Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania major

UniProt:

Q4Q2R4_LEIMA

TriTrypDb:

LmjF.34.2800 , LMJLV39_340033500 , LMJSD75_340033600

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q2R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.349
CLV_NRD_NRD_1	126	128	PF00675	0.335
CLV_NRD_NRD_1	279	281	PF00675	0.587
CLV_NRD_NRD_1	389	391	PF00675	0.518
CLV_NRD_NRD_1	463	465	PF00675	0.603
CLV_PCSK_KEX2_1	120	122	PF00082	0.329
CLV_PCSK_KEX2_1	126	128	PF00082	0.326
CLV_PCSK_KEX2_1	279	281	PF00082	0.587
CLV_PCSK_KEX2_1	389	391	PF00082	0.518
CLV_PCSK_KEX2_1	463	465	PF00082	0.605
CLV_PCSK_PC7_1	275	281	PF00082	0.600
CLV_PCSK_SKI1_1	184	188	PF00082	0.403
CLV_PCSK_SKI1_1	275	279	PF00082	0.604
CLV_PCSK_SKI1_1	353	357	PF00082	0.629
CLV_PCSK_SKI1_1	474	478	PF00082	0.487
CLV_PCSK_SKI1_1	493	497	PF00082	0.462
DEG_APCC_DBOX_1	274	282	PF00400	0.425
DEG_APCC_DBOX_1	492	500	PF00400	0.378
DOC_CYCLIN_RxL_1	179	189	PF00134	0.614
DOC_MAPK_gen_1	140	149	PF00069	0.547
DOC_MAPK_gen_1	309	317	PF00069	0.331
DOC_MAPK_gen_1	389	396	PF00069	0.277
DOC_MAPK_MEF2A_6	232	240	PF00069	0.390
DOC_MAPK_MEF2A_6	309	317	PF00069	0.297
DOC_MAPK_MEF2A_6	389	398	PF00069	0.286
DOC_PP1_RVXF_1	285	292	PF00149	0.246
DOC_PP2B_PxIxI_1	285	291	PF00149	0.297
DOC_PP2B_PxIxI_1	42	48	PF00149	0.495
DOC_PP4_FxxP_1	40	43	PF00568	0.643
DOC_USP7_MATH_1	19	23	PF00917	0.474
DOC_USP7_MATH_1	516	520	PF00917	0.388
DOC_USP7_UBL2_3	237	241	PF12436	0.351
DOC_WW_Pin1_4	359	364	PF00397	0.289
DOC_WW_Pin1_4	39	44	PF00397	0.562
LIG_14-3-3_CanoR_1	250	255	PF00244	0.569
LIG_14-3-3_CanoR_1	463	470	PF00244	0.371
LIG_Actin_WH2_2	209	227	PF00022	0.191
LIG_Actin_WH2_2	312	329	PF00022	0.354
LIG_APCC_ABBA_1	96	101	PF00400	0.485
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_CaMK_CASK_1	533	538	PF00069	0.302
LIG_deltaCOP1_diTrp_1	533	542	PF00928	0.325
LIG_eIF4E_1	470	476	PF01652	0.307
LIG_FHA_1	255	261	PF00498	0.387
LIG_FHA_1	360	366	PF00498	0.285
LIG_FHA_1	405	411	PF00498	0.430
LIG_FHA_1	76	82	PF00498	0.547
LIG_FHA_2	551	557	PF00498	0.359
LIG_LIR_Gen_1	373	383	PF02991	0.258
LIG_LIR_Gen_1	414	421	PF02991	0.319
LIG_LIR_Gen_1	454	465	PF02991	0.346
LIG_LIR_Nem_3	201	206	PF02991	0.453
LIG_LIR_Nem_3	373	378	PF02991	0.261
LIG_LIR_Nem_3	414	418	PF02991	0.327
LIG_LIR_Nem_3	454	460	PF02991	0.355
LIG_LIR_Nem_3	49	55	PF02991	0.538
LIG_LIR_Nem_3	78	82	PF02991	0.522
LIG_NRP_CendR_1	558	559	PF00754	0.595
LIG_PCNA_yPIPBox_3	126	137	PF02747	0.503
LIG_Pex14_2	138	142	PF04695	0.541
LIG_Pex14_2	218	222	PF04695	0.291
LIG_PTB_Apo_2	536	543	PF02174	0.286
LIG_PTB_Apo_2	82	89	PF02174	0.537
LIG_REV1ctd_RIR_1	4	13	PF16727	0.536
LIG_SH2_CRK	203	207	PF00017	0.275
LIG_SH2_CRK	528	532	PF00017	0.365
LIG_SH2_CRK	79	83	PF00017	0.510
LIG_SH2_GRB2like	470	473	PF00017	0.283
LIG_SH2_NCK_1	528	532	PF00017	0.358
LIG_SH2_PTP2	316	319	PF00017	0.342
LIG_SH2_SRC	316	319	PF00017	0.342
LIG_SH2_SRC	528	531	PF00017	0.379
LIG_SH2_STAP1	32	36	PF00017	0.507
LIG_SH2_STAT3	148	151	PF00017	0.456
LIG_SH2_STAT5	148	151	PF00017	0.547
LIG_SH2_STAT5	316	319	PF00017	0.342
LIG_SH2_STAT5	429	432	PF00017	0.358
LIG_SH2_STAT5	470	473	PF00017	0.356
LIG_SH2_STAT5	52	55	PF00017	0.528
LIG_SH3_3	11	17	PF00018	0.633
LIG_SH3_3	280	286	PF00018	0.385
LIG_SH3_3	405	411	PF00018	0.326
LIG_SUMO_SIM_anti_2	361	368	PF11976	0.306
LIG_SUMO_SIM_par_1	416	422	PF11976	0.340
LIG_SUMO_SIM_par_1	42	49	PF11976	0.528
LIG_TRAF2_1	128	131	PF00917	0.475
LIG_TYR_ITIM	526	531	PF00017	0.332
LIG_TYR_ITSM	199	206	PF00017	0.519
LIG_UBA3_1	364	368	PF00899	0.251
MOD_CK1_1	22	28	PF00069	0.653
MOD_CK1_1	399	405	PF00069	0.417
MOD_CK1_1	466	472	PF00069	0.284
MOD_CK2_1	370	376	PF00069	0.336
MOD_CK2_1	550	556	PF00069	0.338
MOD_GlcNHglycan	203	206	PF01048	0.285
MOD_GlcNHglycan	207	210	PF01048	0.278
MOD_GlcNHglycan	270	274	PF01048	0.622
MOD_GlcNHglycan	465	468	PF01048	0.506
MOD_GlcNHglycan	493	496	PF01048	0.542
MOD_GlcNHglycan	499	502	PF01048	0.550
MOD_GlcNHglycan	518	521	PF01048	0.648
MOD_GlcNHglycan	543	546	PF01048	0.479
MOD_GlcNHglycan	9	12	PF01048	0.392
MOD_GlcNHglycan	92	95	PF01048	0.292
MOD_GSK3_1	201	208	PF00069	0.446
MOD_GSK3_1	250	257	PF00069	0.502
MOD_LATS_1	461	467	PF00433	0.375
MOD_N-GLC_1	75	80	PF02516	0.368
MOD_N-GLC_1	84	89	PF02516	0.371
MOD_NEK2_1	224	229	PF00069	0.342
MOD_NEK2_1	243	248	PF00069	0.366
MOD_NEK2_1	254	259	PF00069	0.504
MOD_NEK2_1	427	432	PF00069	0.335
MOD_NEK2_1	482	487	PF00069	0.359
MOD_NEK2_1	541	546	PF00069	0.325
MOD_NEK2_1	7	12	PF00069	0.546
MOD_NEK2_2	19	24	PF00069	0.485
MOD_PIKK_1	226	232	PF00454	0.350
MOD_PIKK_1	427	433	PF00454	0.361
MOD_PKA_1	463	469	PF00069	0.425
MOD_PKA_2	319	325	PF00069	0.321
MOD_PKA_2	463	469	PF00069	0.376
MOD_PKB_1	267	275	PF00069	0.284
MOD_Plk_1	269	275	PF00069	0.379
MOD_Plk_1	322	328	PF00069	0.408
MOD_Plk_1	396	402	PF00069	0.302
MOD_Plk_1	84	90	PF00069	0.602
MOD_Plk_2-3	371	377	PF00069	0.306
MOD_Plk_2-3	84	90	PF00069	0.550
MOD_Plk_4	27	33	PF00069	0.531
MOD_ProDKin_1	359	365	PF00069	0.284
MOD_ProDKin_1	39	45	PF00069	0.552
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.292
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.248
TRG_ENDOCYTIC_2	203	206	PF00928	0.307
TRG_ENDOCYTIC_2	316	319	PF00928	0.342
TRG_ENDOCYTIC_2	528	531	PF00928	0.358
TRG_ENDOCYTIC_2	79	82	PF00928	0.585
TRG_ER_diArg_1	119	121	PF00400	0.657
TRG_ER_diArg_1	165	168	PF00400	0.638
TRG_ER_diArg_1	278	280	PF00400	0.395
TRG_ER_diArg_1	389	391	PF00400	0.302
TRG_ER_diArg_1	463	465	PF00400	0.450
TRG_ER_diArg_1	557	559	PF00400	0.397
TRG_NES_CRM1_1	324	339	PF08389	0.355
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	42%	85%
A0A0N1PB02	Leptomonas seymouri	73%	85%
A0A0S4J6C6	Bodo saltans	46%	86%
A0A1X0P9A6	Trypanosomatidae	57%	82%
A0A3Q8IHH1	Leishmania donovani	39%	77%
A0A3R7K2Y9	Trypanosoma rangeli	55%	81%
A0A3S5H668	Leishmania donovani	51%	100%
A0A3S5H669	Leishmania donovani	47%	88%
A0A3S7X835	Leishmania donovani	90%	100%
A4H5C9	Leishmania braziliensis	49%	100%
A4H5D0	Leishmania braziliensis	46%	94%
A4HAZ7	Leishmania braziliensis	66%	100%
A4HAZ9	Leishmania braziliensis	70%	90%
A4HB01	Leishmania braziliensis	70%	96%
A4HTM0	Leishmania infantum	51%	100%
A4HTM1	Leishmania infantum	47%	88%
A4IA57	Leishmania infantum	90%	100%
C6K3V8	Leptomonas seymouri	51%	92%
C6K3V9	Leptomonas seymouri	45%	85%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	83%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	89%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	92%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	88%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1U8	Leishmania major	40%	100%
Q4Q310	Leishmania major	40%	84%
Q4Q312	Leishmania major	40%	84%
Q4Q340	Leishmania major	40%	84%
Q4Q342	Leishmania major	40%	84%
Q4QI90	Leishmania major	46%	88%
Q4QI91	Leishmania major	50%	100%