483
MOD_GSK3_1	469	476	PF00069	0.476
MOD_GSK3_1	506	513	PF00069	0.672
MOD_GSK3_1	562	569	PF00069	0.744
MOD_N-GLC_1	117	122	PF02516	0.273
MOD_N-GLC_1	580	585	PF02516	0.750
MOD_N-GLC_1	60	65	PF02516	0.287
MOD_NEK2_1	117	122	PF00069	0.473
MOD_NEK2_1	147	152	PF00069	0.563
MOD_NEK2_1	276	281	PF00069	0.525
MOD_NEK2_1	341	346	PF00069	0.459
MOD_NEK2_1	362	367	PF00069	0.511
MOD_NEK2_1	473	478	PF00069	0.474
MOD_NEK2_1	494	499	PF00069	0.538
MOD_NEK2_1	5	10	PF00069	0.366
MOD_NEK2_2	337	342	PF00069	0.539
MOD_PIKK_1	11	17	PF00454	0.478
MOD_PIKK_1	238	244	PF00454	0.515
MOD_PIKK_1	390	396	PF00454	0.457
MOD_PIKK_1	520	526	PF00454	0.679
MOD_PKA_1	92	98	PF00069	0.563
MOD_PKA_2	137	143	PF00069	0.396
MOD_PKA_2	171	177	PF00069	0.500
MOD_PKA_2	199	205	PF00069	0.539
MOD_PKA_2	238	244	PF00069	0.396
MOD_PKA_2	341	347	PF00069	0.521
MOD_PKA_2	446	452	PF00069	0.473
MOD_PKA_2	505	511	PF00069	0.646
MOD_PKA_2	95	101	PF00069	0.507
MOD_Plk_1	117	123	PF00069	0.473
MOD_Plk_1	141	147	PF00069	0.490
MOD_Plk_1	358	364	PF00069	0.511
MOD_Plk_1	5	11	PF00069	0.387
MOD_Plk_1	520	526	PF00069	0.604
MOD_Plk_2-3	562	568	PF00069	0.687
MOD_Plk_4	469	475	PF00069	0.446
MOD_Plk_4	5	11	PF00069	0.420
MOD_Plk_4	510	516	PF00069	0.637
MOD_Plk_4	548	554	PF00069	0.467
MOD_ProDKin_1	368	374	PF00069	0.502
MOD_ProDKin_1	394	400	PF00069	0.467
MOD_ProDKin_1	506	512	PF00069	0.668
MOD_ProDKin_1	55	61	PF00069	0.505
MOD_SUMO_for_1	274	277	PF00179	0.368
MOD_SUMO_for_1	91	94	PF00179	0.535
MOD_SUMO_rev_2	157	167	PF00179	0.511
MOD_SUMO_rev_2	268	276	PF00179	0.530
MOD_SUMO_rev_2	44	52	PF00179	0.513
TRG_DiLeu_BaEn_1	413	418	PF01217	0.479
TRG_DiLeu_BaEn_4	413	419	PF01217	0.534
TRG_ENDOCYTIC_2	175	178	PF00928	0.448
TRG_ENDOCYTIC_2	325	328	PF00928	0.468
TRG_ENDOCYTIC_2	54	57	PF00928	0.533
TRG_ER_diArg_1	113	116	PF00400	0.459
TRG_ER_diArg_1	297	299	PF00400	0.473
TRG_ER_diArg_1	341	343	PF00400	0.496
TRG_ER_diArg_1	353	355	PF00400	0.413
TRG_ER_diArg_1	39	41	PF00400	0.506
TRG_PTS2	1	43	PF00400	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH42	Leptomonas seymouri	68%	99%
A0A0S4J2Z5	Bodo saltans	44%	100%
A0A1X0PAR6	Trypanosomatidae	47%	100%
A0A3S7X839	Leishmania donovani	92%	100%
A4HAZ6	Leishmania braziliensis	81%	100%
A4IA56	Leishmania infantum	93%	100%
C9ZM46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B570	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q00004	Canis lupus familiaris	25%	96%
Q8BMA6	Mus musculus	26%	96%
Q9UHB9	Homo sapiens	26%	96%
Q9VSS2	Drosophila melanogaster	23%	99%
V5BV06	Trypanosoma cruzi	49%	100%