Cytosolic carboxypeptidase-like protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Carboxypeptidase-like protein

Species:

Leishmania major

UniProt:

Q4Q2R3_LEIMA

TriTrypDb:

LmjF.34.2810 , LMJLV39_340033600 , LMJSD75_340033800

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0005737	cytoplasm	2	2
GO:0005819	spindle	5	10
GO:0030496	midbody	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q2R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018200	peptidyl-glutamic acid modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0035608	protein deglutamylation	7	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004180	carboxypeptidase activity	5	10
GO:0004181	metallocarboxypeptidase activity	6	10
GO:0005488	binding	1	10
GO:0008233	peptidase activity	3	10
GO:0008235	metalloexopeptidase activity	5	10
GO:0008237	metallopeptidase activity	4	10
GO:0008238	exopeptidase activity	4	10
GO:0008270	zinc ion binding	6	10
GO:0016787	hydrolase activity	2	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.665
CLV_C14_Caspase3-7	181	185	PF00656	0.699
CLV_C14_Caspase3-7	308	312	PF00656	0.706
CLV_C14_Caspase3-7	471	475	PF00656	0.444
CLV_C14_Caspase3-7	617	621	PF00656	0.464
CLV_NRD_NRD_1	282	284	PF00675	0.572
CLV_NRD_NRD_1	488	490	PF00675	0.435
CLV_NRD_NRD_1	573	575	PF00675	0.419
CLV_NRD_NRD_1	796	798	PF00675	0.699
CLV_NRD_NRD_1	821	823	PF00675	0.670
CLV_PCSK_KEX2_1	282	284	PF00082	0.602
CLV_PCSK_KEX2_1	490	492	PF00082	0.333
CLV_PCSK_KEX2_1	521	523	PF00082	0.369
CLV_PCSK_KEX2_1	573	575	PF00082	0.419
CLV_PCSK_KEX2_1	796	798	PF00082	0.721
CLV_PCSK_KEX2_1	820	822	PF00082	0.707
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.333
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.401
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.485
CLV_PCSK_SKI1_1	356	360	PF00082	0.435
CLV_PCSK_SKI1_1	366	370	PF00082	0.401
CLV_PCSK_SKI1_1	499	503	PF00082	0.312
CLV_PCSK_SKI1_1	508	512	PF00082	0.329
CLV_PCSK_SKI1_1	641	645	PF00082	0.384
CLV_PCSK_SKI1_1	765	769	PF00082	0.566
CLV_PCSK_SKI1_1	824	828	PF00082	0.738
DEG_APCC_DBOX_1	498	506	PF00400	0.298
DEG_APCC_DBOX_1	640	648	PF00400	0.481
DEG_Nend_UBRbox_3	1	3	PF02207	0.693
DOC_CDC14_PxL_1	455	463	PF14671	0.401
DOC_CKS1_1	156	161	PF01111	0.585
DOC_CKS1_1	548	553	PF01111	0.344
DOC_CYCLIN_RxL_1	496	504	PF00134	0.298
DOC_CYCLIN_RxL_1	762	771	PF00134	0.549
DOC_MAPK_gen_1	219	231	PF00069	0.635
DOC_MAPK_gen_1	820	828	PF00069	0.709
DOC_MAPK_MEF2A_6	106	114	PF00069	0.591
DOC_MAPK_MEF2A_6	224	233	PF00069	0.551
DOC_MAPK_MEF2A_6	251	259	PF00069	0.544
DOC_MAPK_MEF2A_6	508	515	PF00069	0.307
DOC_PP1_RVXF_1	578	585	PF00149	0.485
DOC_PP2B_LxvP_1	292	295	PF13499	0.644
DOC_PP2B_PxIxI_1	254	260	PF00149	0.524
DOC_PP4_FxxP_1	37	40	PF00568	0.508
DOC_USP7_MATH_1	281	285	PF00917	0.593
DOC_USP7_MATH_1	394	398	PF00917	0.344
DOC_USP7_MATH_1	698	702	PF00917	0.582
DOC_USP7_UBL2_3	167	171	PF12436	0.653
DOC_USP7_UBL2_3	219	223	PF12436	0.662
DOC_USP7_UBL2_3	236	240	PF12436	0.414
DOC_USP7_UBL2_3	692	696	PF12436	0.571
DOC_USP7_UBL2_3	725	729	PF12436	0.497
DOC_WW_Pin1_4	155	160	PF00397	0.584
DOC_WW_Pin1_4	205	210	PF00397	0.787
DOC_WW_Pin1_4	243	248	PF00397	0.563
DOC_WW_Pin1_4	251	256	PF00397	0.526
DOC_WW_Pin1_4	547	552	PF00397	0.344
DOC_WW_Pin1_4	622	627	PF00397	0.597
DOC_WW_Pin1_4	629	634	PF00397	0.500
DOC_WW_Pin1_4	797	802	PF00397	0.745
LIG_14-3-3_CanoR_1	18	28	PF00244	0.691
LIG_14-3-3_CanoR_1	301	310	PF00244	0.767
LIG_14-3-3_CanoR_1	378	382	PF00244	0.268
LIG_14-3-3_CanoR_1	736	740	PF00244	0.541
LIG_APCC_ABBA_1	509	514	PF00400	0.344
LIG_APCC_ABBAyCdc20_2	508	514	PF00400	0.302
LIG_BRCT_BRCA1_1	119	123	PF00533	0.561
LIG_BRCT_BRCA1_1	345	349	PF00533	0.662
LIG_BRCT_BRCA1_1	556	560	PF00533	0.328
LIG_BRCT_BRCA1_1	56	60	PF00533	0.499
LIG_BRCT_BRCA1_1	799	803	PF00533	0.674
LIG_Clathr_ClatBox_1	65	69	PF01394	0.490
LIG_deltaCOP1_diTrp_1	31	37	PF00928	0.601
LIG_EH1_1	495	503	PF00400	0.369
LIG_eIF4E_1	496	502	PF01652	0.401
LIG_FHA_1	198	204	PF00498	0.689
LIG_FHA_1	415	421	PF00498	0.369
LIG_FHA_1	595	601	PF00498	0.374
LIG_FHA_1	654	660	PF00498	0.531
LIG_FHA_1	665	671	PF00498	0.470
LIG_FHA_1	748	754	PF00498	0.532
LIG_FHA_2	370	376	PF00498	0.369
LIG_FHA_2	633	639	PF00498	0.485
LIG_FHA_2	725	731	PF00498	0.506
LIG_FHA_2	78	84	PF00498	0.508
LIG_FHA_2	830	836	PF00498	0.784
LIG_GBD_Chelix_1	670	678	PF00786	0.542
LIG_HOMEOBOX	125	128	PF00046	0.561
LIG_Integrin_isoDGR_2	326	328	PF01839	0.578
LIG_IRF3_LxIS_1	368	374	PF10401	0.444
LIG_LIR_Apic_2	244	248	PF02991	0.663
LIG_LIR_Gen_1	124	133	PF02991	0.577
LIG_LIR_Gen_1	346	354	PF02991	0.535
LIG_LIR_Nem_3	124	130	PF02991	0.516
LIG_LIR_Nem_3	158	164	PF02991	0.590
LIG_LIR_Nem_3	266	270	PF02991	0.434
LIG_LIR_Nem_3	346	352	PF02991	0.587
LIG_LIR_Nem_3	550	555	PF02991	0.369
LIG_LIR_Nem_3	73	79	PF02991	0.526
LIG_LIR_Nem_3	737	742	PF02991	0.409
LIG_LIR_Nem_3	744	748	PF02991	0.389
LIG_LYPXL_yS_3	161	164	PF13949	0.612
LIG_MYND_1	459	463	PF01753	0.401
LIG_MYND_1	825	829	PF01753	0.554
LIG_NRBOX	643	649	PF00104	0.380
LIG_Pex14_2	123	127	PF04695	0.508
LIG_Pex14_2	56	60	PF04695	0.490
LIG_Pex14_2	687	691	PF04695	0.442
LIG_PTB_Apo_2	536	543	PF02174	0.401
LIG_PTB_Phospho_1	536	542	PF10480	0.401
LIG_SH2_CRK	140	144	PF00017	0.473
LIG_SH2_CRK	245	249	PF00017	0.672
LIG_SH2_CRK	542	546	PF00017	0.369
LIG_SH2_NCK_1	140	144	PF00017	0.604
LIG_SH2_NCK_1	245	249	PF00017	0.672
LIG_SH2_PTP2	413	416	PF00017	0.401
LIG_SH2_STAP1	140	144	PF00017	0.515
LIG_SH2_STAP1	496	500	PF00017	0.444
LIG_SH2_STAP1	542	546	PF00017	0.369
LIG_SH2_STAT3	268	271	PF00017	0.485
LIG_SH2_STAT5	140	143	PF00017	0.438
LIG_SH2_STAT5	245	248	PF00017	0.658
LIG_SH2_STAT5	258	261	PF00017	0.336
LIG_SH2_STAT5	265	268	PF00017	0.428
LIG_SH2_STAT5	353	356	PF00017	0.416
LIG_SH2_STAT5	413	416	PF00017	0.401
LIG_SH2_STAT5	48	51	PF00017	0.503
LIG_SH2_STAT5	552	555	PF00017	0.369
LIG_SH2_STAT5	593	596	PF00017	0.355
LIG_SH2_STAT5	79	82	PF00017	0.511
LIG_SH3_2	760	765	PF14604	0.480
LIG_SH3_3	132	138	PF00018	0.558
LIG_SH3_3	153	159	PF00018	0.573
LIG_SH3_3	162	168	PF00018	0.585
LIG_SH3_3	249	255	PF00018	0.525
LIG_SH3_3	604	610	PF00018	0.441
LIG_SH3_3	757	763	PF00018	0.494
LIG_SH3_4	167	174	PF00018	0.657
LIG_SUMO_SIM_anti_2	367	372	PF11976	0.401
LIG_SUMO_SIM_anti_2	749	756	PF11976	0.525
LIG_SUMO_SIM_par_1	369	375	PF11976	0.344
LIG_SUMO_SIM_par_1	544	550	PF11976	0.345
LIG_SUMO_SIM_par_1	749	756	PF11976	0.555
LIG_SUMO_SIM_par_1	823	833	PF11976	0.738
LIG_TRAF2_1	718	721	PF00917	0.622
LIG_TYR_ITIM	540	545	PF00017	0.369
LIG_UBA3_1	643	651	PF00899	0.412
LIG_UBA3_1	709	715	PF00899	0.457
LIG_WRC_WIRS_1	71	76	PF05994	0.291
LIG_WRC_WIRS_1	742	747	PF05994	0.510
LIG_WW_3	762	766	PF00397	0.481
MOD_CDK_SPxxK_3	205	212	PF00069	0.790
MOD_CK1_1	213	219	PF00069	0.768
MOD_CK1_1	335	341	PF00069	0.732
MOD_CK1_1	374	380	PF00069	0.392
MOD_CK1_1	504	510	PF00069	0.463
MOD_CK1_1	547	553	PF00069	0.363
MOD_CK1_1	625	631	PF00069	0.674
MOD_CK1_1	632	638	PF00069	0.550
MOD_CK1_1	682	688	PF00069	0.457
MOD_CK1_1	705	711	PF00069	0.477
MOD_CK1_1	807	813	PF00069	0.630
MOD_CK1_1	830	836	PF00069	0.700
MOD_CK2_1	299	305	PF00069	0.803
MOD_CK2_1	698	704	PF00069	0.683
MOD_CK2_1	724	730	PF00069	0.527
MOD_CK2_1	829	835	PF00069	0.784
MOD_Cter_Amidation	571	574	PF01082	0.485
MOD_DYRK1A_RPxSP_1	251	255	PF00069	0.498
MOD_GlcNHglycan	213	216	PF01048	0.721
MOD_GlcNHglycan	307	310	PF01048	0.742
MOD_GlcNHglycan	345	348	PF01048	0.703
MOD_GlcNHglycan	396	399	PF01048	0.394
MOD_GlcNHglycan	408	411	PF01048	0.385
MOD_GlcNHglycan	570	573	PF01048	0.444
MOD_GlcNHglycan	61	64	PF01048	0.344
MOD_GlcNHglycan	681	684	PF01048	0.487
MOD_GlcNHglycan	704	707	PF01048	0.637
MOD_GlcNHglycan	739	742	PF01048	0.497
MOD_GlcNHglycan	770	773	PF01048	0.673
MOD_GlcNHglycan	777	780	PF01048	0.661
MOD_GlcNHglycan	792	795	PF01048	0.592
MOD_GSK3_1	117	124	PF00069	0.418
MOD_GSK3_1	203	210	PF00069	0.757
MOD_GSK3_1	301	308	PF00069	0.769
MOD_GSK3_1	322	329	PF00069	0.718
MOD_GSK3_1	343	350	PF00069	0.647
MOD_GSK3_1	468	475	PF00069	0.369
MOD_GSK3_1	55	62	PF00069	0.344
MOD_GSK3_1	554	561	PF00069	0.350
MOD_GSK3_1	591	598	PF00069	0.425
MOD_GSK3_1	621	628	PF00069	0.638
MOD_GSK3_1	632	639	PF00069	0.421
MOD_GSK3_1	659	666	PF00069	0.515
MOD_GSK3_1	698	705	PF00069	0.593
MOD_GSK3_1	709	716	PF00069	0.510
MOD_GSK3_1	737	744	PF00069	0.557
MOD_GSK3_1	763	770	PF00069	0.505
MOD_GSK3_1	775	782	PF00069	0.606
MOD_GSK3_1	816	823	PF00069	0.758
MOD_GSK3_1	829	836	PF00069	0.569
MOD_LATS_1	470	476	PF00433	0.369
MOD_N-GLC_1	229	234	PF02516	0.426
MOD_N-GLC_1	439	444	PF02516	0.444
MOD_N-GLC_1	558	563	PF02516	0.344
MOD_N-GLC_2	806	808	PF02516	0.700
MOD_NEK2_1	117	122	PF00069	0.155
MOD_NEK2_1	399	404	PF00069	0.458
MOD_NEK2_1	501	506	PF00069	0.375
MOD_NEK2_1	54	59	PF00069	0.369
MOD_NEK2_1	566	571	PF00069	0.375
MOD_NEK2_1	636	641	PF00069	0.492
MOD_NEK2_1	664	669	PF00069	0.490
MOD_NEK2_1	709	714	PF00069	0.513
MOD_NEK2_1	755	760	PF00069	0.513
MOD_NEK2_1	767	772	PF00069	0.509
MOD_NEK2_1	97	102	PF00069	0.444
MOD_PIKK_1	19	25	PF00454	0.743
MOD_PIKK_1	399	405	PF00454	0.408
MOD_PIKK_1	55	61	PF00454	0.444
MOD_PIKK_1	659	665	PF00454	0.592
MOD_PIKK_1	753	759	PF00454	0.512
MOD_PKA_1	219	225	PF00069	0.693
MOD_PKA_1	521	527	PF00069	0.444
MOD_PKA_1	574	580	PF00069	0.485
MOD_PKA_1	796	802	PF00069	0.793
MOD_PKA_1	820	826	PF00069	0.785
MOD_PKA_2	281	287	PF00069	0.643
MOD_PKA_2	300	306	PF00069	0.713
MOD_PKA_2	377	383	PF00069	0.298
MOD_PKA_2	521	527	PF00069	0.444
MOD_PKA_2	636	642	PF00069	0.514
MOD_PKA_2	735	741	PF00069	0.539
MOD_PKA_2	796	802	PF00069	0.762
MOD_PKA_2	820	826	PF00069	0.744
MOD_Plk_1	229	235	PF00069	0.427
MOD_Plk_1	288	294	PF00069	0.677
MOD_Plk_1	366	372	PF00069	0.444
MOD_Plk_1	374	380	PF00069	0.444
MOD_Plk_1	595	601	PF00069	0.368
MOD_Plk_1	6	12	PF00069	0.704
MOD_Plk_1	830	836	PF00069	0.704
MOD_Plk_2-3	724	730	PF00069	0.539
MOD_Plk_4	263	269	PF00069	0.523
MOD_Plk_4	366	372	PF00069	0.415
MOD_Plk_4	521	527	PF00069	0.434
MOD_Plk_4	625	631	PF00069	0.453
MOD_Plk_4	682	688	PF00069	0.501
MOD_Plk_4	705	711	PF00069	0.482
MOD_ProDKin_1	155	161	PF00069	0.576
MOD_ProDKin_1	205	211	PF00069	0.788
MOD_ProDKin_1	243	249	PF00069	0.568
MOD_ProDKin_1	251	257	PF00069	0.521
MOD_ProDKin_1	547	553	PF00069	0.344
MOD_ProDKin_1	622	628	PF00069	0.594
MOD_ProDKin_1	629	635	PF00069	0.490
MOD_ProDKin_1	797	803	PF00069	0.746
MOD_SUMO_for_1	235	238	PF00179	0.564
MOD_SUMO_rev_2	234	242	PF00179	0.354
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.667
TRG_DiLeu_BaLyEn_6	729	734	PF01217	0.563
TRG_DiLeu_LyEn_5	382	387	PF01217	0.408
TRG_ENDOCYTIC_2	125	128	PF00928	0.389
TRG_ENDOCYTIC_2	140	143	PF00928	0.363
TRG_ENDOCYTIC_2	161	164	PF00928	0.556
TRG_ENDOCYTIC_2	267	270	PF00928	0.440
TRG_ENDOCYTIC_2	413	416	PF00928	0.368
TRG_ENDOCYTIC_2	542	545	PF00928	0.344
TRG_ENDOCYTIC_2	552	555	PF00928	0.344
TRG_ENDOCYTIC_2	79	82	PF00928	0.444
TRG_ER_diArg_1	820	822	PF00400	0.750
TRG_NLS_MonoCore_2	217	222	PF00514	0.695
TRG_NLS_MonoExtC_3	218	223	PF00514	0.718
TRG_NLS_MonoExtC_3	488	493	PF00514	0.366
TRG_NLS_MonoExtN_4	218	224	PF00514	0.751
TRG_NLS_MonoExtN_4	487	493	PF00514	0.366
TRG_Pf-PMV_PEXEL_1	676	681	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSB1	Leptomonas seymouri	65%	66%
A0A0S4J4P7	Bodo saltans	38%	100%
A0A1X0PB49	Trypanosomatidae	47%	100%
A0A3S7X873	Leishmania donovani	92%	99%
A4HB04	Leishmania braziliensis	77%	94%
A4IA60	Leishmania infantum	93%	99%
C9ZM45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B572	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	95%